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Megan J Kelman et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1805-1810 (2015-09-04)
Many species of Alternaria damage important agricultural crops, including small grains and tomatoes. These fungi can produce a variety of secondary metabolites, some of which are toxic to humans and animals. Interest in screening for conjugated or 'modified' mycotoxins has
M M F Queiroz et al.
Phytochemical analysis : PCA, 26(3), 183-188 (2015-01-27)
Tetrapterys mucronata Cav. (Malpighiaceae) is a plant used in some regions of Brazil in the preparation of ayahuasca. To determine the content of the main tryptamine alkaloids in the stem bark of T. mucronata Cav. and assess their possible toxic
Changtao Jiang et al.
The Journal of clinical investigation, 125(1), 386-402 (2014-12-17)
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine model of high-fat diet-induced (HFD-induced) NAFLD was used, and the effects of alterations in the gut
Elisa A Nickum et al.
Journal of chromatographic science, 53(1), 38-46 (2014-03-29)
A considerable number of erectile dysfunction products, and dietary supplements suspected of containing phosphodiesterase-5 (PDE-5) inhibitors, have been analyzed by the US Food and Drug Administration. Often these samples are found to contain the approved active pharmaceutical ingredients (APIs) such
Chun-Ying Liu et al.
Journal of ginseng research, 39(3), 221-229 (2015-07-23)
Minor ginsenosides, those having low content in ginseng, have higher pharmacological activities. To obtain minor ginsenosides, the biotransformation of American ginseng protopanaxadiol (PPD)-ginsenoside was studied using special ginsenosidase type-I from Aspergillus niger g.848. DEAE (diethylaminoethyl)-cellulose and polyacrylamide gel electrophoresis were
Athanasios K Anagnostopoulos et al.
Journal of proteome research, 14(2), 1076-1088 (2014-12-30)
CNS tumors are the leading cause of cancer-related death in children. Medulloblastoma is the commonest pediatric CNS malignancy, wherein, despite multimodal therapy with surgery, radiation, and chemotherapy, 5 year survival rates merely approach 60%. Until present, gene expression and cytogenetic
Habib Bagheri et al.
Analytica chimica acta, 886, 56-65 (2015-09-01)
A nanocomposite of silica-polydiphenylamine doped with silver nanoparticles (Ag-SiO2-PDPA) was successfully synthesized by the sol-gel process. For its preparation, PDPA was mixed with butanethiol capped Ag nanoparticles (NPs) and added to the silica sol solution. The Ag NPs were stabilized
Anna Smolira et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1811-1816 (2015-09-04)
The PR-39 porcine cathelicidin occurs naturally in animal neutrophils. Its main function is antimicrobial activity, which potentially can be used in antibiotic treatments in veterinary medicine. Investigations concerning such a use require the detection and quantification of PR-39 in a
G Groeneveld et al.
Scientific reports, 5, 11716-11716 (2015-06-30)
Despite the proven capabilities of Matrix Assisted Laser Desorption Ionisation Mass Spectrometry (MALDI MS) in laboratory settings, research is still needed to integrate this technique into current forensic fingerprinting practice. Optimised protocols enabling the compatible application of MALDI to developed
Cai Tie et al.
Journal of pharmaceutical and biomedical analysis, 111, 14-20 (2015-04-02)
Oligosaccharides, which exist widely in herbs, present diverse important pharmacological activities. However, the complexity of oligosaccharides seriously challenges their profiling, quality control, and elucidation of activity. In this paper, a novel oligosaccharide analytical method based on a new derivatization pretreatment
Jessica Quijada et al.
Journal of agricultural and food chemistry, 63(28), 6346-6354 (2015-06-13)
Plants containing condensed tannins (CTs) may hold promise as alternatives to synthetic anthelmintic (AH) drugs for controlling gastrointestinal nematodes (GINs). However, the structural features that contribute to the AH activities of CTs remain elusive. This study probed the relationships between
X Y Chen et al.
Poultry science, 94(11), 2597-2603 (2015-10-11)
Cold stress triggers an anti-oxidative response in animals regulated by Nrf2 (nuclear factor 2-like, NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes. To identify chicken Nrf2-regulated genes, 3 genetically related experimental groups (EG) with 40 Huainan partridge chickens in
Juan C Domínguez-Romero et al.
Journal of chromatography. A, 1361, 34-42 (2014-08-21)
Sample preparation is a critical step in large-scale multiclass analysis such as sport drug testing. Due to the wide heterogeneity of the analytes and the complexity of the matrix, the selection of a correct sample preparation method is essential, looking
Andrew R S Ross et al.
Analytica chimica acta, 889, 147-155 (2015-09-08)
Polyethoxylated tallow amine (POEA) surfactants have been used in many glyphosate-based herbicide formulations for agricultural, industrial and residential weed control. The potential for release of these compounds into the environment is of increasing concern due to their toxicity towards aquatic
Wei Ye et al.
Journal of separation science, 38(13), 2340-2347 (2015-04-18)
This study provided a novel and generally applicable method to determine ziyuglycoside I and ziyuglycoside II in rat plasma based on liquid chromatography with tandem mass spectrometry. A single step of liquid-liquid extraction with n-butanol was utilized, and ginsenoside Rg3 was chosen as internal
Volker Strenger et al.
The Journal of antimicrobial chemotherapy, 69(9), 2522-2526 (2014-06-04)
Although amphotericin B (AmB) and its lipid formulations are used for the treatment of fungal infections of the CNS, the kinetics of AmB in the CSF after intravenous administration of liposomal amphotericin B (LAmB) are not well characterized. From 14
Yuanyan Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 90-98 (2014-06-20)
Frankincense resins are extensively used as natural remedies in regions ranging from North Africa to China. Triterpenoid metabolites from frankincense exhibit notable anti-inflammatory and anti-tumor properties. In the present paper, without the use of an isolation process, the fragmentation rules
Natalia Karna et al.
Biopolymers, 104(3), 206-212 (2015-04-24)
Recently, we described a process of trypsin-assisted peptide splicing of analogs of trypsin inhibitor SFTI-1, that seems to be very similar to proteasome-catalyzed peptide splicing. Here, we show, for the first time, that a peptide-peptoid hybrid (peptomer) can also be
Victor K Langsi et al.
Journal of chromatography. A, 1402, 17-26 (2015-06-02)
Nanometer control over the porous shell thickness of sub-2-μm-shell particles is investigated. Three seeded growth mesoporous thin shell particles for HPLC were prepared, with 0.05μm (or 50nm) porous shell layers: particle sizes 1.5μm (solid core diameters 1.4μm), 1.7μm (solid core
Verónica S Mary et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 75, 104-111 (2014-12-03)
Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) are mycotoxins widely found as cereal contaminants and their co-occurrence in corn has been associated with a high incidence of liver cancer. Both toxins are immunotoxic, with AFB1 being a procarcinogen, and its
Fei Yang et al.
Journal of chromatographic science, 52(8), 788-792 (2013-07-28)
A liquid chromatography-tandem quadrupole mass spectrometry (LC-MS-MS) multi-residue method for the simultaneous target analysis of a wide range of pesticides in tobacco has been developed. Gradient elution has been used in conjunction with positive mode electrospray ionization tandem mass spectrometry
Annette M Hormann et al.
PloS one, 9(10), e110509-e110509 (2014-10-23)
Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone's urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is
Renu Chadha et al.
Pharmaceutical research, 31(9), 2479-2489 (2014-04-23)
The present work aims at improving the physicochemical properties of hydrochlorothiazide, a poorly water soluble antihypertensive drug by preparing its multi-component crystals with nicotinic acid (HCT-NA) and 2-picolinic acid (HCT-PIC). The crystals prepared by solution crystallization were investigated by thermoanalytical
Jon Draher et al.
Journal of chromatography. A, 1373, 106-113 (2014-12-02)
A method for the rapid quantification of 9 potential nitrogen-rich economic adulterants (dicyandiamide, urea, biuret, cyromazine, amidinourea, ammeline, amidinourea, melamine, and cyanuric acid) in five milk and soy derived nutritional ingredients, i.e. whole milk powder, nonfat dry milk, milk protein
Angelique Vandemoortele et al.
Journal of agricultural and food chemistry, 63(23), 5694-5701 (2015-05-29)
The impact of temperature, emulsifier, and protein type on the reactivity of malondialdehyde in oil-in-water emulsions was elucidated. Malondialdehyde recoveries in aqueous buffer, protein solutions, saturated oil, and fully hydrogenated coconut oil-in-water emulsions stabilized by whey proteins or Tween 20
Lijuan Su et al.
Rapid communications in mass spectrometry : RCM, 28(11), 1265-1272 (2014-04-25)
Monitoring the concentrations of pharmaceuticals and personal care products (PPCPs) in wastewater is an integral step toward understanding the fate of these contaminants in wastewater treatment plants (WWTPs). This paper aims to develop a method that allows for the simultaneous
Roshan M Borkar et al.
Journal of pharmaceutical and biomedical analysis, 102, 386-399 (2014-12-03)
Fidarestat, an aldose reductase inhibitor, has been used for the treatment of the diabetic associated complications such as retinopathy, neuropathy and nephropathy. To better understand the metabolism and pharmacokinetics of fidarestat, we have evaluated plasma protein binding, pharmacokinetics, tissue distribution
Zhi-Ying Teng et al.
Scientific reports, 5, 15592-15592 (2015-10-30)
Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is severely limited by serious side effects, of which nephrotoxicity is the most important. In this study, we investigated whether Qiong-Yu-Gao (QYG), a popular traditional Chinese medicinal formula
Marion Girod et al.
PloS one, 9(7), e101642-e101642 (2014-07-08)
Accumulation of oxidative damage in proteins correlates with aging since it can cause irreversible and progressive degeneration of almost all cellular functions. Apparently, native protein structures have evolved intrinsic resistance to oxidation since perfectly folded proteins are, by large most
Gomathinayagam Ponniah et al.
Analytical chemistry, 87(5), 2718-2726 (2015-02-04)
Oligosaccharides are critical for structural integrity, stability, and biological functions of recombinant monoclonal antibodies. It is relatively easy to characterize, quantify, and determine the impact of major glycoforms. While challenging to detect and quantify, certain low abundance oligosaccharides are highly
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页码 1 来自 185