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Jirí Molácek et al.
Journal of vascular research, 46(1), 1-5 (2008-06-03)
Many studies have been performed in order to model abdominal aortic aneurysm (AAA) in an experimental animal, most commonly in small laboratory animals. In our study, we tried to find the best AAA model in a pig by using various
Jianling Zhang et al.
Cellular immunology, 286(1-2), 11-15 (2013-11-26)
Apoptosis induced by Pseudomonas aeruginosa in host cells plays a role in pathogenesis. However, little is known how the apoptosis of macrophages harboring P. aeruginosa affects the host or pathogen. In this study, the viability of J774 macrophages phagocytosing Pa
O T Titarenko et al.
Biomeditsinskaia khimiia, 58(4), 467-474 (2013-02-19)
Functional activity of circulating phagocytes (macrophages--Ms and neutrophils--Ns) was studied in 30 patients with infiltrative (I) and 30 patients with fibro-cavernous (FC) pulmonary tuberculosis (PT). Difference of the functional activity of both types of cells depending on the PT form
Hu Wan et al.
PloS one, 8(1), e53343-e53343 (2013-01-12)
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation. While spider-derived Kunitz-type proteins show activity in trypsin or chymotrypsin inhibition and K(+) channel blocking, no additional role for these
Chenyu Jiang et al.
Nature communications, 12(1), 4395-4395 (2021-07-22)
The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Although previous studies have focused on the design and synthesis of self-healing materials, their application in in vivo settings remains limited. Here, we design a
Deniz Doğru et al.
The Turkish journal of pediatrics, 55(1), 50-57 (2013-05-23)
In cystic fibrosis (CF), if Pseudomonas aeruginosa (Pa) infection is not diagnosed and treated early, chronic colonization occurs, which causes rapid decline in pulmonary functions. The aim of this study was to evaluate Pa antibodies, compare them with Pa cultures
Yoshiteru Tada et al.
Stroke, 45(2), 579-586 (2013-12-29)
Systemic hypertension has long been considered a risk factor of aneurysmal rupture. However, a causal link between systemic hypertension and the development of aneurysmal rupture has not been established. In this study, using a mouse model of intracranial aneurysm rupture
Takafumi Toyohara et al.
Cell stem cell, 27(1), 147-157 (2020-05-16)
Although susceptibility to cardiovascular disease (CVD) is different for every patient, why some patients with type 2 diabetes mellitus (T2DM) develop CVD while others are protected has not yet been clarified. Using T2DM-patient-derived human induced pluripotent stem cells (hiPSCs), we
Nadine Ziemert et al.
Applied and environmental microbiology, 76(11), 3568-3574 (2010-04-07)
Microviridins are ribosomally synthesized tricyclic depsipeptides produced by different genera of cyanobacteria. The prevalence of the microviridin gene clusters and the natural diversity of microviridin precursor sequences are currently unknown. Screening of laboratory strains and field samples of the bloom-forming
Guizhen Zhao et al.
JCI insight, 6(5) (2021-01-29)
Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Krüppel-like factor 11 (KLF11) plays an essential role in maintaining vascular homeostasis, at least partially through inhibition
Kelly Gomes Santana et al.
Frontiers in immunology, 12, 684076-684076 (2021-08-10)
Cholesterol-ester transfer protein (CETP) plays a role in atherosclerosis, the inflammatory response to endotoxemia and in experimental and human sepsis. Functional alterations in lipoprotein (LP) metabolism and immune cell populations, including macrophages, occur during sepsis and may be related to
Carlos-Ernesto Fernandez-García et al.
Clinical science (London, England : 1979), 131(22), 2707-2719 (2017-10-07)
Abdominal aortic aneurysm (AAA) evolution is unpredictable and no specific treatment exists for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated with CVD, but its potential role in AAA has not been addressed. Galectin-3 levels were
Qianyu Zhang et al.
International journal of chronic obstructive pulmonary disease, 16, 147-158 (2021-02-04)
Chronic obstructive pulmonary disease (COPD), characterized by irreversible airflow limitation, is a highly prevalent lung disease worldwide and imposes increasing disease burdens globally. Emphysema is one of the primary pathological features contributing to the irreversible decline of pulmonary function in
Phuong T T Nguyen et al.
The Journal of steroid biochemistry and molecular biology, 141, 16-25 (2014-01-01)
Cortisol bound to corticosteroid binding globulin (CBG) contributes up to 90% of the total cortisol concentration in circulation. Therefore, changes in the binding kinetics of cortisol to CBG can potentially impact on the concentration of free cortisol, the only form
Takuto Yoshida et al.
International archives of allergy and immunology, 161 Suppl 2, 138-146 (2013-06-05)
A recent study suggested that protease-activated receptors (PARs) are involved in allergic respiratory diseases, such as asthma. Chronic rhinosinusitis (CRS) is one of the most common chronic airway diseases, but little is understood about its pathogenesis. The purpose of this
Fengqi Yao et al.
European journal of pharmacology, 860, 172559-172559 (2019-07-22)
Abdominal aortic aneurysm (AAA) is characterized with progressive weakening and considerable dilation of the aortic wall. Despite the high risk of mortality in the elderly population, there are still no clinical pharmacological therapies to alleviate AAA progression. Macrophage-derived MMP9 acts
Endothelial MMP-9 drives the inflammatory response in abdominal aortic aneurysm (AAA)
Ramella M, et al.
American Journal of Translational Research, 9(12), 5485-5485 (2017)
E V Urazovskaia et al.
Klinicheskaia laboratornaia diagnostika, (12)(12), 8-10 (2013-03-14)
It is established that the most informative blood biochemical indicators of destructive process in patients with onycholysis are to be considered concentration of oxiproline in blood. The changing of ratio of fractions oxiproline, balance between concentration of enzymes of antioxidant
Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice
Napp LC, et al.
Vascular Cell, 8(1), 4-4 (2016)
Arthur J Michalek et al.
Journal of biomechanics, 42(14), 2279-2285 (2009-08-12)
Shear strain has been implicated as an initiator of intervertebral disc anulus failure, however a clear, multi-scale picture of how shear strain affects the tissue microstructure has been lacking. The purposes of this study were to measure microscale deformations in
Anna Piaszyk-Borychowska et al.
Frontiers in immunology, 10, 1253-1253 (2019-06-25)
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and atherosclerosis. Interferon (IFN)α, IFNγ, and Toll-like
Christine Terryn et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 83(2), 235-241 (2012-12-06)
The spatial organization of proteins in a cell population or in tissues is an important parameter to study the functionality of biological specimens. In this article, we have focused on tight junctions which form network-like features in immunofluorescence microscopy images.
Elena Burillo et al.
Clinical science (London, England : 1979), 130(12), 1027-1038 (2016-03-20)
Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches.
Charles R Esther et al.
American journal of physiology. Lung cellular and molecular physiology, 304(7), L504-L509 (2013-01-29)
Measurement of exhaled breath condensate (EBC) biomarkers offers a noninvasive means to assess airway disease, but the ability of EBC biomarkers to track longitudinal changes in disease severity remains unproven. EBC was collected from pediatric patients with cystic fibrosis (CF)
Y Bi et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(2), 145-152 (2013-01-03)
To modify the method for creating an abdominal aortic aneurysm in rabbits, and to study its performance. A total of 24 New Zealand white rabbits were induced topically with 10 μl of porcine elastase (0, 0.1, 5 and 10 units
F D T Q S Lopes et al.
Histology and histopathology, 28(2), 269-276 (2013-01-01)
A single instillation of porcine pancreatic elastase (PPE) results in significant airspace enlargement on the 28th day after instillation, whereas cigarette smoke (CS) exposure requires 6 months to produce mild emphysema in rodents. Considering that there are differences in the
Baumstark, J.S., et al.
Biochimica et Biophysica Acta, 77, 676-676 (1963)
Tao Shang et al.
The Journal of surgical research, 188(1), 316-325 (2014-02-04)
We investigated the hypothesis that an antioxidant, Vitamin C, could attenuate abdominal aortic aneurysm (AAA) development in a rat model. An AAA model induced by intraluminal infusion was created in 36 male Sprague Dawley rats, which were randomly distributed into
Shuai Liu et al.
Journal of the American Heart Association, 9(8), e014757-e014757 (2020-04-21)
Background The protective effects of polyamines on cardiovascular disease have been demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied. In this study, we investigated the influence
Qiu Renfeng et al.
Molecular medicine reports, 24(5) (2021-09-08)
An abdominal aortic aneurysm (AAA) is a life‑threatening disease associated with a high mortality rate. At present, surgery or minimally invasive interventions are used in clinical treatment, especially for small aneurysms. However, the benefits of surgical repair are not obvious
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