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Yarlini Balarajan et al.
The Journal of nutrition, 143(8), 1309-1315 (2013-06-14)
Improving maternal nutrition is an important step toward reducing low birth weight (LBW) and its sequelae. In India, an estimated 7.5 million babies are born each year with LBW, which accounts for more than one-third of the global burden. In
Henrik Kempe et al.
Pharmaceutical research, 32(2), 375-388 (2014-08-12)
To develop and evaluate molecularly imprinted nanocarriers for sustained release of erythromycin in physiological buffer media. Erythromycin-imprinted poly(methacrylic acid-co-trimethylolpropane trimethacrylate) nanocarriers and corresponding control nanocarriers were prepared by free-radical precipitation polymerization. The nanocarriers were characterized by transmission electron microscopy, dynamic
Patrick O'Donoghue et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17206-17211 (2014-11-19)
Expanding the genetic code is an important aim of synthetic biology, but some organisms developed naturally expanded genetic codes long ago over the course of evolution. Less than 1% of all sequenced genomes encode an operon that reassigns the stop
Wei-liang Ye et al.
PloS one, 9(5), e97358-e97358 (2014-05-16)
A PEG-based, folate mediated, active tumor targeting drug delivery system using DOX-hyd-PEG-FA nanoparticles (NPs) were prepared. DOX-hyd-PEG-FA NPs showed a significantly faster DOX release in pH 5.0 medium than in pH 7.4 medium. Compared with DOX-hyd-PEG NPs, DOX-hyd-PEG-FA NPs increased
[Pregnancy again? The importance of folic acid].
Sarah Poulin-Chartrand
Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec, 11(3), 10-10 (2014-05-28)
Xiali Zhu et al.
Journal of drug targeting, 22(9), 822-828 (2014-06-26)
This report focuses on the in vitro and in vivo anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free
Per Ashorn et al.
The American journal of clinical nutrition, 101(2), 387-397 (2015-02-04)
Small birth size, often associated with insufficient maternal nutrition, contributes to a large share of global child undernutrition, morbidity, and mortality. We developed a small-quantity lipid-based nutrient supplement (SQ-LNS) to enrich the diets of pregnant women. The objective was to
Myra A Carpenter et al.
Journal of the American Society of Nephrology : JASN, 25(7), 1554-1562 (2014-03-15)
The optimal BP level in kidney transplant recipients remains uncertain. This post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial cohort assessed associations of BP with a pooled cardiovascular disease (CVD) outcome and with
Arnold L M Dekkers et al.
The Journal of nutrition, 144(12), 2083-2091 (2014-10-17)
For the evaluation of both the adequacy of intakes and the risk of excessive intakes of micronutrients, all potential sources should be included. In addition to micronutrients naturally present in foods, micronutrients can also be derived from fortified foods and
Audrey J Gaskins et al.
Obstetrics and gynecology, 124(1), 23-31 (2014-06-06)
To evaluate prospectively the relationship between prepregnancy folate intake and risk of spontaneous abortion and stillbirth. Women in the Nurses' Health Study II who self-reported a pregnancy between 1992 and 2009 were included in this analysis. Dietary folate and supplement
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2102-2109 (2014-08-15)
We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the
Karine Meisser-Redeuil et al.
Journal of AOAC International, 97(4), 1121-1126 (2014-08-26)
A UHPLC-MS/MS method for the determination of folate (vitamin B9) in infant formula and adult/pediatric nutritional formula was assessed for compliance with standard method performance requirements set forth by the AOAC INTERNATIONAL Stakeholder Panel for Infant Formula and Adult Nutritionals
Shougang Jiang et al.
Drug delivery, 22(2), 206-213 (2014-01-30)
Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction
Zhiyao He et al.
Journal of biomedical nanotechnology, 9(5), 833-844 (2013-06-28)
Folate receptor alpha (FRalpha) is overexpressed on ovarian cancer cells and is a promising molecular target for ovarian cancer gene therapy, but there was still no related report. In this study, folate modified cationic liposomes (F-PEG-CLPs) for ovarian cancer gene
Valproate and folic acid in pregnancy: associations with autism.
Peter Baxter
Developmental medicine and child neurology, 56(7), 604-604 (2014-06-14)
P M Tedeschi et al.
Cell death & disease, 4, e877-e877 (2013-10-26)
Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed
Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis.
Beverley Shea
Journal of evidence-based medicine, 6(3), 202-203 (2013-12-12)
Mariano Licciardi et al.
Journal of biomedical nanotechnology, 9(6), 949-964 (2013-07-19)
Dual targeted drug delivery systems represent a potential platform for developing efficient vector to tumor sites. In this study we evaluated a folate- and magnetic-targeted nanocarriers based on 10 nm iron oxide nanodomais coated with the properly synthesized and characterized
Helene McNulty et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 348-354 (2013-06-26)
Scientific evidence supports a number of roles for folate in maintaining health from early life to old age. Folate is required for one-carbon metabolism, including the remethylation of homocysteine to methionine; thus elevated plasma homocysteine reflects functional folate deficiency. Optimal
Mingjun Xuan et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(11), 2255-2260 (2014-04-18)
The synthesis of an innovative self-propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and
Suhair Sunoqrot et al.
Journal of controlled release : official journal of the Controlled Release Society, 191, 115-122 (2014-05-20)
Nanoparticle (NP)-based drug delivery platforms have received a great deal of attention over the past two decades for their potential in targeted cancer therapies. Despite the promises, passive targeting approaches utilizing relatively larger NPs (typically 50-200nm in diameter) allow for
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:
Nikita L van der Zwaluw et al.
Neurology, 83(23), 2158-2166 (2014-11-14)
We investigated the effects of 2-year folic acid and vitamin B12 supplementation on cognitive performance in elderly people with elevated homocysteine (Hcy) levels. This multicenter, double-blind, randomized, placebo-controlled trial included 2,919 elderly participants (65 years and older) with Hcy levels
Susanna Kariluoto et al.
International journal of food microbiology, 176, 38-48 (2014-02-25)
The objective was to study folate production of yeast strains, bacteria isolated from oat bran, and selected lactic acid bacteria as well as one propionibacterium in oat and barley based models. Simultaneously, we aimed at sustaining the stability of viscosity
Barbara Anne Jennings et al.
Cancer letters, 356(2 Pt A), 224-230 (2014-03-13)
Folate was identified as an essential micronutrient early in the twentieth century and anti-folate chemotherapy such as 5-fluorouracil (5-FU) has been central to the medical management of solid tumours including colorectal cancer for more than five decades. In the intervening
Flow injection chemiluminometric determination of folic acid in pharmaceutical formulations
Analytical Sciences, 10(6), 919-922 (1994)
Cheng Yang et al.
Journal of nanoscience and nanotechnology, 13(10), 6553-6559 (2013-11-20)
In this study, thermosensitive and folate functionalized poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer was synthesized. The structure and molecular weight of the copolymer were confirmed by 1H NMR, FT-IR and GPC, respectively. The lower critical solution temperature (LCST) of
W Al-Darzi et al.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 20(9), 561-568 (2014-10-25)
Egypt has a high incidence of neural tube defects. Folic acid supplementation in the periconceptional period is known to lower the risk of such defects. This cross-sectional study aimed to measure the level of knowledge about periconceptional folic acid use
Sonia Trombino et al.
Anticancer research, 33(11), 4847-4854 (2013-11-14)
The aim of the present study was to prepare a hydrogel, based on ellagic acid and glycine, embedded with folic acid, as a subcutaneous implant for the treatment of breast cancer. The function of folic acid is to selectively and
Rima Obeid et al.
Journal of perinatal medicine, 41(5), 469-483 (2013-03-14)
Women have higher requirements for folate during pregnancy. An optimal folate status must be achieved before conception and in the first trimester when the neural tube closes. Low maternal folate status is causally related to neural tube defects (NTDs). Many
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