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关键词:'F5636'
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Sandrine Tury et al.
Oncotarget, 7(51), 85124-85141 (2016-11-12)
COX-2 expression level and prognostic value are still a matter of debate in breast cancer (BC). We addressed these points in the context of PIK3CA mutational status. Based on an interesting study of aspirin efficacy in colorectal cancer, we hypothesized
Dongxi Xiang et al.
Theranostics, 5(10), 1083-1097 (2015-07-23)
Insufficient penetration of therapeutic agents into tumor tissues results in inadequate drug distribution and lower intracellular concentration of drugs, leading to the increase of drug resistance and resultant failure of cancer treatment. Targeted drug delivery to solid tumors followed by
Kazuyuki Kasahara et al.
Nature microbiology, 3(12), 1461-1471 (2018-11-07)
Humans with metabolic and inflammatory diseases frequently harbour lower levels of butyrate-producing bacteria in their gut. However, it is not known whether variation in the levels of these organisms is causally linked with disease development and whether diet modifies the
Hiam Abdala-Valencia et al.
Journal of immunology (Baltimore, Md. : 1950), 177(9), 6379-6387 (2006-10-24)
Lymphocyte binding to VCAM-1 activates endothelial cell NADPH oxidase, resulting in the generation of 1 muM H(2)O(2). This is required for VCAM-1-dependent lymphocyte migration. In this study, we identified a role for protein kinase Calpha (PKCalpha) in VCAM-1 signal transduction
R Chignola et al.
Clinical and experimental immunology, 122(3), 429-436 (2000-12-21)
Two monoclonal antibodies (1H6.2 and 45.30) were raised against MBP purified from human brain under experimental conditions that allowed MBP to retain binding to surrounding myelin lipids (human lipid-bound MBP (hLB-MBP)). 1H6.2 and 45.30 MoAbs were selected on the basis
Pedro M Costa et al.
Molecular therapy. Nucleic acids, 2, e100-e100 (2013-06-20)
The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity
Przemysław Kaczor et al.
Frontiers in cellular neuroscience, 9, 120-120 (2015-04-29)
Gamma aminobutric acid (GABA) is the major inhibitory neurotransmitter in the adult brain and mechanisms of GABAergic inhibition have been intensely investigated in the past decades. Recent studies provided evidence for an important role of astrocytes in shaping GABAergic currents.
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