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William H Fissell et al.
Journal of membrane science, 326(1), 58-63 (2010-01-08)
Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration...
T Sakurai et al.
Clinical and experimental immunology, 178(1), 65-74 (2014-06-20)
Invariant natural killer T (iNKT) cells play important immunoregulatory functions in allergen-induced airway hyperresponsiveness and inflammation. To clarify the role of iNKT cells in allergic rhinitis (AR), we generated bone marrow-derived dendritic cells (BMDCs), which were pulsed by ovalbumin (OVA)...
Yun Xia et al.
Cell, 175(4), 1059-1073 (2018-10-03)
Motivated by the clinical observation that interruption of the mevalonate pathway stimulates immune responses, we hypothesized that this pathway may function as a druggable target for vaccine adjuvant discovery. We found that lipophilic statin drugs and rationally designed bisphosphonates that...
Sheng Zeng et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(4), 360-365 (2014-02-26)
It has been reported that adoptive transfer of γδ T cells increases the cellular infiltration, especially eosinophils, in the lungs of allergic mice, suggesting that γδ T cells may play a proinflammatory role in allergic airway inflammation. Respiratory syncytial virus...
G H Grit et al.
Parasite immunology, 36(4), 157-169 (2014-01-01)
Giardia duodenalis is an important intestinal parasite in animals and humans. The role of dendritic cells (DC) in the initiation of the immune response against G. duodenalis is poorly documented. The aim of this study was to test the hypothesis that...
Afonso P Basto et al.
Molecular immunology, 64(1), 36-45 (2014-12-04)
The use of immunogenic formulations targeting pattern recognition receptors towards modulation of immune responses is a promising strategy to develop better vaccines against infectious and malignant diseases. Molecules targeting TLR2 offer interesting properties that are relevant for vaccine development, including...
Jason S Weinstein et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3166-3179 (2014-03-13)
B cells are required for follicular Th (Tfh) cell development, as is the ICOS ligand (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh cell development and function are unknown. We find that...
Rylie P Flesher et al.
Clinical science (London, England : 1979), 126(11), 805-814 (2013-12-19)
Endogenous mediators, such as RvE1 (resolvin E1), promote resolution of an inflammatory response and have potential as novel therapeutic agents. In the present study, we investigated the activity of RvE1 in a model of an acute exacerbation of chronic allergic...
Zheng-Rong Chen et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(4), 276-281 (2013-09-24)
B7 molecules play a key role in regulating allergen-induced T cell activation in asthma, which may occur through T cell recruitment and T helper cell differentiation on allergen provocation. Initial studies have shown that B7-H3 (CD276), a recently identified B7...
Niels-Erik Viby et al.
Endocrinology, 154(12), 4503-4511 (2013-10-05)
The incretin hormone glucagon-like peptide-1 (GLP-1) is an important insulin secretagogue and GLP-1 analogs are used for the treatment of type 2 diabetes. GLP-1 displays antiinflammatory and surfactant-releasing effects. Thus, we hypothesize that treatment with GLP-1 analogs will improve pulmonary...
Kathrin Straubinger et al.
The Journal of allergy and clinical immunology, 134(6), 1271-1279 (2014-07-22)
Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH1 and subsequent TH2 phase to a regulatory state, and is associated with dampened allergic reactions within the host. We sought to evaluate whether...
Yosuke Kumamoto et al.
Immunity, 39(4), 733-743 (2013-10-01)
Unlike other types of T helper (Th) responses, whether the development of Th2 cells requires instruction from particular subset of dendritic cells (DCs) remains unclear. By using an in vivo depletion approach, we have shown that DCs expressing CD301b were...
J Kelley Bentley et al.
The Journal of allergy and clinical immunology, 134(6), 1433-1442 (2014-07-06)
Periostin, a secreted extracellular matrix protein, has been localized to deposits of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13. We hypothesized that periostin is required for airway inflammatory responses to a physiologic...
G Wu et al.
Journal of physiology and biochemistry, 65(3), 235-241 (2010-02-02)
Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid clearance. Scavenger endothelial cells (SECs) play the primary role in clearing glycoproteins via receptor-mediated endocytosis in adult animals. We found that horseradish peroxidase (HRP), a glycoprotein, was...
Mohammad Hossein Boskabady et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 200-208 (2013-04-12)
The effects of carvacrol on tracheal responsiveness (TR) to methacholine and ovalbumin (OA), serum nitric oxide (NO) concentration, total and differential white blood cells (WBC) in blood of sensitized guinea pigs were examined. Five groups of guinea pigs sensitized to...
Federica Moalli et al.
The Journal of experimental medicine, 211(13), 2507-2517 (2014-12-10)
Interactions between dendritic cells (DCs) and T cells control the decision between activation and tolerance induction. Thromboxane A2 (TXA2) and its receptor TP have been suggested to regulate adaptive immune responses through control of T cell-DC interactions. Here, we show...
Daria Esterházy et al.
Nature, 569(7754), 126-130 (2019-04-17)
The intestinal immune system has the challenging task of tolerating foreign nutrients and the commensal microbiome, while excluding or eliminating ingested pathogens. Failure of this balance leads to conditions such as inflammatory bowel diseases, food allergies and invasive gastrointestinal infections1....
Emma D Flood et al.
International journal of molecular sciences, 21(17) (2020-09-06)
Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited EFS-induced contraction in tissues with but not without perivascular adipose tissue (PVAT)....
Patrick Trépanier et al.
Immunology, 141(2), 233-241 (2013-10-17)
Intravenous immunoglobulin (IVIg) is successfully used in the treatment of autoimmune diseases involving self-reactive CD8(+) T cells. However, its direct influence on the cytotoxic response remains unknown. Using an antigen cross-presentation assay and a mouse model of ovalbumin (OVA) immunization...
A D Nisbet et al.
European journal of biochemistry, 115(2), 335-345 (1981-04-01)
The complete amino acid sequence of hen ovalbumin, comprising 385 residues, has been determined. The sequence was deduced from the 17 cyanogen bromide fragments and from peptides derived by digestion with a number of proteolytic enzymes. The molecular weight of...
JangEun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3190-3199 (2014-02-26)
Fatty acids (FAs) are essential constituents of cell membranes, signaling molecules, and bioenergetic substrates. Because CD8(+) T cells undergo both functional and metabolic changes during activation and differentiation, dynamic changes in FA metabolism also occur. However, the contributions of de...
Shelly Leung et al.
Cellular immunology, 282(2), 79-84 (2013-06-19)
OT-II mice were evaluated as a transgenic strain-specific model to assess T-cell help for B-cell responses. OT-II CD4(+) T-cells express transgenic OVA-specific αβ-TCRs. This high frequency of antigen-specific helper T-lymphocytes may augment induction of B-cell responses. Unexpectedly, OT-II mice did...
Hasan Yuksel et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 150-155 (2013-04-04)
Vascular endothelial growth factor (VEGF) is an important mediator of the neoangiogenesis component of remodeling in asthma. To evaluate the influence of VEGF blockage on airway remodeling, specifically epithelium thickness, subepithelial smooth muscle thickness, number of mast and goblet cells...
Nanna Fyhrquist et al.
The Journal of allergy and clinical immunology, 134(6), 1301-1309 (2014-09-30)
The human commensal microbiota interacts in a complex manner with the immune system, and the outcome of these interactions might depend on the immune status of the subject. Previous studies have suggested a strong allergy-protective effect for Gammaproteobacteria. Here we...
M Antošová et al.
Advances in experimental medicine and biology, 838, 1-10 (2014-09-26)
Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive oxygen species (ROS)....
Oliver T Burton et al.
The Journal of allergy and clinical immunology, 134(6), 1310-1317 (2014-07-22)
Food-induced anaphylaxis is triggered by specific IgE antibodies. Paradoxically, some subjects with significant IgE levels can ingest allergenic foods without incident. Similarly, subjects completing oral immunotherapy (OIT) tolerate food challenges despite persistent high-titer food-specific IgE. We sought to test whether...
A differential scanning calorimetric study of conversion of ovalbumin to S-ovalbumin in eggs.
J W Donovan et al.
Journal of the science of food and agriculture, 27(2), 197-204 (1976-02-01)
Shin Yoshino et al.
Immunology, 141(4), 617-627 (2013-12-07)
Fab fragments (Fabs) maintain the ability to bind to specific antigens but lack effector functions due to the absence of the Fc portion. In the present study, we tested whether Fabs of an allergen-specific monoclonal antibody (mAb) were able to...
M Ritter et al.
Clinical and experimental immunology, 178(2), 212-223 (2014-06-20)
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type...
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