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关键词:'G8540'
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Alison C Macleod et al.
Molecular cancer therapeutics, 13(12), 2840-2851 (2014-09-26)
Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin
Ryan Salvador et al.
Infection and immunity, 82(9), 3687-3696 (2014-06-18)
The Chagas' disease parasite Trypanosoma cruzi elicits a potent inflammatory response in acutely infected hearts that keeps parasitism in check and triggers cardiac abnormalities. A most-studied mechanism underlying innate immunity in T. cruzi infection is Toll-like receptor (TLR) activation by
Catarina Mota et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 5854-5862 (2014-11-05)
FOXP3-expressing regulatory T cells (Treg) are essential for the prevention of autoimmunity and were shown to be reduced and/or dysfunctional in several autoimmune diseases. Although Treg-based adoptive transfer represents a promising therapy, the large cell number required to achieve clinical
C M Lee et al.
Genes and immunity, 16(5), 356-361 (2015-04-24)
Epithelium-specific Ets transcription factor 1 (ESE-1) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that ESE-1 is constitutively expressed
Filip Bochner et al.
Scientific reports, 5, 12446-12446 (2015-07-25)
The ovary is a dynamic organ that undergoes dramatic remodeling throughout the ovulatory cycle. Maturation of the ovarian follicle, release of the oocyte in the course of ovulation as well as formation and degradation of corpus luteum involve tightly controlled
Ina Kurth et al.
Oncotarget, 6(33), 34494-34509 (2015-10-16)
Despite recent advances in understanding of the molecular pathogenesis and improvement of treatment techniques, locally advanced head and neck squamous cell carcinoma (HNSCC) remains associated with an unfavorable prognosis. Compelling evidence suggests that cancer stem cells (CSC) may cause tumor
Jenni Küblbeck et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1759-1765 (2015-07-19)
Discovery of receptor-dependent mechanisms for regulation of drug metabolism has provided a new way to evaluate the propensity of drug candidates to cause induction of cytochrome P450 enzymes. Therefore, receptor-based reporter assays have become common in early stages of drug
Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis
Rival C, et al.
Journal of Reproductive Immunology, 70(1-2), 43-58 (2006)
Chen Dai et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5980-5989 (2015-05-13)
CXCL14 is a chemokine with an atypical, yet highly conserved, primary structure characterized by a short N terminus and high sequence identity between human and mouse. Although it induces chemotaxis of monocytic cells at high concentrations, its physiological role in
Martin Trapecar et al.
Journal of muscle research and cell motility, 35(5-6), 249-257 (2014-11-09)
Research on skeletal muscles suffers from a lack of appropriate human models to study muscle formation and regeneration on the regulatory level of single cells. This hampers both basic understanding and the development of new therapeutic approaches. The use of
Bettina M Jensen et al.
Journal of leukocyte biology, 95(6), 893-901 (2014-02-05)
Different protocols exist for in vitro development of HuMCs from hematopoietic stem cells, which results in distinct mast cells regarding molecular markers and activation patterns. Here, we introduce a SR profile using immunological, neurogenic, and pharmacological stimuli to characterize cellular
Sigalit Meker et al.
ChemMedChem, 9(6), 1294-1298 (2014-03-29)
Nanoparticles of titanium(IV) complexes of phenolato ligands were formed and evaluated for cytotoxicity toward human HT-29 colon cancer, murine T-25 lymphoma, and murine HU-2 multidrug-resistant (MDR) cells. The nano-formulation, besides increasing the complexes' shelf lives, is particularly efficient in overcoming
Maria T Contestabile et al.
Molecular vision, 20, 325-333 (2014-03-29)
To describe the clinical and molecular findings of an Italian family with a new mutation in the choroideremia (CHM) gene. We performed a comprehensive ophthalmologic examination, fundus photography, macular optical coherence tomography, perimetry, electroretinography, and fluorescein angiography in an Italian
Yun Hua et al.
Assay and drug development technologies, 12(7), 395-418 (2014-09-03)
The androgen receptor-transcriptional intermediary factor 2 (AR-TIF2) positional protein-protein interaction (PPI) biosensor assay described herein combines physiologically relevant cell-based assays with the specificity of binding assays by incorporating structural information of AR and TIF2 functional domains along with intracellular targeting
Saad B Qasim et al.
Acta biomaterialia, 23, 317-328 (2015-05-15)
Guided tissue regeneration (GTR) membranes have been used for the management of destructive forms of periodontal disease as a means of aiding regeneration of lost supporting tissues, including the alveolar bone, cementum, gingiva and periodontal ligaments (PDL). Currently available GTR
Jochen A Ackermann et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4650-4656 (2015-04-12)
Signals from the BCR are required for Ag-specific B cell recruitment into the immune response. Binding of Ag to the BCR induces phosphorylation of immune receptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling subunits
Kathryne E Taylor et al.
Journal of virology, 89(19), 9841-9852 (2015-07-17)
It has recently been proposed that the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral signaling and in promoting viral replication in addition to its well-known proteasome-dependent functions in the nucleus. However, the mechanisms through which
L N Moro et al.
Reproduction in domestic animals = Zuchthygiene, 50(5), 849-857 (2015-09-04)
The aim of this study was to evaluate three different cloning strategies in the domestic cat (Felis silvestris) and to use the most efficient to generate wild felid embryos by interspecific cloning (iSCNT) using Bengal (a hybrid formed by the
M Jesús Corral et al.
The Journal of antimicrobial chemotherapy, 69(12), 3268-3274 (2014-08-07)
To evaluate the efficacy of the combination of allicin and amphotericin deoxycholate (AmB) in the chemotherapy of Leishmania infantum infection with the final aim of reducing the dose of AmB in the chemotherapy of visceral leishmaniasis. Hamsters were intraperitoneally (ip)
Sandeep Sampangi et al.
PloS one, 10(7), e0134688-e0134688 (2015-08-01)
Proximal tubule epithelial cells (PTEC) of the kidney line the proximal tubule downstream of the glomerulus and play a major role in the re-absorption of small molecular weight proteins that may pass through the glomerular filtration process. In the perturbed
Marina Theodorou et al.
Human gene therapy methods, 26(4), 107-122 (2015-06-25)
Parkinson's disease is one of the most common neurodegenerative disorders characterized by cell death of dopaminergic neurons in the substantia nigra. Recent research has focused on cellular replacement through lineage reprogramming as a potential therapeutic strategy. This study sought to
Ken-Ming Chang et al.
Bioorganic & medicinal chemistry, 23(13), 3852-3859 (2015-04-25)
Recent studies have demonstrated that oxidative stress insult is one of major causes of tumor formation. Therefore, identify the effective anti-oxidative agents as a preventive approach to stop cancer progression has widely explored. Although, many potent anti-oxidative ingredients in the
Q Li et al.
Cancer gene therapy, 22(5), 227-237 (2015-04-04)
An increasing number of studies indicate that during development, endothelial and hematopoietic cells derive from common progenitors named hemangioblasts that have important roles in the pathogenesis. This is particularly true in chronic myeloid leukemia (CML). Here, we isolated fetal liver
Anna Kreutzman et al.
Oncoimmunology, 3, e28925-e28925 (2014-08-02)
Tyrosine kinase inhibitors (TKIs) have dramatically improved the outcome of chronic myeloid leukemia (CML). Besides inhibiting target kinases in leukemic cells, 2nd generation TKI dasatinib also inhibits off-targets in immune effector cells resulting in atypical immune responses in some patients.
Kazuki Takeishi et al.
Cell reports, 31(9), 107711-107711 (2020-06-04)
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been previously described. By improving methods
Atsushi Terunuma et al.
The Journal of clinical investigation, 124(1), 398-412 (2013-12-10)
Metabolic profiling of cancer cells has recently been established as a promising tool for the development of therapies and identification of cancer biomarkers. Here we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these
Wei Zhu et al.
PloS one, 10(7), e0134729-e0134729 (2015-07-30)
Articular cartilage is prone to degeneration and possesses extremely poor self-healing capacity due to inherent low cell density and the absence of a vasculature network. Tissue engineered cartilage scaffolds show promise for cartilage repair. However, there still remains a lack
Ingrid Stroo et al.
PloS one, 10(4), e0123203-e0123203 (2015-04-16)
Temporal expression of chemokines is a crucial factor in the regulation of renal ischemia/reperfusion (I/R) injury and repair. Beside their role in the migration and activation of inflammatory cells to sites of injury, chemokines are also involved in other processes
Jason W Ashley et al.
Journal of cellular biochemistry, 116(11), 2598-2609 (2015-04-29)
The role of Notch signaling in osteoclast differentiation is controversial with conflicting experimental evidence indicating both stimulatory and inhibitory roles. Differences in experimental protocols and in vivo versus in vitro models may explain the discrepancies between studies. In this study
Ursula Thormann et al.
Journal of pharmaceutical sciences, 103(10), 3139-3152 (2014-09-02)
The objective of this work was first to investigate the chemical degradation of the sesquiterpene lactone nobilin and determine its solubility under conditions of concurrent degradation for partially amorphous starting material; second, to determine the effect of biorelevant media used
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