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Girish G Ariga et al.
Biopolymers, 103(11), 646-657 (2015-07-29)
The fluorescence, ultraviolet (UV) absorption, time resolved techniques, circular dichroism (CD), and infrared spectral methods were explored as tools to investigate the interaction between histamine H1 drug, epinastine hydrochloride (EPN), and bovine serum albumin (BSA) under simulated physiological conditions. The
Yingxin Zou et al.
International journal of molecular medicine, 36(4), 939-946 (2015-08-05)
This study investigated the effect of Cordyceps sinensis oral liquid (CSOL) on the lifespan of Drosophila melanogaster (fruit fly). Following the lifelong treatment of fruit flies with CSOL, lifespan was examined. The activity of copper-zinc-containing superoxide dismutase 1 (SOD1), manganese-containing superoxide dismutase 2 (SOD2)
E L Dryburgh et al.
The Journal of parasitology, 101(4), 462-467 (2015-03-27)
Sarcocystis neurona is considered the major etiologic agent of equine protozoal myeloencephalitis (EPM), a neurological disease in horses. Raccoon ( Procyon lotor ) is considered the most important intermediate host in the life cycle of S. neurona in the United
Stephen W Stein et al.
Molecular pharmaceutics, 12(9), 3455-3467 (2015-08-11)
A simulation model has been established to predict the residual aerodynamic particle size distribution (APSD) of dual-component pressurized metered dose inhalers (pMDIs). More specifically, this model estimates the APSD of pMDI formulations containing dissolved and suspended compounds for various formulations
Serkan Koldaş et al.
Journal of the science of food and agriculture, 95(4), 786-798 (2014-09-10)
A detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time
Kevin M Cooper et al.
Journal of chromatography. A, 1358, 20-28 (2014-07-20)
Heterocyclic aromatic amines (HCA) are carcinogenic mutagens formed during cooking of proteinaceous foods, particularly meat. To assist in the ongoing search for biomarkers of HCA exposure in blood, a method is described for the extraction from human plasma of the
Yehua Han et al.
Journal of chromatography. A, 1395, 1-6 (2015-04-18)
A supercritical fluid extraction (SFE) method with an online solid collection trap has been developed for the quantitative analysis of 16 polycyclic aromatic hydrocarbons (PAHs) and 15 typical PAH derivatives in solid matrix. Compared with liquid trapping and C18 solid-phase
Stacie M Gutowski et al.
Biomaterials, 44, 55-70 (2015-01-27)
Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement disorders. Chronically implanted neural electrodes induce an unfavorable tissue response which includes inflammation, scar formation, and neuronal cell death, eventually
Katharina Schueller et al.
Journal of agricultural and food chemistry, 63(29), 6535-6545 (2015-06-26)
The natural anti-inflammatory compound resveratrol (RES) is metabolized upon ingestion. After dietary-scale doses, plasma concentrations of sulfated and glucuronated metabolites in humans exceed those of RES. The aim of this in vitro study was to assess the effect of physiological
Daniel T Bowers et al.
ACS nano, 8(12), 12080-12091 (2014-11-27)
Oxygenation in tissue scaffolds continues to be a limiting factor in regenerative medicine despite efforts to induce neovascularization or to use oxygen-generating materials. Unfortunately, many established methods to measure oxygen concentration, such as using electrodes, require mechanical disturbance of the
DeQing Cao et al.
Drug and chemical toxicology, 38(1), 44-49 (2014-03-22)
A Type II pyrethroid pesticide β-cypermethrin is widely used in agriculture and domestic applications for pest control. However, the effect of β-cypermethrin on the glutamate neurotransmitter has not been well-documented. In the current study, mice were treated with 20, 40
Weiwei Ye et al.
Journal of chromatographic science, 53(5), 716-724 (2014-09-23)
DB-6, with an IUPAC name of (Z)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5'-methyl-7,7'-dimethoxy-[4,4'-bibenzo[d][1,3]dioxole]-5,5'-dicarboxylate, is an investigational agent for acute liver failure. The focus of this study is the identification and characterization of major unknown impurities in DB-6 bulk drug samples. Four major impurities of DB-6 were
Hyunji Lee et al.
Applied microbiology and biotechnology, 99(22), 9473-9481 (2015-06-11)
The enzyme ferulic acid decarboxylase (FADase) from Enterobacter sp. Px6-4 catalyzes the decarboxylation reaction of lignin monomers and phenolic compounds such as p-coumaric acid, caffeic acid, and ferulic acid into their corresponding 4-vinyl derivatives, that is, 4-vinylphenol, 4-vinylcatechol, and 4-vinylguaiacol
Leigh Guerin et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 74(2), 126-135 (2015-03-06)
CD11c(HI) human decidual macrophages express several isoforms of CD1 molecules. Their expression pattern and function required investigation. CD11c(HI) macrophages were isolated from decidua. Expression of CD1 isoforms and their ability to present lipid antigens to T cells was studied. CD1a
Steven Pauwels et al.
Analytical and bioanalytical chemistry, 407(20), 6191-6199 (2015-06-15)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the method of choice for quantifying small molecules in research and clinical setting. Although there is a large toolkit to increase quantification levels for LC-MS/MS, these techniques are sometimes insufficient to attain the needed
Tarek A Ahmed et al.
AAPS PharmSciTech, 15(3), 772-780 (2014-03-22)
The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ microparticles (ISM). N-Methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), triacetin
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty
Urszula Kwolek et al.
The journal of physical chemistry. B, 119(31), 10042-10051 (2015-07-15)
We consider the impact of phosphatidic acid (namely, 1,2-dioleoyl-sn-glycero-3-phosphate, DOPA) on the properties of a zwitterionic (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) bilayer used as a model system for protein-free cell membranes. For this purpose, experimental measurements were performed using differential scanning calorimetry and
Jae Kyoo Lee et al.
Quarterly reviews of biophysics, 48(4), 437-444 (2015-11-06)
Using high-resolution mass spectrometry, we have studied the synthesis of isoquinoline in a charged electrospray droplet and the complexation between cytochrome c and maltose in a fused droplet to investigate the feasibility of droplets to drive reactions (both covalent and
Nikolett Baranyi et al.
Acta biologica Hungarica, 66(3), 339-347 (2015-09-08)
The occurrence of potential aflatoxin producing fungi was examined in various agricultural products and indoor air in Central European countries including Hungary, Serbia and Croatia. For species identification, both morphological and sequence based methods were applied. Aspergillus flavus was detected
Anna C C Aguiar et al.
Memorias do Instituto Oswaldo Cruz, 110(7), 906-913 (2015-11-13)
Several species of Aspidosperma plants are used to treat diseases in the tropics, including Aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed. The species, known as guatambu-yellow, yellow peroba, coffee-peroba and matiambu, grows in the Atlantic
Roman Generalov et al.
Colloids and surfaces. B, Biointerfaces, 129, 79-86 (2015-04-02)
Nanoparticulates responsive to X-rays offer increased efficacy of radiation therapy. However, successful demonstrations of such nanoparticle use are limited so far due to lack of significant radiosensitizing effects or poor nanoparticle stability in a biological system. Zinc oxide (ZnO) is
Ting-Wen Yang et al.
Journal of pharmaceutical and biomedical analysis, 114, 280-287 (2015-06-21)
Single standard to determine multi-components (SSDMC) is a practical pattern for quality evaluation of herbal medicines (HMs). However, it remains challenging because of potential inconsistency of relative response factors (RRF) on different instruments. In this work, the effects of two
Sung Pil Hyun et al.
Environmental science and pollution research international, 22(21), 16463-16474 (2015-08-19)
Cis-1,2,-dichloroethylene (cis-DCE) is a toxic, persistent contaminant occurring mainly as a daughter product of incomplete degradation of perchloroethylene (PCE) and trichloroethylene (TCE). This paper reports on abiotic reductive dechlorination of cis-DCE by mackinawite (FeS1-x), a ferrous monosulfide, under variable geochemical
Francesca Giuffrida et al.
Lipids, 49(10), 997-1004 (2014-09-05)
It has been reported that dietary gangliosides may have an important role in preventing infections and in brain development during early infancy. However, data related to the evolution of their concentration over the different stages of lactation are scarce. Liquid
Isabelle A Kagan et al.
Natural product communications, 10(7), 1263-1267 (2015-09-29)
Red clover (Trifolium pratense) contains soluble phenolic compounds with roles in inhibiting proteolysis and ammonia production. Alfalfa (Medicago sativa) has been found to have a low phenolic content, but few alfalfa and red clover cultivars have been compared for phenolic
Juan M Quiles et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 83, 222-228 (2015-07-07)
Aflatoxins (AFs) are secondary metabolites produced by different species of Aspergillus, such as Aspergillus flavus and Aspergillus parasiticus, which possess mutagenic, teratogenic and carcinogenic activities in humans. In this study, active packaging devices containing allyl isothiocyanate (AITC) or oriental mustard
Stavros Melemenidis et al.
Theranostics, 5(5), 515-529 (2015-03-15)
Angiogenesis is an essential component of tumour growth and, consequently, an important target both therapeutically and diagnostically. The cell adhesion molecule α(v)β(3) integrin is a specific marker of angiogenic vessels and the most prevalent vascular integrin that binds the amino
Filip Sucharski et al.
Pharmacological reports : PR, 66(6), 1003-1010 (2014-12-03)
Phosphorylation is a key process regulating a large number of fundamental biochemical reactions in living organisms. It is known that many mechanisms of response to chronic drugs administration are regulated by phosphorylation. It can be assumed that some of the
Sara Benedé et al.
International archives of allergy and immunology, 165(2), 83-90 (2014-11-02)
This paper reports the case of an egg-allergic pediatric patient who, once desensitized to egg following a successful rush oral immunotherapy protocol, could also tolerate Lizipaina®, a drug containing lysozyme (LYS) and papain, which had previously caused him a severe
页码 1 来自 233
页码 1 来自 233