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Jun Li et al.
Brain research, 1356, 11-23 (2010-08-17)
Transient cerebral ischemia may result in neuronal apoptosis. During this process, several apoptosis-regulatory genes are induced in apoptotic cells. Among these genes, cysteinyl aspartate-specific protease-3 (caspase-3) and B-cell leukemia-2 (Bcl-2) are the most effective apoptotic regulators because they play a
Mariola Śliwińska-Mossoń et al.
Applied immunohistochemistry & molecular morphology : AIMM, 23(4), 288-296 (2014-09-10)
The aim of this study is to prove the influence of tobacco smoking on the endothelin-1 (ET-1) level in the plasma and on the immunohistochemical localization in the pancreatic tissues. The blood was collected from 50 healthy individuals and 63
Martijn L L Chatrou et al.
PloS one, 10(11), e0142335-e0142335 (2015-11-12)
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of calcification and the expression of proteins involved in mineralization are usually based on whole section analysis, thereby often ignoring regional differences in atherosclerotic lesions. At present, limited information is
Ha Na Oh et al.
Cornea, 34(9), 1130-1136 (2015-07-24)
To evaluate the effect of treatment with quercetin in a mouse model of dry eye. 0.5% quercetin eye drops were prepared and an experimental dry eye model was induced in NOD.B10.H2(b) mice through desiccation stress. The mice were divided into
Paul R Gielen et al.
Journal of neuropathology and experimental neurology, 74(5), 390-400 (2015-04-09)
Myeloid-derived suppressor cells (MDSCs), defined as CD33-positive major histocompatibility complex class II-negative cells, are increased in a variety of human tumors and are associated with immunosuppression. Myeloid-derived suppressor cells can be further subdivided into CD14-positive monocytic MDSC and CD15-positive granulocytic
Hui Wang et al.
Arthritis research & therapy, 17, 4-4 (2015-01-13)
Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder that has pain and loss of joint function as major pathological features. In the present study, we explored the mechanisms of possible involvement and regulation of substance P (SP)
Chellappagounder Thangavel et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(21), 5468-5482 (2014-08-29)
Perturbations in the retinoblastoma pathway are over-represented in advanced prostate cancer; retinoblastoma loss promotes bypass of first-line hormone therapy. Conversely, preliminary studies suggested that retinoblastoma-deficient tumors may become sensitized to a subset of DNA-damaging agents. Here, the molecular and in
Jialin Liu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 2305017-2305017 (2020-04-25)
Xiaoyukang Jiaonang (XYK) is a Chinese patent medicine approved by the National Medical Product Administration which is used to treat intracranial hematoma in China. In this study, we observed the molecular mechanism of XYK in hypoxia-inducible factor 1α (HIF-1α), inflammation
Jianglong Yu et al.
International journal of clinical and experimental medicine, 8(8), 13377-13382 (2015-11-10)
The present study is to investigate the pathological changes in rabbits with traumatic optic neuropathy (TON), as well as the effect of fasudil on the lesions. A total of 144 New Zealand rabbits were successfully established as TON models. Twelve
Wen-Zhi Bi et al.
Scientific reports, 5, 16392-16392 (2015-11-07)
The D104N polymorphism (p.D104N) in endostatin has been previously identified in many types of cancer, and this polymorphism is believed to be a phenotypic modulator in some tumors. However, it is unknown whether endostatin p.D104N affects the risk and progression
Mohammad Reza Arab et al.
Cell journal, 17(3), 422-428 (2015-10-16)
The aim of the present study was to evaluate the protective effects of gadoli- num on pneumotoxic effects of styrene in rats as an experimental model. In this experimental study a total number of 40 adult male Sprague Dawley rats
Teresa Wierzba-Bobrowicz et al.
Folia neuropathologica, 52(4), 457-466 (2015-01-13)
Frontotemporal lobar degeneration (FTLD) with mutations in the MAPT (microtubule-associated protein tau) gene (FTLD with MAPT mutation) is a neurodegenerative disease with various clinical phenotypes. We present an Italian- Polish family with a IVS10+3G>A mutation in the MAPT gene, linked
Tatyana Isayeva et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(5), 631-653 (2014-12-20)
A large body of evidence shows that p16(INK4a) overexpression predicts improved survival and increased radiosensitivity in HPV-mediated oropharyngeal squamous cell carcinomas.(OPSCC). Here we demonstrate that the presence of transcriptionally active HPV16 in oral cavity squamous cell carcinomas does not correlate
Rebecca A Previs et al.
Molecular cancer therapeutics, 14(12), 2677-2686 (2015-10-31)
There is growing recognition of the important role of metronomic chemotherapy in cancer treatment. On the basis of their unique antiangiogenic effects, we tested the efficacy of nab-paclitaxel, which stimulates thrombospondin-1, and topotecan, which inhibits hypoxia-inducible factor 1-α, at metronomic
Ajlan Al Zaki et al.
Journal of biomedical nanotechnology, 11(10), 1836-1846 (2015-10-28)
Long-circulating gold nanoparticles (AuNPs) have garnered a great deal of interest as both imaging and therapeutic agents. However, their protracted elimination and long-term persistence within many organ systems remains a concern for clinical translation. To improve the excretion of long-circulating
Giuseppe Di Taranto et al.
Cytotherapy, 17(8), 1076-1089 (2015-05-24)
Subcutaneous fat represents a valuable reservoir of adipose-derived stem cells (ASCs) in the stromal vascular fraction (SVF), widely exploited in regenerative medicine applications, being easily harvested through lipoaspiration. The lack of standardized procedures for autologous fat grafting guided research efforts
María M Milesi et al.
Molecular and cellular endocrinology, 401, 248-259 (2014-12-09)
We investigated whether neonatal exposure to low doses of endosulfan affects fertility and uterine functional differentiation at pre-implantation in rats. Newborn female rats received the vehicle, 0.2 µg/kg/d of diethylstilbestrol (DES), 6 µg/kg/d of endosulfan (Endo6) or 600 µg/kg/d of endosulfan (Endo600) on
Kamran Badizadegan et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(10), G1002-G1012 (2014-09-13)
The enteric nervous system (ENS) is composed of neural crest-derived neurons (also known as ganglion cells) the cell bodies of which are located in the submucosal and myenteric plexuses of the intestinal wall. Intramucosal ganglion cells are known to exist
Luigi Strizzi et al.
Oncotarget, 6(33), 34071-34086 (2015-10-16)
Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatment of C8161
Diane G Elliott et al.
Diseases of aquatic organisms, 114(1), 21-43 (2015-05-12)
Non-lethal pathogen testing can be a useful tool for fish disease research and management. Our research objectives were to determine if (1) fin clips, gill snips, surface mucus scrapings, blood draws, or kidney biopsies could be obtained non-lethally from 3
Eeva Castrén et al.
Stem cell research & therapy, 6, 167-167 (2015-09-09)
Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering. Autologous MSCs can potentially be used to replace tissue defects, but the procedure also carries risks such as immunization and
Liu Junhui et al.
Microscopy research and technique, 78(9), 754-760 (2015-07-17)
To describe the microarchitecture of the annulus-endplate region with reference to disc herniation. Twenty-five motion segments (L1-2 to L5-S1) were harvested from five cadaveric spines (four males, one female). Superior and inferior annulus-endplate junctions were divided into anterior, lateral and
Young-Sun Nam et al.
World journal of gastroenterology, 21(7), 2030-2039 (2015-02-27)
To investigate the effects of mesenchymal stem cells (MSCs) on dextran sulfate sodium-induced inflammatory bowel disease (IBD). C57BL/6 mice were fed 3.5% (g/L) dextran sulfate sodium. On day seven, the mice received intraperitoneal injections of 1×10(6) MSCs. The survival rate
Zhiyun Cao et al.
Nutrition research and practice, 9(2), 129-136 (2015-04-11)
A variety of immunomodulators can improve the efficacy of low-dose chemotherapeutics. Active hexose correlated compound (AHCC), a mushroom mycelia extract, has been shown to be a strong immunomodulator. Whether AHCC could enhance the antitumor effect of low-dose 5-fluorouracil (5-FU) via
Bo Peng et al.
The Journal of clinical endocrinology and metabolism, 100(1), E19-E29 (2014-10-15)
GnRH and its receptor, GnRHR, were shown to promote trophoblastic cell invasion. Detection of elevated early development-related transcription factor TWIST and adhesion molecule N-cadherin in the invasive trophoblastic cells could suggest that GnRH promotes trophoblastic cell invasion through TWIST-regulated N-cadherin
Henriette Jülke et al.
Cell transplantation, 24(6), 1111-1125 (2013-12-18)
The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep
Yifei Zhong et al.
PloS one, 10(1), e0116873-e0116873 (2015-01-31)
Nephrokeli (NPKL) is a Chinese herbal formula that has been used to treat patients with IgA nephropathy (IgAN) for improvement of proteinuria and kidney injury. However, the mechanism remains unclear. Sphingosine-1-phosphate (S1P) and its receptors S1PR2 and S1PR3 are known
Aline A F Carmo et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3654-3663 (2014-08-29)
The plasminogen (Plg)/plasmin (Pla) system is associated with a variety of biological activities beyond the classical dissolution of fibrin clots, including cell migration, tissue repair, and inflammation. Although the capacity of Plg/Pla to induce cell migration is well defined, the
Shuji Sugiura et al.
The Journal of investigative dermatology, 135(3), 776-785 (2014-10-15)
Human prolactin-induced protein (PIP) is a major protein found in exocrine fluids such as saliva and sweat. Intriguingly, PIP possesses residues (human PIP (hPIP): PIP (29-63)) that display similarity to the aspartic peptidase candidapepsin. Here, we aimed to determine the
Yongji Li et al.
Molecular pharmaceutics, 12(5), 1485-1500 (2015-03-24)
About 40% of the marketed drugs and 70-90% of new drug candidates are insoluble in water and therefore poorly bioavailable, which significantly compromises their therapeutic effects. A formulation of nanosuspensions achieved by reducing the pure drug particle size down to
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