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关键词:'G5146'
显示 1-30 共 1913 条结果 关于 "G5146" 范围 论文
Christophe Varin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9900-9911 (2015-07-15)
Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poorly understood. Here, we
Ke Wang et al.
PloS one, 9(5), e96894-e96894 (2014-05-14)
Diabetes exacerbates abnormal vascular smooth muscle cell (VSMC) accumulation in response to arterial wall injury. Vinpocetine has been shown to improve vascular remolding; however, little is known about the direct effects of vinpocetine on vascular complications mediated by diabetes. The
Marilyn G Wiebe et al.
Applied microbiology and biotechnology, 99(22), 9439-9447 (2015-08-13)
An open reading frame CC1225 from the Caulobacter crescentus CB15 genome sequence belongs to the Gfo/Idh/MocA protein family and has 47 % amino acid sequence identity with the glucose-fructose oxidoreductase from Zymomonas mobilis (Zm GFOR). We expressed the ORF CC1225
Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Audrey Beaussart et al.
Nanoscale, 7(36), 14996-15004 (2015-08-27)
Many fungal pathogens produce cell surface polysaccharides that play essential roles in host-pathogen interactions. In Aspergillus fumigatus, the newly discovered polysaccharide galactosaminogalactan (GAG) mediates adherence to a variety of substrates through molecular mechanisms that are poorly understood. Here we use
P A Adhikari et al.
Journal of animal science, 93(1), 209-216 (2015-01-09)
The aim was to determine the true total tract digestibility (TTTD) and standardized total tract digestibility (STTD) of P in canola meals from Brassica napus black (BNB) and Brassica juncea yellow (BJY) fed to growing pigs. Fifty-four barrows with an
Yi-Chun Chen et al.
Diabetologia, 57(10), 2066-2075 (2014-07-06)
EGF and gastrin co-administration reverses type 1 diabetes in rodent models. However, the failure of this to translate into a clinical treatment suggests that EGF-mediated tissue repair is a complicated process and warrants further investigation. Thus, we aimed to determine
C Ekman et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(9), 953-960 (2015-09-05)
Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response
N V Batista et al.
Clinical and experimental immunology, 178(3), 416-427 (2014-08-13)
The prevalence of food allergy is rising in the western world. Allergen restriction is the chosen treatment in this condition, but continuous ingestion of the antigen has shown positive results in clinical trials. In a previous study, we have shown
Shefeeq M Theparambil et al.
Glia, 63(9), 1581-1594 (2015-03-31)
Cytosolic H(+) buffering plays a major role for shaping intracellular H(+) shifts and hence for the availability of H(+) for biochemical reactions and acid/base-coupled transport processes. H(+) buffering is one of the prime means to protect the cell from large
Sujatha Kandasamy et al.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 46(3), 659-666 (2015-09-29)
Ten bacterial strains that utilize cyanide (CN) as a nitrogen source were isolated from cassava factory wastewater after enrichment in a liquid media containing sodium cyanide (1 mM) and glucose (0.2% w/v). The strains could tolerate and grow in cyanide
V A Gault et al.
Acta diabetologica, 52(3), 461-471 (2014-11-07)
Xenin-25 is co-secreted with glucose-dependent insulinotropic polypeptide (GIP) from intestinal K-cells following a meal. Xenin-25 is believed to play a key role in glucose homoeostasis and potentiate the insulinotropic effect of GIP. This study investigated the effects of sub-chronic administration
Natasha R Ryz et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(9), G730-G742 (2015-09-05)
Vitamin D deficiency affects more that 1 billion people worldwide. Although thought to increase risk of bacterial infections, the importance of vitamin D on host defense against intestinal bacterial pathogens is currently unclear since injection of the active form of
Clara Iannuzzi et al.
Journal of cellular physiology, 230(11), 2807-2820 (2015-04-08)
Protein glycation is a non-enzymatic, irreversible modification of protein amino groups by reactive carbonyl species leading to the formation of advanced glycation end products (AGEs). Several proteins implicated in neurodegenerative diseases have been found to be glycated in vivo and
Benoît Chatin et al.
Molecular therapy. Nucleic acids, 4, e244-e244 (2015-06-24)
The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzyme and the anti-cytokeratin8 (K8) antibody, using liposome-based formulation.
Roosmarijn Tm van Hooijdonk et al.
Annals of intensive care, 4(1), 8-8 (2014-03-07)
OptiScanner devices, continuous glucose monitoring devices that perform automated blood draws via a central venous catheter and create plasma through centrifugation, measure plasma glucose levels through mid-infrared spectroscopy at the bedside. The objective of this study was to determine accuracy
Justin R Yates et al.
Behavioural brain research, 291, 201-208 (2015-05-26)
Negative urgency is a facet of impulsivity that reflects mood-based rash action and is associated with various maladaptive behaviors in humans. However, the underlying neural mechanisms of negative urgency are not fully understood. Several brain regions within the mesocorticolimbic pathway
S Villarruel et al.
Materials science & engineering. C, Materials for biological applications, 56, 545-554 (2015-08-08)
This work was focused on: i) developing single and blend films based on carboxymethyl cellulose (CMC) and polyvinyl alcohol (PVOH) studying their properties, ii) analyzing the interactions between CMC and PVOH and their modifications UV-induced in the presence of sodium
Charles T Putman et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 40(7), 671-682 (2015-06-04)
This study tested the hypothesis that elevating the intracellular phosphorylation potential (IPP = [ATP]/[ADP]free) within rat fast-twitch tibialis anterior muscles by creatine (Cr) loading would prevent fast-to-slow fibre transitions induced by chronic low-frequency electrical stimulation (CLFS, 10 Hz, 12 h/day).
Jiayin Wu et al.
Molecular immunology, 64(2), 235-243 (2015-01-01)
Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors
Lu Sun et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4922-4932 (2015-10-04)
TRPMLs (or mucolipins) constitute a family of endosomal cation channels with homology to the transient receptor potential superfamily. In mammals, the TRPML family includes three members: TRPML1-3. Although TRPML1 and TRPML3 have been well characterized, the cellular function of TRPML2
Hala Attia et al.
Pakistan journal of pharmaceutical sciences, 28(2), 499-508 (2015-03-03)
Cardiovascular complications have become a major cause of mortality for diabetic patients. Glibenclamide is an effective hypoglycemic agent, but failed to alleviate diabetic complications. This study aimed to evaluate whether the addition of zinc to glibenclamide could mitigate such complications.
Aghil Sharifzadeh et al.
Mycoses, 58(8), 478-484 (2015-07-15)
The purposes of this study were to investigate the enzymatic activity of different Candida species and their antifungal susceptibility patterns. The study involved a total of 83 isolates of Candida from the genital tract of the female Camelus dromedarius. After
Sung Ouk Nam et al.
Cancer medicine, 4(4), 575-587 (2015-02-04)
Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality worldwide. Amphiregulin (AREG), a member of the epidermal growth factor family and a rational target for CRC therapy, is essential for the three-dimensional structure
Woong Jin Bae et al.
Journal of Korean medical science, 30(9), 1313-1320 (2015-09-05)
Diabetes is related with a number of cystopathic complications. However, there have been no studies about the influence of alcohol consumption in the bladder of type 2 diabetes. Thus, we investigated the effect of moderate alcohol intake in the bladder
Ender Gedik et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 13 Suppl 1, 294-300 (2015-04-22)
The goal of this study was to compare the effects of 2 different regimens on blood glucose levels of living-donor liver transplant. The study participants were randomly allocated to the dextrose in water plus insulin infusion group (group 1, n
Johan B Fagman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1540-1550 (2015-01-01)
Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)-dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)
M Sumit et al.
Integrative biology : quantitative biosciences from nano to macro, 7(11), 1378-1386 (2015-09-17)
Many biological processes are rhythmic and proper timing is increasingly appreciated as being critical for development and maintenance of physiological functions. To understand how temporal modulation of an input signal influences downstream responses, we employ microfluidic pulsatile stimulation of a
Ilaria De Pasquale et al.
Applied and environmental microbiology, 80(19), 6243-6255 (2014-08-03)
Pyrosequencing of the 16S rRNA targeting RNA, community-level physiological profiles made with Biolog EcoPlates, proteolysis, and volatile component (VOC) analyses were mainly used to characterize the manufacture and ripening of the pasta filata cheese Caciocavallo Pugliese. Plate counts revealed that
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