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Ana Primo et al.
Nature communications, 6, 8561-8561 (2015-10-29)
Metal oxide nanoparticles supported on graphene exhibit high catalytic activity for oxidation, reduction and coupling reactions. Here we show that pyrolysis at 900 °C under inert atmosphere of copper(II) nitrate embedded in chitosan films affords 1.1.1 facet-oriented copper nanoplatelets supported...
R Shukla et al.
The International journal of neuroscience, 116(12), 1391-1402 (2006-12-06)
Evidence from clinical and experimental studies supports the hypothesis of free radical-mediated damage of dopaminergic neurons in the pathology of Parkin's disease (PD). The present study was undertaken to evaluate the role of nitric oxide and oxidative stress in PD....
Rebekka Hueting et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 128-134 (2013-12-18)
(64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazonate), (64)Cu-ATSM, continues to be investigated clinically as a PET agent both for delineation of tumor hypoxia and as an effective indicator of patient prognosis, but there are still aspects of the mechanism of action that are not fully understood....
Donita C Brady et al.
Nature, 509(7501), 492-496 (2014-04-11)
The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and...
Huma Khalid et al.
Mini reviews in medicinal chemistry, 13(13), 1944-1956 (2013-09-28)
Free radicals or reactive oxygen species (ROS) are highly toxic and their damaging effects result in a variety of detrimental health issues such as neurodegenerative, cardiovascular and age-related diseases. Human body has evolved an effective defense system including superoxide dismutase...
Tjaard Ubbo Hoogenraad
Brain & development, 28(3), 141-146 (2006-02-10)
Zinc therapy has replaced penicillamine as first-line therapy for Wilson's disease. New guidelines reflect the paradigm shift in treatment that has occurred in recent years. In the old paradigm, Wilson's disease was seen as genetic disorder associated with the accumulation...
R M Mohamed et al.
Journal of nanoscience and nanotechnology, 13(7), 4975-4980 (2013-08-02)
The photo-assisted deposition (PAD) and impregnation (Img) synthesis of nano-sized Cu metal on TiO2-SiO2 are reported. The prepared catalysts were characterized by different techniques such as XRD, EXAFS, TEM and nitrogen adsorption analysis. Photocatalytic reactivity using Cu-TiO2-SiO2 catalysts under visible-light...
Wei-Dan Jiang et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 301-313 (2014-08-05)
The brain is the center of the nervous system in all vertebrates, and homeostasis of the brain is crucial for fish survival. Copper (Cu) is essential for normal cellular processes in most eukaryotic organisms but is toxic in excess. Although...
A Gomiero et al.
Environmental pollution (Barking, Essex : 1987), 194, 262-271 (2014-08-29)
Trace metals and broad-spectrum antibiotic drugs are common environmental contaminants, the importance of which is increasing due to global climate change-related effects. In the present study, the biological model organism E. crassus was first acclimated to five temperatures, from 25 °C to...
Zhiguo Pei et al.
Environmental pollution (Barking, Essex : 1987), 184, 579-585 (2013-11-10)
Effects of copper (Cu) and aluminum (Al) on the adsorption of sulfathiazole (STZ) and tylosin (T) to peat and soil were investigated using a batch equilibration method. Results show that Cu suppressed STZ adsorption onto peat and soil at pH < 5.0...
Fabio Perlatti et al.
The Science of the total environment, 500-501, 91-102 (2014-09-14)
The potentially hazardous effects of rock wastes disposed at open pit in three different areas (Pr: Ore processing; Wr: Waste rock and Bd: Border) of an abandoned copper mine were evaluated in this study, with emphasis on acid drainage generation...
Cu and Cu-based nanoparticles: synthesis and applications in catalysis
Gawande MB, et al.
Chemical Reviews, 116(6), 3722-3811 (2016)
Wen Zhang et al.
The Analyst, 129(3), 229-234 (2004-02-24)
The fabrication and application of a novel electrochemical detector (ED) with nano crystalline Ce-doped lead dioxide film chemically modified electrode (CME) for liquid chromatography (LC) were described. The Ce-doped PbO(2) film was characterized by X-ray diffractometer (XRD) and scanning tunnel...
Ewa Sitkiewicz et al.
Journal of molecular biology, 426(15), 2871-2885 (2014-05-27)
Oligomers formed by amyloid β (Aβ) peptide are widely believed to be the main neurotoxic agent in Alzheimer's disease. Studies discovered a broad variety of oligomeric forms, which display different levels of toxicity. Some of these forms may further assemble...
I P Zaĭtseva et al.
Voenno-meditsinskii zhurnal, 334(3), 36-40 (2013-07-03)
According to examination, with the help of emission spectrum analysis method, of 24 cadets-athletes of different specialization it was determined that during physical exercise in summer and in winter loss of ferrum and copper with excrements exceeded the intake if...
H U Shetty et al.
Clinical chemistry, 42(2), 298-302 (1996-02-01)
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy...
D A Loeffler et al.
Journal of neural transmission. Parkinson's disease and dementia section, 9(1), 45-53 (1995-01-01)
Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease (PD), CSF HVA is normal in mildly affected patients. To explore why, we measured DA and its...
Dongsoo Kim et al.
Journal of nanoscience and nanotechnology, 13(11), 7581-7585 (2013-11-20)
A special sort of laser methods such as direct writing of metal and thin film deposition from liquid precursors was developed for the surface processing and the localized metallization of different kinds of materials. Laser radiation initiates the chemical reaction...
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal...
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite...
Ahmad El Hajj et al.
Journal of nanoscience and nanotechnology, 13(7), 5227-5232 (2013-08-02)
The development of indium-free transparent conductive oxides (TCOs) on polymer substrates for flexible devices requires deposition at low temperatures and a limited thermal treatment. In this paper, we investigated the optical and electrical properties of ZnO/Cu/ZnO multi-layer electrodes obtained by...
A Matsui et al.
Journal of clinical pathology, 35(9), 1011-1017 (1982-09-01)
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin...
Seiko Ishida et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19507-19512 (2013-11-13)
Copper is an essential trace element, the imbalances of which are associated with various pathological conditions, including cancer, albeit via largely undefined molecular and cellular mechanisms. Here we provide evidence that levels of bioavailable copper modulate tumor growth. Chronic exposure...
R Squitti et al.
Neurology, 67(1), 76-82 (2006-07-13)
To assess whether serum copper in Alzheimer disease (AD) correlates with cognitive scores, beta-amyloid, and other CSF markers of neurodegeneration. The authors studied copper, ceruloplasmin, total peroxide, and antioxidants levels (TRAP) in serum; beta-amyloid in plasma; and copper, beta-amyloid, h-tau...
H Kodama et al.
Journal of inherited metabolic disease, 28(6), 971-978 (2006-01-26)
Menkes disease (MD) is a neurodegenerative disorder characterized by a copper deficiency in the brain. It is caused by the defective intestinal absorption of copper resulting from a deficiency of a copper-transporting ATPase, ATP7A. This gives rise to an accumulation...
Miao Chen et al.
Journal of environmental sciences (China), 25(9), 1865-1873 (2014-02-14)
Biogas residue (BR) is widely used as a new green fertilizer in agriculture in China. However, it often contains a high concentration of heavy metals so its application should cause our concern. An incubation experiment was conducted to study the...
David L Choveaux et al.
Experimental parasitology, 148, 30-39 (2014-12-03)
Copper is an essential micronutrient for all living organisms as an important catalytic co-factor for key enzymes. In higher eukaryotes intracellular copper is distributed by copper metallochaperones. Copper chelators such as neocuproine and tetrathiomolybdate inhibit Plasmodium falciparum erythrocytic development, indicating...
Renée C Pompei-Reynolds et al.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 146(2), 215-226 (2014-08-03)
The manufacturing process for copper-nickel-titanium archwires is technique sensitive. The primary aim of this investigation was to examine the interlot consistency of the mechanical properties of copper-nickel-titanium wires from 2 manufacturers. Wires of 2 sizes (0.016 and 0.016 × 0.022...
The formation of 3-hydroxy-4-methoxyphenylalanine and 3-hydroxy-4-methoxyphenethylamine in plasma during L-DOPA therapy in patients with Parkinson's disease.
T Ishimitsu et al.
Chemical & pharmaceutical bulletin, 32(8), 3320-3322 (1984-08-01)
Tao Zhang et al.
Chemosphere, 109, 1-6 (2014-05-31)
The development of more selective chelators for the washing of heavy metal contaminated soil is desirable in order to avoid excessive dissolution of soil minerals. Speciation and mobility of Cu, Zn, Pb, and Ni in a contaminated soil washed with...