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关键词:'A3262'
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Entsar Saheb et al.
Iranian journal of parasitology, 10(2), 213-229 (2015-08-08)
Acanthamoeba castellanii forms a resistant cyst that protects the parasite against the host's immune response. Acanthamoeba Type-I metacaspase (Acmcp) is a caspase-like protein that has been found to be expressed during the encystations. Dictyostelium discoideum is an organism closely related
Natascha Fussi et al.
Cell death & disease, 9(7), 757-757 (2018-07-11)
Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson's disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by wrapping them into autophagosomes, followed by fusion with lysosomes. We had previously shown that pharmacological activation of macroautophagy
Floriana Volpicelli et al.
PloS one, 9(10), e109671-e109671 (2014-10-29)
Estrogens promote a plethora of effects in the CNS that profoundly affect both its development and mature functions and are able to influence proliferation, differentiation, survival and neurotransmission. The biological effects of estrogens are cell-context specific and also depend on
Debolina Ray et al.
The American journal of pathology, 185(4), 1061-1072 (2015-03-22)
During cholestatic liver disease, there is dysregulation in the balance between biliary growth and loss in bile duct-ligated (BDL) rats modulated by neuroendocrine peptides via autocrine/paracrine pathways. Gonadotropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and
Hui-Hui Chai et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 8853-8864 (2019-04-30)
Depression is increasingly recognized as an inflammatory disease, with inflammatory crosstalk in the brain contributing its pathogenesis. Life stresses may up-regulate inflammatory processes and promote depression. Although cytokines are central to stress-related immune responses, their contribution to stress-induced depression remains
Fangfang Niu et al.
Journal of cellular physiology, 234(11), 20057-20065 (2019-04-12)
This study aims to examine the impact of ursodeoxycholic acid (UDCA) on pulmonary edema and explore the underlying molecular mechanisms. The effects of UDCA on pulmonary edema were assessed through hematoxylin and eosin (H&E) staining, lung dry/wet (W/D) ratio, TNF-α/IL-1β
Caroline Honaiser Lescano et al.
Food & function, 12(2), 802-814 (2021-01-05)
Alibertia edulis leaf extract is commonly used in folk medicine, with rutin caffeic and vanillic acids being its major compounds. The Alibertia edulis leaf extract was investigated for its pharmacological effects via platelet aggregation, calcium mobilization, cyclic nucleotides levels, vasodilator-stimulated
Satoshi Mikami et al.
Chemical & pharmaceutical bulletin, 65(11), 1058-1077 (2017-11-03)
It has been hypothesized that selective inhibition of phosphodiesterase (PDE) 2A could potentially be a novel approach to treat cognitive impairment in neuropsychiatric and neurodegenerative disorders through augmentation of cyclic nucleotide signaling pathways in brain regions associated with learning and
Hany H Arab et al.
ACS chemical neuroscience, 12(4), 689-703 (2021-02-06)
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has emerged as a promising neuroprotective agent in murine models of epilepsy and obesity-induced cognitive impairment through its marked antioxidant/antiapoptotic features. However, the impact of dapagliflozin on the pathogenesis of Parkinson's disease
Ketty Bacallao et al.
PloS one, 10(2), e0116948-e0116948 (2015-02-24)
Isolated Schwann cells (SCs) respond to cAMP elevation by adopting a differentiated post-mitotic state that exhibits high levels of Krox-20, a transcriptional enhancer of myelination, and mature SC markers such as the myelin lipid galactocerebroside (O1). To address how cAMP
Junko Nio-Kobayashi et al.
Molecular human reproduction, 21(8), 645-654 (2015-05-25)
Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and
Elizabeth A Corey et al.
Molecular and cellular neurosciences, 110, 103585-103585 (2020-12-29)
Olfactory GPCRs (ORs) in mammalian olfactory receptor neurons (ORNs) mediate excitation through the Gαs family member Gαolf. Here we tentatively associate a second G protein, Gαo, with inhibitory signaling in mammalian olfactory transduction by first showing that odor evoked phosphoinositide
M Kyle Cromer et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), 4062-4067 (2015-03-20)
Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the transcription factor Yin Yang 1 (YY1). Chromatin
Ti Lu et al.
Applied and environmental microbiology, 86(24) (2020-03-08)
Enterotoxigenic Escherichia coli (ETEC) strains producing K88 (F4) or F18 fimbriae and enterotoxins are the predominant cause of pig postweaning diarrhea (PWD). We recently identified neutralizing epitopes of fimbriae K88 and F18, heat-labile toxin (LT), heat-stable toxins type I (STa)
Wararat Kittikulsuth et al.
BMC nephrology, 18(1), 292-292 (2017-09-09)
The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in substantial part through activation of adenylyl cyclase (AC); however
Krishnaveni Mohareer et al.
Frontiers in cellular and infection microbiology, 10, 457-457 (2020-10-27)
Mitochondria, are undoubtedly critical organelle of a eukaryotic cell, which provide energy and offer a platform for most of the cellular signaling pathways that decide cell fate. The role of mitochondria in immune-metabolism is now emerging as a crucial process
Hai-Fan Yu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 3820-3837 (2020-01-17)
Malic enzyme 1 (Me1), a member of the malic enzymes involving in glycolytic pathway and citric acid cycle, is essential for the energy metabolism and maintenance of intracellular redox balance state, but its physiological role and regulatory mechanism in the
Shobana Navaneethabalakrishnan et al.
Clinical science (London, England : 1979), 134(24), 3237-3257 (2020-12-22)
Hypertension is one of the most prevalent diseases that leads to end organ damage especially affecting the heart, kidney, brain, and eyes. Numerous studies have evaluated the association between hypertension and impaired sexual health, in both men and women. The
Michaela Liegertová et al.
Scientific reports, 5, 11885-11885 (2015-07-15)
Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been resolved. Here
Débora Lanznaster et al.
Cells, 8(12) (2019-12-19)
Guanosine, a guanine-based purine nucleoside, has been described as a neuromodulator that exerts neuroprotective effects in animal and cellular ischemia models. However, guanosine's exact mechanism of action and molecular targets have not yet been identified. Here, we aimed to elucidate
Eva Rodríguez-Traver et al.
Stem cell research, 42, 101663-101663 (2019-12-04)
Here, we present the characterization of three iPSC lines derived from dermal fibroblasts of old healthy subjects. Fibroblasts were reprogrammed using Sendai viral vectors encoding OCT4, SOX2, KLF4 and c-MYC. The iPSCs expressed endogenous pluripotency markers, could generate the three
Momoka Yamaguchi et al.
Biological & pharmaceutical bulletin, 40(5), 658-664 (2017-05-02)
During liver injury, hepatic stellate cells (HSCs) are activated by various cytokines and transdifferentiated into myofibroblast-like activated HSCs, which produce collagen, a major source of liver fibrosis. Therefore, the suppression of HSC activation is regarded as a therapeutic target for
Alexander García-Ponce et al.
Cells, 9(10) (2020-10-01)
Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key properties of barriers between endothelial cells derived from wild-type
Lucia M Moreira et al.
Nature, 587(7834), 460-465 (2020-11-06)
Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in humans1. Atrial-tissue fibrosis is a central pathophysiological feature of atrial fibrillation that also hampers its treatment; the underlying molecular
Hyun Lee et al.
EMBO reports, 21(11), e49416-e49416 (2020-10-09)
Prominin-1 (Prom1) is a major cell surface marker of cancer stem cells, but its physiological functions in the liver have not been elucidated. We analyzed the levels of mRNA transcripts in serum-starved primary WT (Prom1+/+ ) and KO (Prom1-/- )
Matthew E Doers et al.
Stem cells and development, 23(15), 1777-1787 (2014-03-25)
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untranslated region of the FMR1 gene on the
Sonali Sinha et al.
Oncogene, 39(6), 1231-1245 (2019-10-17)
Arginine vasopressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and water homeostasis by the kidneys. V2R activation also stimulates proliferation of renal cell carcinoma (RCC) cell lines in vitro. The current studies
Morihiro Fujimura et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 543-551 (2014-06-15)
We characterized TRK-130 (N-[(5R,6R,14S)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]phthalimide; naltalimide), an opioid ligand, to clarify the therapeutic potential for overactive bladder (OAB). In radioligand-binding assays with cells expressing human µ-opioid receptors (MORs), δ-opioid receptors (DORs), or κ-opioid receptors (KORs), TRK-130 showed high selectivity for MORs
Xing Liu et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 38(6), 394-399 (2015-02-27)
Humans have dopamine D5 receptors (hD5R) with single-nucleotide polymorphisms and a diminished function. We generated hD5(F173L) cDNA that has a decreased response to D5R agonist-mediated increase in cAMP production and increased production of reactive oxygen species, relative to wild-type hD5R
E C Alexandre et al.
British journal of pharmacology, 173(3), 415-428 (2015-10-24)
This article is commented on by Michel, M. C., pp. 429-430 of this issue. To view this commentary visit http://dx.doi.org/10.1111/bph.13379. Mirabegron is the first β3 -adrenoceptor agonist approved for treatment of overactive bladder syndrome. This study aimed to investigate the
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