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Petra Halang et al.
Journal of bacteriology, 195(21), 4888-4899 (2013-08-27)
Vibrio cholerae is motile by its polar flagellum, which is driven by a Na(+)-conducting motor. The stators of the motor, composed of four PomA and two PomB subunits, provide access for Na(+) to the torque-generating unit of the motor. To
Hisako Hikiji et al.
Journal of materials science. Materials in medicine, 25(6), 1531-1538 (2014-02-28)
Rapid and efficient animal models are needed for evaluating the effectiveness of many new candidate bone regenerative materials. We developed an in vivo model screening for calvarial bone regeneration in lipopolysaccharide (LPS)-treated mice, in which materials were overlaid on the
Xi Zhan et al.
Pharmaceutical research, 32(7), 2280-2291 (2015-01-17)
A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular functions. In this study, we examined the intracellular distribution of both fluorecent
Yu Huang et al.
ACS nano, 10(11), 10489-10499 (2016-11-05)
Recent years have witnessed significant progress in the field of two-photon-activated photodynamic therapy (2P-PDT). However, the traditional photosensitizer (PS)-based 2P-PDT remains a critical challenge in clinics due to its low two-photon absorption (2PA) cross sections. Here, we propose that the
Jaleh Varshosaz et al.
Journal of liposome research, 25(2), 157-165 (2014-10-03)
The objective of the present study was to prepare a micellar polymeric carrier for the delivery of Docetaxel (DTX) as a kind of polysorbate free preparation. Pluronic F127 (PF127) was conjugated to cholesterol (Chol) via succinyl linkage and characterized by
Rachel Wallen et al.
Nanoscale research letters, 10(1), 978-978 (2015-06-25)
Vertically aligned single-walled carbon nanotube (VASWCNT) assemblies are generated on cysteamine and 2-mercaptoethanol (2-ME)-functionalized gold surfaces through amide bond formation between carboxylic groups generated at the end of acid-shortened single-walled carbon nanotubes (SWCNTs) and amine groups present on the gold
Sergey K Filippov et al.
Carbohydrate polymers, 134, 314-323 (2015-10-03)
This article describes the synthesis of novel starch-antioxidant conjugates, which show great potential for biomedical applications to protect cells from oxidative damage. These conjugates were synthesized by the modification of a hydroxyethyl starch (molecular weight=200,000g/mol) with various sterically hindered phenols
Phthalocyanine-titanate nanotubes: a promising nanocarrier detectable by optical imaging in the so-called imaging window.
Paris J, et al.
Royal Society of Chemistry Advances, 5(9), 6315-6322 (2015)
Riccardo Bruni et al.
Journal of controlled release : official journal of the Controlled Release Society, 255, 94-107 (2017-04-12)
We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to podocytes, in order to overcome the failure of current therapeutic regimens in patients with proteinuric (i.e. abnormal amount of proteins
Rongqiang Liao et al.
Chembiochem : a European journal of chemical biology, 16(11), 1622-1628 (2015-06-03)
A targeting gene carrier for cancer-specific delivery was successfully developed through a "multilayer bricks-mortar" strategy. The gene carrier was composed of adamantane-functionalized folic acid (FA-AD), an adamantane-functionalized poly(ethylene glycol) derivative (PEG-AD), and β-cyclodextrin-grafted low-molecular-weight branched polyethylenimine (PEI-CD). Carriers produced by
Fatemeh Zeinali Nasrabadi et al.
Molecular diversity, 15(3), 791-798 (2011-03-23)
Reactions of (N-isocyanimino)triphenylphosphorane with N,N-dicyclohexylcarbodiimide in the presence of aromatic (or heteroaromatic) carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild
Haijun Xiao et al.
International journal of nanomedicine, 10, 5309-5325 (2015-09-09)
To study the effects of X-shaped amphiphilic block copolymers on delivery of docetaxel (DTX) and the reduction-sensitive property on drug release, a novel reduction-sensitive amphiphilic copolymer, (PLGA)2-SS-4-arm-PEG2000 with a Gemini-like X-shape, was successfully synthesized. The formation of nanomicelles was proved
Diego Sanchez et al.
Experimental gerontology, 67, 19-47 (2015-04-15)
A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mechanisms must contribute to the adaptability and plasticity still present in the healthy aged
Shaona Cao et al.
FEBS letters, 587(9), 1310-1315 (2013-03-12)
Non-photochemical quenching (NPQ) of chlorophyll fluorescence is thought to be an indicator of an essential regulation and photoprotection mechanism against high-light stress in photosynthetic organisms. In this report, special chemicals were used to perturb the kinetics of the ΔpH build-up
Simona Matrella et al.
Macromolecular bioscience, 15(7), 927-940 (2015-03-18)
Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by
Yuzhi Liu et al.
Leukemia & lymphoma, 56(6), 1863-1868 (2014-11-14)
Considering the variable and often modest therapeutic efficacy of rituximab for a substantial proportion of patients suffering from non-Hodgkin lymphomas (NHLs), various type II anti-CD20 monoclonal antibodies (mAbs) with excellent ability in inducing programmed cell death (PCD) are currently being
L Kostka et al.
Physiological research, 64 Suppl 1, S29-S40 (2015-10-09)
Efficient intravenous delivery is the greatest single hurdle, with most nanotherapeutics frequently found to be unstable in the harsh conditions of the bloodstream. In the case of nanotherapeutics for gene delivery, viral vectors are often avidly recognized by both the
Petra Votavova et al.
Journal of biomedical nanotechnology, 11(9), 1662-1673 (2015-10-22)
Interleukin-2 (IL-2) possesses a strong stimulatory activity for activated T and NK cells and it is an attractive molecule for immunotherapy. Nevertheless, extremely short half-life and severe toxicities associated with high-dose IL-2 treatment are serious and limiting drawbacks. In order
Armin Osmanagic et al.
The American journal of cardiology, 116(2), 225-229 (2015-05-15)
In patients with persistent atrial fibrillation (AF), the sinus rhythm (SR) can be restored by direct current cardioversion (DCC), although the recurrence of AF after successful DCC is common. We examined whether transesophageal echocardiography (TEE)-guided early DCC, compared with the
Cornelia Podjaski et al.
Brain : a journal of neurology, 138(Pt 6), 1598-1612 (2015-04-24)
Blood-brain barrier function is driven by the influence of astrocyte-secreted factors. During neuroinflammatory responses the blood-brain barrier is compromised resulting in central nervous system damage and exacerbated pathology. Here, we identified endothelial netrin 1 induction as a vascular response to
Amanda J Sutherland et al.
PloS one, 10(5), e0121966-e0121966 (2015-05-13)
Extracellular matrix (ECM)-based materials are attractive for regenerative medicine in their ability to potentially aid in stem cell recruitment, infiltration, and differentiation without added biological factors. In musculoskeletal tissue engineering, demineralized bone matrix is widely used, but recently cartilage matrix
Keisuke Toda et al.
Clinical epigenetics, 7, 73-73 (2015-07-25)
The gene expressions of netrin-1 dependence receptors, DCC and UNC5C, are frequently downregulated in many cancers. We hypothesized that downregulation of DCC and UNC5C has an important growth regulatory function in gastric tumorigenesis. In the present study, a series of
Mar Castillo-Paterna et al.
EMBO reports, 16(7), 851-862 (2015-05-08)
Controlling the axon growth rate is fundamental when establishing brain connections. Using the thalamocortical system as a model, we previously showed that spontaneous calcium activity influences the growth rate of thalamocortical axons by regulating the transcription of Robo1 through an
Zulfiqar Ahmad et al.
Biochemistry, 53(47), 7376-7385 (2014-11-07)
This paper describes the role of α-subunit VISIT-DG sequence residue αThr-349 in the catalytic sites of Escherichia coli F1Fo ATP synthase. X-ray structures show the highly conserved αThr-349 in the proximity (2.68 Å) of the conserved phosphate binding residue βR182
Yunrui Li et al.
ACS applied materials & interfaces, 10(30), 25213-25218 (2018-07-07)
In this work, the highly efficient target recycling-based netlike Y-shaped DNA (Y-DNA), which regulated the electrocatalysis of Fe3O4@CeO2-Pt nanoparticles (Fe3O4@CeO2-PtNPs) toward methylene blue (MB) for signal amplification, was developed to prepare a sensitive DNA biosensor for detecting the DNA associated
Yanyan Jiang et al.
Macromolecular bioscience, 15(7), 965-978 (2015-03-27)
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioconjugation was achieved in a site-specific manner to yield well-defined polymer-protein conjugates. The biohybrid was
Zenghui Cheng et al.
International journal of biological macromolecules, 131, 387-395 (2019-03-19)
Utilization of natural sustainable feedstock to fabricate polymers has attracted remarkable attention. In this work, we reported a strategy to prepare a series of grafted copolymers from rosin, fatty acids and ethyl cellulose. The process involved the preparation of EC-based
Xuanang Gong et al.
Carbohydrate polymers, 250, 116846-116846 (2020-10-15)
In this work, reversible addition-fragmentation chain transfer (RAFT) polymerization and Schiff base chemistry was combined to fabricate self-healing adhesives. An esterification reaction was first performed to prepare ethyl cellulose based macroinitiators. Then, a "grafting from" RAFT of vanillin methacrylate and
Xian Zhang et al.
Toxicon : official journal of the International Society on Toxinology, 106, 89-96 (2015-09-28)
Ochratoxin A (OTA) is one of the most commonly occurring mycotoxins produced by some species of Aspergillus and can contaminate cereal and cereal products. A high-affinity anti-OTA monoclonal antibody (mAb) was generated from a hybridoma cell line 2D8 using splenocytes
Seryoung Kim et al.
MicrobiologyOpen, 4(4), 632-643 (2015-06-16)
We previously reported that the alaE gene of Escherichia coli encodes the l-alanine exporter AlaE. The objective of this study was to elucidate the mechanism of the AlaE exporter. The minimum inhibitory concentration of l-alanine and l-alanyl-l-alanine in alaE-deficient l-alanine-nonmetabolizing
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