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Reply to letter: "propranolol: a novel antihemangioma agent with multiple potential mechanisms of action".
Harvey Chim
Annals of surgery, 261(2), e53-e53 (2014-01-01)
Failure of systemic propranolol therapy for choroidal hemangioma of Sturge-Weber syndrome: a report of 2 cases.
Hatem Krema et al.
JAMA ophthalmology, 131(5), 681-683 (2013-03-30)
Ronan Shaughnessy et al.
The FEBS journal, 281(9), 2172-2189 (2014-03-07)
Epidermal growth factor receptor (EGFR) exaggerated (oncogenic) function is currently targeted in cancer treatment with drugs that block receptor ligand binding or tyrosine kinase activity. Because endocytic trafficking is a crucial regulator of EGFR function, its pharmacological perturbation might provide...
Thatiana L Assis de Brito et al.
Life sciences, 100(2), 138-146 (2014-02-25)
β-Adrenoceptors modulate acute wound healing; however, few studies have shown the effects of β-adrenoceptor blockade on chronic wounds. Therefore, this study investigated the effect of β1-/β2-adrenoceptor blockade in wound healing of pressure ulcers. Male mice were daily treated with propranolol...
Aliasghar Pourshanazari et al.
Neurosciences (Riyadh, Saudi Arabia), 18(2), 126-132 (2013-04-03)
To investigate the effect of estrogen exerted through the autonomic system in the nucleus tractus solitarii (NTS) on increasing the sensitivity of the baroreflex under conditions of acute hypertension in ovariectomized rats. In this experimental study, conducted in Kerman University...
Young Woon Park et al.
The Journal of dermatological treatment, 25(5), 391-395 (2013-01-01)
Propranolol has recently become a successful first-line therapy in the treatment of infantile hemangiomas (IHs). To evaluate and analyze the authors' experience of propranolol treatment for IHs. A retrospective, observational study was conducted. Medical records were reviewed. To evaluate the...
Silvia Franzellitti et al.
Aquatic toxicology (Amsterdam, Netherlands), 140-141, 249-256 (2013-07-09)
Aquatic organisms are unintentionally exposed to a large number of pharmaceutical residues in their natural habitats. Ecotoxicological studies have agreed that these compounds are not harmful to aquatic organisms, as their environmental concentrations are typically too low. However, recent reports...
Oral propranolol versus placebo for retinopathy of prematurity: a pilot, randomised, double-blind prospective study.
Imad R Makhoul et al.
Archives of disease in childhood, 98(7), 565-567 (2013-05-02)
Christine Léauté-Labrèze et al.
The New England journal of medicine, 372(8), 735-746 (2015-02-19)
Oral propranolol has been used to treat complicated infantile hemangiomas, although data from randomized, controlled trials to inform its use are limited. We performed a multicenter, randomized, double-blind, adaptive, phase 2-3 trial assessing the efficacy and safety of a pediatric-specific...
Yue Ma et al.
Journal of molecular recognition : JMR, 26(5), 240-251 (2013-03-26)
Bisphenol A (BPA) and propranolol-imprinted polymers have been prepared via both reversible addition-fragmentation chain transfer "bulk" polymerization (RAFTBP) and traditional radical "bulk" polymerization (TRBP) under similar reaction conditions, and their equilibrium binding properties were compared in detail for the first...
Adel Ahmed Ali et al.
Pharmaceutical development and technology, 18(5), 1238-1246 (2012-05-16)
Press-coated sustained release tablets offer a valuable, cheap and easy manufacture alternative to the highly expensive, multi-step manufacture and filling of coated beads. In this study, propranolol HCl press-coated tablets were prepared using hydroxylpropylmethylcellulose (HPMC) as tablet coating material together...
Lixin Su et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 73(1), 92-98 (2014-12-17)
To summarize the characteristics of Kasabach-Merritt syndrome (KMS) and to evaluate the therapeutic effect of drug therapy combined with transarterial embolization. From 2007 to 2011, 6 cases of KMS that underwent drug therapy and transarterial embolization were retrospectively analyzed, comprising...
Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon.
Zuopeng Wang et al.
Pediatric blood & cancer, 61(8), 1518-1519 (2014-02-01)
Geoffrey H Tofler et al.
The American journal of cardiology, 111(12), 1755-1758 (2013-04-09)
Heavy physical exertion, emotional stress, heavy meals, and respiratory infection transiently increase the risk of myocardial infarction, sudden cardiac death, and stroke; however, it remains uncertain how to use this information for disease prevention. We determined whether it was feasible...
Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the ?-adrenoceptor/cAMP/protein kinase A axis during oxidative stress.
Brunyanszki A, Olah G, Coletta C, et al.
Molecular Pharmacology, 86(4), 450-462 (2014)
Brook E Tlougan et al.
Journal of pediatric hematology/oncology, 35(8), 618-622 (2013-06-19)
Kasabach-Merritt phenomenon (KMP) is a rare consumptive coagulopathy characterized by profound thrombocytopenia and hypofibrinogenemia occurring in association with the vascular tumors kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). Treatment remains challenging without consensus on the optimal medical management. The authors...
Paroxysmal sympathetic hyperactivity, traumatic brain injury, and β-blockers.
Daniel Agustín Godoy et al.
The journal of trauma and acute care surgery, 77(2), 387-387 (2014-07-25)
Rangmar Goelz et al.
Archives of disease in childhood. Fetal and neonatal edition, 100(1), F85-F91 (2014-10-30)
Infantile haemangioma (IH) are vascular tumours with a unique growth dynamic, mostly absent at birth, growth in the first months followed by involution over several years, often resulting in residual skin changes. Immune-histologically, IH cells are exclusively glucose transporter protein-1...
Effects of catecholamines on thymocyte apoptosis and proliferation depend on thymocyte microenvironment.
Radojevic K, Rakin A, Pilipovic I, et al.
Journal of Neuroimmunology, 272(1-2), 16-28 (2014)
Luca Filippi et al.
The Journal of pediatrics, 163(6), 1570-1577 (2013-09-24)
To evaluate safety and efficacy of oral propranolol administration in preterm newborns affected by an early phase of retinopathy of prematurity (ROP). Fifty-two preterm newborns with Stage 2 ROP were randomized to receive oral propranolol (0.25 or 0.5 mg/kg/6 hours)...
Letitia E Bible et al.
The journal of trauma and acute care surgery, 77(1), 54-60 (2014-07-01)
Bone marrow (BM) dysfunction is common in severely injured trauma patients, resulting from elevated catecholamines and plasma granulocyte colony-stimulating factor (G-CSF) as well as prolonged mobilization of hematopoietic progenitor cells (HPCs). We have previously shown that propranolol (β-blocker [BB]) reduces...
Alvaro Ábarzúa-Araya et al.
Journal of the American Academy of Dermatology, 70(6), 1045-1049 (2014-03-25)
Infantile hemangiomas have a dramatic response to propranolol, a nonselective beta-blocker. However, this treatment is not risk-free and many patients are excluded because of respiratory comorbidities. Atenolol is a cardioselective beta-blocker that may have fewer adverse events. We sought to...
Daniela A G Goncalves et al.
Journal of orofacial pain, 27(4), 325-335 (2013-10-31)
To investigate the effectiveness of single and concomitant treatment of migraine and temporomandibular disorders (TMD) in women with the comorbidity. Eligible female patients met International Classification of Headache Disorders, second edition (ICHD-2) criteria for migraine with or without aura and...
William J Anderson et al.
Clinical science (London, England : 1979), 127(11), 635-643 (2014-06-19)
The murine asthma model shows that switching off airway β2 receptors with an inverse agonist may confer anti-inflammatory effects as well as corticosteroid-sparing activity. We have assessed for any corticosteroid-sparing effects of propranolol, an inverse agonist, added to low-dose inhaled...
[Propranolol first choice in infantile hemangiomas. Large randomized trials are needed to determine the dosage and duration of treatment].
Carl-Fredrik Wahlgren
Lakartidningen, 110(19-20), 938-939 (2013-06-12)
Oral propranolol (Hemangeol) for infantile hemangioma.
The Medical letter on drugs and therapeutics, 56(1447), 61-62 (2014-07-22)
Chong Wang et al.
Science (New York, N.Y.), 340(6132), 610-614 (2013-03-23)
Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the human 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine. The structures reveal...
Pawel Szychta et al.
Plastic and reconstructive surgery, 133(4), 852-862 (2013-12-20)
Infantile hemangioma is a vascular tumor and requires treatment in lesions manifested by potentially dangerous symptoms. Several publications have reported that involution of infantile hemangioma could be accelerated by propranolol but have used only invalidated subjective measures of assessment. The...
Yoshiyuki Kubo et al.
Journal of pharmaceutical sciences, 102(9), 3332-3342 (2013-04-10)
The influx transport of propranolol across the inner blood-retinal barrier (BRB) was investigated. In the in vivo analysis of carotid artery single-injection method, [(3) H]propranolol uptake by the retina was greater than that of an internal reference compound, and was...
Howard B Pride et al.
Journal of the American Academy of Dermatology, 68(6), 899-899 (2013-05-18)
The field of pediatric dermatology has been rich in new developments. Part II of this continuing medical education article will focus on new therapeutic modalities for several entities encountered in pediatric dermatology. The treatment of atopic dermatitis, exciting advances in...
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