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Daria Esterházy et al.
Nature, 569(7754), 126-130 (2019-04-17)
The intestinal immune system has the challenging task of tolerating foreign nutrients and the commensal microbiome, while excluding or eliminating ingested pathogens. Failure of this balance leads to conditions such as inflammatory bowel diseases, food allergies and invasive gastrointestinal infections1.
Emma D Flood et al.
International journal of molecular sciences, 21(17) (2020-09-06)
Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited EFS-induced contraction in tissues with but not without perivascular adipose tissue (PVAT).
Oliver T Burton et al.
The Journal of allergy and clinical immunology, 134(6), 1310-1317 (2014-07-22)
Food-induced anaphylaxis is triggered by specific IgE antibodies. Paradoxically, some subjects with significant IgE levels can ingest allergenic foods without incident. Similarly, subjects completing oral immunotherapy (OIT) tolerate food challenges despite persistent high-titer food-specific IgE. We sought to test whether
Nanna Fyhrquist et al.
The Journal of allergy and clinical immunology, 134(6), 1301-1309 (2014-09-30)
The human commensal microbiota interacts in a complex manner with the immune system, and the outcome of these interactions might depend on the immune status of the subject. Previous studies have suggested a strong allergy-protective effect for Gammaproteobacteria. Here we
Hasan Yuksel et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 150-155 (2013-04-04)
Vascular endothelial growth factor (VEGF) is an important mediator of the neoangiogenesis component of remodeling in asthma. To evaluate the influence of VEGF blockage on airway remodeling, specifically epithelium thickness, subepithelial smooth muscle thickness, number of mast and goblet cells
Shin Yoshino et al.
Immunology, 141(4), 617-627 (2013-12-07)
Fab fragments (Fabs) maintain the ability to bind to specific antigens but lack effector functions due to the absence of the Fc portion. In the present study, we tested whether Fabs of an allergen-specific monoclonal antibody (mAb) were able to
Cynthia Kanagaratham et al.
American journal of respiratory cell and molecular biology, 51(6), 783-792 (2014-06-03)
Arachidonic acid (AA) and docosahexaenoic acid (DHA) play important roles in inflammation and disease progression, where AA is viewed as proinflammatory and DHA as antiinflammatory. We observe in our model of allergic asthma that the AA/DHA ratio is significantly skewed
A differential scanning calorimetric study of conversion of ovalbumin to S-ovalbumin in eggs.
J W Donovan et al.
Journal of the science of food and agriculture, 27(2), 197-204 (1976-02-01)
Alison J Hodgkinson et al.
The British journal of nutrition, 112(3), 390-397 (2014-05-30)
Epidemiological studies have shown an association between the consumption of raw farm milk and reduced incidence of allergy. In the present study, we fed untreated raw milk, gamma-sterilised milk, heat-treated milk or water to mice and compared their responses to
M Antošová et al.
Advances in experimental medicine and biology, 838, 1-10 (2014-09-26)
Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive oxygen species (ROS).
JangEun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3190-3199 (2014-02-26)
Fatty acids (FAs) are essential constituents of cell membranes, signaling molecules, and bioenergetic substrates. Because CD8(+) T cells undergo both functional and metabolic changes during activation and differentiation, dynamic changes in FA metabolism also occur. However, the contributions of de
Joel R Wilmore et al.
Journal of immunology (Baltimore, Md. : 1950), 191(9), 4731-4739 (2013-10-02)
High rates of coinfection occur in malaria endemic regions, leading to more severe disease outcomes. Understanding how coinfecting pathogens influence the immune system is important in the development of treatment strategies that reduce morbidity and mortality. Using the Plasmodium chabaudi
Kamal Srivastava et al.
American journal of physiology. Lung cellular and molecular physiology, 305(12), L1002-L1010 (2013-10-29)
Our previous studies have shown that the anti-asthma traditional Chinese medicine herbal formula ASHMI (anti-asthma simplified herbal medicine intervention) inhibits acetylcholine-induced contractions of tracheal rings from ovalbumin-sensitized and naive mice in a β-adrenoceptor-independent manner. We sought to determine whether acute
Adam Williams et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 6955-6960 (2013-04-10)
The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is
pH control in the midgut of
Denise Barguil Nepomuceno et al.
The Journal of experimental biology, 220(Pt 18), 3355-3362 (2017-09-22)
So Ri Kim et al.
The Journal of allergy and clinical immunology, 132(6), 1397-1408 (2013-10-29)
Despite many studies on endoplasmic reticulum (ER) stress in patients with various inflammatory diseases, there is scarce information on ER stress in patients with bronchial asthma. In this study we aimed to elucidate the role of ER stress in the
Chia-Chi Wang et al.
BMC complementary and alternative medicine, 13, 154-154 (2013-07-03)
Arecae semen, the dried slice of areca nuts, is a traditional Chinese medicine used to treat intestinal parasitosis, rectal tenesmus and diarrhea. Areca nuts contain a rich amount of polyphenols that have been shown to modulate the functionality of mast
Shinji Toki et al.
Journal of leukocyte biology, 94(1), 77-88 (2013-04-30)
PGI₂ signaling through IP inhibits allergen-induced inflammatory responses in mice. We reported previously that PGI₂ analogs decreased proinflammatory cytokine and chemokine production by mature BMDCs. However, whether PGI₂ modulates the function of immature DCs has not been investigated. We hypothesized
Jaba Gamrekelashvili et al.
The Journal of clinical investigation, 123(11), 4755-4768 (2013-11-13)
Cross-priming of CD8+ T cells and generation of effector immune responses is pivotal for tumor immunity as well as for successful anticancer vaccination and therapy. Dead and dying cells produce signals that can influence Ag processing and presentation; however, there
Benjamin Brinkhoff et al.
European journal of immunology, 44(4), 1213-1224 (2013-12-18)
Immunotherapy of solid tumors is often hampered by the low frequency of tumor-specific T cells elicited by current vaccination strategies. Here, we describe a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid (PLGA) microspheres followed
Hannah E Cummings et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5807-5810 (2013-11-19)
Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences. In this article, we demonstrate that LTC4, but not
Chakkrit Khanaree et al.
Oncology research, 20(9), 427-435 (2013-08-09)
Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo. The tumor-suppressing effects of maspin depend in part on its ability to enhance cell adhesion to extracellular matrix. Although the molecular mechanism of maspin's
Karin M Knudson et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5797-5801 (2013-11-19)
CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal
M Ritter et al.
Clinical and experimental immunology, 178(2), 212-223 (2014-06-20)
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type
Ruchi Roy et al.
Toxicology letters, 230(3), 421-433 (2014-08-17)
Our previous studies indicated that zinc oxide nanoparticles (ZnO NPs) have adjuvant properties to a known allergen ovalbumin (OVA) in Balb/c mice. Therefore, in this study, we focused on the mechanisms involved in adjuvant responses induced by ZnO NPs. The
Tim Koopmans et al.
Scientific reports, 10(1), 6754-6754 (2020-04-23)
Asthma is a heterogeneous disease characterized by chronic inflammation and structural changes in the airways. The airway smooth muscle (ASM) is responsible for airway narrowing and an important source of inflammatory mediators. We and others have previously shown that WNT5A
Saki Kawashima et al.
International archives of allergy and immunology, 161 Suppl 2, 118-124 (2013-06-05)
Recent studies have shown that prolonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling, in part through the induction of resistin-like molecule α (RELMα) expression. However, the role of interleukin-25 (IL-25; which promotes this inflammation) in the development
Preety Sahdev et al.
Journal of biomedical nanotechnology, 9(1), 132-141 (2013-05-01)
The main objective of this study was to investigate the potential of calcium phosphate (CAP) nanoparticles for transcutaneous vaccine delivery. CAP nanoparticles were prepared by nanoprecipitation method followed by sequential adsorption of sugars and ovalbumin. Nanoparticles were characterized using dynamic
S B Wang et al.
Scandinavian journal of immunology, 78(6), 507-515 (2013-10-12)
Lactoferrin (LF) can downregulate allergic airway inflammation in asthma. However, the in vivo effect of exogenous LF on allergic rhinitis (AR), a disease attributed to airway inflammation, has yet to be determined. We investigated the effect of intranasal administration recombinant
Dharmesh M Kanani et al.
Journal of membrane science, 349(1-2), 405-405 (2010-02-18)
The effects of pore size on the performance of ultrafiltration membranes are fairly well understood, but there is currently no information on the impact of pore geometry on the trade-off between the selectivity and permeability for membranes with pore size
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