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Timothy D Rohrbach et al.
International journal of oncology, 46(3), 1079-1088 (2014-12-20)
Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pro-growth, pro-survival signaling pathways. Myristoylated alanine rich C-kinase substrate
Shahram Khosravi et al.
The Journal of investigative dermatology, 135(5), 1358-1367 (2015-01-07)
Human cutaneous melanoma is a devastating skin cancer because of its invasive nature and high metastatic potential. We used tissue microarray to study the role of human eukaryotic translation initiation factor 4E (eIF4E) in melanoma progression in 448 melanocytic lesions
Tomohiro Nakano et al.
Biochemical and biophysical research communications, 464(4), 1084-1089 (2015-07-22)
The anti-tumor activity of gemcitabine (GEM) has been clinically proven in several solid tumors, including pancreatic cancer, biliary tract cancer, urinary bladder cancer, and non-small cell lung cancer. However, problems remain with issues such as acquisition of chemoresistance against GEM.
Takashi Toyao et al.
ChemSusChem, 8(22), 3905-3912 (2015-09-24)
Various N-doped nanoporous carbons containing metal species were prepared by direct thermal conversion of zeolitic imidazolate frameworks (ZIFs; ZIF-7, -8, -9, and -67) at different temperatures (600, 800, and 1000 °C). These materials were utilized as bifunctional acid-base catalysts to promote
Qi Fei et al.
Nature communications, 6, 8651-8651 (2015-10-17)
SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates melanoma formation. However, the mechanism by which SETDB1 regulates tumorigenesis remains unknown. Here we report the
Song Nie et al.
Journal of proteome research, 14(2), 814-822 (2014-12-04)
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, with dismal survival outcomes. Recently, cancer stem cells (CSCs) have been demonstrated to play a role in therapeutic resistance and are considered to be the most likely cause of cancer relapse.
Neerja Vajpayee et al.
Clinical lymphoma, myeloma & leukemia, 15(3), 159-163 (2014-12-03)
The mammalian target of rapamycin (mTOR) pathway regulates many major cellular processes and is implicated in an increasing number of neoplasms, including lymphoma. We correlated immunohistochemical expression of mTOR with germinal center and nongerminal center phenotype, B cell lymphoma-2 (bcl-2)
Shou-Tian Zheng et al.
Angewandte Chemie (International ed. in English), 50(35), 8034-8037 (2011-07-16)
A tale of two polyhedra: two nested Archimedean metal-organic polyhedra, a rhombicuboctahedron (Co(48) cage) and a cuboctahedron (Co(24) cage), have been assembled from two types of cobalt dimers and two complementary ligands. Within the 3D covalent cubic array of outer
Wies van Roosmalen et al.
The Journal of clinical investigation, 125(4), 1648-1664 (2015-03-17)
Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost
T T Seppälä et al.
British journal of cancer, 112(12), 1966-1975 (2015-05-15)
The objective of the study was to examine the role of microsatellite instability (MSI) and BRAF(V600E)mutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. Tumour samples from 762 population-based patients with sporadic CRC
L Tomiyama et al.
Oncogene, 34(9), 1141-1149 (2014-03-26)
Dlg5 has been reported to participate in cancer progression; however, its role in prostate cancer still remains poorly understood. In this study, we demonstrate that Dlg5 is frequently downregulated in prostate cancer. We show here that Dlg5 is involved in
Alexey V Sorokin et al.
Cancer research, 75(9), 1846-1858 (2015-04-17)
The protein tyrosine phosphatase receptor PTPRN2 is expressed predominantly in endocrine and neuronal cells, where it functions in exocytosis. We found that its immature isoform proPTPRN2 is overexpressed in various cancers, including breast cancer. High proPTPRN2 expression was associated strongly
Melissa R Junttila et al.
Science translational medicine, 7(314), 314ra186-314ra186 (2015-11-20)
Cancer stem cells (CSCs) are hypothesized to actively maintain tumors similarly to how their normal counterparts replenish differentiated cell types within tissues, making them an attractive therapeutic target for the treatment of cancer. Because most CSC markers also label normal
Andreas Greuling et al.
Journal of physics. Condensed matter : an Institute of Physics journal, 22(34), 345008-345008 (2011-03-16)
The adsorption behavior of trimesic acid (TMA) on rutile TiO(2)(110) is studied by means of non-contact atomic force microscopy (NC-AFM) and density-functional theory (DFT). Upon low-coverage adsorption at room temperature, NC-AFM imaging reveals individual molecules, centered above the surface titanium
Kitty Pavlakis et al.
Pathology oncology research : POR, 21(2), 273-282 (2014-08-08)
To investigate the immunohistochemical expression of p85 in a cohort of trastuzumab-treated HER2-positive and HER2-negative metastatic breast cancer patients. The medical records of all patients with metastatic breast cancer treated with trastuzumab-based regimens between 1998 and 2010 were reviewed and
Catherine A Powell et al.
Oncotarget, 6(8), 6373-6385 (2015-03-18)
Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown to play a role in various cancers, including breast cancer. However, FABP5 and its role in triple negative breast cancer (TNBC) have not been studied. We
Jared B Decoste et al.
Journal of the American Chemical Society, 134(3), 1486-1489 (2012-01-14)
Metal organic frameworks (MOFs) are a leading class of porous materials for a wide variety of applications, but many of them have been shown to be unstable toward water. Cu-BTC (1,3,5 benzenetricarboxylic acid, BTC) was treated with a plasma-enhanced chemical
Lynnette A Ruiz et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(12), 1496-1508 (2015-05-13)
Lysyl oxidases (LOXs) are enzymes involved in collagen deposition, extracellular membrane remodeling, and invasive/metastatic potential. Previous studies reveal an association of LOXs and endometriosis. We aimed to identify the mechanisms activated by upregulation of lysyl oxidases (LOX) in endometriotic cells
J Stebbing et al.
Oncogene, 34(16), 2103-2114 (2014-06-10)
Kinase suppressor of Ras-1 (KSR1) facilitates signal transduction in Ras-dependent cancers, including pancreatic and lung carcinomas but its role in breast cancer has not been well studied. Here, we demonstrate for the first time it functions as a tumor suppressor
Heounjeong Go et al.
European journal of cancer (Oxford, England : 1990), 51(14), 1937-1945 (2015-08-05)
Sphingosine-1-phosphate receptor 1 (S1PR1) promotes tumour cell survival, invasion, anti-apoptosis, metastasis and radio/chemo-resistance in various cancers. However, the expression pattern and prognostic implications of S1PR1 in urothelial carcinoma remain unclear and thus were addressed here. Tissue microarrays composed of 395
Wanming Hu et al.
Medicine, 94(27), e979-e979 (2015-07-15)
CPEB4 plays an important role in cancer progression. However, the clinicopathological significance of CPEB4 expression to glioma and its expression levels in glioma tissues and cell lines are unknown. The present study investigated the potential prognostic value of CPEB4 for
Anna Bergamaschi et al.
Breast cancer research : BCR, 16(5), 436-436 (2014-09-13)
The forkhead transcription factor FOXM1 coordinates expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression. We previously showed that FOXM1 acts downstream of 14-3-3ζ signaling, the elevation of which correlates with a more aggressive
Bo Gun Jang et al.
Virchows Archiv : an international journal of pathology, 467(3), 285-294 (2015-06-14)
Olfactomedin 4 (OLFM4) has been demonstrated to be upregulated in various cancers and involved in many cellular processes such as cell adhesion, apoptosis, and cell proliferation. In gastric cancer, clinicopathological relevance of OLFM4 expression has been reported. However, there are
Jia-Ray Yu et al.
Genes & development, 29(3), 250-261 (2015-02-04)
The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4
Ashima Saxena et al.
Chemico-biological interactions, 238, 161-169 (2015-07-07)
Serum-derived human butyrylcholinesterase (Hu BChE) is a stoichiometric bioscavenger that is being developed as a potential prophylactic nerve agent countermeasure. Previously, we reported the prophylactic efficacy of Hu BChE in Göttingen minipigs against a whole-body exposure to 4.1mg/m(3) of sarin
Vita Golubovskaya et al.
Journal of cancer research and clinical oncology, 141(9), 1613-1631 (2015-02-07)
Focal adhesion kinase is an important survival signal in cancer. Recently, we demonstrated that the autophosphorylation inhibitor of FAK, Y15, effectively inhibited cancer cell growth. We detected many cancer cell lines sensitive to Y15 and also detected several cell lines
Ion Cristóbal et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 347-356 (2014-11-13)
SET is an endogenous PP2A inhibitor that might represent a novel molecular target for antitumor therapy. The aim of this study was to evaluate the molecular effects of SET deregulation and its potential clinical significance in metastatic colorectal cancer (mCRC).
Nicolas A Giraldo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 3031-3040 (2015-02-18)
Clear cell renal cell carcinoma (ccRCC) has shown durable responses to checkpoint blockade therapies. However, important gaps persist in the understanding of its immune microenvironment. This study aims to investigate the expression and prognostic significance of immune checkpoints in primary
J Cheng et al.
Prostate cancer and prostatic diseases, 18(2), 182-189 (2015-04-15)
Fatty-acid synthase (FASN), selectively overexpressed in prostate cancer (PCa) cells, has been described as linked to the aggressiveness of PCa. Constitutional genetic variation of the FASN gene and the expression levels of FASN protein in cancer cells could thus be
Shafei Wu et al.
Thoracic cancer, 6(4), 413-420 (2015-08-15)
c-ros oncogene 1 (ROS1) rearrangement presents one of the newest molecular targets in non-small cell lung cancer (NSCLC). ROS1 rearrangement is predominantly found in adenocarcinoma cases and is exclusive to other oncogenes, such as epidermal growth factor receptor (EGFR), Kirsten
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