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Marcian E Van Dort et al.
Bioorganic & medicinal chemistry, 23(7), 1386-1394 (2015-03-15)
The MAP kinase (Ras/MEK/ERK) and PI3K/Akt/mTOR oncogenic signaling pathways are central regulators of KRAS-mediated transformation. Molecular reciprocity between the Ras/MEK/ERK and PI3K/Akt/mTOR pathways provides cancer cells with the ability to evade treatment when targeting only one pathway with monotherapy. Multi-kinase
Kengo Kanazaki et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(8), 2051-2060 (2015-08-05)
Photoacoustic (PA) imaging is a promising imaging modality that provides biomedical information with high sensitivity and resolution. Iron oxide nanoparticles (IONPs) have been regarded as remarkable PA contrast agents because of their low toxicity and biodegradable properties. However, IONP delivery
Leland L Black et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4685-4698 (2015-10-16)
Apolipoprotein (Apo)A-I, the major lipid-binding protein of high-density lipoprotein, can prevent autoimmunity and suppress inflammation in hypercholesterolemic mice by attenuating lymphocyte cholesterol accumulation and removing tissue-oxidized lipids. However, whether ApoA-I mediates immune-suppressive or anti-inflammatory effects under normocholesterolemic conditions and the
Elisa A Nickum et al.
Journal of chromatographic science, 53(1), 38-46 (2014-03-29)
A considerable number of erectile dysfunction products, and dietary supplements suspected of containing phosphodiesterase-5 (PDE-5) inhibitors, have been analyzed by the US Food and Drug Administration. Often these samples are found to contain the approved active pharmaceutical ingredients (APIs) such
D R Ceratti et al.
Nanoscale, 7(12), 5371-5382 (2015-02-28)
Capillary phenomena governing the mass-transport (capillary filling, condensation/evaporation) has been experimentally investigated in around 20 different silica thin films exhibiting various porosities with pores dimension ranging from 2 to 200 nm. Films have been prepared by sol-gel chemistry combined with
Akihiro Ishiwata et al.
Chembiochem : a European journal of chemical biology, 16(5), 731-737 (2015-02-18)
The oligosaccharyltransferase PglB from Campylobacter jejuni catalyses the N-glycosylation reaction with undecaprenyl-pyrophosphate-linked Glc1 GalNAc5 Bac1 (Und-PP-Glc1 GalNAc5 Bac1 ). Experiments using chemically synthesized donors coupled to fluorescently tagged peptides confirmed that biosynthetic intermediate Und-PP-Bac1 and Und-PP-GalNAc2 Bac1 are transferred efficiently
Josep Anton Mir-Tutusaus et al.
The Science of the total environment, 500-501, 235-242 (2014-09-15)
Use of agrochemicals is a worldwide practice that exerts an important effect on the environment; therefore the search of approaches for the elimination of such pollutants should be encouraged. The degradation of the insecticides imiprothrin (IP) and cypermethrin (CP), the
Ángela Martínez-García et al.
Microbial ecology, 70(4), 1024-1033 (2015-06-17)
Oily secretions produced in the uropygial gland of incubating female hoopoes contain antimicrobial-producing bacteria that prevent feathers from degradation and eggs from pathogenic infection. Using the beak, females collect the uropygial gland secretion and smear it directly on the eggshells
Mohammed Auwal Ibrahim et al.
Acta poloniae pharmaceutica, 70(4), 709-719 (2013-08-08)
The present study was conducted to investigate the anti-oxidative activities of different solvent extracts of Cassia singueana parts. Our results indicate that all the extracts have reducing power (Fe3+ --> Fe2+) and DPPH radical scavenging abilities. However, the ethyl acetate
Klaus Gerwert et al.
Biochimica et biophysica acta, 1837(5), 606-613 (2013-09-24)
Protein-bound internal water molecules are essential features of the structure and function of microbial rhodopsins. Besides structural stabilization, they act as proton conductors and even proton storage sites. Currently, the most understood model system exhibiting such features is bacteriorhodopsin (bR).
Esther Nkuipou-Kenfack et al.
Oncotarget, 6(33), 34106-34117 (2015-10-03)
To assess normal and pathological peptidomic changes that may lead to an improved understanding of molecular mechanisms underlying ageing, urinarypeptidomes of 1227 healthy and 10333 diseased individuals between 20 and 86 years of age were investigated. The diseases thereby comprised
Stephen Estes et al.
Developmental neurobiology, 75(5), 435-451 (2014-09-25)
The electrical activity in developing and mature neurons determines the intracellular calcium concentration ([Ca(2+)]i), which in turn is translated into biochemical activities through various signaling cascades. Electrical activity is under control of neuromodulators, which can alter neuronal responses to incoming
Sebastien Trachsel et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(6), 768-775 (2015-01-01)
Inhaled nitric oxide (INO) improves ventilation-perfusion matching and alleviates pulmonary hypertension in patients with acute respiratory distress syndrome. However, outcome has not yet been shown to improve, and nonresponse is common. A better understanding of the mechanisms by which INO
Izabela Laczmanska et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12397-12401 (2014-09-10)
The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D. VDR response has been found to play a role in various
Buzhu Yu et al.
Phytochemistry, 108, 77-86 (2014-10-14)
The remodelling of membrane lipids contributes to the tolerance of plants to stresses, such as freezing and deprivation of phosphorus. However, whether and how this remodelling relates to tolerance of PEG-induced osmotic stress has seldom been reported. Thellungiella salsuginea is
Asya Akbar et al.
International journal of food microbiology, 188, 116-121 (2014-08-12)
Two new species of Aspergillus (A. aculeatinus, A. sclerotiicarbonarius) were previously isolated from coffee in Thailand. The objective of this study was to examine the effect of interacting environmental factors of water availability (water activity, aw) and temperature on lag
Chieh-Jui Tsou et al.
Nanoscale, 7(9), 4217-4225 (2015-02-13)
Continuous and simultaneous 3D single-particle movement and local pH detection in HeLa cells were demonstrated for the first time by combining fluorescent mesoporous silica nanoparticles (FMSNs) and a single-particle tracking (SPT) technique with a precision of ∼10 nm. FMSNs, synthesized
José Zorzin et al.
The journal of adhesive dentistry, 16(6), 541-546 (2014-12-18)
To evaluate the bonding performance of self-adhesive resin cements to zirconia and lithium disilicate in self- and dual-curing modes before and after thermocycling. Rectangular bars (3 mm high, 3 mm wide, 9 mm long) were manufactured from zirconia (Vita In-Ceram
Should water precautions be recommended for children with tympanostomy tubes?
Lyndy J Wilcox et al.
The Laryngoscope, 124(1), 10-11 (2013-12-07)
Bjoern Traenkle et al.
Molecular & cellular proteomics : MCP, 14(3), 707-723 (2015-01-18)
β-catenin is the key component of the canonical Wnt pathway and plays a crucial role in a multitude of developmental and homeostatic processes. The different tasks of β-catenin are orchestrated by its subcellular localization and participation in multiprotein complexes. To
James W Wynne et al.
Genome biology, 15(11), 532-532 (2014-11-16)
Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics
Yi Li et al.
SpringerPlus, 4, 637-637 (2015-11-07)
CYP3A5 and ABCB1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements, but the conclusion in the current reports were inconformity. Sirolimus are also metabolized by CYP3A subfamily and are substrates of the P-gp. The aim was
A Overbeck et al.
Letters in applied microbiology, 61(4), 333-338 (2015-07-21)
Industrial biotechnology uses microbiological cells to produce a wide range of products. While the organisms in question are well understood regarding their genetic and molecular properties, less is known about their mechanical properties. Previous work has established a testing procedure
Lucio Isa
Chimia, 67(4), 231-235 (2013-08-24)
Since the seminal work of Pickering and Ramsden more than a century ago, adsorption of solid micro- and nanoparticles at the interface between two fluids has been recognized as a means to enormously improve emulsion stability against coalescence. Despite their
Sorina Motoc et al.
Journal of environmental sciences (China), 25(4), 838-847 (2013-08-09)
This work describes the electrochemical behaviour of ibuprofen on two types of multi-walled carbon nanotubes based composite electrodes, i.e., multi-walled carbon nanotubes-epoxy (MWCNT) and silver-modified zeolite-multi-walled carbon nanotubes-epoxy (AgZMWCNT) composites electrodes. The composite electrodes were obtained using two-roll mill procedure.
Anne-Coline Laurent et al.
Cardiovascular research, 105(1), 55-64 (2014-11-21)
Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activated by cAMP 1 (Epac1)-induced hypertrophy in primary cardiomyocytes. Among the
Shaoyin Wang et al.
Organic letters, 16(13), 3592-3595 (2014-06-25)
A novel Lewis acid catalyzed dehydrative [3 + 3]-annulation of readily available benzylic alcohols and propargylic alcohols was developed to give polysubstituted carbazoles and naphthalenes in moderate to good yields with water as the only byproduct. The reaction was presumed
Fanbin Meng et al.
International journal of oncology, 46(3), 1109-1120 (2014-12-17)
CCL18 is a chemokine that is primarily expressed in monocytes, macrophages and immature dendritic cells and plays a crucial role in immune and inflammation responses. Recently, CCL18 was found to play pivotal roles in the development of several kinds of
Bo-Ram Kim et al.
Tissue engineering. Part A, 20(23-24), 3279-3289 (2014-06-18)
To confirm the effect of recombinant human bone morphogenetic protein-2 (BMP-2) for bone regeneration, BMP-2-loaded polycaprolactone (PCL)-gelatin (Gel)-biphasic calcium phosphate (BCP) fibrous scaffolds were fabricated using the electrospinning method. The electrospinning process to incorporate BCP nanoparticles into the PCL-Gel scaffolds
Rachel Parke-Houben et al.
Journal of materials science. Materials in medicine, 26(2), 107-107 (2015-02-11)
Three-dimensional scaffolds based on inverted colloidal crystals (ICCs) were fabricated from sequentially polymerized interpenetrating polymer network (IPN) hydrogels of poly(ethyleneglycol) and poly(acrylic acid). This high-strength, high-water-content IPN hydrogel may be suitable for use in an artificial cornea application. Development of
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