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Rebekka Hueting et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 128-134 (2013-12-18)
(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clinically as a PET agent both for delineation of tumor hypoxia and as an effective indicator of patient prognosis, but there are still aspects of the mechanism of action that are not fully understood.
R Shukla et al.
The International journal of neuroscience, 116(12), 1391-1402 (2006-12-06)
Evidence from clinical and experimental studies supports the hypothesis of free radical-mediated damage of dopaminergic neurons in the pathology of Parkin's disease (PD). The present study was undertaken to evaluate the role of nitric oxide and oxidative stress in PD.
Huma Khalid et al.
Mini reviews in medicinal chemistry, 13(13), 1944-1956 (2013-09-28)
Free radicals or reactive oxygen species (ROS) are highly toxic and their damaging effects result in a variety of detrimental health issues such as neurodegenerative, cardiovascular and age-related diseases. Human body has evolved an effective defense system including superoxide dismutase
Donita C Brady et al.
Nature, 509(7501), 492-496 (2014-04-11)
The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and
Tjaard Ubbo Hoogenraad
Brain & development, 28(3), 141-146 (2006-02-10)
Zinc therapy has replaced penicillamine as first-line therapy for Wilson's disease. New guidelines reflect the paradigm shift in treatment that has occurred in recent years. In the old paradigm, Wilson's disease was seen as genetic disorder associated with the accumulation
Collin D Kraus et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 145(5), 655-666 (2014-05-03)
The purpose of this study was to evaluate the biologic response of dentoalveolar bone to archwire expansion with light-to-moderate continuous forces. With a split-mouth experimental design, the maxillary right second premolars of 7 adult male dogs were expanded for 9
Yaser A Almaroai et al.
Environmental technology, 34(5-8), 747-755 (2013-07-11)
Kinetic aspects of metal release were investigated to understand the effects of synthetic chelating agents (EDTA, EDDS and NTA) and low molecular weight (LMW) organic acids (oxalic and citric acids) on the release kinetics of Cr, Cu and As in
Wei-Dan Jiang et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 301-313 (2014-08-05)
The brain is the center of the nervous system in all vertebrates, and homeostasis of the brain is crucial for fish survival. Copper (Cu) is essential for normal cellular processes in most eukaryotic organisms but is toxic in excess. Although
Ana Primo et al.
Nature communications, 6, 8561-8561 (2015-10-29)
Metal oxide nanoparticles supported on graphene exhibit high catalytic activity for oxidation, reduction and coupling reactions. Here we show that pyrolysis at 900 °C under inert atmosphere of copper(II) nitrate embedded in chitosan films affords 1.1.1 facet-oriented copper nanoplatelets supported
Parthasarathi Chakraborty et al.
Environmental pollution (Barking, Essex : 1987), 194, 138-144 (2014-08-12)
The current study aims to understand the speciation and fate of Cu complexes in hydrothermally altered sediments from the Central Indian Ocean Basin and assess the probable impacts of deep-sea mining on speciation of Cu complexes and assess the Cu
Teaching NeuroImages: Menkes kinky hair syndrome.
Roopa Seshadri et al.
Neurology, 81(2), e12-e13 (2013-07-10)
Tony I Venelinov et al.
Analytical and bioanalytical chemistry, 379(5-6), 777-780 (2004-03-03)
A method based on dialysis in the presence of histidine, and subsequent copper adsorption and preconcentration using Chelex-100 resin, has been developed for selective extraction of exchangeable copper from blood plasma. The method was verified by comparative analysis using two
Nina Dib et al.
European journal of gastroenterology & hepatology, 18(1), 43-47 (2005-12-17)
We report the coexistence of Wilson's disease and genetic haemochromatosis in one family. The diagnosis of genetic haemochromatosis was established in a 52-year-old man. Among his siblings, one 57-year-old sister and one 55-year-old brother had decreased copper and ceruloplasmin levels
Y Kotake et al.
Journal of neurochemistry, 65(6), 2633-2638 (1995-12-01)
1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls
D A Loeffler et al.
Journal of neural transmission. Parkinson's disease and dementia section, 9(1), 45-53 (1995-01-01)
Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease (PD), CSF HVA is normal in mildly affected patients. To explore why, we measured DA and its
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite
Ahmad El Hajj et al.
Journal of nanoscience and nanotechnology, 13(7), 5227-5232 (2013-08-02)
The development of indium-free transparent conductive oxides (TCOs) on polymer substrates for flexible devices requires deposition at low temperatures and a limited thermal treatment. In this paper, we investigated the optical and electrical properties of ZnO/Cu/ZnO multi-layer electrodes obtained by
A Gomiero et al.
Environmental pollution (Barking, Essex : 1987), 194, 262-271 (2014-08-29)
Trace metals and broad-spectrum antibiotic drugs are common environmental contaminants, the importance of which is increasing due to global climate change-related effects. In the present study, the biological model organism E. crassus was first acclimated to five temperatures, from 25 °C to
Seiko Ishida et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19507-19512 (2013-11-13)
Copper is an essential trace element, the imbalances of which are associated with various pathological conditions, including cancer, albeit via largely undefined molecular and cellular mechanisms. Here we provide evidence that levels of bioavailable copper modulate tumor growth. Chronic exposure
R Squitti et al.
Neurology, 67(1), 76-82 (2006-07-13)
To assess whether serum copper in Alzheimer disease (AD) correlates with cognitive scores, beta-amyloid, and other CSF markers of neurodegeneration. The authors studied copper, ceruloplasmin, total peroxide, and antioxidants levels (TRAP) in serum; beta-amyloid in plasma; and copper, beta-amyloid, h-tau
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal
David L Choveaux et al.
Experimental parasitology, 148, 30-39 (2014-12-03)
Copper is an essential micronutrient for all living organisms as an important catalytic co-factor for key enzymes. In higher eukaryotes intracellular copper is distributed by copper metallochaperones. Copper chelators such as neocuproine and tetrathiomolybdate inhibit Plasmodium falciparum erythrocytic development, indicating
A Matsui et al.
Journal of clinical pathology, 35(9), 1011-1017 (1982-09-01)
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin
Fabio Perlatti et al.
The Science of the total environment, 500-501, 91-102 (2014-09-14)
The potentially hazardous effects of rock wastes disposed at open pit in three different areas (Pr: Ore processing; Wr: Waste rock and Bd: Border) of an abandoned copper mine were evaluated in this study, with emphasis on acid drainage generation
Zhiguo Pei et al.
Environmental pollution (Barking, Essex : 1987), 184, 579-585 (2013-11-10)
Effects of copper (Cu) and aluminum (Al) on the adsorption of sulfathiazole (STZ) and tylosin (T) to peat and soil were investigated using a batch equilibration method. Results show that Cu suppressed STZ adsorption onto peat and soil at pH < 5.0
H Kodama et al.
Journal of inherited metabolic disease, 28(6), 971-978 (2006-01-26)
Menkes disease (MD) is a neurodegenerative disorder characterized by a copper deficiency in the brain. It is caused by the defective intestinal absorption of copper resulting from a deficiency of a copper-transporting ATPase, ATP7A. This gives rise to an accumulation
Miao Chen et al.
Journal of environmental sciences (China), 25(9), 1865-1873 (2014-02-14)
Biogas residue (BR) is widely used as a new green fertilizer in agriculture in China. However, it often contains a high concentration of heavy metals so its application should cause our concern. An incubation experiment was conducted to study the
Dongsoo Kim et al.
Journal of nanoscience and nanotechnology, 13(11), 7581-7585 (2013-11-20)
A special sort of laser methods such as direct writing of metal and thin film deposition from liquid precursors was developed for the surface processing and the localized metallization of different kinds of materials. Laser radiation initiates the chemical reaction
Lihong Zhu et al.
Journal of nanoscience and nanotechnology, 13(7), 5104-5108 (2013-08-02)
Improving photocatalytic activity and stability of TiO2/Cu2O composite is a challenge in generating hydrogen from water. In this paper, the TiO2 film/Cu2O microgrid composite was prepared via a microsphere lithography technique, which possesses a remarkable performance of producing H2 under
Jie Zhang
Journal of environmental sciences (China), 25(11), 2331-2337 (2014-02-21)
Thiosemicarbazide-grafted multi-walled carbon nanotubes were prepared and employed to investigate the pre-concentration of Cd(II), Cu(II) and Pb(II) from aqueous solution prior to their determination by ICP-OES. The resulting material was characterized by FT-IR, TGA and SEM. Various factors influencing the
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