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Satoshi Hara et al.
The American journal of pathology, 185(8), 2118-2131 (2015-06-15)
Intracapillary foam cell infiltration with podocyte alterations is a characteristic pathology of focal segmental glomerulosclerosis (FSGS). We investigated the possible role of podocyte injury in glomerular macrophage and foam cell infiltration in a podocyte-selective injury model (NEP25 mice) and hypercholesterolemic...
Chia-Yang Lu et al.
Biochemical pharmacology, 91(1), 40-50 (2014-07-08)
Andrographolide, the major bioactive component of Andrographis paniculata, has been demonstrated to have various biological properties including anti-inflammation, antioxidation, and anti-hepatotoxicity. Oxidative stress is considered a major risk factor in aging, inflammation, cancer, atherosclerosis, and diabetes mellitus. NADPH oxidase is...
Andreea Prisecaru et al.
Nucleic acids research, 42(22), 13474-13487 (2014-11-22)
The substitution-inert polynuclear platinum(II) complex (PPC) series, [{trans-Pt(NH3)2(NH2(CH2)nNH3)}2-μ-(trans-Pt(NH3)2(NH2(CH2)nNH2)2}](NO3)8, where n = 5 (AH78P), 6 (AH78 TriplatinNC) and 7 (AH78H), are potent non-covalent DNA binding agents where nucleic acid recognition is achieved through use of the 'phosphate clamp' where the square-planar...
Sougata Roy Chowdhury et al.
PloS one, 9(11), e113663-e113663 (2014-11-21)
Continuous free radical assault upsets cellular homeostasis and dysregulates associated signaling pathways to promote stress-induced cell death. In spite of the continuous development and implementation of effective therapeutic strategies, limitations in treatments for stress-induced toxicities remain. The purpose of the...
Dongnian Li et al.
Biochemical and biophysical research communications, 458(4), 941-945 (2015-02-28)
It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family...
Kimbell L Hetzler et al.
Biochimica et biophysica acta, 1852(5), 816-825 (2015-01-04)
A devastating aspect of cancer cachexia is severe loss of muscle and fat mass. Though cachexia occurs in both sexes, it is not well-defined in the female. The Apc(Min/+) mouse is genetically predisposed to develop intestinal tumors; circulating IL-6 is...
Chiung-Mei Chen et al.
PloS one, 9(7), e101392-e101392 (2014-07-17)
Mutations in the F-box only protein 7 gene (FBXO7), the substrate-specifying subunit of SCF E3 ubiquitin ligase complex, cause Parkinson's disease (PD)-15 (PARK15). To identify new variants, we sequenced FBXO7 cDNA in 80 Taiwanese early onset PD patients (age at...
Dae Hyun Kim et al.
Oncotarget, 6(33), 34143-34157 (2015-10-28)
The beneficial role of FoxO during aging has been proposed for its promotion of resistance to oxidative stress and inhibition of pro-inflammatory mediators. On the other hand, NF-κB is a pro-inflammatory transcription factor which is a key mediator of inflammatory...
Takeshi Tomita et al.
PloS one, 10(3), e0118835-e0118835 (2015-03-05)
Serum amyloid A3 (SAA3) possesses characteristics distinct from the other serum amyloid A isoforms, SAA1, SAA2, and SAA4. High density lipoprotein contains the latter three isoforms, but not SAA3. The expression of mouse SAA3 (mSAA3) is known to be up-regulated...
Dunja Aksentijević et al.
PloS one, 9(10), e109021-e109021 (2014-10-02)
Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established, but antioxidant activity could contribute to the cardioprotective effect of creatine in...
Kha Tram et al.
PloS one, 10(5), e0126402-e0126402 (2015-05-07)
Many DNAzymes have been isolated from synthetic DNA pools to cleave natural RNA (D-RNA) substrates and some have been utilized for the design of aptazyme biosensors for bioanalytical applications. Even though these biosensors perform well in simple sample matrices, they...
A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers.
Kimberly A Toops et al.
Experimental eye research, 124, 74-85 (2014-05-28)
Marlon J A Jetten et al.
Toxicology, 323, 61-69 (2014-06-21)
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for...
Bastian Roth et al.
Pflugers Archiv : European journal of physiology, 467(8), 1835-1849 (2014-10-04)
To understand the impact of ionizing irradiation from diagnostics and radiotherapy on cells, we examined K(+) channel activity before and immediately after exposing cells to X-rays. Already, low dose in the cGy range caused in adenocarcinoma A549 cells within minutes...
Andrew N Gray et al.
eLife, 4 (2015-05-08)
To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that...
Marthe Heylen et al.
PloS one, 9(10), e110002-e110002 (2014-10-15)
Although helminthic therapy as a possible new option to treat inflammatory bowel disease is a well-established concept by now, the search for immunomodulatory helminth-derived compounds and their mechanisms of action is still ongoing. We investigated the therapeutic potential and the...
Yin-Sha Miao et al.
Cellular signalling, 27(1), 156-167 (2014-12-03)
The purposes of this study were to investigate the possible molecular mechanisms of miR-18a regulating the permeability of blood-tumor barrier (BTB) via down-regulated expression and distribution of runt-related transcription factor 1 (RUNX1). An in vitro BTB model was established with...
Asheesh Gupta et al.
Journal of biophotonics, 8(6), 489-501 (2014-09-11)
Low-level laser therapy (LLLT) using superpulsed near-infrared light can penetrate deeper in the injured tissue and could allow non-pharmacological treatment for chronic wound healing. This study investigated the effects of superpulsed laser (Ga-As 904 nm, 200 ns pulse width; 100...
Sung Lyea Park et al.
Oncology reports, 34(3), 1605-1612 (2015-07-15)
MicroRNAs (miRs) serve either as oncogenes or tumor-suppressor genes in tumor progression. MicroRNA-20b (miR‑20b) is known to be involved with the oncomirs of several types of cancers. However, in the present study we describe how miR-20b inhibits the proliferation, migration...
Camila Guerra Martinez et al.
Scientific reports, 5, 16940-16940 (2015-11-26)
Autoantibodies against the M2 receptors (M2AChR) have been associated with Dilated Cardiomyopathy (DCM). In the heart, P2×7 receptors influence electrical conduction, coronary circulation and response to ischemia. They can also trigger pro-inflammatory responses and the development of neurological, cardiac and...
Brandon M Schickling et al.
Oncology reports, 33(2), 533-538 (2014-11-26)
In breast cancers, the large conductance Ca2+ and voltage sensitive K+ (BKCa) channels have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of channel activity impacts oncogenesis. We demonstrated herein that iberiotoxin (IbTX), an inhibitor of...
Izabel J M Di Fiore et al.
Virus research, 208, 89-97 (2015-06-17)
Rotavirus infection is a major cause of life-threatening infantile gastroenteritis. The innate immune system provides an immediate mechanism of suppressing viral replication and is necessary for an effective adaptive immune response. Innate immunity involves host recognition of viral infection and...
Leonie Hussaarts et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 3027-3039 (2015-04-09)
Chronic low-grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short-lived infection with rodent nematodes was reported to improve glucose tolerance in obese...
Andrea Mihalikova et al.
Neuroscience research, 81-82, 85-91 (2014-02-26)
Previously, we found that the C-terminus of the glycine transporter GlyT1 loses the most of its epitopes during pathological calcium increase in rodent synaptosomes but that the more internal epitopes are spared. We also found that epitope immunoreactivity likely decreases...
Bryan M Dunyak et al.
ACS chemical biology, 10(11), 2441-2447 (2015-09-01)
In drug discovery, small molecules must often discriminate between healthy and diseased cells. This feat is usually accomplished by binding to a protein that is preferentially expressed in the target cell or on its surface. However, in many cases, the...
Akshatha Daddangadi et al.
Cryobiology, 93, 49-55 (2020-03-01)
This study investigated if in vitro maturation (IVM) before or after vitrification would be more successful for prepubertal oocytes. To mimic prepubertal conditions in an experimental setup, oocytes were collected from healthy 14, 21 and 28day old Swiss albino mice....
Yugen Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2394-2404 (2014-07-30)
IFN-β has been implicated as an effector of oviduct pathology resulting from genital chlamydial infection in the mouse model. In this study, we investigated the role of cytosolic DNA and engagement of DNA sensors in IFN-β expression during chlamydial infection....
Merve Bacanlı et al.
Environmental toxicology and pharmacology, 38(3), 774-782 (2014-10-13)
Oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Ferulic acid (FA), a well-established natural antioxidant, has several pharmacological activities including anti-inflammatory, anticancer and hepatoprotective. This study aimed to investigate the effects of FA on sepsis-induced...
David J Busch et al.
Nature communications, 6, 7875-7875 (2015-07-25)
Assembly of highly curved membrane structures is essential to cellular physiology. The prevailing view has been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are required for bending membranes. Here we report that...
Angélica T Vieira et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(6), 1646-1656 (2015-04-29)
Host-microbial interactions are central in health and disease. Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1β (IL-1β) production and neutrophil recruitment. This study was undertaken to investigate the relevance of gut microbiota, acetate...
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页码 1 来自 145