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Shufan Ge et al.
Journal of agricultural and food chemistry, 63(11), 2902-2910 (2015-02-27)
Chrysin, a flavone found in many plants, is also available as a dietary supplement because of its reported anticancer activities. However, its bioavailability is very poor due to extensive phase II metabolism. The purpose of this study was to develop
Luís R Silva et al.
Asian Pacific journal of tropical medicine, 8(11), 889-897 (2015-11-29)
To improve the knowledge on the metabolite composition of Endopleura uchi bark, concerning phenolic compounds, and to evaluate some of its biological capacities for further possible exploitation in food and pharmaceutical industries associated to their health-promoting qualities. Two different extracts
Wilfried Jonkers et al.
PLoS genetics, 10(11), e1004783-e1004783 (2014-11-21)
Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC-1, MEK-2 and MAK-2. During chemotrophic growth in germlings, the MAP kinase cascade
Jie Qu et al.
Journal of environmental management, 161, 350-357 (2015-07-24)
Long term residues of organochlorine pesticides (OCPs) in soils are of great concerning because they seriously threaten food security and human health. This article focuses on isolation of OCP-degrading strains and their performance in bioremediation of contaminated soil under ex
Pauline M Snijder et al.
Nitric oxide : biology and chemistry, 42, 87-98 (2014-12-03)
Hypertension and proteinuria are important mediators of renal damage. Despite therapeutic interventions, the number of patients with end stage renal disease steadily increases. Hydrogen sulfide (H(2)S) is an endogenously produced gasotransmitter with vasodilatory, anti-inflammatory and antioxidant properties. These beneficial characteristics
Zhuo Qu et al.
Journal of ethnopharmacology, 155(1), 203-212 (2014-06-15)
Wei-Chang-An pill (WCA pill), a traditional Chinese medicine, has been used for treating various gastrointestinal diseases for several decades. Despite the popular medicinal use of WCA pill, less data was available to its activity and mechanism in gastrointestinal disorders. To
Annette R Rowe et al.
Applied microbiology and biotechnology, 99(5), 2313-2327 (2014-12-04)
To better understand the quantitative relationships between messenger RNA (mRNA) and protein biomarkers relevant to bioremediation, we quantified and compared respiration-associated gene products in an anaerobic syntrophic community. Respiration biomarkers for Dehalococcoides, an organohalide reducer, and Methanospirillum, a hydrogenotrophic methanogen
Liru Song et al.
Proteomics, 15(11), 1884-1905 (2015-02-03)
Thermosensitive genic male sterile (TGMS) rice line has made great economical contributions in rice production. However, the fertility of TGMS rice line during hybrid seed production is frequently influenced by low temperature, thus leading to its fertility/sterility alteration and hybrid
Raquel Garcia et al.
Journal of separation science, 38(7), 1204-1212 (2015-02-07)
Aiming to implement an analytical methodology that is highly selective for the extraction and quantification of terbuthylazine from olive oil, we successfully achieved: (i) the development of a molecularly imprinted polymer by bulk polymerization using terbuthylazine as template molecule, methacrylic
Aihua Zhang et al.
Food & function, 6(11), 3540-3549 (2015-08-25)
Limonin has been found to possess significant anti-inflammatory properties in animal tests and with, human cells, however, its precise metabolism mechanism has not been well explored. The aim of this study was to investigate the anti-inflammatory effects of limonin in
Zhi-li Guo et al.
Acta pharmacologica Sinica, 36(6), 748-757 (2015-05-06)
To determine how the relative amino acid contents and metabolic pathways regulate the pharmacological phenotypes in rats with cerebral ischemia after treatment with varying doses of DanHong injection (DHI). Adult male rats underwent middle cerebral artery occlusion (MCAO), and were
Fazli Nasir et al.
Drug development and industrial pharmacy, 40(11), 1503-1508 (2013-08-30)
The objective of the current work was to develop and evaluate thermoreversible subcutaneous drug delivery system for Insulin. Thermoreversible in-situ gel system was developed and evaluated both in-vitro and in-vivo comprising of pluronic F-127 alone or in combination with methylcellulose
Jiake He et al.
Molecular pharmaceutics, 11(8), 2745-2754 (2014-06-25)
A novel positron emission tomography (PET) tracer, [(11)C]-rosuvastatin (RSV), was developed to dynamically and noninvasively measure hepatobiliary transport and tissue distribution of [(11)C]-RSV in rats. Male Sprague-Dawley rats were administered either an Oatp inhibitor, rifampin (RIF, 40 mg/kg iv bolus
Wenping Tang et al.
Journal of agricultural and food chemistry, 63(44), 9722-9728 (2015-10-23)
The hepatoprotective activities of two different extracts, a hydroethanolic crude bulb extract (CB) and a steroidal glycoside-rich 1-butanol extract (BuOH), prepared from the bulbs of Easter lily (Lilium longiflorum Thunb.), were evaluated in a 24 week study in the female
Giovanni García-Morales et al.
Archives of pharmacal research, 38(7), 1369-1379 (2015-03-06)
Bouvardia ternifolia has been used medicinally to treat inflammation. In the present study, we investigate the anti-Alzheimer's potential effect of the hydroalcoholic extract of B. ternifolia through evaluation of anti-inflammatory and antioxidant activities, quantification of the percentage inhibition of acetylcholinesterase
C A Ledesma-Escobar et al.
Journal of mass spectrometry : JMS, 50(11), 1196-1205 (2015-10-28)
Eighty four metabolites (32 flavonoids, 15 amino acids, nine carboxylic acids, six coumarins, six sugars, five phenolic acids and 11 unclassified compounds) have been tentatively identified in a polar extract from lemon, without reference standards, based on their liquid chromatography-quadrupole-time-of-flight
Paulo Cicero Nascimento et al.
Journal of separation science, 38(13), 2238-2244 (2015-04-18)
An analytical method using liquid chromatography coupled to mass spectrometry with atmospheric pressure chemical ionization for the determination of polycyclic aromatic hydrocarbons in asphalt fractions has been developed. The 14 compounds determined, characterized by having two or more condensed aromatic
Hongbin Liu et al.
Journal of pharmaceutical and biomedical analysis, 109, 142-149 (2015-03-17)
RP-HPLC has been demonstrated as a powerful tool to study antibody free thiol and disulfide variants. Recently, the introduction of UHPLC columns with wide pore size (300Å) and small particle size (1.7μm) offered the opportunity to further improve the separation
Chrysoula Gousiadou et al.
Phytochemistry, 115, 171-174 (2015-02-18)
In our continued investigation of plants from the family Oleaceae we have now investigated Picconia azorica endemic to the Azores. Like most species within the family it contains the oleoside-based secoiridoid glucosides ligstroside and oleuropein as the main compounds and
Matthias Schwebe et al.
Biochemical pharmacology, 94(2), 109-129 (2015-02-11)
The clinical efficiency of the highly potent antitumor agent doxorubicin is limited by cardiotoxic effects. In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET-1) expression and cardioprotective effects of the dual ET-1 blocker bosentan were demonstrated. To date it is
Libo Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1004, 37-45 (2015-10-08)
Penehyclidine hydrochloride (PHC) is an anticholinergic drug with both antimuscarinic and antinicotinic activity. In order to compare the pharmacokinetics of two administration routes (intravenous injection (i.v.) and intramuscular injection (i.m.)) of PHC, an improved High Performance Liquid Chromatography Tandem Mass
B Gómara et al.
Journal of chromatography. A, 1423, 86-95 (2015-11-11)
The retention behavior of nine MPAEs has been studied, using commercial LC columns with octadecylsilane (ODS), phenyl, and amide-type SPs. First, it was found that the use of methanol in the mobile phase is not advisable, because induce a transesterification
Leland L Black et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4685-4698 (2015-10-16)
Apolipoprotein (Apo)A-I, the major lipid-binding protein of high-density lipoprotein, can prevent autoimmunity and suppress inflammation in hypercholesterolemic mice by attenuating lymphocyte cholesterol accumulation and removing tissue-oxidized lipids. However, whether ApoA-I mediates immune-suppressive or anti-inflammatory effects under normocholesterolemic conditions and the
Martine Cao et al.
Pharmacological research, 100, 135-147 (2015-08-05)
Two new analogues of CDDO-Imidazolide (CDDO-Im), namely 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-2-yl)-1H-imidazole ("CDDO-2P-Im") and 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-3-yl)-1H-imidazole ("CDDO-3P-Im") have been synthesized and tested for their potential use as chemopreventive drugs. At nanomolar concentrations, they were equipotent to CDDO-Im for inducing differentiation and apoptosis in U937 leukemia
Michael P Torrens-Spence et al.
Phytochemistry, 106, 37-43 (2014-08-12)
Plant aromatic amino acid decarboxylases (AAADs) catalyze the decarboxylation of aromatic amino acids with either benzene or indole rings. Because the substrate selectivity of AAADs is intimately related to their physiological functions, primary sequence data and their differentiation could provide
Nanbo Wang et al.
BMC genomics, 16, 432-432 (2015-06-06)
Drought is one of major abiotic stresses constraining crop productivity worldwide. To adapt to drought stress, plants have evolved sophisticated defence mechanisms. Wild barley germplasm is a treasure trove of useful genes and offers rich sources of genetic variation for
C F Massaro et al.
Fitoterapia, 95, 247-257 (2014-04-08)
Propolis of Australian stingless bees (Tetragonula carbonaria, Meliponini) originating from Corymbia torelliana (Myrtaceae) fruit resins was tested for its antimicrobial activities as well as its flavonoid contents. This study aimed at the isolation, structural elucidation and antibacterial testing of flavanones
Marilena E Dasenaki et al.
Journal of agricultural and food chemistry, 63(18), 4493-4508 (2015-04-01)
A wide-scope screening methodology has been developed for the identification of veterinary drugs and pharmaceuticals in fish tissue and milk using ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS). The method was validated using a qualitative approach at two
Shu Jiang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 27-32 (2014-07-01)
Scutellaria-coptis herb couple is widely used traditional Chinese medicine (TCM) in treating type 2 diabetes; however, the in vivo integrated metabolism of its main bioactive components in type 2 diabetic rats remains unknown. In this paper, ultra-performance liquid chromatography (UPLC)
Parunya Chaiyawat et al.
Oncology reports, 34(4), 1933-1942 (2015-08-08)
O-GlcNAcylation is a dynamic post-translational modification that has extensive crosstalk with phosphorylation either at the same or adjacent sites of various proteins. We have previously reported that O-GlcNAcylation level was increased in primary breast and colorectal cancer, but the interplay
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