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Duolink® Proximity Ligation Assay (PLA) Multicolor Kits for Sensitive Multiplex Detection
Duolink® PLA Multicolor technology and the quantification of protein-protein interactions in fixed tissues and cells.
Duolink® PLA – Protein Detection Technology
Duolink based on Proximity Ligation Assay (in situ PLA) technology when combined with qualified antibodies outperforms traditional immunoassays, such as co-IP, through a simple and sensitive in situ detection of endogenous proteins. This technology enables you to visualize protein interactions...
Duolink® PLA Troubleshooting Guide
Support information including tips and tricks, frequently asked questions, and basic troubleshooting.
Studies of Dimerization and Activation of Receptors in the EGFR-Family Using Duolink® Assays
Our aim was to investigate the dimerization and activation pattern of two receptors, EGFR (ErbB1) and HER2 (ErbB2), in the EGFR-family using breast cancer cell lines and selected colon tissues as model systems.
Dopamine Receptors
We offer many products related to dopamine receptors for your research needs.
Phosphoprotein Phosphatases (Serine/Threonine)
We offers many products related to phosphoprotein phosphatases (Serine/Threonine) for your research needs.
Canonical Wnt / β-Catenin Signaling
We review the Wnt signaling pathway (also, canonical Wnt or beta (β)-catenin pathway) and provide links to related products at
NF-κB and Inflammation
Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.
GABAA Receptors
We offer many products related to GABAA receptors for your research needs.
Metabolic Pathways
IUBMB-Sigma- Nicholson Metabolic Pathway Charts. The 22nd edition of the IUBMB-Sigma-Nicholson Metabolic Pathways Chart contains updated pathways involved in ATP metabolism in the mitochondria and chloroplast. It contains the Glycolytic Pathway followed by the TCA (Krebs) Cycle and the Respiratory...
Nitric Oxide Synthases
We offer many products related to nitric oxide synthases for your research needs.
Glutamine Metabolism is Dysregulated in Many Cancer Cells
This is an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative...
Opioid Receptors
We offers many products related to opioid receptors for your research needs.
Glycogen Synthase Kinase 3 (GSK-3) Overview
We offers many products related to GSK-3 for your research needs.
Nuclear Receptors (Non-Steroids)
We offer many products related to non-steroid nuclear receptors for your research needs.
EX-CELL® Glycosylation Adjust (GAL+)
Our protein quality supplement, EX-CELL® Glycosylation Adjust (Gal+), provides customers with a novel chemically defined product which targets glycosylation attributes.
The focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that distinctly co-localizes with integrins at sites of attachment to their ligands.
Prostanoid Receptors
We offer many products related to prostanoid receptors for your research needs.
Proteinase-Activated Receptors
The search for a functional thrombin receptor, using expression cloning methods, led to the discovery of a G protein-coupled receptor that mediates the actions of thrombin on platelets and endothelial cells.
Cyclin-dependent Kinases (CDKs)
Cyclin dependent kinases (CDKs) are typical serine/threonine kinases that display the 11 subdomains shared by all kinases. The complete sequence of the Homo sapiens genome shows that among the ~30,000 predicted genes, there are 13 CDKs and 25 cyclins. Eleven...
ATP Synthase
Learn about ATP synthase with our molecular machine video animation showing this mechanism that provides energy to cells. Our animation is provided in partnership with Dr Nicholson and the IUBMB.
VEGF Pathway
Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.
Glutamate/GABA Synthesis and Metabolism
Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. The neurotransmitter glutamate can be synthesized from glutamine by the action of...
Platelet Derived Growth Factors (PDGF)
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
Dopamine, Norepinephrine and Ephinephrine Synthesis
Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate...
Phosphoprotein Phosphatases (Tyrosine)
Sigma-Aldrich offers many products related to phosphoprotein phosphatases (Tyrosine) for your research needs.
Troubleshooting in pGEX Expression Vectors
This page describes troubleshooting strategies for cloning the gene or gene fragment into a pGEX expression vector.
Leukotriene Receptors
We offer many products related to leukotriene receptors for your research needs.
Antilipemic Agents
Randomized controlled clinical studies have suggested 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both primary and secondary prevention of cardiovascular disease (CVD) events.
Directed Evolution
An overview of directed evolution and the methods for generating proteins with optimized or entirely new functions.
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