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关键词:'C3117'
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Ivana Savic Azoulay et al.
Redox biology, 51, 102253-102253 (2022-03-06)
Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca2+, Mg2+ and
Pai-Sheng Chen et al.
The Journal of clinical investigation, 121(9), 3442-3455 (2011-08-16)
MicroRNAs (miRNAs) influence many biological processes, including cancer. They do so by posttranscriptionally repressing target mRNAs to which they have sequence complementarity. Although it has been postulated that miRNAs can regulate other miRNAs, this has never been shown experimentally to
Aereas Aung et al.
Science (New York, N.Y.), 379(6630), eabn8934-eabn8934 (2023-01-27)
The structural integrity of vaccine antigens is critical to the generation of protective antibody responses, but the impact of protease activity on vaccination in vivo is poorly understood. We characterized protease activity in lymph nodes and found that antigens were
Yejun Tan et al.
Frontiers in immunology, 14, 1149810-1149810 (2023-04-11)
Patients with diabetes mellitus (DM) have a higher incidence of malignant tumors than people without diabetes, but the underlying molecular mechanisms are still unclear. To investigate the link between DM and cancer, we screened publicly available databases for diabetes and
25th Anniversary Article: Design of Polymethine Dyes for All-Optical Switching Applications: Guidance from Theoretical and Computational Studies
Gieseking RL, et al.
Advanced Materials, 26(1), 68-84 (2014)
Yiqing Li et al.
Cell death & disease, 11(4), 221-221 (2020-04-07)
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy that is characterized by a high frequency of induction failure and by early relapse. Many studies have revealed that metadherin (MTDH) is highly expressed in a variety of malignant solid
Wei Li et al.
Animal models and experimental medicine (2023-08-11)
The effect of platelet factor 4 (PF4) on bone marrow mesenchymal stem cells (BMMSCs) and osteoporosis is poorly understood. Therefore, this study aimed to evaluate the effects of PF4-triggered bone destruction in mice and determine the underlying mechanism. First, in
Yan Liu et al.
Journal of translational medicine, 20(1), 167-167 (2022-04-11)
Calcific aortic valve disease (CAVD) is the most commonly valvular disease in the western countries initiated by inflammation and abnormal calcium deposition. Currently, there is no clinical drug for CAVD. Neutrophil elastase (NE) plays a causal role in inflammation and
Lan-Tian Lai et al.
Experimental cell research, 319(3), 46-55 (2012-11-21)
Cell research often requires combinational detection of RNA and DNA by fluorescence in situ hybridization (RNA-DNA FISH). However, it is difficult to preserve the fragile RNA signals through the harsh conditions used to denature the DNA template in DNA FISH.
Peng-Wei Yu et al.
Microbiology spectrum, 10(2), e0227621-e0227621 (2022-04-12)
Porcine reproductive and respiratory syndrome virus (PRRSV) infection leads to late-term reproductive failure and respiratory illness that affect the global swine industry. Epigallocatechin gallate (EGCG) is a polyphenolic compound from green tea that exerts antiviral activity against diverse viruses. This
Quantitative profile of the uropathogenic Escherichia coli outer membrane proteome during growth in human urine
Alteri CJ and Mobley HLT
Infection and Immunity, 75(6), 2679-2688 (2007)
Chao-Yue Yang et al.
Chinese journal of traumatology = Zhonghua chuang shang za zhi, 26(3), 155-161 (2023-04-06)
This study aims to elucidate the electrotaxis response of alveolar epithelial cells (AECs) in direct-current electric fields (EFs), explore the impact of EFs on the cell fate of AECs, and lay the foundation for future exploitation of EFs for the
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