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Yang-Chi Fan et al.
Journal of AOAC International, 98(3), 575-579 (2015-05-31)
Danofloxacin is an antibacterial drug of the fluoroquinolone group developed for therapeutic purposes in veterinary medicine. The studies described here include investigations of the residues following a single dose or multiple doses of danofloxacin. Residue depletion studies were performed to...
Hong Zhu et al.
Environmental science and pollution research international, 22(18), 14299-14306 (2015-05-16)
Monochloroacetic acid (MCA) is a chemically stable and biologically toxic pollutant. It is often generated during the production of the pesticide dimethoate. Conventional wastewater treatment processes have difficulty degrading it. In this work, the dechlorination effects of Ni-Fe bimetal prepared...
Slavko Klobčar et al.
Biomedical chromatography : BMC, 29(12), 1901-1906 (2015-05-27)
The isolation of four oxidative degradation products of atorvastatin using preparative high-performance liquid chromatography applying at least two chromatographic steps is known from the literature. In this paper it is shown that the same four impurities could be isolated from...
Maryam Vosough et al.
Journal of chromatographic science, 53(2), 233-239 (2014-06-13)
In the present study, a simple strategy based on solid-phase extraction (SPE) with a cation exchange sorbent (Finisterre SCX) followed by fast high-performance liquid chromatography (HPLC) with diode array detection coupled with chemometrics tools has been proposed for the determination...
Marija T Popovic-Milenkovic et al.
Acta poloniae pharmaceutica, 71(2), 279-285 (2014-10-03)
Hawthorn has been present for a long time in traditional medicine as antihypertensive, hypolipidemic, anti-inflammatory, gastroprotective, antimicrobial agent. Hawthorn can be used for the cure of stress, nervousness but there is no published paper about actions of Crataegus nigra Wald....
Alexander T Ciota et al.
The Journal of general virology, 95(Pt 6), 1281-1288 (2014-03-20)
Understanding the potential for host range shifts and expansions of RNA viruses is critical to predicting the evolutionary and epidemiological paths of these pathogens. As arthropod-borne viruses (arboviruses) experience frequent spillover from their amplification cycles and are generalists by nature...
Germaine L Truisi et al.
Toxicology letters, 233(2), 172-186 (2015-01-13)
Common in vitro toxicity testing often neglects the fate and intracellular concentration of tested compounds, potentially limiting the predictability of in vitro results for in vivo extrapolation. We used in vitro long-term cultures of primary rat (PRH) and human hepatocytes...
L Rascón-Valenzuela et al.
Journal of ethnopharmacology, 171, 280-286 (2015-06-13)
Asclepias subulata Decne. is a shrub occurring in Sonora-Arizona desert (Mexico-USA). The ethnic groups, Seris and Pimas, use this plant for the treatment of sore eyes, gastrointestinal disorders and cancer. To isolate the compounds responsible for antiproliferative activity of the...
Francisco A Guardiola et al.
Fish & shellfish immunology, 45(1), 112-123 (2015-02-24)
Aquatic animals are continuously exposed to chemical pollutants but the effects evoked in skin surfaces, which receive the most direct contact with them, are poorly investigated. Terminal carbohydrate composition and immunological components present in skin mucus of gilthead seabream (Sparus...
Luisa Islas et al.
International journal of pharmaceutics, 488(1-2), 20-28 (2015-04-22)
Acrylic acid (AAc) and poly(ethylene glycol) methacrylate (PEGMA) were singly and dually grafted onto poly(vinyl chloride) (PVC) urinary catheters with the aim of preventing biofouling by endowing the catheters with the ability to load and release antimicrobial agents and to...
Rhun Yian Koh et al.
Molecular medicine reports, 11(5), 3808-3813 (2015-01-15)
Idiopathic pulmonary fibrosis is a chronic pulmonary disease that is characterized by formation of scar tissue in lungs. Transforming growth factor-β (TGF-β) is considered an important cytokine in the pathogenesis of this disease. Hence, the antifibrotic effect of an inhibitor...
Li Feng et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 784-785, 10-14 (2015-06-06)
We assessed dose levels and the persistence of chromosomal aberrations and micronuclei in three individuals in the 8 year following accidental (60)Co radiation exposure. Venous blood samples were collected and used for analyses: traditional chromosome aberration (CA) measurement, G-banding, and...
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Chengming Fei et al.
European journal of haematology, 93(6), 476-486 (2014-06-04)
The contribution of bone marrow mesenchymal stromal cells (BMMSCs) to the pathogenesis of myelodysplastic syndrome (MDS) has created controversies. In this study, we confirmed that BMMSCs from MDS patients showed prominent features of senescence, which were characterized by increased cell...
Antoine Sadiki Kishabongo et al.
PloS one, 10(3), e0120112-e0120112 (2015-03-18)
Although assessment of glycated nail proteins may be a useful marker for monitoring of diabetes, their nature and formation are still poorly understood. Besides a detailed anatomical analysis of keratin glycation, the usefulness of glycated nail protein assessment for monitoring...
R L Ambrose et al.
Virology, 481, 95-106 (2015-03-17)
The West Nile virus strain Kunjin virus (WNVKUN) NS4A protein is a multifunctional protein involved in many aspects of the virus life-cycle and is a major component of the WNVKUN replication complex (RC). Previously we identified a conserved region in...
K Schulz et al.
Die Pharmazie, 68(5), 311-316 (2013-06-28)
For estradiol (E2) the separation of the degradation products delta6- and delta9,11-E2 is especially challenging due to their structural similarity. There is no method described in the literature yet which adequately addresses this problem. The present study describes a HPLC...
Erin L Pflaster et al.
Eukaryotic cell, 13(11), 1431-1438 (2014-09-23)
Analysis of fatty acid methyl esters (FAMEs) by gas chromatography (GC) is a common technique for the quantitative and qualitative analysis of acyl lipids. Methods for FAME preparation are typically time-consuming and labor-intensive and require multiple transfers of reagents and...
Yu Ping Tang et al.
Neuroscience letters, 583, 26-31 (2014-09-16)
This study investigated relationships among disruption of normal vocal learning, brain-derived neurotrophic factor (BDNF), and the morphology of song nuclei in juvenile male zebra finches. The tracheosyringeal nerves were bilaterally transected at post-hatching day 20-25, so that the animals could...
Young Il Kim et al.
Molecular medicine reports, 12(1), 657-662 (2015-03-12)
Orostachys japonicus has been used in traditional medicine as an anticancer agent. The present study aimed to investigate the mechanism by which O. japonicus extract affects the expression of matrix metalloproteinase (MMP)-2 and MMP-9, its association with the expression of...
Daniel Moreno-Martínez et al.
Oncotarget, 5(12), 4337-4346 (2014-06-24)
Acute myeloid leukemia (AML) is a neoplasia characterized by the rapid expansion of immature myeloid blasts in the bone marrow, and marked by poor prognosis and frequent relapse. As such, new therapeutic approaches are required for remission induction and prevention...
Maurizio Cutolo et al.
The Journal of rheumatology, 42(3), 456-463 (2015-01-17)
To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite ACT-132577, and bosentan on myofibroblast activation and extracellular matrix production induced by ET-1 in cultured systemic sclerosis (SSc) and control skin fibroblasts. Fibroblasts were...
Zhuo Zhao et al.
Biochemical and biophysical research communications, 459(1), 131-136 (2015-02-26)
Chronic activation of the novel estrogen receptor GPR30 by its agonist G1 mitigates the adverse effects of estrogen (E2) loss on cardiac structure and function. Using the ovariectomized (OVX) mRen2.Lewis rat, an E2-sensitive model of diastolic dysfunction, we found that...
A Shimasue et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(1), 48-54 (2014-10-15)
Detection and analysis of a small subpopulation of cells such as stem cells or cancer stem cells are recognized to be a key technique in a recent regeneration and cancer science. However, in the thyroid, no marker that identifies stem...
Paul M Flanigan et al.
Journal of the American Society for Mass Spectrometry, 25(9), 1572-1582 (2014-07-12)
The internal energy distributions for dried and liquid samples that were vaporized with femtosecond duration laser pulses centered at 800 nm and postionized by electrospray ionization-mass spectrometry (LEMS) were measured and compared with conventional electrospray ionization mass spectrometry (ESI-MS). The...
Min-Yu Chung et al.
Journal of medicinal food, 18(6), 648-655 (2014-12-03)
Green tea extract (GTE) protects against nonalcoholic steatohepatitis (NASH) by decreasing hepatic steatosis and nuclear factor kappa B (NFκB) activation. We hypothesized that hypolipidemic and anti-inflammatory activities of GTE would protect against NASH by reducing cyclooxygenase-2 (COX-2), an NFκB-dependent enzyme...
James W Sutherland et al.
Environmental science & technology, 49(5), 2665-2674 (2015-01-27)
The Adirondack Mountain region is an extensive geographic area (26,305 km(2)) in upstate New York where acid deposition has negatively affected water resources for decades and caused the extirpation of local fish populations. The water quality decline and loss of...
Takayuki Nakajima et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(7), 1099-1104 (2015-05-15)
A simple and accurate analytical method for the determination of acaricides in honey was developed and validated in accordance with Japanese validation guidelines. Analytes - amitraz, N-2,4-dimethylphenyl-N-methylformamidine (DMPF), etoxazole, fenpyroximate, fipronil, hexythiazox, propargite, pyridaben and spirodiclofen - were extracted with...
Mohammad Najlah et al.
Journal of liposome research, 25(1), 32-37 (2014-06-26)
In this study, a niosome nanodispersion was manufactured using high-pressure homogenization following the hydration of proniosomes. Using beclometasone dipropionate (BDP) as a model drug, the characteristics of the homogenized niosomes were compared with vesicles prepared via the conventional approach of...
Erik Selander et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(20), 6395-6400 (2015-04-29)
Interactions among microscopic planktonic organisms underpin the functioning of open ocean ecosystems. With few exceptions, these organisms lack advanced eyes and thus rely largely on chemical sensing to perceive their surroundings. However, few of the signaling molecules involved in interactions...