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Ramin Tajbakhsh et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24(4), 702-706 (2013-07-03)
Chronic renal disorders have a progressive course in most cases, and finally result in end-stage renal disease (ESRD). Hemodialysis (HD) is one of the mainstays in the treatment of these patients. Disturbance in calcium (Ca) and phosphorus (P) metabolism and
Nicholas J D Wright et al.
Invertebrate neuroscience : IN, 15(1), 175-175 (2014-11-09)
The generation of the novel messenger molecule nitric oxide (NO) has been demonstrated in many tissues across phyla including nervous systems. It is produced on demand by the enzyme nitric oxide synthase often stimulated by intracellular calcium and typically affecting
Wencheng Li et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 352-361 (2014-11-26)
We previously reported that binding of prorenin to the (pro)renin receptor (PRR) plays a major role in brain angiotensin II formation and the development of deoxycorticosterone acetate (DOCA)-salt hypertension. Here, we designed and developed an antagonistic peptide, PRO20, to block
Bin Duan et al.
Tissue engineering. Part C, Methods, 21(8), 795-807 (2015-01-17)
Living tissue-engineered heart valves (TEHV) would be a major benefit for children who require a replacement with the capacity for growth and biological integration. A persistent challenge for TEHV is accessible human cell source(s) that can mimic native valve cell
Marie-Lucile Figueres et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 65(1), 122-126 (2014-12-03)
Loss-of-function mutations of CYP24A1, the enzyme that converts the major circulating and active forms of vitamin D to inactive metabolites, recently have been implicated in idiopathic infantile hypercalcemia. Patients with biallelic mutations in CYP24A1 present with severe hypercalcemia and nephrocalcinosis
Todd Scheuer
Handbook of experimental pharmacology, 221, 269-291 (2014-04-17)
Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts. Key elements of
A B Kotliarova et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 27-36 (2014-02-01)
The role of inositol-1,4,5-trisphosphate of (IP3)-sensitive Ca2+ channels in Ca2+ homeostasis maintenance under activation of M-cholinergic receptors and P2Y receptors in the secretory cells of the rat lacrimal gland was investigated. The study was carried out on intact and permeabilized
Jason Karch et al.
PloS one, 10(6), e0130520-e0130520 (2015-06-11)
During apoptosis the pro-death Bcl-2 family members Bax and Bak induce mitochondrial outer membrane permeabilization (MOMP) to mediate cell death. Recently, it was shown that Bax and Bak are also required for mitochondrial permeability transition pore (MPTP)-dependent necrosis, where, in
Byrappa Venkatesh et al.
Nature, 505(7482), 174-179 (2014-01-10)
The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins and immunoglobulin-based adaptive immunity. Gnathostomes subsequently diverged into two groups, the cartilaginous fishes and the bony vertebrates.
M A Lovell et al.
Archives of neurology, 58(3), 392-396 (2001-03-20)
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overlap between patients with AD and control subjects. To determine the ratio
Eric Dubuis et al.
Pain, 155(11), 2408-2417 (2014-09-25)
Complex regional pain syndrome (CRPS) is a limb-confined posttraumatic pain syndrome with sympathetic features. The cause is unknown, but the results of a randomized crossover trial on low-dose intravenous immunoglobulins (IVIG) treatment point to a possible autoimmune mechanism. We tested
Tao Jiang et al.
International journal of pharmaceutics, 475(1-2), 547-557 (2014-09-10)
Delivering drugs specifically to bone tissue is very challenging due to the architecture and structure of bone tissue. Poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) hold great promise for the delivery of therapeutics to bone tissue. The goal of the present research
Bhupesh Mehta et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(18), 6233-6244 (2014-05-03)
Ribbon-type presynaptic active zones are a hallmark of excitatory retinal synapses, and the ribbon organelle is thought to serve as the organizing point of the presynaptic active zone. Imaging of exocytosis from isolated retinal neurons, however, has revealed ectopic release
Sibel Sen Kavurmaci et al.
Environmental technology, 35(17-20), 2389-2400 (2014-08-26)
Application of photocatalysis for degradation of natural organic matter (NOM) has received wide interest during the last decades. Besides NOM, model compounds more specifically humic acids (HAs) were also studied. As a continuation of the previous research, TiO2 photocatalytic degradation
Hui Li et al.
Gene, 551(2), 279-289 (2014-09-10)
The signal transducer and activator of transcription 5a (Stat5a) modulates genes involved in proliferation and survival and plays pivotal roles in regulating the function of the mammary gland during pregnancy, lactation, and involution. However, there is little information about the
Brandie M Cross et al.
American journal of physiology. Cell physiology, 306(6), C515-C526 (2013-11-15)
Breast cancer is the second leading cause of cancer mortality in women, estimated at nearly 40,000 deaths and more than 230,000 new cases diagnosed in the U.S. this year alone. One of the defining characteristics of breast cancer is the
Rajesh Tota-Maharaj et al.
Mayo Clinic proceedings, 89(10), 1350-1359 (2014-09-23)
To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. This is a secondary analysis of data from a prospective, multiethnic, population-based cohort study designed to study subclinical atherosclerosis. A
Grazyna Cichosz et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 35(210), 397-401 (2014-02-05)
Critical theories regarding proteins of anima origin are still and still popularized, though they are ungrounded from scientific point of view. Predominance of soya proteins over the animal ones in relation to their influence on calcium metabolism, bone break risk
Christina J Dreyton et al.
Biochemistry, 53(27), 4426-4433 (2014-07-06)
Citrullination, which is catalyzed by protein arginine deiminases (PADs 1-4 and 6), is a post-translational modification (PTM) that effectively neutralizes the positive charge of a guanidinium group by its replacement with a neutral urea. Given the sequence similarity of PAD2
C A Vodounon et al.
Pakistan journal of biological sciences : PJBS, 16(24), 1873-1883 (2014-02-13)
The emergence of various diseases specifically severe diseases such as bronchial asthma is associated with apoptosis of lymphocytes. One of the major biochemical features of apoptosis is chromosome DNA fragmentation implemented by apoptotic nucleases. The inactivation of these apoptotic nucleases
A H Perera et al.
Annals of the Royal College of Surgeons of England, 96(4), 284-288 (2014-05-02)
The main barriers to short stay thyroidectomy are haemorrhage, bilateral recurrent laryngeal nerve palsy causing respiratory compromise and hypocalcaemia. This study assessed the safety and effectiveness of thyroidectomy as a 23-hour stay procedure. All patients undergoing total or completion thyroidectomy
Heehong Hwang et al.
Biochemical and biophysical research communications, 450(1), 875-879 (2014-06-28)
Imiquimod is an itch-promoting, small, synthetic compound that is generally used to treat genital warts and basal cell carcinoma. The pruritogenic effect of imiquimod is considered to be due to TLR7 activation; however that idea has been challenged by our
Lesley A Wilson et al.
Biochemical and biophysical research communications, 456(1), 398-402 (2014-12-06)
CRACR2A protein is described in T cells as an EF-hand-containing modulator of calcium-release-activated calcium (CRAC) channels. Here we sought relevance to calcium entry of endothelial cells. Unexpectedly, short interfering RNA designed to deplete CRACR2A had no effect on CRAC channels
Asifiqbal Kadari et al.
Stem cell reviews, 11(4), 560-569 (2014-11-14)
Various strategies have been published enabling cardiomyocyte differentiation of human induced pluripotent stem (iPS) cells. However the complex nature of signaling pathways involved as well as line-to-line variability compromises the application of a particular protocol to robustly obtain cardiomyocytes from
Bicheng Yang et al.
Life sciences, 114(2), 70-76 (2014-08-21)
Promoter-targeted small activating RNAs (saRNAs) have been shown to be able to induce target gene expression, a mechanism known as RNA activation (RNAa). The present study tested whether saRNA can induce the overexpression of TRPV5 in human cells derived from
Ryan M Sheehy et al.
Cancer biology & therapy, 16(8), 1259-1268 (2015-06-06)
Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether inhibitors of P-glycoprotein (Pgp), in a manner analogous to other natural products, might enhance schweinfurthins' growth inhibitory actions by increasing intracellular
Refining coronary heart disease event prediction in young and old individuals by coronary artery calcification imaging with computed tomography.
Thomas C Gerber et al.
Mayo Clinic proceedings, 89(10), 1324-1327 (2014-09-23)
Archana Jha et al.
The Journal of cell biology, 202(1), 71-79 (2013-07-03)
Ca(2+) influx by store-operated Ca(2+) channels (SOCs) mediates all Ca(2+)-dependent cell functions, but excess Ca(2+) influx is highly toxic. The molecular components of SOC are the pore-forming Orai1 channel and the endoplasmic reticulum Ca(2+) sensor STIM1. Slow Ca(2+)-dependent inactivation (SCDI)
Jian-ping Jia et al.
Chinese medical journal, 117(8), 1161-1164 (2004-09-14)
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD). The purpose of
Shin'Ichiro Satake et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1462-1474 (2014-01-24)
The concomitant release of multiple numbers of synaptic vesicles [multivesicular release (MVR)] in response to a single presynaptic action potential enhances the flexibility of synaptic transmission. However, the molecular mechanisms underlying MVR at a single CNS synapse remain unclear. Here
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页码 1 来自 12