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Paloma G Krempel et al.
Investigative ophthalmology & visual science, 55(8), 5109-5115 (2014-07-26)
Extracellular matrix (ECM) and cellular membrane proteoglycans (PGs) play important roles in neural differentiation and cell adhesion. Vascular endothelial growth factor, an important signal protein in vascular and retinal neural cell development, is retained in the ECM due to its...
Lokman Varisli et al.
Journal of cellular biochemistry, 116(1), 170-178 (2014-08-30)
Previously, it has been reported that HN1 is involved in cytoplasmic retention and degradation of androgen receptor in an AKT dependent manner. As HN1 is a hormone inducible gene, and has been shown that it is upregulated in various cancers...
Mitsuhiro Tsujiwaki et al.
Medical molecular morphology, 48(1), 33-43 (2014-04-17)
The liver comprises hepatocytes and non-parenchymal cells such as bile duct epithelial cells. Claudin-4 and -7 are not expressed in hepatocytes under physiological conditions. It was reported that claudin-7 increased in human pulmonary fibroses. We therefore investigated claudin-4 and -7...
Andrea Khong et al.
BMC cancer, 14, 969-969 (2014-12-19)
Tumor debulking surgery followed by adjuvant chemotherapy or radiotherapy is a standard treatment for many solid malignancies. Although this approach can be effective, it often has limited success against recurrent or metastatic cancers and new multimodality approaches are needed. Adjuvant...
Andrea Mendes Pereira et al.
BMC research notes, 7, 460-460 (2014-07-20)
Very few studies have been carried out so far aiming at modulating cellular immune responses in dogs. In this study, we evaluated the ability of recombinant canine IL-2 (rcaIL-2) and IL-12, in the form of a single-chain fusion protein (rsccaIL-12)...
Rafał Biedroń et al.
PloS one, 10(4), e0123293-e0123293 (2015-04-08)
The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing. Paradoxically, endocytic receptors involved in antigen uptake do not bind the majority of proteins, which may...
SuFey Ong et al.
The American journal of pathology, 185(3), 847-861 (2015-01-28)
Myocarditis is a leading cause of sudden cardiac failure in young adults. Natural killer (NK) cells, a subset of the innate lymphoid cell compartment, are protective in viral myocarditis. Herein, we demonstrated that these protective qualities extend to suppressing autoimmune...
Nan Hu et al.
Pharmacological research, 100, 175-189 (2015-08-16)
Second hand smoke is an independent risk factor for cardiovascular disease. Adiponectin (APN), an adipose-derived adipokine, has been shown to offer cardioprotective effect through an AMPK-dependent manner. This study was designed to evaluate the impact of adiponectin deficiency on second...
Leonardo P Franchi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1319-1331 (2015-06-02)
Metallic nanoparticles such as silver (Ag), cerium dioxide (CeO2) and titanium dioxide (TiO2) are produced at a large scale and included in many consumer products. It is well known that most metallic NPs are toxic to humans which raise concerns...
Yakov Y Woldman et al.
Biochemical and biophysical research communications, 465(2), 232-238 (2015-08-09)
A chemiluminescent method is proposed for quantitation of NO generation in cell cultures. The method is based on activation of soluble guanylyl cyclase by NO. The product of the guanylyl cyclase reaction, pyrophosphate, is converted to ATP by ATP sulfurylase...
Gabsik Yang et al.
Journal of medicinal food, 18(9), 1013-1021 (2015-06-24)
Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae...
Elisa Merega et al.
Neuroscience letters, 600, 50-55 (2015-06-07)
Previous studies have demonstrated that complement alone releases glutamate from human and mouse cortical terminals in an antibody-independent manner. In order to expand our knowledge on complement-mediated effects, we investigated whether the presence of an antigen-antibody complex in synaptosomal plasmamembranes...
Zhonghua Liu et al.
Electrophoresis, 36(17), 2002-2016 (2015-06-04)
Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats fed either a...
Varun Kesherwani et al.
Neuroscience letters, 576, 45-50 (2014-06-07)
Fasudil (HA-1077), a specific Rho kinase II (ROCKII) inhibitor, is in clinical trials for recovery from spinal cord injury (SCI). The primary role of Fasudil is in axonal regeneration, as it inhibits ROCKII, the key signaling molecule involved in collapse...
Bryan A Wilson et al.
American journal of physiology. Renal physiology, 308(6), F594-F601 (2015-01-09)
Angiotensin 1-7 [ANG-(1-7)] is expressed within the kidney and exhibits renoprotective actions that antagonize the inflammatory, fibrotic, and pro-oxidant effects of ANG II. We previously identified an peptidase that preferentially metabolized ANG-(1-7) to ANG-(1-4) in the brain medulla and cerebrospinal...
Anja Balk et al.
Pharmaceutical research, 32(6), 2154-2167 (2014-12-24)
A poorly water soluble acidic active pharmaceutical ingredient (API) was transformed into an ionic liquid (IL) aiming at faster and higher oral availability in comparison to a prodrug. API preparations were characterized in solid state by single crystal and powder...
N M Violato et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(9), 615-620 (2014-03-20)
Insulin secretion is mainly regulated by blood glucose concentration. On the other hand, changes in peripheral insulin sensitivity induce compensatory adaptations in pancreatic β-cells to maintain normoglycaemia. Tumour presence causes dramatic alterations in glucose homeostasis and insulin secretion because of...
K Kataoka et al.
Cell death & disease, 6, e1731-e1731 (2015-04-24)
Detachment of photoreceptors from the retinal pigment epithelium is seen in various retinal disorders, resulting in photoreceptor death and subsequent vision loss. Cell death results in the release of endogenous molecules that activate molecular platforms containing caspase-1, termed inflammasomes. Inflammasome...
Jennifer Edwards et al.
PLoS neglected tropical diseases, 9(3), e0003604-e0003604 (2015-03-15)
Two platyhelminths of biomedical and commercial significance are Schistosoma mansoni (blood fluke) and Fasciola hepatica (liver fluke). These related trematodes are responsible for the chronic neglected tropical diseases schistosomiasis and fascioliasis, respectively. As no vaccine is currently available for anti-flukicidal...
Olena Kamenyeva et al.
PLoS pathogens, 11(4), e1004827-e1004827 (2015-04-18)
Neutrophils form the first line of host defense against bacterial pathogens. They are rapidly mobilized to sites of infection where they help marshal host defenses and remove bacteria by phagocytosis. While splenic neutrophils promote marginal zone B cell antibody production...
Cheng-Fang Tsai et al.
BMC cancer, 14, 556-556 (2014-08-02)
The widespread use of phthalates as plasticizers has raised public health concerns regarding their adverse effects, including an association with cancer. Although animal investigations have suggested an association between phthalate exposure and hepatocellular carcinoma, the mechanisms are unknown. The hepatocellular...
Katrin M Hinz et al.
Molecular endocrinology (Baltimore, Md.), 29(6), 933-942 (2015-05-07)
Thyroid hormones (THs) are transported across cell membranes by different transmembrane transporter proteins. In previous studies, we showed marked 3,3'-diiodothyronine (3,3'-T2) but moderate T3 uptake by the L-type amino acid transporter 2 (Lat2). We have now studied the structure-function relationships...
Yanhui Cai et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4884-4891 (2015-10-04)
To our knowledge, this study demonstrates for the first time that the AIDS virus differentially impacts two distinct subsets of lung macrophages. The predominant macrophages harvested by bronchoalveolar lavage (BAL), alveolar macrophages (AMs), are routinely used in studies on human...
Larissa B Thackray et al.
Journal of virology, 88(19), 11007-11021 (2014-07-18)
Upon activation of Toll-like and RIG-I-like receptor signaling pathways, the transcription factor IRF5 translocates to the nucleus and induces antiviral immune programs. The recent discovery of a homozygous mutation in the immunoregulatory gene guanine exchange factor dedicator of cytokinesis 2...
Christina Gosmann et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2248-2257 (2014-07-27)
Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial hyperplasia that can progress to cancer and is thought to depend on immunosuppressive mechanisms that prevent viral clearance by the host. IL-17 is a cytokine with diverse functions in host defense...
Elizabeth M Bafaro et al.
Metallomics : integrated biometal science, 7(9), 1319-1330 (2015-04-18)
The human (h) ZIP4 transporter is a plasma membrane protein which functions to increase the cytosolic concentration of zinc. hZIP4 transports zinc into intestinal cells and therefore has a central role in the absorption of dietary zinc. hZIP4 has eight...
Núria M Pastor-Soler et al.
American journal of physiology. Renal physiology, 308(12), F1452-F1462 (2015-05-01)
Ischemia-reperfusion injury (IRI) due to hypotension is a common cause of human acute kidney injury (AKI). Hypoxia-inducible transcription factors (HIFs) orchestrate a protective response in renal endothelial and epithelial cells in AKI models. As human mucin 1 (MUC1) is induced...
Anggakusuma et al.
Journal of virology, 89(7), 3833-3845 (2015-01-23)
Hepatitis C virus (HCV) efficiently infects only humans and chimpanzees. Although the detailed mechanisms responsible for this narrow species tropism remain elusive, recent evidence has shown that murine innate immune responses efficiently suppress HCV replication. Therefore, poor adaptation of HCV...
Kenji Kato et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(9), 1560-1571 (2015-03-13)
Growth plates are specialized cartilage structures that ensure the elongation of most skeletal primordia during vertebrate development. They are made by chondrocytes that proliferate in longitudinal columns and then progress in a staggered manner towards prehypertrophic, hypertrophic and terminal maturation....
Derek H Rosenzweig et al.
International journal of molecular sciences, 16(7), 15118-15135 (2015-07-08)
Painful degeneration of soft tissues accounts for high socioeconomic costs. Tissue engineering aims to provide biomimetics recapitulating native tissues. Biocompatible thermoplastics for 3D printing can generate high-resolution structures resembling tissue extracellular matrix. Large-pore 3D-printed acrylonitrile butadiene styrene (ABS) and polylactic...
页码 1 来自 142
页码 1 来自 142