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Fumbling at your soul: from celestial to chemical ether, the hypothesis of anesthesia in Emily Dickinson's poem 315 ("He fumbles at your soul").
Claire Poinsot et al.
Anesthesiology, 117(6), 1381-1384 (2012-10-24)
Natasha Arksey et al.
Bioorganic & medicinal chemistry, 22(15), 3931-3937 (2014-07-16)
The 2-[(18)F]fluoro-3-pent-4-yn-1-yloxypyridine ([(18)F]FPyKYNE) analog of the potent non-peptide angiotensin II type 1 receptor (AT1R) blocker losartan was produced via click chemistry linking [(18)F]FPyKYNE to azide-modified tetrazole-protected losartan followed by TFA deprotection. Preliminary small animal imaging with positron emission tomography (PET)
Assem Barakat et al.
Molecules (Basel, Switzerland), 20(11), 20642-20658 (2015-11-28)
The synthesis of the new diethyl ammonium salt of diethylammonium(E)-5-(1,5-bis(4-fluorophenyl)-3-oxopent-4-en-1-yl)-1,3-diethyl-4,6-dioxo-2-thioxohexaydropyrimidin-5-ide 3 via a regioselective Michael addition of N,N-diethylthiobarbituric acid 1 to dienone 2 is described. In 3, the carboanion of the thiobarbituric moiety is stabilized by the strong intramolecular electron
Maria Campaña-Seoane et al.
International journal of pharmaceutics, 477(1-2), 495-505 (2014-12-03)
The aim of this study is to propose that mucoadhesive vaginal emulsions can be able to resist the clearance effect of vaginal fluid and to have an effective control release of progesterone. With this goal, silicon derivative, cyclomethicone pentamer, was
Tiziana Rubino et al.
Neurobiology of disease, 73, 60-69 (2014-10-05)
Current concepts suggest that exposure to THC during adolescence may act as a risk factor for the development of psychiatric disorders later in life. However, the molecular underpinnings of this vulnerability are still poorly understood. To analyze this, we investigated
Maria Grazia Sarpietro et al.
International journal of pharmaceutics, 471(1-2), 69-74 (2014-05-23)
In this study we prepared solid lipid nanoparticles (SLN), by the phase inversion temperature (PIT) method, using cetyl palmitate as solid lipid and three different non-ionic emulsifiers of the polyoxyethylene ethers family (ceteth-20, isoceteth-20, oleth-20). These SLN were loaded with
Adam J McShane et al.
Journal of the American Society for Mass Spectrometry, 25(10), 1694-1704 (2014-08-06)
Direct reductive methylation of peptides is a common method for quantitative proteomics. It is an active derivatization technique; with participation of the dimethylamino group, the derivatized peptides preferentially release intense a1 ions. The advantageous generation of a1 ions for quantitative
Ana-Maria Rosu et al.
Carbohydrate polymers, 93(1), 184-190 (2013-03-08)
For the development of renewable bioproducts able to solubilize organic persistent pollutant such as benzo[a]pyrene (BaP), modified potato starch was synthesized by alkylation. The addition of alkyl chains was performed with three different alkylation agents: epoxyalkane, alkenyl succinic anhydride and
Cristiane dos Santos Giuberti et al.
Journal of liposome research, 23(3), 220-227 (2013-05-11)
Recent studies using long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) have resulted in a formulation with improved pharmacokinetic, toxicity and tumor localization properties. In this study, SpHL-CDDP were prepared in both laboratory and pilot scales. This study evaluated the possibility
Olumuyiwa N Adedeji et al.
Antimicrobial agents and chemotherapy, 59(9), 5114-5122 (2015-04-22)
Artemisinin-based combination therapies (ACTs) have been adopted by most African countries, including Nigeria, as first-line treatments for uncomplicated falciparum malaria. Fixed-dose combinations of these ACTs, amodiaquine-artesunate (FDC AQAS) and artemether-lumefantrine (AL), were introduced in Nigeria to improve compliance and achieve
Eunseok Seo et al.
Microvascular research, 98, 172-182 (2014-02-19)
A bio-inspired in vitro disease model was developed to investigate the basic biophysics of atherosclerotic diseases. In vivo study was conducted in advance using zebrafish fed with a normal diet and a cholesterol-enriched diet. The endothelial cells (ECs) of the
Yoshimasa Taniguchi et al.
Journal of agricultural and food chemistry, 63(46), 10181-10191 (2015-10-29)
The bitter taste of beer originates from resins in hops (Humulus lupulus L.), which are classified into two subtypes (soft and hard). Whereas the nature and reactivity of soft-resin-derived compounds, such as α-, β-, and iso-α-acids, are well studied, there
Julia J Griese et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17189-17194 (2013-10-09)
Although metallocofactors are ubiquitous in enzyme catalysis, how metal binding specificity arises remains poorly understood, especially in the case of metals with similar primary ligand preferences such as manganese and iron. The biochemical selection of manganese over iron presents a
Chang Yoon Moon et al.
Biomaterials, 41, 53-68 (2014-12-20)
Oncolytic adenoviruses (Ads) have shown great promise in cancer gene therapy but their efficacy has been compromised by potent immunological, biochemical, and specific tumor-targeting limitations. To take full advantage of the innate cancer-specific killing potency of oncolytic Ads but also
Rohit Mishra et al.
Nanotechnology, 25(22), 225501-225501 (2014-05-09)
We investigate here the nanomechanical response of microcantilever sensors in real-time for detecting a range of ultra-low concentrations of oligonucleotides in a complex background of total cellular RNA extracts from cell lines without labeling or amplification. Cantilever sensor arrays were
Nicolas Chevalier et al.
Human reproduction (Oxford, England), 30(2), 447-453 (2014-12-21)
Does a relationship exist between insulin-like peptide 3 (INSL3) and selected environmental endocrine disruptors (EEDs) in human cord blood (cb)? In the whole population (cryptorchid and control boys) cbINSL3 correlated negatively with cb free bisphenol A (BPA) providing indirect evidence
Patrick Fénichel et al.
Clinical endocrinology, 82(2), 242-247 (2014-05-16)
Cryptorchidism, the most frequent congenital malformation in full-term male newborns, increases the risk of hypofertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested a role of both genetic and environmental factors. Physiological testicular descent
Peter Chhour et al.
ACS nano, 8(9), 9143-9153 (2014-09-05)
Nanoparticles of complex architectures can have unique properties. Self-assembly of spherical nanocrystals is a high yielding route to such systems. In this study, we report the self-assembly of a polymer and nanocrystals into aggregates, where the location of the nanocrystals
K M Sharif et al.
Biomedical chromatography : BMC, 29(12), 1826-1833 (2015-06-03)
Multivariate analysis of thin-layer chromatography (TLC) images was modeled to predict antioxidant activity of Pereskia bleo leaves and to identify the contributing compounds of the activity. TLC was developed in optimized mobile phase using the 'PRISMA' optimization method and the
Anna K E Gallien et al.
Dalton transactions (Cambridge, England : 2003), 43(35), 13278-13292 (2014-07-25)
Two different structure types were found for a series of mononuclear dinitrosyl complexes of the general formula [RuL2(NO)2X]BF4 (L = monodentate phosphane, X = Cl, Br, I). The {Ru(NO)2}(8)-type target compounds were prepared by the reduction of the respective {RuNO}(6)
Umile Gianfranco Spizzirri et al.
Pharmaceutical development and technology, 20(3), 288-296 (2013-12-03)
In this study, pH-responsive hydrogels, synthesized by the coupling reaction of polyacrylic acid and catechin, are proposed as carriers of oxidable drugs toward the GI tract. The presence of polyphenolic moieties in the network gives the polymers properties suitable for
Fotini A Trikka et al.
BMC genomics, 16, 935-935 (2015-11-18)
Salvia diterpenes have been found to have health promoting properties. Among them, carnosic acid and carnosol, tanshinones and sclareol are well known for their cardiovascular, antitumor, antiinflammatory and antioxidant activities. However, many of these compounds are not available at a
Tadashi Okano et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 20(6), 1106-1113 (2015-08-22)
Leptin is an adipocytokine produced by adipocytes and controlling body weight. It is unclear whether leptin works as a proinflammatory or an anti-inflammatory cytokine. We investigated the effects of hyperleptinemia on leptin transgenic (LepTg) mice in terms of cartilage destruction
Counting backward.
Vincent J Kopp
Anesthesiology, 118(5), 1224-1226 (2012-11-21)
Milena R Simic et al.
Archiv der Pharmazie, 348(2), 100-112 (2015-02-11)
Cytoprotective compounds such as amifostine play an important role in chemo- and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class
Distribution of selenoglucosinolates and their metabolites in Brassica treated with sodium selenate.
Adam J Matich et al.
Journal of agricultural and food chemistry, 63(7), 1896-1905 (2015-01-28)
In Brassica species, hydrolysis of (methylthio)glucosinolates produces sulfur-containing aglycons which have demonstrated anticancer benefits. Selenized Brassicaceae contain (methylseleno)glucosinolates and their selenium-containing aglycons. As a prelude to biological testing, broccoli, cauliflower, and forage rape plants were treated with sodium selenate and
Jenny Liu et al.
Journal of visualized experiments : JoVE, (80)(80), doi:10-doi:10 (2013-10-23)
Convenient methods for the rapid, parallel synthesis of diversely functionalized nanoparticles will enable discovery of novel formulations for drug delivery, biological imaging, and supported catalysis. In this report, we demonstrate parallel synthesis of brush-arm star polymer (BASP) nanoparticles by the
Fränze Progatzky et al.
Nature communications, 5, 5864-5864 (2014-12-24)
Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide. In vivo information regarding the local and direct inflammatory effect of these dietary components in the intestine and
Emmanuel Derivery et al.
Nature, 528(7581), 280-285 (2015-12-15)
During asymmetric division, fate determinants at the cell cortex segregate unequally into the two daughter cells. It has recently been shown that Sara (Smad anchor for receptor activation) signalling endosomes in the cytoplasm also segregate asymmetrically during asymmetric division. Biased
Chun-Yen Chen et al.
Bioresource technology, 200, 500-505 (2015-11-01)
The efficiencies of extraction and preservation of lutein from microalgae are critical for the success of its commercialization. In this study, lutein was produced by Chlorella sorokiniana MB-1 via semi-batch mixotrophic cultivation. The microalgal biomass with a lutein content of
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