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Tao Shang et al.
The Journal of surgical research, 188(1), 316-325 (2014-02-04)
We investigated the hypothesis that an antioxidant, Vitamin C, could attenuate abdominal aortic aneurysm (AAA) development in a rat model. An AAA model induced by intraluminal infusion was created in 36 male Sprague Dawley rats, which were randomly distributed into...
Baumstark, J.S., et al.
Biochimica et Biophysica Acta, 77, 676-676 (1963)
Arthur J Michalek et al.
Journal of biomechanics, 42(14), 2279-2285 (2009-08-12)
Shear strain has been implicated as an initiator of intervertebral disc anulus failure, however a clear, multi-scale picture of how shear strain affects the tissue microstructure has been lacking. The purposes of this study were to measure microscale deformations in...
Anna Piaszyk-Borychowska et al.
Frontiers in immunology, 10, 1253-1253 (2019-06-25)
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and atherosclerosis. Interferon (IFN)α, IFNγ, and Toll-like...
Elena Burillo et al.
Clinical science (London, England : 1979), 130(12), 1027-1038 (2016-03-20)
Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches....
Christine Terryn et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 83(2), 235-241 (2012-12-06)
The spatial organization of proteins in a cell population or in tissues is an important parameter to study the functionality of biological specimens. In this article, we have focused on tight junctions which form network-like features in immunofluorescence microscopy images....
Charles R Esther et al.
American journal of physiology. Lung cellular and molecular physiology, 304(7), L504-L509 (2013-01-29)
Measurement of exhaled breath condensate (EBC) biomarkers offers a noninvasive means to assess airway disease, but the ability of EBC biomarkers to track longitudinal changes in disease severity remains unproven. EBC was collected from pediatric patients with cystic fibrosis (CF)...
Y Bi et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(2), 145-152 (2013-01-03)
To modify the method for creating an abdominal aortic aneurysm in rabbits, and to study its performance. A total of 24 New Zealand white rabbits were induced topically with 10 μl of porcine elastase (0, 0.1, 5 and 10 units...
F D T Q S Lopes et al.
Histology and histopathology, 28(2), 269-276 (2013-01-01)
A single instillation of porcine pancreatic elastase (PPE) results in significant airspace enlargement on the 28th day after instillation, whereas cigarette smoke (CS) exposure requires 6 months to produce mild emphysema in rodents. Considering that there are differences in the...
Sandra Cerqueira Barros et al.
Biopolymers, 98(6), 576-590 (2012-12-04)
Chronic nonhealing skin wounds, such as leg ulcers and pressure sores, represent a major clinical problem and a financial burden for the health care systems. Chronic wounds are characterized by prolonged inflammatory phase that results in high levels of elastase...
Yoshiyuki Okumura et al.
Journal of medical microbiology, 53(Pt 5), 351-354 (2004-04-21)
Elastolytic and elastase inhibitory activities were investigated for 13 strains of Aspergillus fumigatus, three strains of Aspergillus flavus and three strains of Aspergillus niger. Nine of the 13 strains of A. fumigatus and all strains of A. flavus demonstrated elastase...
Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice
Napp LC, et al.
Vascular Cell, 8(1), 4-4 (2016)
Fengqi Yao et al.
European journal of pharmacology, 860, 172559-172559 (2019-07-22)
Abdominal aortic aneurysm (AAA) is characterized with progressive weakening and considerable dilation of the aortic wall. Despite the high risk of mortality in the elderly population, there are still no clinical pharmacological therapies to alleviate AAA progression. Macrophage-derived MMP9 acts...
E V Urazovskaia et al.
Klinicheskaia laboratornaia diagnostika, (12)(12), 8-10 (2013-03-14)
It is established that the most informative blood biochemical indicators of destructive process in patients with onycholysis are to be considered concentration of oxiproline in blood. The changing of ratio of fractions oxiproline, balance between concentration of enzymes of antioxidant...
Endothelial MMP-9 drives the inflammatory response in abdominal aortic aneurysm (AAA)
Ramella M, et al.
American Journal of Translational Research, 9(12), 5485-5485 (2017)
Takuto Yoshida et al.
International archives of allergy and immunology, 161 Suppl 2, 138-146 (2013-06-05)
A recent study suggested that protease-activated receptors (PARs) are involved in allergic respiratory diseases, such as asthma. Chronic rhinosinusitis (CRS) is one of the most common chronic airway diseases, but little is understood about its pathogenesis. The purpose of this...
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet
Metghalchi S, et al.
PLoS ONE, 13(3), e0193737-e0193737 (2018)
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
W Bode et al.
Biochemistry, 28(5), 1951-1963 (1989-03-07)
Brian P O'Sullivan et al.
The Journal of pediatrics, 162(4), 808-812 (2012-12-19)
To describe pancreatic function during the first year of life in infants diagnosed with cystic fibrosis (CF) using serial fecal elastase measurements. This was a longitudinal study of 82 infants diagnosed with CF through newborn screening. Monthly stool samples were...
Ping-Chung Kuo et al.
Journal of natural products, 76(2), 230-236 (2013-01-26)
Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data...
Navin Chicooree et al.
Rapid communications in mass spectrometry : RCM, 27(1), 127-134 (2012-12-15)
Identification of sites of protein SUMOylation is of great importance due its functional diversity within the cell. To date, most approaches to this problem rely on site-directed mutagenesis and/or highly specialised mass spectrometry approaches. We present a novel alternative approach...
Jason W Nichol et al.
Tissue engineering. Part A, 15(6), 1281-1290 (2008-10-22)
We previously demonstrated the ability to create engineered arteries by carefully controlling the mechanical environment of intact arteries perfused ex vivo, yielding engineered arteries with native appearance and vasoactive response. Increased axial strain was sufficient to increase length up to...
Yao Chen et al.
Aging, 12(7), 5651-5674 (2020-04-02)
Vascular calcification is a common phenomenon in older adults. Intermedin (IMD) is a cardiovascular bioactive peptide inhibiting vascular calcification. In this study, we aimed to investigate whether IMD1-53 attenuates aging-associated vascular calcification. Vascular calcification was induced by vitamin D3 plus...
Sean Yang-Yi Tan et al.
Antimicrobial agents and chemotherapy, 57(11), 5629-5641 (2013-09-05)
Bacteria communicate by means of small signal molecules in a process termed quorum sensing (QS). QS enables bacteria to organize their activities at the population level, including the coordinated secretion of virulence factors. Certain small-molecule compounds, known as quorum-sensing inhibitors...
Boyer, P. D.
The Enzymes, 3(3), 323-373 (1971)
Kohta Unno et al.
Applied microbiology and biotechnology, 104(12), 5293-5302 (2020-04-18)
Microviridins are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) that have been isolated from a wide variety of cyanobacterial strains. There are similar gene clusters of RiPPs distributed in the genomes of bacteria belonging to the phyla...
Nazareth de Novaes Rocha et al.
Respiratory research, 18(1), 185-185 (2017-11-05)
Emphysema is a progressive disease characterized by irreversible airspace enlargement followed by a decline in lung function. It also causes extrapulmonary effects, such as loss of body mass and cor pulmonale, which are associated with shorter survival and worse clinical...
Artem A Tykhomyrov et al.
Life sciences, 134, 22-29 (2015-06-03)
Angiogenesis and chronic inflammation are known to be co-dependent in atherosclerosis and cardiovascular diseases. This study was undertaken to investigate whether simvastatin could affect serum levels of angiostatin, a potent endogenous inhibitor of neovascularization, in patients with ischemic heart disease...
Carlos Tarín et al.
Journal of the American Heart Association, 3(4), doi:10-doi:10 (2014-08-06)
Abdominal aortic aneurysm (AAA) involves leukocyte recruitment, inflammatory cytokine production, vascular cell apoptosis, neovascularization, and vascular remodeling, all of which contribute to aortic dilatation. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a cytokine implicated in proinflammatory responses, angiogenesis...
Ming-Chang Lin et al.
Journal of natural products, 76(9), 1661-1667 (2013-09-12)
Eleven new eunicellin-based diterpenoids possessing a cladiellane skeleton with a C-2, C-9 ether bridge, klymollins I-S (1-11), have been isolated from the EtOAc extract of the soft coral Klyxum molle from Taiwan waters. The structures of compounds 1-11 were elucidated...
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