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Rossana Berardi et al.
Journal of toxicology and environmental health. Part A, 78(1), 1-6 (2014-11-27)
The aim of the study was to determine the potential role of occupational exposures to chromium (Cr) in the onset of extragonadal germinal embryonal carcinoma. The first two cases of workers in a company with Cr exposure are reported. The...
C R Kirman et al.
Chemico-biological interactions, 204(1), 13-27 (2013-04-23)
A multi-compartment physiologically based pharmacokinetic (PBPK) model was developed to describe the behavior of Cr(III) and Cr(VI) in humans. Compartments were included for gastrointestinal lumen, oral mucosa, stomach, small intestinal tissue, blood, liver, kidney, bone, and a combined compartment for...
Petr Tůma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)
Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in...
Poyil Pratheeshkumar et al.
Toxicology and applied pharmacology, 281(2), 230-241 (2014-12-03)
Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with the incidence of lung cancer. Inhibition of metal induced carcinogenesis by a dietary antioxidant is a novel approach. Luteolin, a natural dietary flavonoid found in fruits and vegetables, possesses potent...
M G Medeiros et al.
Mutagenesis, 18(1), 19-24 (2002-12-11)
DNA-protein crosslinks (DPC) are a promising biomarker of exposure to hexavalent chromium, a known human carcinogen. Although trivalent chromium is considered to have much lower toxicity, the risk involved in chronic exposure is uncertain. DPC may be a useful tool...
M Y Khuhawar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 873(1), 15-19 (2008-09-02)
Capillary gas chromatographic (GC) determination of methylglyoxal (MGo) was developed on the basis of precolumn derivatization with 1,2-diaminopropane (DAP) at pH 3. The elution was carried out on an HP-5 (30 m x 0.32 mm i.d.) connected with FID. The...
Regaldo Luciana et al.
Journal of environmental biology, 35(4), 689-697 (2014-07-10)
Chronic toxicity tests were conducted to assess the effect of Cu, Cr and Pb on Moinodaphnia macleayi and Ceriodaphnia dubia -two cladoceran species from the Argentinian Fluvial Littoral Zone (AFLZ)- and Daphnia magna -an holarctic species-. The specimens were exposed...
I Onakpoya et al.
Obesity reviews : an official journal of the International Association for the Study of Obesity, 14(6), 496-507 (2013-03-19)
The increased prevalence of obesity has made the use of dietary supplements as weight reducing agents highly popular, but their efficacy has not been proven. One such supplement is chromium. The purpose of this review was to evaluate the evidence...
Jaime Guevara-Aguirre et al.
Diabetes technology & therapeutics, 9(4), 372-376 (2007-08-21)
The aim of this study was to compare the glucose pharmacodynamics after oral spray insulin (Oral-lyn , Generex Biotechnology, Toronto, ON, Canada) and subcutaneous (sc) injection of regular insulin in 10 subjects with type 1 diabetes mellitus (T1DM). Basal therapy...
Janez Stupar et al.
Metabolism: clinical and experimental, 56(1), 94-104 (2006-12-13)
Longitudinal hair chromium (H-Cr) profiles in a group of patients with type 2 diabetes mellitus (n = 59; age, 62 +/- 9 years) and healthy elderly (control) subjects (n = 49; age, 59 +/- 10 years) matched by age and...
Xin Wang et al.
Toxicology letters, 224(1), 16-23 (2013-10-22)
Insulin resistance is the hallmark of type 2 diabetes. As an essential trace element, selenium (Se) is recommended worldwide for supplementation to prevent Se-deficient pathological conditions, including diabetes and insulin resistance. However, recent evidence has shown that supra-nutritional Se intake...
Marilda Helena Toledo Brandão et al.
Anais brasileiros de dermatologia, 87(2), 269-276 (2012-05-10)
Metals, especially nickel, are the most common contact allergens in children. Recent data has shown increased incidence of allergy in industrialized countries. Sensitization can occur at any age, even in neonates. Costume jewelry, particularly earrings, is linked to increased sensitization...
S J MacDonald et al.
Clinical orthopaedics and related research, (406)(406), 282-296 (2003-02-13)
A prospective, randomized, blinded clinical trial was done to evaluate polyethylene versus metal bearing surfaces in total hip replacement. Forty-one patients were randomized to receive either a metal (23 patients) or a polyethylene (18 patients) insert. The femoral and acetabular...
Jonathon R Campbell et al.
Clinical chemistry and laboratory medicine, 51(1), 213-220 (2012-10-02)
Individuals with advanced hip disease suffer from pain, impaired hip function, and decreased quality of life. Roughly one million metal-on-metal (MoM) hip prostheses have been implanted worldwide in order to ameliorate these issues. While most MoM hip replacements are successful...
Thomas K Fehring et al.
Clinical orthopaedics and related research, 472(2), 517-522 (2013-08-22)
The key to successful management of patients with metal-on-metal (MOM) THAs is to diagnose adverse local tissue reactions (ALTRs) early. ALTRs have been described in asymptomatic patients with resurfacing arthroplasties. Whether this concerning finding applies to modular MOM THAs is...
Yanshuang Song et al.
Toxicology letters, 226(2), 198-205 (2014-02-25)
Our previous epidemiological study revealed that co-exposure of [Cr(VI)] with small amount of heavy metals could induce peripheral blood element imbalance, but little was known about the contribution of Cr(VI) itself and the multi-element distribution profile in other target tissues....
Joanna Burger et al.
Environmental monitoring and assessment, 186(10), 6947-6958 (2014-07-13)
The health of horseshoe crab (Limulus polyphemus) eggs is important not only to maintain horseshoe crab populations, but because they are a resource for higher trophic levels, such as fish and shorebirds. We examined the concentrations of arsenic, cadmium, chromium...
Ying Xie et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31(2-3), 473-485 (2013-04-04)
In the present study, we explored reactive axygen species (ROS) production in mitochondria, the mechanism of hexavalent chromium (Cr(VI)) hepatotoxicity, and the role of protection by GSH. Intact mitochondria were isolated from rat liver tissues and mitochondrial basal respiratory rates...
Erick Aranda-García et al.
Environmental monitoring and assessment, 186(10), 6207-6221 (2014-06-02)
The ability of Quercus crassipes acorn shells (QCS) to remove Cr(VI) and total chromium from aqueous solutions was investigated as a function of the solution pH, ionic strength, and background electrolytes. It was found that Cr(VI) and total chromium removal...
Yana Chervona et al.
Metallomics : integrated biometal science, 4(7), 619-627 (2012-04-05)
Carcinogenic metals, such as nickel, arsenic, and chromium, are widespread environmental and occupational pollutants. Chronic exposure to these metals has been connected with increased risks of numerous cancers and as well as non-carcinogenic health outcomes, including cardiovascular disease, neurologic deficits...
Gintaras Svecevičius et al.
Bulletin of environmental contamination and toxicology, 92(4), 440-445 (2014-03-04)
One-year-old Atlantic salmon smolts were exposed for 2 weeks either to six priority heavy metal mixture or to Ni, Pb, and Cr singly at a concentration corresponding to Lithuanian inland water standards: Cu - 0.01, Zn - 0.1, Ni -...
H M Liebich et al.
Journal of chromatography, 239, 343-349 (1982-04-30)
The endogenous aliphatic alcohols ethanol, n-propanol, n-butanol, isobutanol and isopentanol in serum and urine were measured by gas chromatography-mass fragmentography. Whereas for the higher-molecular-weight alcohols extraction with dichloromethane is used, ethanol is determined by direct injection of serum and urine....
L Kocadereli et al.
The Angle orthodontist, 70(6), 431-434 (2001-01-04)
The purpose of this study was to determine the alterations in the chromium and nickel concentrations in the saliva of orthodontic patients treated with fixed orthodontic appliances. Forty-five orthodontic patients were included in this study. The first group consisted of...
G Toncev et al.
European journal of neurology, 9(3), 221-226 (2002-05-03)
Several findings suggest lower levels of serum uric acid in multiple sclerosis (MS) patients. The aim of this study is to investigate relationships of uric acid serum levels in relapse-remitting (RR) MS patients with clinical activity of disease and blood-brain...
M Torra et al.
Biological trace element research, 70(2), 183-189 (1999-10-27)
Plasma chromium levels were determined in 243 healthy subjects. The study group consisted of 134 men and 109 women, ages 19-71 yr, all residing in Barcelona in northeastern Spain. The study was designed to assess the reference levels for plasma...
Changfeng Ding et al.
Ecotoxicology and environmental safety, 108, 179-186 (2014-07-30)
Soil environmental quality standards in respect of heavy metals for farmlands should be established considering both their effects on crop yield and their accumulation in the edible part. A greenhouse experiment was conducted to investigate the effects of chromium (Cr)...
Shinichiro Mine et al.
Endocrine journal, 53(6), 761-766 (2006-09-13)
Accumulation of hyaluronan (HA) around smooth muscle cells in lesions of atherosclerosis in diabetic patients suggests that this protein plays an important role in diabetic angiopathy. The aim of this study was to determine the correlation between serum HA concentrations...
Hualin Chen et al.
Chemosphere, 112, 412-419 (2014-07-23)
Chromium (Cr) commonly enters the food chain through uptake by vegetables. However, accurate prediction of plant uptake of Cr (and other metals) still remains a challenge. In this study, we evaluated 5 indices of availability for Cr (and other metals)...
Goran Gajski et al.
Biochimica et biophysica acta, 1840(1), 565-576 (2013-10-22)
The main objective of the present study was to investigate chemical composition and possible cyto/genotoxic potential of several medical implant materials commonly used in total hip joint replacement. Medical implant metal alloy (Ti6Al4V and CoCrMo) and high density polyethylene particles...
Erik Wennerberg et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(22), 5733-5744 (2014-09-13)
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive forms of cancer with no curative therapies available. To date, strategies to target ATC by immunotherapy have not been evaluated. We investigated whether ATC would be a suitable target for...
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