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Satoshi Hara et al.
The American journal of pathology, 185(8), 2118-2131 (2015-06-15)
Intracapillary foam cell infiltration with podocyte alterations is a characteristic pathology of focal segmental glomerulosclerosis (FSGS). We investigated the possible role of podocyte injury in glomerular macrophage and foam cell infiltration in a podocyte-selective injury model (NEP25 mice) and hypercholesterolemic...
In-Pyeong Hwang et al.
Investigative radiology, 50(11), 798-804 (2015-07-07)
To evaluate the differentiating potentials of computed tomography texture analysis for invasive pulmonary adenocarcinomas (IPAs) from their preinvasive lesions or minimally invasive adenocarcinomas (MIAs) manifesting as persistent pure ground-glass nodules (PGGNs) larger than 5 mm. This institutional review board-approved retrospective...
Chike F Oguejiofor et al.
Biology of reproduction, 93(4), 101-101 (2015-09-12)
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial lipopolysaccharide (LPS). Primary cultures of...
Simrinder Singh Sodhi et al.
Gene, 546(2), 233-242 (2014-06-10)
RNA-seq is being rapidly adopted for the profiling of the transcriptomes in different areas of biology, especially in the studies related to gene regulation. The discovery of differentially expressed genes (DEGs) between adult animals of Jeju Native Pig (JNP) and...
Michael K Wong et al.
PloS one, 10(3), e0122295-e0122295 (2015-03-27)
Maternal nicotine exposure has been associated with many adverse fetal and placental outcomes. Although underlying mechanisms remain elusive, recent studies have identified that augmented endoplasmic reticulum (ER) stress is linked to placental insufficiency. Moreover, ER function depends on proper disulfide...
Amanda E Hargrove et al.
PloS one, 10(11), e0143161-e0143161 (2015-11-17)
Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significantly downregulates...
Ajay Chauhan et al.
Bioorganic & medicinal chemistry, 22(16), 4422-4429 (2014-06-26)
A modular synthesis of l-proline derived peptidomimetics has been developed using the Cu(I) catalyzed Huisgen cycloaddition between an azido prolinamide with pyridine and benzene dicarboxamide containing dialkynes. Förster Resonance Energy Transfer (FRET) melting assay provided an initial indication that the...
Xiaofeng Dai et al.
PloS one, 10(9), e0124964-e0124964 (2015-09-12)
WDR5 is a core component of the human mixed lineage leukemia-2 complex, which plays central roles in ER positive tumour cells and is a major driver of androgen-dependent prostate cancer cell proliferation. Given the similarities between breast and prostate cancers...
Rosie May Walker et al.
Journal of psychiatric research, 62, 48-55 (2015-02-25)
Bipolar disorder (BD) is a highly heritable psychiatric disorder characterised by recurrent episodes of mania and depression. Many studies have reported altered gene expression in BD, some of which may be attributable to the dysregulated expression of miRNAs. Studies carried...
Carmen Marin-Bañasco et al.
Stem cell research & therapy, 5(6), 134-134 (2014-12-17)
Mesenchymal stem cells (MSCs) are a multipotent population of adult stem cells, which may represent a promising therapeutic approach for neurological autoimmune diseases such as multiple sclerosis. The mouse is the most used species for obtaining and studying the characteristics...
Renee R Hood et al.
Small (Weinheim an der Bergstrasse, Germany), 11(43), 5790-5799 (2015-09-24)
Liposomes represent a leading class of nanoparticles for drug delivery. While a variety of techniques for liposome synthesis have been reported that take advantage of microfluidic flow elements to achieve precise control over the size and polydispersity of nanoscale liposomes...
Cristian Palmiere et al.
Forensic science international, 226(1-3), 54-61 (2013-01-15)
The aim of this study was to investigate the usefulness of postmortem biochemical investigations in the diagnosis of fatal hypothermia. 10 cases of fatal hypothermia and 30 control cases were selected. A series of biochemical parameters, such as glucose, acetone...
Kurt A Gust et al.
BMC genomics, 16, 587-587 (2015-08-08)
A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT). A subchronic 60 d toxicology...
Sarah K Henke et al.
PloS one, 9(5), e96757-e96757 (2014-05-13)
Group II biotin protein ligases (BPLs) are characterized by the presence of an N-terminal DNA binding domain that allows transcriptional regulation of biotin biosynthetic and transport genes whereas Group I BPLs lack this N-terminal domain. The Bacillus subtilis BPL, BirA...
Rick W Fedeniuk et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 1-9 (2015-01-24)
Separate methods for the quantitation and confirmation of regulatory relevant residue concentrations of total florfenicol and tulathromycin residues in multiple tissue matrices were developed and validated. Total florfenicol residues, determined and expressed as florfenicol amine (FFA) equivalents, were quantified and...
Xiaolei Yu et al.
ACS applied materials & interfaces, 7(43), 24001-24007 (2015-10-22)
As "liquid biopsies", circulating tumor cells (CTCs) have been thought to hold significant insights for cancer diagnosis and treatment. Despite the advances of microfluidic techniques that improve the capture of CTCs to a certain extent, recovering the captured CTCs with...
Zhenzhen Wang et al.
Analytical chemistry, 86(21), 10600-10607 (2014-10-10)
Engineering of specialized metabolites in plants, microbes, and other organisms is hindered by significant knowledge gaps about metabolic pathways responsible for metabolite accumulation and degradation. While isotopic tracers have provided important information about metabolic fluxes in central metabolism, limitations of...
Dany Spaggiari et al.
Journal of chromatography. A, 1371, 244-256 (2014-12-03)
The goal of this study was to evaluate the combination of powerful chromatographic methods and compact single quadrupole MS device for simple in vitro cytochrome P450 (CYP) inhibition assay, instead of more expensive triple quadrupole MS/MS detectors. For this purpose...
Maha F Abdel-Ghany et al.
Journal of AOAC International, 98(5), 1215-1225 (2015-11-04)
Accurate, reliable, and sensitive spectrophotometric and chemometric methods were developed for simultaneous determination of octinoxate (OMC), oxybenzone (OXY), and octocrylene (OCR) in a sunscreen formulation without prior separation steps, including derivative ratio spectra zero crossing (DRSZ), double divisor ratio spectra...
Wan Cao et al.
Electrophoresis, 36(7-8), 1055-1063 (2015-02-03)
This report describes the use of surfactant-coated graphitized multiwalled carbon nanotubes (SC-GMWNTs) as a novel pseudostationary phase in CE with diode array detection for the determination of phenolic acids and tanshinones in herbal and urine samples. Several parameters influencing the...
Junying Zheng et al.
BMC genomics, 16, 984-984 (2015-11-22)
Although extensive studies have investigated radiation-induced injuries in particular gastrointestinal (GI) segments, a systematic comparison among the different segments on the basis of mode, magnitude and mechanism has not been reported. Here, a comparative study of segment-specific molecular and cellular...
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage...
Fabrizio Scorrano et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(3), 859-867 (2014-11-16)
The evaluation of chronic activity of the hypothalamic-pituitary-adrenal (HPA) axis is critical for determining the impact of chronic stressful situations. However, current methods have important limitations. The potential use of hair glucocorticoids as a noninvasive retrospective biomarker of long-term HPA...
M Currò et al.
Journal of biological regulators and homeostatic agents, 28(3), 497-506 (2014-10-16)
The ablative role of minimally invasive surgery (MIS) in neuroblastoma (NB) is still controversial due to the possible CO₂ pneumoperitoneum side-effects on tumor aggressiveness. It is known that CO₂ produces hypoxic condition with changes in tumor microenvironment influencing cell functions....
Eike Müller et al.
Biomaterials, 53, 709-715 (2015-04-22)
Deciphering exogenous cues that determine stem cell fate decisions is a persisting challenge of cell biology and bioengineering. In an effort to unravel the role of spatial constraints in the cell-instructive characteristics of bone marrow microenvironments, murine hematopoietic stem and...
Aditya S Pandey et al.
World neurosurgery, 82(5), 684-695 (2013-09-03)
A subarachnoid hemorrhage is neurologically devastating, with 50% of patients becoming disabled or deceased. Advent of Guglielmi detachable coils in 1995 permitted endovascular treatment of cerebral aneurysms. Coiling is efficacious and safe, but durability needs improvement, as nearly 20% of...
Peter C Grayson et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(7), 1922-1932 (2015-04-22)
To discover biomarkers involved in the pathophysiology of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and to determine whether low-density granulocytes (LDGs) contribute to gene expression signatures in AAV. The source of clinical data and linked biologic specimens was a randomized controlled...
Klara Slezakova et al.
Journal of toxicology and environmental health. Part A, 78(13-14), 886-896 (2015-07-15)
Due to their detrimental effects on human health, scientific interest in ultrafine particles (UFP), has been increasing but available information is far from comprehensive. Children, who represent one of the most susceptible subpopulation, spend the majority of time in schools...
Dezhou Cui et al.
PloS one, 10(2), e0116697-e0116697 (2015-02-07)
Salinity is a major abiotic stress that limits plant productivity and quality throughout the world. Roots are the sites of salt uptake. To better understand salt stress responses in maize, we performed a comparative proteomic analysis of seedling roots from...
De-Ju Chen et al.
Proteomics, 15(17), 3075-3086 (2015-05-08)
For years, many studies have been conducted to investigate the intracellular response of cells challenged with toxic metal(s), yet, the corresponding secretome responses, especially in human lung cells, are largely unexplored. Here, we provide a secretome analysis of human bronchial...
页码 1 来自 57
页码 1 来自 57