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S Doyon et al.
Emergency medicine clinics of North America, 12(2), 301-316 (1994-05-01)
Flumazenil is an important adjunct to the diagnosis and treatment of benzodiazepine toxicity. It must be used cautiously with attention to a number of clinical caveats. Currently it is advised that flumazenil should not be used routinely in all patients...
Stefan Vallo et al.
Translational oncology, 8(3), 210-216 (2015-06-10)
Combination chemotherapy with gemcitabine and cisplatin in patients with metastatic urothelial cancer of the bladder frequently results in the development of acquired drug resistance. Availability of cell culture models with acquired resistance could help to identify candidate treatments for an...
Arianna Pompilio et al.
Frontiers in microbiology, 8, 2591-2591 (2018-01-10)
Yuzhang Zhu et al.
Biochemical and biophysical research communications, 447(4), 707-714 (2014-04-29)
Accumulating clinical evidence suggests that hyperuricemia is strongly associated with abnormal glucose metabolism and insulin resistance. However, how high uric acid (HUA) level causes insulin resistance remains unclear. We aimed to determine the direct role of HUA in insulin resistance...
Hye Young Jung et al.
Journal of biomedical nanotechnology, 9(5), 901-906 (2013-06-28)
An enzyme stimulated deposition of prussian blue onto the gold-coated magnetic microparticles is described. We propose to synthesize the continuous outer gold layer on the magnetic particle for a gold working electrode and its superparamagnetic property. In-depth characterization of the...
Fernando G Vieira et al.
PloS one, 10(8), e0135570-e0135570 (2015-08-20)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons. The mechanisms leading to motor neuron degeneration in ALS are unclear. However, there is evidence for involvement of endoplasmic reticulum (ER) stress and the unfolded...
Natalia Sumption et al.
PloS one, 10(8), e0134046-e0134046 (2015-08-08)
Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk...
David Cruz-Garcia et al.
The Journal of cell biology, 207(6), 695-703 (2014-12-17)
Upon starvation, Grh1, a peripheral membrane protein located at endoplasmic reticulum (ER) exit sites and early Golgi in Saccharomyces cerevisiae under growth conditions, relocates to a compartment called compartment for unconventional protein secretion (CUPS). Here we report that CUPS lack...
Sally Vanden-Hehir et al.
Biomacromolecules, 20(10), 4008-4014 (2019-08-14)
Polymeric nanoparticles (NPs) are attractive candidates for the controlled and targeted delivery of therapeutics in vitro and in vivo. However, detailed understanding of the uptake, location, and ultimate cellular fate of the NPs is necessary to satisfy safety concerns, which...
Youjun Zhang et al.
FEBS letters, 588(20), 3726-3731 (2014-09-01)
Changes in carbon flow and sink/source activities can affect floral, architectural, and reproductive traits of plants. In potato, overexpression (OE) of the purple acid phosphatase 2 of Arabidopsis (AtPAP2) resulted in earlier flowering, faster growth rate, increased tubers and tuber...
Dong-il Kim et al.
Archives of biochemistry and biophysics, 560, 36-43 (2014-07-30)
Hyperglycemia-induced apoptosis of retinal pigment epithelial (RPE) cells is considered to be involved in the progression of diabetic retinopathy. Histone arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) has emerged as an important histone modification involved in gene regulation. However...
Dextrose saline compared with normal saline rehydration of hyperemesis gravidarum: a randomized controlled trial.
Geoffrey H Gordon
Obstetrics and gynecology, 121(6), 1360-1360 (2013-07-03)
Yasuhiko Matsumoto et al.
Biochemical and biophysical research communications, 455(3-4), 159-164 (2014-12-03)
We established a transgenic silkworm strain expressing the human insulin receptor (hIR) using the GAL4/UAS system. Administration of human insulin to transgenic silkworms expressing hIR decreased hemolymph sugar levels and facilitated Akt phosphorylation in the fat body. The decrease in...
Keyu Chen et al.
The Journal of cell biology, 219(8) (2020-07-09)
Giant ankyrin-B (gAnkB) is a 440-kD neurospecific ankyrin-B isoform and a high-confidence target for autism mutations. gAnkB suppresses axon branching through coordination of cortical microtubules, and autism-related mutation of gAnkB results in ectopic neuronal connectivity. We identified a bipartite motif...
V N Titov et al.
Terapevticheskii arkhiv, 82(10), 71-77 (2011-02-24)
If a lot of carbohydrates cannot be in vivo stored as glycogen, the synthesis of palmitic fatty acid (FA) from glucose and its adipocyte deposition as triglycerides are under way in phylogenesis. With impaired biological function of exotrophy (fasting, early...
C Harkin et al.
Journal of applied microbiology, 118(4), 954-965 (2015-02-04)
To isolate bacteria from soil for microbial pretreatment of brown crab (Cancer pagurus) shell waste and the production of chitin. Isolates were screened for protease enzymes and acid production in order to facilitate the removal of protein and calcium carbonate...
Jinzeng Yang
Progress in molecular biology and translational science, 121, 133-163 (2014-01-01)
As the single largest organ in the body, the skeletal muscle is the major site of insulin-stimulated glucose uptake in the postprandial state. Skeletal muscles provide the physiological foundation for physical activities and fitness. Reduced muscle mass and strength is...
Phing-How Lou et al.
Anesthesia and analgesia, 120(2), 329-340 (2014-12-02)
The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose...
Kyra-Melinda Alexacou et al.
Bioorganic & medicinal chemistry, 19(17), 5125-5136 (2011-08-09)
Electrophilic halogenation of C-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl) 1,4-dimethoxybenzene (1) afforded regioselectively products halogenated at the para position to the D-glucosyl moiety (8, 9) that were deacetylated to 3 (chloride) and 16 (bromide). For preparing meta regioisomers, 1 was efficiently oxidized with CAN to...
Rong Rong Liu et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1303-H1313 (2015-09-16)
A growing number of studies have suggested microRNAs (miRNAs) are involved in the modulation of myocardial ischemia-reperfusion (MI/R) injury; however, the role of endogenous miRNAs targeting endothelial cells (ECs) and its interaction with ICAM-1 in the setting of MI/R remain...
Harry P Selker et al.
The American journal of cardiology, 113(10), 1599-1605 (2014-05-06)
The Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care Trial of very early intravenous glucose-insulin-potassium (GIK) for acute coronary syndromes (ACS) in out-of-hospital emergency medical service (EMS) settings showed 80% reduction in infarct size at 30...
Zhichun Chen et al.
Progress in neurobiology, 108, 21-43 (2013-07-16)
Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which severely impacts on the global economic development and healthcare system. Though AD has been studied for more than 100 years since 1906, the exact cause(s) and pathogenic mechanism(s) remain to...
Kate Keogh et al.
Physiological genomics, 47(8), 344-354 (2015-05-28)
The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian...
Stefano Romano et al.
Archives of microbiology, 196(2), 97-107 (2013-12-21)
In this study, we evaluated the effectiveness of lake sediment as inoculum for hydrogen production through dark fermentation in a repeated batch process. In addition, we investigated the effect of heat treatment, applied to enrich hydrogen-producing bacteria, on the bacterial...
Colin R Garner et al.
British journal of clinical pharmacology, 80(1), 157-167 (2015-01-27)
The aims of the study were to compare [(14)C]-paracetamol ([(14)C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old...
Ken-ichi Sato et al.
Natural product communications, 8(7), 987-998 (2013-08-29)
This report describes the stereocontrolled total synthesis of the multi-functionalized cyclitol derivative, tetrodotoxin, containing eight asymmetric carbons and different types of branched-chains, from myo-inositol and D-glucose using three different methods. The tetrodotoxin derivatives possess a relatively small molecular weight but...
Zhiwei Li et al.
PloS one, 10(11), e0143405-e0143405 (2015-11-26)
The use of the immunosuppressive drug tacrolimus (TAC) is related to new onset diabetes after transplantation. Herein, we examined the effect of intraperitoneal administered TAC on intestinal glucose absorption in mice. Animals received low, medium, or high dose TAC (0.5...
Medicine. Why does gastric bypass surgery work?
Hans-Rudolf Berthoud
Science (New York, N.Y.), 341(6144), 351-352 (2013-07-28)
Weight-loss surgery: A gut-wrenching question.
Virginia Hughes
Nature, 511(7509), 282-284 (2014-07-18)
Suzan A Khayyat et al.
Journal of nanoscience and nanotechnology, 14(5), 3569-3574 (2014-04-17)
CuO spheres composed of finely arranged nanobricks were synthesized by simple and facile hydrothermal process and used as efficient electron mediators for the fabrication of highly sensitive non-enzymatic glucose sensor. The CuO spheres were synthesized at low-temperature of -30 degrees...