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Z Lei et al.
Neuroscience, 165(2), 350-362 (2009-10-28)
Somatodendritic Kv4.2 channels mediate transient A-type potassium currents (I(A)), and play critical roles in controlling neuronal excitability and modulating synaptic plasticity. Our studies have shown an NMDA receptor-dependent downregulation of Kv4.2 and I(A). NMDA receptors are heteromeric complexes of NR1
Gabriella Miklóssy et al.
Protein engineering, design & selection : PEDS, 21(7), 453-461 (2008-05-16)
An intracellularly expressed defective human immunodeficiency virus type-1 (HIV-1) protease (PR) monomer could function as a dominant-negative inhibitor of the enzyme that requires dimerization for activity. Based on in silico studies, two mutant PRs harboring hydrophilic mutations, capable of forming
Gerald L Murray et al.
Infection and immunity, 77(3), 952-958 (2008-12-24)
Leptospira interrogans is responsible for leptospirosis, a zoonosis of worldwide distribution. LipL32 is the major outer membrane protein of pathogenic leptospires, accounting for up to 75% of total outer membrane protein. In recent times LipL32 has become the focus of
Alexis N Orr et al.
International journal of molecular sciences, 22(5) (2021-04-04)
Transglutaminases (TGs) are crosslinking enzymes best known for their vascular remodeling in hypertension. They require calcium to form an isopeptide bond, connecting a glutamine to a protein bound lysine residue or a free amine donor such as norepinephrine (NE) or
Gamze Dereli Can et al.
Cytotherapy, 21(1), 83-95 (2018-12-05)
Several methods to cultivate limbal epithelial stem cells (LESCs) in vitro with the support of feeder layers and different growth medium formulations have been established for several years. The initial green medium consists of various ingredients that exhibit a non-optimal
Shamsan A Almowallad et al.
Saudi journal of biological sciences, 29(2), 963-969 (2022-02-25)
The pectinase enzymes are involved in several industrial applications, and industrial waste is one of the largest environmental pollutants, so this study aims to Endo-polygalacturonase (endo-PG) producing using Aspergillus niger AUMC 4156, Penicillium oxalicum AUMC 4153 and P. variotii AUMC
Nancy Hachicho et al.
PloS one, 10(8), e0134755-e0134755 (2015-08-21)
Morphology and physiology of fish embryos undergo dramatic changes during their development until the onset of feeding, supplied only by endogenous yolk reserves. For obtaining an insight how these restructuring processes are reflected by body mass related parameters, dry weights
Jun-Bean Park et al.
PloS one, 6(11), e28327-e28327 (2011-12-06)
The role and underlying mechanisms of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, on myocardial infarction are poorly understood. We investigated the effects of this PPAR-γ agonist on the expression of tissue factor (TF), a primary molecule for thrombosis, and
Elena Stocco et al.
Journal of tissue engineering and regenerative medicine, 11(7), 2060-2070 (2015-10-30)
The desired clinical outcome after implantation of engineered tissue substitutes depends strictly on the development of biodegradable scaffolds. In this study we fabricated 1% and 2% oxidized polyvinyl alcohol (PVA) hydrogels, which were considered for the first time for tissue-engineering
Claudia X Dominguez et al.
Cancer discovery, 10(2), 232-253 (2019-11-09)
With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart the fibroblastic landscape during pancreatic ductal adenocarcinoma (PDAC) progression in animal models. We identify a
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Shahin Homaeigohar et al.
Materials science & engineering. C, Materials for biological applications, 116, 111248-111248 (2020-08-19)
Here, for the first time, a nanofibrous (NF) wound dressing comprising biomineralized polyacrylonitrile (PAN) nanofibers is developed. In contrast to the majority of the currently available nanofibrous wound dressings that are based on natural polymers, PAN is a synthetic, industrial
Jemma Victoria Walker et al.
Nature communications, 10(1), 3596-3596 (2019-08-11)
Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs
Yojana J P Carreón et al.
Scientific reports, 8(1), 9580-9580 (2018-06-27)
The deposit patterns derived from droplet evaporation allow current development of medical tests and new strategies for diagnostic in patients. For such purpose, the development and implementation of algorithms capable of characterizing and differentiating deposits are crucial elements. We report
Francesco Paonessa et al.
Cell reports, 26(3), 582-593 (2019-01-17)
The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal dementia (FTD), but the underlying pathogenic mechanisms are unclear. Using human stem cell models of FTD due to MAPT
Cristina Cigana et al.
PloS one, 4(12), e8439-e8439 (2009-12-29)
Pseudomonas aeruginosa can establish life-long airways chronic infection in patients with cystic fibrosis (CF) with pathogenic variants distinguished from initially acquired strain. Here, we analysed chemical and biological activity of P. aeruginosa Pathogen-Associated Molecular Patterns (PAMPs) in clonal strains, including
Gunter Almer et al.
International journal of nanomedicine, 6, 1279-1290 (2011-07-15)
Atherosclerosis is a leading cause of mortality in the Western world, and plaque diagnosis is still a challenge in cardiovascular medicine. The main focus of this study was to make atherosclerotic plaques visible using targeted nanoparticles for improved imaging. Today
Emily R Billinge et al.
Analytical chemistry, 86(2), 1030-1037 (2014-01-02)
Aptamers are short single-stranded pieces of DNA or RNA capable of binding to analytes with specificity and high affinity. Due to their comparable selectivity, stability, and cost, over the last two decades, aptamers have started to challenge antibodies in their
Ashim Chandra Bhowal et al.
Colloids and surfaces. B, Biointerfaces, 133, 263-269 (2015-06-30)
Photoluminescence behavior of globular proteins, lysozyme and bovine serum albumin (BSA), from their bulk and thin film conformations have been studied in presence of mono-, di- and tri-valent ions by using fluorescence and UV-Vis spectroscopy at two different temperatures and
Vasiliki Gkretsi et al.
Experimental cell research, 352(2), 281-292 (2017-02-18)
A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton thus enabling cells to respond to mechanical cues. Vasodilator-stimulated phosphoprotein (VASP)
Christopher R Bethel et al.
Antimicrobial agents and chemotherapy, 52(9), 3135-3143 (2008-06-19)
The partnering of a beta-lactam with a beta-lactamase inhibitor is a highly effective strategy that can be used to combat bacterial resistance to beta-lactam antibiotics mediated by serine beta-lactamases (EC 3.2.5.6). To this end, we tested two novel penem inhibitors
Chandrashekhar Charavaryamath et al.
Journal of occupational medicine and toxicology (London, England), 3, 24-24 (2008-11-01)
Swine barn air contains endotoxin and many other noxious agents. Single or multiple exposures to pig barn air induces lung inflammation and loss of lung function. However, we do not know the effect of exposure to pig barn air on
Hazem A H Kataya et al.
Evidence-based complementary and alternative medicine : eCAM, 5(3), 281-287 (2008-10-03)
The protective action against oxidative stress of red cabbage (Brassica oleracea) extract was investigated. Diabetes was induced in male Wistar rats using streptozotocin (60 mg/kg body weight). Throughout the experimental period (60 days), diabetic rats exhibited many symptoms including loss
Giulia Guarnieri et al.
International journal of molecular sciences, 21(17) (2020-08-29)
TNFα is the main proinflammatory cytokine implicated in the pathogenesis of neurodegenerative disorders, but it also modulates physiological functions in both the developing and adult brain. In this study, we investigated a potential direct role of TNFα in determining phenotypic
A A Troussard et al.
The Journal of biological chemistry, 270(29), 17068-17071 (1995-07-21)
Adenovirus vector-mediated transfer of the receptor-associated protein (RAP) gene into low density lipoprotein (LDL) receptor-deficient mice was shown to achieve plasma concentrations ranging between 20 and 200 micrograms/ml and to result in the accumulation of remnant lipoproteins (Willnow, T. E.
Zhe-Wei Yang et al.
Sensors (Basel, Switzerland), 22(4) (2022-02-27)
A graphene-based surface plasmon resonance (SPR) prism coupler sensor is proposed for the rapid detection of immunoglobulin G (IgG) antibodies. The feasibility of the proposed sensor is demonstrated by measuring the IgG concentration in phantom mouse and human serum solutions
Margherita Leonardi et al.
Autophagy, 15(2), 312-326 (2018-10-06)
Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in
Yooju Jung et al.
Biochemical and biophysical research communications, 539, 28-33 (2021-01-09)
Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into
Suhanya Duraiswamy et al.
Infection and immunity, 86(4) (2018-01-31)
Urinary tract infections (UTIs) are a major infection of humans, particularly affecting women. Recurrent UTIs can cause significant discomfort and expose patients to high levels of antibiotic use, which in turn contributes to the development of higher antibiotic resistance rates.
Oliver Friedrich et al.
PloS one, 3(3), e1762-e1762 (2008-06-03)
In dystrophic mdx skeletal muscle, aberrant Ca2+ homeostasis and fibre degeneration are found. The absence of dystrophin in models of Duchenne muscular dystrophy (DMD) has been connected to altered ion channel properties e.g. impaired L-type Ca2+ currents. In regenerating mdx
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