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Patric J D Delhanty et al.
Endocrinology, 155(11), 4287-4295 (2014-07-26)
Ghrelin receptor-deficient (Ghsr-/-) mice that lack acylated ghrelin (AG) signaling retain a metabolic response to unacylated ghrelin (UAG). Recently, we showed that Ghsr-deficiency affects bone metabolism. The aim of this study was to further establish the impact of AG and
Tsz Kin Ng et al.
Scientific reports, 5, 7828-7828 (2015-01-17)
Cigarette smoking contributes to the development of destructive periodontal diseases and delays its healing process. Our previous study demonstrated that nicotine, a major constituent in the cigarette smoke, inhibits the regenerative potentials of human periodontal ligament-derived stem cells (PDLSC) through
Soohwan Yum et al.
Fitoterapia, 103, 55-62 (2015-03-24)
We investigated a potential molecular target for anti-colitic effects of esculetin, 6,7-dihydroxycoumarin. Esculetin administered rectally effectively ameliorated TNBS-induced rat colitis and attenuated the expression of pro-inflammatory mediators in the inflamed colon. In human colon carcinoma HCT116 cells, esculetin induced hypoxia-inducible
Irene Dini et al.
Journal of natural products, 71(12), 2036-2037 (2008-11-28)
A new cysteine sulfoxide, (S(S)R(C))-S-(3-pentenyl)-L-cysteine sulfoxide (1), was identified from the seeds of Allium cepa var. tropeana, together with the known methiin, etiin, alliin, isoalliin, propiin, and butiin. The structure of compound 1 was established by analysis of its physical
Fiona Allum et al.
Nature communications, 6, 7211-7211 (2015-05-30)
Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for
Yi-Chun Kuo et al.
PloS one, 6(7), e22382-e22382 (2011-08-06)
Surface plasmon resonance (SPR) biosensors have been recognized as a useful tool and widely used for real-time dynamic analysis of molecular binding affinity because of its high sensitivity to the change of the refractive index of tested objects. The conventional
Hemant Mittal et al.
International journal of biological macromolecules, 79, 8-20 (2015-05-03)
Biodegradable hydrogels of gum ghatti (Gg) with a co-polymer mixture of acrylamide (AAm) and methacrylic acid (MAA) (termed as Gg-cl-P(AAm-co-MAA)) were synthesised by microwave-assisted free radical graft co-polymerisation technique. The hydrogel polymer was characterized by FTIR, SEM, and Brunauer-Emmett-Teller techniques.
Dongfeng Wei et al.
Carbohydrate polymers, 125, 161-168 (2015-04-11)
Beta-amyloid (Aβ) peptide, the hallmark of Alzheimer's disease, invokes oxidative damage to neurons and eventually leads to neuronal death. Selenylation modification of polysaccharide obtained from Radix hedysari (RHP) was studied to access antioxidant activities and neuroprotective effects against oxidative stress
Hannah E Da Silva et al.
Journal of the Academy of Nutrition and Dietetics, 114(8), 1181-1194 (2014-03-19)
Poor diet and a sedentary lifestyle can contribute to nonalcoholic fatty liver disease (NAFLD). Our aim was to compare diet and physical activity of patients with NAFLD and healthy controls with current recommendations. This was a cross-sectional study. Seventy-four patients
Basavaraj Girennavar et al.
Bioorganic & medicinal chemistry, 15(11), 3684-3691 (2007-04-03)
Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against
Larissa Nelson et al.
Cartilage, 5(4), 203-214 (2015-06-13)
Osteoarthritis (OA) is a debilitating disease affecting more than 4 million people in the United Kingdom. Despite its prevalence, there is no successful cell-based therapy currently used to treat patients whose cartilage is deemed irrecoverable. The present study aimed to
Pratima Tripathi et al.
Indian journal of biochemistry & biophysics, 50(2), 99-104 (2013-06-01)
Increased production of oxygen free radicals and decreased oxidant capacity occur in coronary artery diseases (CAD) This pro-oxidant shift in intracellular redox state may induce cell death by either direct cell membrane damage by lipic peroxidation or apoptosis through activation
Henriette Jülke et al.
Cell transplantation, 24(6), 1111-1125 (2013-12-18)
The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep
Partha Pratim Roy et al.
Bioorganic chemistry, 56, 1-7 (2014-06-03)
The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation. Both experimental and computational approaches were taken to the work. The experiments were
Hyoung Ja Kim et al.
Journal of natural products, 69(4), 600-603 (2006-04-29)
Bioassay-directed chromatographic fractionation of an ethyl acetate extract of Gardenia jasminoides (Gardeniae Fructus) afforded a new vanillic acid 4-O-beta-d-(6'-sinapoyl)glucopyranoside (1) and five new quinic acid derivatives, methyl 5-O-caffeoyl-3-O-sinapoylquinate (2), ethyl 5-O-caffeoyl-3-O-sinapoylquinate (3), methyl 5-O-caffeoyl-4-O-sinapoylquinate (4), ethyl 5-O-caffeoyl-4-O-sinapoylquinate (5), and methyl
Chih-Chiang Chen et al.
Journal of dermatological science, 75(1), 55-62 (2014-05-08)
EGb-761 is an antioxidant and anticarcinogen; however, its role as a photoprotector remains unknown. To determine whether EGb-761 photoprotects human dermal fibroblasts and BALB/c mice skin against ultraviolet B (UVB) light irradiation. To simulate chronic photodamage, shaved BALB/c mice were
Hiroki Teraoka et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 19-26 (2014-05-27)
The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of aryl hydrocarbon receptor type 2 (AHR2) and AHR
Qin-Hua Gu et al.
Nature communications, 6, 6789-6789 (2015-04-11)
Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. It is associated with the formation and enlargement of dendritic spines-tiny protrusions accommodating excitatory synapses. Both LTP and spine remodelling are crucial for brain development
Shigeyuki Chaki et al.
Pharmacology, biochemistry, and behavior, 135, 154-168 (2015-06-06)
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence that the blockade of the MCH1 receptor exhibits antidepressant and
Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor.
A Maqbool et al.
eLife, 4 (2015-08-26)
Plants have evolved intracellular immune receptors to detect pathogen proteins known as effectors. How these immune receptors detect effectors remains poorly understood. Here we describe the structural basis for direct recognition of AVR-Pik, an effector from the rice blast pathogen
Kathrin Schneider et al.
Journal of natural products, 72(10), 1768-1772 (2009-10-24)
A family of new secondary metabolites with a carbazole moiety and an alkyl side chain was isolated from Tsukamurella pseudospumae strain Acta 1857. They were named lipocarbazoles in accordance with their chemical structures, which were determined by mass spectrometry and
Juliane Meyer et al.
Aesthetic surgery journal, 35(8), 1030-1039 (2015-05-27)
In recent years the therapeutic application of extracted adipose tissue for autologous fat grafting and the application of adipose tissue-derived mesenchymal stem cells (adMSC) isolated thereof has progressed. Water-jet assisted liposuction (WAL) is 1 procedure for harvesting adipose tissue and
Feng Shi et al.
Bioorganic & medicinal chemistry letters, 19(19), 5565-5568 (2009-09-05)
The green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives was achieved in water via microwave-assisted three-component reactions of malononitrile, aromatic aldehydes and 2-mercaptoacetic acid with molar ratios of 2:1:1.5 and 2:2.2:1, respectively. These compounds were subject to the experiments of antioxidant activity
Lean-Teik Ng et al.
Bioorganic & medicinal chemistry, 17(13), 4360-4366 (2009-06-02)
Deoxybenzoins (DOBs) are one-pot synthetic precursors of isoflavones with feature analogous to those beneficial polyphenols such as resveratrol (stilbene) and phloretin (dihydrochalcone). In this study, seventeen polyphenolic DOBs were synthesized and evaluated by various antioxidant assays and tyrosinase inhibitory effect
Kanagalakshmi Ambothi et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 82, 72-78 (2015-05-20)
The aim of this study was to evaluate the photochemopreventive effects of ferulic acid (FA) against chronic ultraviolet-B (290-320 nm) induced oxidative stress, inflammation and angiogenesis in the skin of Swiss albino mice. Chronic UVB exposure (180 mJ/cm(2) for 30 weeks;
Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.
Hiroyuki Moriyama et al.
Stem cells and development, 23(18), 2211-2224 (2014-06-01)
Human adipose tissue-derived multilineage progenitor cells (hADMPCs) are attractive for cell therapy and tissue engineering because of their multipotency and ease of isolation without serial ethical issues. However, their limited in vitro lifespan in culture systems hinders their therapeutic application.
Yusuke Takahashi et al.
Phytotherapy research : PTR, 28(10), 1513-1519 (2014-05-07)
Evidences are accumulating that extract of Acanthopanax senticosus Harms (ASH; syn Eleutherococcus senticosus [Rupr. & Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on
Ewa Pomianowska et al.
BMC cancer, 14, 413-413 (2014-06-11)
Several studies have described an increased cyclooxygenase-2 (COX-2) expression in pancreatic cancer, but the role of COX-2 in tumour development and progression is not clear. The aim of the present study was to examine expression of COX-2 in cancer cells
Enrico Lucarelli et al.
Journal of translational medicine, 12, 95-95 (2014-04-11)
In osteosarcoma (OS) and most Ewing sarcoma (EWS) patients, the primary tumor originates in the bone. Although tumor resection surgery is commonly used to treat these diseases, it frequently leaves massive bone defects that are particularly difficult to be treated.
Koji Mizuhashi et al.
PloS one, 10(7), e0133704-e0133704 (2015-07-25)
Various kinds of transmembrane and secreted proteins play pivotal roles in development through cell-cell communication. We previously reported that Obif (Osteoblast induction factor, Tmem119), encoding a single transmembrane protein, is expressed in differentiating osteoblasts, and that Obif-/- mice exhibit significantly
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