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Masahito Shimizu et al.
International journal of cancer, 135(4), 774-784 (2014-01-30)
We previously reported the cancer chemopreventive activity of 4'-geranyloxyferulic acid (GOFA, Miyamoto et al., Nutr Cancer 2008; 60:675-84) and a β-cyclodextrin inclusion compound of GOFA (Tanaka et al., Int J Cancer 2010; 126:830-40) in colitis-related colorectal carcinogenesis. In our study
D I Peregud et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(3), 3-6 (2013-06-19)
This study was aimed at evaluating the role of nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) cascade in mechanisms of morphine dependency formation. Morphine was introduced by intraperitoneal (i.p.) injections in rats twice per day over six days in doses increasing
Serap Gur et al.
Urology, 82(3), 745-745 (2013-07-17)
To evaluate the effect of the tyrosine kinase inhibitor imatinib mesylate (Gleevec) on human corpus cavernosum (HCC) smooth muscle tone. HCC were obtained from 18 erectile dysfunction (ED) patients undergoing penile prosthesis surgery. The effects of imatinib in HCC strips
María A Rodríguez-Hernández et al.
Biochemical pharmacology, 176, 113902-113902 (2020-03-12)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the fourth most frequent cause of cancer-related death worldwide. Sorafenib is the first line recommended therapy for patients with locally advanced/metastatic HCC. The low response rate is
Jacqueline K Limberg et al.
American journal of physiology. Heart and circulatory physiology, 319(1), H162-H170 (2020-06-06)
Vasodilatory effects of insulin support the delivery of insulin and glucose to skeletal muscle. Concurrently, insulin exerts central effects that increase sympathetic nervous system activity (SNA), which is required for the acute maintenance of blood pressure (BP). Indeed, in a
Yolanda Mendizábal et al.
Life sciences, 93(25-26), 1023-1032 (2013-11-10)
We have studied the vasoactive role of prostaglandins derived from perivascular adipose tissue (PVAT) and their effects on endothelial function in healthy rats and rats with metabolic syndrome (SHROB). Mesenteric resistance arteries (MRA) from SHROB and control rats (WKY) were
Esra Eyiiş et al.
Turkish journal of pharmaceutical sciences, 17(6), 586-592 (2021-01-05)
Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain killers. Based on this, extensive researches are carried out on
Kristine H Kurtz et al.
Microcirculation (New York, N.Y. : 1994), 21(7), 593-605 (2014-04-08)
This study investigated the roles of the H1 and H2 histamine receptors, NO synthase, and sGC cyclase in histamine-induced modulation of rat mesenteric collecting lymphatic pumping. Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-μM histamine. Histamine receptors
Heng-Huei Lin et al.
Clinical science (London, England : 1979), 133(23), 2361-2378 (2019-11-26)
Contrast medium-induced acute kidney injury (CI-AKI) is one of the most common causes of hospital-acquired acute renal failure. However, the pathogenesis of CI-AKI remains unclear. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor that is largely metabolised
Lindsey A Ramirez et al.
American journal of physiology. Renal physiology, 319(2), F192-F201 (2020-07-01)
We have previously shown that hypertensive female rats have more regulatory T cells (Tregs), which contribute more to blood pressure (BP) control in female versus male rats. Based on known protective properties of Tregs, the goal of the present study
Jaume Padilla et al.
Endocrinology, 160(12), 2918-2928 (2019-10-17)
Obesity and insulin resistance stiffen the vasculature, with females appearing to be more adversely affected. As augmented arterial stiffness is an independent predictor of cardiovascular disease (CVD), the increased predisposition of women with obesity and insulin resistance to arterial stiffening
María Elena Sánchez-Mendoza et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-14)
Peptic ulcer disease, the most common gastrointestinal disorder, is currently treated with several types of drugs, but all have severe side effects. The aim of the present study was to evaluate the gastroprotective activity of juanislamin, isolated from Calea urticifolia
James T Pearson et al.
Clinical science (London, England : 1979), 135(2), 327-346 (2021-01-23)
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation and redox stress but only partially
S Haul et al.
Journal of neurophysiology, 81(2), 494-497 (1999-02-26)
The role of the possible retrograde messenger nitric oxide (NO) in the induction of long-term potentiation (LTP) was studied in supragranular layers of somatosensory cortical slices obtained from adult mice. High-frequency stimulation produced a slowly rising, long-lasting (50 min) and
Beijian Zhang et al.
Frontiers in cardiovascular medicine, 8, 647806-647806 (2021-03-23)
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined. Here, we explored the N6-methyladenosine (m6A) RNA methylation alteration in patients with HFpEF and mouse model of
Feimei Zhu et al.
Cell death & disease, 11(6), 459-459 (2020-06-17)
Macrophages play critical roles in the first-line immune defense against airway infections caused by Pseudomonas aeruginosa (PA). The redox-active phenazine-pyocyanin (PCN), as one of the most essential virulence factors, facilities PA-related infection via a wide spectrum of cellular oxidative damages.
Xia Wang et al.
Molecules (Basel, Switzerland), 24(13) (2019-07-03)
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is recognized as a critical regulator in physiological and pathophysiological processes of atherosclerosis (AS). However, the underlying mechanism remains unclear. As the precursor cells of endothelial cells (ECs), endothelial progenitor cells (EPCs) can prevent AS
George F Lasker et al.
American journal of physiology. Heart and circulatory physiology, 304(12), H1670-H1679 (2013-04-16)
Nitric oxide (NO) is the principal mediator of penile erection, and soluble guanylate cyclase (sGC) is the receptor for NO. In pathophysiological conditions when sGC is inactivated and not responsive to NO or sGC stimulators a new class of agents
Simone R Potje et al.
Free radical biology & medicine, 106, 148-157 (2017-02-14)
Nicotinamide adenine dinucleotide phosphate oxidase (NAD(P)H-oxidase) is a multicomponent enzyme system that generates superoxide anion by one-electron reduction of molecular oxygen and represents the major source of reactive oxygen species (ROS) in the vascular cells. Apocynin has been extensively used
Shusei Yamamoto et al.
Experimental and molecular pathology, 114, 104437-104437 (2020-04-05)
Nonalcoholic steatohepatitis (NASH) is linked to an increased risk of cardiovascular disease, regardless of the risk factors in metabolic syndrome. However, the intermediary factors between NASH and cardiovascular disease are still unknown. A previous study revealed that serum and hepatic
Tao Jiang et al.
Pakistan journal of pharmaceutical sciences, 28(1 Suppl), 313-318 (2015-01-30)
Acanthopanax senticosus, a traditional herb commonly found in Northeastern Asia,has been used for treating neurodegenerative diseases. However, the molecular and cellular mechanisms of its effect on neuroinflammation have not been investigated. In the current study, quantitative proteomics approach was applied
Panagiotis Laspas et al.
Experimental eye research, 127, 1-8 (2014-07-16)
Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS isoforms to vascular responses
Jiyu Chen et al.
Journal of cellular and molecular medicine, 25(1), 345-357 (2020-12-16)
In this study, we investigated the protective effects of gastrodin (Gas) against homocysteine-induced human umbilical vein endothelial cell (HUVEC) injury and the role of the phosphoinositide 3-kinase (PI3K)/threonine kinase 1 (Akt)/endothelial nitric oxide synthase (eNOS) and NF-E2-related factor 2 (Nrf2)/antioxidant
Pratish Thakore et al.
eLife, 10 (2021-02-27)
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagating retrograde signal that dilates
Christopher G Scully et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(11), R929-R939 (2013-04-05)
Laser speckle perfusion imaging (LSPI) has become an increasingly popular technique for monitoring vascular perfusion over a tissue surface. However, few studies have utilized the full range of spatial and temporal information generated by LSPI to monitor spatial properties of
Andrew G Masoud et al.
The Journal of clinical investigation, 130(1), 94-107 (2019-11-19)
Sustained, indolent immune injury of the vasculature of a heart transplant limits long-term graft and recipient survival. This injury is mitigated by a poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in the embryo by differentiation
Fiorentina Roviezzo et al.
Clinical science (London, England : 1979), 126(8), 545-556 (2013-10-18)
S1P (sphingosine 1-phosphate) represents one of the key latest additions to the list of vasoactive substances that modulate vascular tone. PAR-2 (proteinase activated receptor-2) has been shown to be involved in cardiovascular function. In the present study, we investigated the
Hélène Alami-Durante et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 242, 110652-110652 (2020-01-11)
Two experiments were conducted to test if manipulations of the Arginine-Nitric oxide pathway during the early life of rainbow trout would act on its early myogenic process. In experiment 1, trout embryos were immersed at 72° days post-fertilization (°dpf) or
Sara Mahmoud H Ahmed et al.
Nature, 584(7821), 415-419 (2020-07-10)
Sexual dimorphism arises from genetic differences between male and female cells, and from systemic hormonal differences1-3. How sex hormones affect non-reproductive organs is poorly understood, yet highly relevant to health given the sex-biased incidence of many diseases4. Here we report
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