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Eloise A Bradley et al.
American journal of physiology. Endocrinology and metabolism, 305(6), E745-E750 (2013-08-01)
Insulin stimulates microvascular recruitment in skeletal muscle, and this vascular action augments muscle glucose disposal by ∼40%. The aim of the current study was to determine the contribution of local nitric oxide synthase (NOS) to the vascular actions of insulin
Fu Li et al.
Acta cirurgica brasileira, 29(4), 237-244 (2014-04-25)
To observe the effect of cholecystectomy on the changes of motion pattern of Beagle dogs' sphincter of Oddi (SO), and investigate the modulatory role of nitric oxide (NO) and cholecystokinin (CCK) in the regulation of SO. Pressure of common bile
Mohammed A Elmetwally et al.
Reproductive toxicology (Elmsford, N.Y.), 83, 73-79 (2018-12-12)
Bisphenol A (BPA) is an endocrine-disrupting chemical used in the manufacture of many products used daily. In the present study, the effects of BPA (1 × 10-4 to 1 × 10-9 M) on migration and on the expression of some apoptotic genes were examined
Jiyu Chen et al.
Journal of cellular and molecular medicine, 25(1), 345-357 (2020-12-16)
In this study, we investigated the protective effects of gastrodin (Gas) against homocysteine-induced human umbilical vein endothelial cell (HUVEC) injury and the role of the phosphoinositide 3-kinase (PI3K)/threonine kinase 1 (Akt)/endothelial nitric oxide synthase (eNOS) and NF-E2-related factor 2 (Nrf2)/antioxidant
Vladimir Pech et al.
American journal of physiology. Renal physiology, 304(11), F1390-F1397 (2013-03-22)
Since nitric oxide (NO) participates in the renal regulation of blood pressure, in part, by modulating transport of Na⁺ and Cl⁻ in the kidney, we asked whether NO regulates net Cl⁻ flux (JCl) in the cortical collecting duct (CCD) and
Bora Lee et al.
Autophagy, 17(7), 1649-1666 (2020-06-25)
The uterus undergoes vascular changes during the reproductive cycle and pregnancy. Steroid hormone deprivation induces macroautophagy/autophagy in major uterine cell types. Herein, we explored the functions of uterine autophagy using the Amhr2-Cre-driven atg7 deletion model. Deletion of Atg7 was confirmed
Olga Y Gasheva et al.
American journal of physiology. Gastrointestinal and liver physiology, 316(1), G217-G227 (2018-11-27)
This study aimed to establish mechanistic links between the prolonged intake of desloratadine, a common H1 receptor blocker (i.e., antihistamine), and development of obesity and metabolic syndrome. Male Sprague-Dawley rats were treated for 16 wk with desloratadine. We analyzed the
Andrew G Masoud et al.
The Journal of clinical investigation, 130(1), 94-107 (2019-11-19)
Sustained, indolent immune injury of the vasculature of a heart transplant limits long-term graft and recipient survival. This injury is mitigated by a poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in the embryo by differentiation
L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
Y Sekii et al.
Communications biology, 5(1), 175-175 (2022-03-02)
Nocturnal polyuria is the most frequent cause of nocturia, a common disease associated with a compromised quality of life and increased mortality. Its pathogenesis is complex, and the detailed underlying mechanism remains unknown. Herein, we report that concomitant intake of
Nitric oxide mediates feedback inhibition in angiotensin II-induced upregulation of vasopressin mRNA
Zhang L, et al.
Peptides, 30(5), 913-917 (2009)
Georg Bauer
Anticancer research, 37(2), 567-581 (2017-02-10)
Tumor cells, in contrast to non-malignant cells, show sustained expression of membrane-associated NADPH oxidase-1 and therefore generate extracellular superoxide anions and their dismutation product H
H Özyurt Bayraktar et al.
Autonomic & autacoid pharmacology, 33(1-2), 7-16 (2013-03-07)
The nitrergic system modulates cardiovascular functions of the central nucleus of amygdala (CeA) and the posterior hypothalamus (PH) which are involved in the central regulation of the cardiovascular system. The aim of this study was to investigate the contribution of
Hélène Alami-Durante et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 242, 110652-110652 (2020-01-11)
Two experiments were conducted to test if manipulations of the Arginine-Nitric oxide pathway during the early life of rainbow trout would act on its early myogenic process. In experiment 1, trout embryos were immersed at 72° days post-fertilization (°dpf) or
Fiorentina Roviezzo et al.
Clinical science (London, England : 1979), 126(8), 545-556 (2013-10-18)
S1P (sphingosine 1-phosphate) represents one of the key latest additions to the list of vasoactive substances that modulate vascular tone. PAR-2 (proteinase activated receptor-2) has been shown to be involved in cardiovascular function. In the present study, we investigated the
M Antošová et al.
Advances in experimental medicine and biology, 838, 1-10 (2014-09-26)
Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive oxygen species (ROS).
Simone R Potje et al.
Free radical biology & medicine, 106, 148-157 (2017-02-14)
Nicotinamide adenine dinucleotide phosphate oxidase (NAD(P)H-oxidase) is a multicomponent enzyme system that generates superoxide anion by one-electron reduction of molecular oxygen and represents the major source of reactive oxygen species (ROS) in the vascular cells. Apocynin has been extensively used
Christopher G Scully et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R929-R939 (2013-04-05)
Laser speckle perfusion imaging (LSPI) has become an increasingly popular technique for monitoring vascular perfusion over a tissue surface. However, few studies have utilized the full range of spatial and temporal information generated by LSPI to monitor spatial properties of
Lisa Nguy et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R744-R752 (2013-03-22)
Rats with adenine-induced chronic renal failure (A-CRF) develop metabolic and cardiovascular abnormalities resembling those in patients with chronic kidney disease. The aim of this study was to investigate the mechanisms of hypertension in this model and to assess aortic stiffness
Geovanna Nallely Quiñonez-Bastidas et al.
Life sciences, 93(17), 637-645 (2013-09-10)
The purpose of this study was to investigate the antinociceptive effect of epicatechin as well as the possible mechanisms of action in diabetic rats. Rats were injected with streptozotocin to produce hyperglycemia. The formalin test was used to assess the
Shinsuke Hanatani et al.
Journal of the American Society of Nephrology : JASN, 25(12), 2800-2811 (2014-07-12)
Muscle wasting is frequently observed in patients with kidney disease, and low muscle strength is associated with poor outcomes in these patients. However, little is known about the effects of skeletal muscle growth per se on kidney diseases. In this
Christopher R Martens et al.
Journal of cardiovascular pharmacology, 63(1), 40-48 (2013-10-03)
Reduced nitric oxide bioavailability contributes to increased cardiovascular disease risk in patients with chronic kidney disease (CKD). Arginase has been implicated as a potential therapeutic target to treat vascular dysfunction by improving substrate availability for endothelial nitric oxide synthase. The
Margarita Rosa Romero-Imbachi et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 240, 108939-108939 (2020-11-10)
Centruroides margaritatus scorpion stings are common in Colombia. However, the cardiovascular toxicity of the venom has not been clarified. To study the effect and mechanisms of action of the complete venom of C. margaritatus (CmV) on the murine cardiovascular system.
Krystal N Brinson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R701-R710 (2013-07-26)
Nitric oxide is a critical regulator of blood pressure (BP) and inflammation, and female spontaneously hypertensive rats (SHR) have higher renal nitric oxide bioavailability than males. We hypothesize that female SHR will have a greater rise in BP and renal
Hayat Banoujaafar et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(10), 1681-1687 (2014-07-24)
We investigated the contribution of blood flow elevation in the cerebrovasculature to physical training-induced brain-derived neurotrophic factor (BDNF) levels elevation in the brain. Brain-derived neurotrophic factor protein levels were measured in the motor cortex 24 h after the last session of
George K E Umanah et al.
Cell reports, 33(5), 108329-108329 (2020-11-05)
The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internalization of AMPARs from the synaptic membrane. Here, we show that
Maximilian Michel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4605-4613 (2013-03-08)
The endogenous circadian clock is a principal factor modulating memory across species. Determining the processes through which the circadian clock modulates memory formation is a key issue in understanding and identifying mechanisms to improve memory. We used the marine mollusk
N M Omar et al.
Acta physiologica Hungarica, 100(3), 266-279 (2013-09-24)
For evaluating the age-related change in noradrenaline (NA)-induced contraction of isolated rat carotid artery (CA), the effect of α and β adrenoreceptor (AR) blockers and the role of nitric oxide (NO) were investigated. Concentration-response curves to NA (10-10-10-4 M) and
Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons.
Wu CL, et al.
Neurotoxicology, 30(4), 718-726 (2009)
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