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solute carrier family 25 (mitochondrial carrier, brain), member 14
Human SLC25A14 (9016), Mouse Slc25a14 (20523), Rat Slc25a14 (85263), cow SLC25A14 (513415), sheep SLC25A14 (100862656), naked mole-rat Slc25a14 (101699995), Domestic Rabbit SLC25A14 (100348432), domestic guinea pig Slc25a14 (100734865), Zebrafish slc25a14 (393133), chicken SLC25A14 (422141), domestic cat SLC25A14 (101082985), dog SLC25A14 (612910)
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene. [provided by RefSeq, Jul 2008