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Shiba Yousefvand et al.
Canadian journal of physiology and pharmacology, 96(12), 1301-1307 (2018-10-17)
Neuropeptide Y (NPY) plays a mediatory role in cerebral insulin function by maintaining energy balance. The current study was designed to determine the role of insulin in food intake and its interaction with NPY receptors in 8 experiments using broiler
Yosuke Ida et al.
Scientific reports, 10(1), 7958-7958 (2020-05-16)
To establish a deepening of the upper eyelid sulcus (DUES) model that can be induced by prostaglandin (PG) analogues, a three-dimension (3D) tissue culture was employed. Upon adipogenesis of the 3T3-L1 organoid, the effects of either Bimatoprost acid (BIM-A), or
Xin Zhou et al.
Nature communications, 11(1), 6088-6088 (2020-12-02)
The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, it is not clear how this complex is regulated at
P H Bessette et al.
The Journal of biological chemistry, 274(12), 7784-7792 (1999-03-13)
We have characterized in vivo and in vitro the recently identified DsbG from Escherichia coli. In addition to sharing sequence homology with the thiol disulfide exchange protein DsbC, DsbG likewise was shown to form a stable periplasmic dimer, and it
Kumiko Iwata et al.
Current aging science, 3(1), 26-33 (2010-03-20)
In cartilage regenerative medicine, which is highly expected in the face of our aging society, insulin is the potent factor for culture media. To secure the safety of culture media, we attempted to use medical insulin formulations, and compared their
H Hanaire et al.
Diabetes & metabolism, 34(4 Pt 2), 401-423 (2008-10-31)
The aim of diabetes treatment is to achieve tight glucose control to avoid the development of chronic diabetic complications while reducing the frequency of hypoglycaemic episodes. Continuous subcutaneous insulin infusion (CSII) using an external pump is an intensive diabetes therapy
Yosuke Ida et al.
Scientific reports, 10(1), 16018-16018 (2020-10-01)
2D and 3D cultures of 3T3-L1 cells were employed in a study of the effects of Omidenepag (OMD), interacting with a non-prostanoid EP2 receptor, on adipogenesis. Upon adipogenesis, the effects on lipid staining, the mRNA expression of adipogenesis-related genes (Pparγ
Quanyan Liu et al.
Nutrition (Burbank, Los Angeles County, Calif.), 27(6), 633-640 (2010-08-27)
The metabolic response to gastrointestinal cancer in patients undergoing surgery is associated with hypermetabolism and insulin resistance. The potential use of synergetic anabolic hormones in conjunction with hypocaloric parenteral nutrition (HPN) has become a significant area of investigation. The presented
M Socha et al.
Drug delivery, 16(8), 430-436 (2009-10-21)
Nanoparticles loaded with two different commercial insulins (Actrapid, Novorapid and based on different blends of a biodegradable polyester (poly-epsilon-caprolactone) and a polycationic non-biodegradable acrylic polymer (Eudragit RS) were characterized in vitro. The zeta potential was positive whenever Eudragit RS was
Dominik Pesta et al.
Frontiers in endocrinology, 12, 693683-693683 (2021-10-19)
The rs540467 SNP in the NDUFB6 gene, encoding a mitochondrial complex I subunit, has been shown to modulate adaptations to exercise training. Interaction effects with diabetes mellitus remain unclear. We assessed associations of habitual physical activity (PA) levels with metabolic
Christian Pehmøller et al.
Diabetes, 61(11), 2743-2752 (2012-08-02)
Excess lipid availability causes insulin resistance. We examined the effect of acute exercise on lipid-induced insulin resistance and TBC1 domain family member 1/4 (TBCD1/4)-related signaling in skeletal muscle. In eight healthy young male subjects, 1 h of one-legged knee-extensor exercise
Ilan Y Benador et al.
Cell metabolism, 27(4), 869-885 (2018-04-05)
Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of interscapular brown adipose tissue reveals that PDM have unique protein composition and cristae structure and remain adherent
Eliana Mariño et al.
Diabetes, 57(2), 395-404 (2007-11-21)
B-cells are important for disease pathogenesis in the nonobese diabetic (NOD) mouse model of type 1 diabetes. Recent studies demonstrate that marginal-zone B-cells (MZBs), which connect innate with adaptive immune responses, are increased in NOD mice. However, beyond this, the
A Tone et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 118(5), 320-324 (2010-01-15)
To compare the glycemic variability of insulin detemir and insulin glargine in type 1 and type 2 diabetic patients. 15 type 1 and 14 type 2 diabetic patients receiving intensive insulin therapy with insulin glargine were enrolled. Before and after
Fumihito Hikage et al.
Endocrinology, 160(1), 20-35 (2018-11-06)
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease associated with autoimmune thyroid disorders. It is a potentially blinding condition, for which no effective pharmacological treatment has been established. Despite a suggested role played by autoimmune thyrotropin receptor activation
M T Ackermans et al.
Annals of clinical biochemistry, 45(Pt 4), 429-430 (2008-06-28)
The aim of this study is to compare the performance of three commonly used insulin assays with respect to the detection of exogenous human and porcine insulin added to human or rat plasma. The DPC Immulite human insulin assay, the
S D Luzio et al.
Diabetes, obesity & metabolism, 12(1), 82-87 (2009-10-01)
Randomized, open, single-centre, two-way crossover study comparing the pharmacokinetic (PK) and pharmacodynamic (PD) properties of subcutaneous (sc) regular human insulin (Actrapid) and oral insulin in a capsule form (Capsulin). Sixteen persons (12 males) with type 2 diabetes on oral hypoglycaemic
J Hans DeVries
Current diabetes reviews, 1(1), 23-26 (2008-01-29)
Insulin pump therapy enjoys a steadily growing number of users and is associated with an approximately 0.5% lower A1c as compared to flexible insulin injection therapy in type 1 diabetes patients. An important question is whether superiority of insulin pump
L Bresson et al.
Journal de gynecologie, obstetrique et biologie de la reproduction, 39(7), 588-591 (2010-07-16)
We describe an acute onset of diabetes mellitus during third trimester of pregnancy revealed by ketoacidosis, complicated by fetal death, which could evoke fulminant type 1 diabetes, a novel subtype of type 1 diabetes first described in Japan and rarely
Ming-Yuh Shiau et al.
Scientific reports, 9(1), 11974-11974 (2019-08-21)
Accumulating evidence indicates that inflammation participates in the pathophysiological progress from insulin resistance, obesity, metabolic abnormalities, and type 2 diabetes mellitus. Our previous study reveals that interleukin-4 (IL-4) inhibits adipogenesis and promotes lipolysis to decrease lipid deposits by enhancing the
Morten Donsmark et al.
Diabetes technology & therapeutics, 11(9), 581-585 (2009-09-22)
Easy-to-use insulin devices are an important tool in the treatment of diabetes. In this study, injection force requirements and dosage scale displays were evaluated for NovoPen 3 and NovoPen 4 (both from Novo Nordisk A/S, Copenhagen, Denmark). To simulate 5
E Søfteland et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 119(10), 604-609 (2011-11-10)
Gastrointestinal symptoms such as pain, bloating, nausea and vomiting are more frequent in pre-diabetic states as well as established diabetes, compared to healthy individuals. The mechanisms behind these symptoms are multi-factorial and complex. Furthermore, the effect of isolated hyperinsulinaemia on
Vinegar decreases postprandial hyperglycemia in patients with type 1 diabetes.
Panayota Mitrou et al.
Diabetes care, 33(2), e27-e27 (2010-01-28)
Michal M Masternak et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 65(1), 24-30 (2009-11-13)
The disruption of the growth hormone (GH) axis in mice promotes insulin sensitivity and is strongly correlated with extended longevity. Ames dwarf (Prop1(df), df/df) mice are GH, prolactin (PRL), and thyrotropin (TSH) deficient and live approximately 50% longer than their
J S Christiansen et al.
Diabetes, obesity & metabolism, 12(2), 105-114 (2009-11-10)
Some patients with type 2 diabetes continue to have high postprandial blood glucose levels on twice-daily regimens of 'low-ratio' premix insulin formulations (up to 30% rapid-acting, with 70% protracted insulin). These patients require intensified insulin therapy, which can be provided
Gleb Zilberstein et al.
Electrophoresis, 29(8), 1749-1752 (2008-04-19)
As a follow-up of our previous report (Anal. Chem. 2007, 79, 821-827) on analytical SDS-PAGE focusing, a refinement of the method for separation of peptides in the small to medium M(r) range (0.5-10 kDa) is here reported, based on a
T G Ramsay et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 136(2), 245-253 (2003-10-08)
This study was designed to develop a culture system from the stromal-vascular fraction of chicken adipose tissue that can be used to characterize hormones that promote preadipocyte differentiation. Abdominal adipose tissue was excised from 2 to 4-week-old male broilers (Gallus
Pamela J Boimel et al.
Breast cancer research : BCR, 14(1), R23-R23 (2012-02-09)
Neu (HER2/ErbB2) is overexpressed in 25% to 30% of human breast cancer, correlating with a poor prognosis. Researchers in previous studies who used the mouse mammary tumor virus Neu-transgenic mouse model (MMTV-Neu) demonstrated that the Neu-YB line had increased production
A role for topical insulin in the management problematic surgical wounds.
J M Wilson et al.
Annals of the Royal College of Surgeons of England, 90(2), 160-160 (2008-03-08)
J Wu et al.
Biology of reproduction, 65(5), 1579-1585 (2001-10-24)
The objective of this study was to assess fertilization and embryonic development following intracytoplasmic sperm injection (ICSI) of oocytes from porcine preantral follicles matured in vitro. Also, another aim was to describe actin filament distribution during fertilization and embryonic development
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