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Joseph S Fruton
The Quarterly review of biology, 77(2), 127-147 (2002-07-02)
Studies on gastric digestion during 1820-1840 led to the discovery of pepsin as the agent which, in the presence of stomach acid, causes the dissolution of nutrients such as meat or coagulated egg white. Soon afterward it was shown that
H Cao et al.
European review for medical and pharmacological sciences, 17(11), 1427-1437 (2013-06-19)
Recently, type II collagen (CII) was found to be effective clinically for treatment of rheumatoid arthritis (RA). However, the molecular properties of CII could be changed during the preparation process. In the present study, we isolated CII from chick sternal
Noor Akmal Syed Husain Sharifah et al.
Methods in molecular biology (Clifton, N.J.), 952, 187-196 (2012-10-27)
Fluorescence in situ hybridization (FISH) is increasingly gaining importance in clinical diagnostics settings. Due to the ability of the technique to detect chromosomal abnormalities in samples with low cellularity or containing a mixed population of cells even at a single-cell
[Current understanding of the role of Helicobacter pylori infection in gastric carcinogenesis and the pepsin- and pepsinogen-producing function of the stomach].
M N Uspenskaia et al.
Voprosy onkologii, 51(5), 533-539 (2006-06-08)
Qiang Zou et al.
Journal of food science, 77(5), M270-M277 (2012-11-21)
Bifidobacterium bifidum F-35 was microencapsulated into whey protein microcapsules (WPMs) by a transglutaminase (TGase)-induced method after optimization of gelation conditions. The performance of these WPMs was compared with that produced by a spray drying method (WPMs-A). WPMs produced by the
Alexandra L Klinger et al.
Biochemistry, 53(49), 7724-7734 (2014-11-11)
Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer's disease typically consist of linear polypeptide segments, oriented approximately perpendicular to the long axis of the fibril, and joined together as parallel in-register β-sheets to form
Testing for laryngopharyngeal reflux in exhaled breath condensate: a pilot study.
C R Davies-Husband et al.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 37(6), 497-498 (2012-12-21)
J Kyle Bohman et al.
Chest, 143(5), 1407-1413 (2012-11-03)
Airway pepsin has been increasingly used as a potentially sensitive and quantifiable biomarker for gastric-to-pulmonary aspiration, despite lack of validation in normal control subjects. This study attempts to define normal levels of airway pepsin in adults and distinguish between pepsin
[The role of hydrochloric acid and pepsin in the etiology of peptic ulcer].
T Mach
Przeglad lekarski, 52(1), 19-21 (1995-01-01)
Elizabeth A Kelly et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(4), 618-624 (2014-01-01)
(1) Investigate the role of reflux, specifically pepsin, in laryngopharyngeal carcinogenesis. (2) Evaluate effects of chronic pepsin exposure on cell migration, apoptosis, and colony-forming ability in hypopharyngeal cells. Translation research. Academic research laboratory. Human hypopharyngeal squamous carcinoma FaDu cells were
J Tack
Alimentary pharmacology & therapeutics, 22 Suppl 1, 48-54 (2005-07-27)
Gastro-oesophageal reflux disease is defined as the presence of symptoms or lesions that can be attributed to the reflux of gastric contents into the oesophagus. Aspiration and prolonged monitoring studies in humans have shown that reflux of gastric contents is
Joycelyn K Quansah et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 68(1), 31-38 (2013-01-29)
The effect of thermal and ultrasonic treatment of cowpea proteins (CP) on amino acid composition, radical scavenging and reducing potential of hydrolysates (CPH) obtained from in vitro simulated gastrointestinal digestion of CP was evaluated. Hydrolysis of native and treated CP
Zhen-Hai Zhang et al.
Journal of biomedical nanotechnology, 9(4), 601-609 (2013-04-30)
N-octyl-N-Arginine chitosan (OACS) was synthesized in an attempt to combine the permeation enhancing effects of arginine-rich peptides and the drug loading capacity of the amphipathic polymers for insulin oral delivery. OACS self-assembled micelles of insulin were prepared by the conventional
Takafumi Mizushige et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(7), 2911-2917 (2013-04-13)
We found previously that dipeptide YL exhibits orally active anxiolytic activity comparable to diazepam. The YL sequence is often observed in the primary structure of natural food proteins. In the present study, we investigated whether YL and YL analogues are
Yi Li et al.
Environmental science and pollution research international, 20(7), 4993-5002 (2013-01-19)
The bioaccessibility of soil heavy metals is the solubility of soil heavy metals in synthetic human digestive juice, which is usually determined using in vitro digestion test. To reveal the effects of digestive enzymes on soil heavy metals bioaccessibility, three
Tomasz Skoczylas et al.
Digestive diseases and sciences, 59(10), 2411-2416 (2014-03-13)
It has been previously demonstrated that the exposure of the lower esophageal mucosa to acid and pepsin results in significant increase in salivary protective factors secretion, mediated by the esophago-salivary reflex. The impact of the upper esophageal mucosal exposure to
Ilhan Inci et al.
The Journal of surgical research, 184(2), 1143-1149 (2013-05-28)
We tested whether an injured lung graft from category-3 donation after cardiac death donor could be reconditioned with an ex vivo lung perfusion (EVLP) system by intrabronchial diluted surfactant lavage before transplantation. In a pig model, cardiac arrest was induced
J A Green et al.
Reviews of reproduction, 3(1), 62-69 (1998-03-24)
The pregnancy-associated glycoproteins (PAGs) were first described as placental antigens of cattle that were also present in the blood serum of the mother after implantation. Molecular cloning studies have shown that they are members of the aspartic proteinase gene family
Yunchang Fan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 297-303 (2013-01-16)
The interaction of an amino-functionalized ionic liquid, 1-(2-aminoethyl)-3-butylimidazolium bromide ([NH(2)C(2)C(4)im]Br) with two enzymes, pepsin and papain was investigated using fluorescence spectroscopic technique. It is found that [NH(2)C(2)C(4)im]Br has strong ability to quench the intrinsic fluorescence of pepsin and papain. Quenching
Dionysios Pantazatos et al.
The Biochemical journal, 461(3), 443-451 (2014-05-13)
Factor VIII enhances the catalytic activity of Factor IXa in a membrane-bound enzyme complex and both proteins are necessary to prevent haemophilia. Tandem lectin-like C domains mediate the membrane binding of Factor VIII and membrane-interactive residues have been identified. However
Tina L Samuels et al.
The Annals of otology, rhinology, and laryngology, 119(3), 203-208 (2010-04-16)
Diagnosis of extraesophageal reflux (EER) currently relies on tools designed for diagnosis of gastroesophageal reflux. Such tools lack the sensitivity and reproducibility to detect the less frequent and mildly acidic reflux associated with upper airway disease. Pepsin has been posited
Michal Ciolkowski et al.
Biochimica et biophysica acta, 1834(10), 1982-1987 (2013-07-16)
In this study the ability of three polyamidoamine (PAMAM) dendrimers with different surface charge (positive, neutral and negative) to interact with a negatively charged protein (porcine pepsin) was examined. It was shown that the dendrimer with a positively charged surface
V van Kampen et al.
Pneumologie (Stuttgart, Germany), 67(5), 260-264 (2013-03-22)
Rennet is a mixture of the proteolytic enzymes pepsin and chymosin (rennin), which is usually obtained from the fourth stomach of young ruminants. While pepsin is also used in the pharmaceutical industry, both enzymes (pepsin and chymosin) are used for
Chuan-Hsiao Han et al.
Food chemistry, 138(2-3), 923-930 (2013-02-16)
Our previous report showed that yam dioscorin and its peptic hydrolysates exhibit radical scavenging activities; however, the functions of these peptic hydrolases are still under investigation. In this study, the thiol-containing peptides derived from computer-aided simulation of pepsin hydrolysis of
Elizabeth A Kelly et al.
JAMA otolaryngology-- head & neck surgery, 139(10), 996-1001 (2013-08-31)
The role of aspiration-associated extraesophageal reflux disease (AERD) in patients with chronic respiratory symptoms is not well defined. Identifying the frequency of AERD in these patients may provide guidance in their treatment. To determine the prevalence of AERD in patients
Alessandra Amoroso et al.
Food chemistry, 140(4), 654-659 (2013-05-23)
α-Dicarbonyl compounds (α-DCs), such as glyoxal, methylglyoxal and 2,3-butanedione, are highly reactive substances occurring in thermally treated and fermented foods, that may react with amino and sulphydryl groups of side chains of proteins to form Maillard reaction end products, inducing
Ana Danić Hadzibegović et al.
Collegium antropologicum, 36 Suppl 2, 93-97 (2013-02-13)
The aim of this crossectional study was to investigate the relationship between pepsin concentration in saliva and the occurrence of tracheoesophageal fistula (TEF) complications and voice prosthesis (VP) complications, after total laryngectomy and VP implantation. We assessed the concentrations of
Christopher S Davis et al.
The Journal of surgical research, 185(2), e101-e108 (2013-07-13)
Aspiration of gastroesophageal refluxate has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and the progression of bronchiolitis obliterans syndrome after lung transplantation. The goals of the present study were to identify lung transplant patients at the greatest
Zhaoping He et al.
Current allergy and asthma reports, 8(6), 513-518 (2008-10-23)
Gastroesophageal reflux and extraesophageal reflux have been postulated to be involved in the pathogenesis of otitis media. This is supported by recent studies revealing the presence of gastric pepsin in the middle ear space of children with otitis media but
[The pepsinogen-pepsin system under normal conditions and in gastric carcinogenesis].
V F Privoritskiĭ et al.
Voprosy onkologii, 39(7-12), 251-259 (1993-01-01)
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