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Kathryn Y Noonan et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 41(9), 1288-1295 (2020-09-15)
The presence and distribution of ionized calcium binding adaptor 1 and CD68 macrophages in the human cochlea is altered in cochlear implantation (CI) compared with the normative or nonimplanted cochlea. It has been hypothesized that CI induces an immunological response...
Shun-Ichi Chitose et al.
The Laryngoscope, 127(7), 1622-1627 (2016-11-20)
Regeneration of the recurrent laryngeal nerve (RLN), which innervates the intrinsic laryngeal muscles such that they can perform complex functions, is particularly difficult to achieve. Synkinesis after RLN neogenesis leads to uncoordinated movement of laryngeal muscles. Recently, some basic research...
P Chen et al.
Reproduction in domestic animals = Zuchthygiene, 52(5), 825-835 (2017-05-18)
The objective of our present study was to determine the effects of insulin-like growth factor I (IGF-I) on the development of yak (Bos grunniens) embryos after cumulus-oocyte complex (COC) vitrification and warming followed by in vitro fertilization (IVF). In Experiment...
Junqing Gao et al.
PloS one, 11(12), e0168219-e0168219 (2016-12-16)
The aim of this study was to evaluate the effect of Ginkgolide B (GB) on doxorubicin (DOX) induced cardiotoxicity in vitro and in vivo. Rat cardiomyocyte cell line H9c2 was pretreated with GB and subsequently subjected to doxorubicin treatment. Cell...
Yue Wang et al.
Pharmacology, 105(7-8), 405-415 (2020-01-30)
The regulatory network of aquaporin (AQP) 1 and renin-angiotensin-aldosterone (ALDO) system are not quite clear in pulmonary arterial hypertension (PAH). Thus, we explored the role of AQP1, ALDO and spirolactone (SP) in the PAH animal model and pulmonary arterial smooth...
Qian Hao et al.
Cell death & disease, 11(3), 197-197 (2020-03-22)
The Shwachman-Bodian Diamond syndrome (SBDS)-associated gene, SBDS, is involved in rRNA synthesis and ribosome maturation, but the role of SBDS in cancer is largely elusive. In this study, we found that SBDS is often overexpressed or amplified in human cancers...
Changhai Zhang et al.
Cardiology, 128(2), 73-85 (2014-02-22)
To investigate whether triptolide can prolong the survival of rat mesenchymal stem cells (MSCs) transfected with the mouse hyperpolarization-activated cyclic nucleotide-gated channel 4 (mHCN4) gene in the myocardium. Grafted cell survival was determined using a sex-mismatched cell transplantation model and...
Tai Wei et al.
Oncotarget, 8(4), 6663-6680 (2016-12-31)
Interleukin-17A (IL-17A), a proinflammatory cytokine mainly produced by T helper 17 cells, exerts protumor or antitumor effects in different cancer entities. However, the exact role of IL-17A in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unclear. Here...
Elina Mäntylä et al.
Journal of virology, 94(4) (2019-11-22)
Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the...
Nipha Chaicharoenaudomrung et al.
Journal of cellular physiology, 234(11), 20085-20097 (2019-04-05)
The three-dimensional (3D) cell culture model has been increasingly used to study cancer biology and screen for anticancer agents due to its close mimicry to in vivo tumor biopsies. In this study, 3D calcium(Ca)-alginate scaffolds were developed for human glioblastoma...
Lin Chen et al.
Cancer research, 76(23), 6828-6838 (2016-10-21)
Tumor relapse after chemotherapy is a major hurdle for successful cancer therapy. Chemotherapeutic drugs select for resistant tumor cells and reshape tumor microenvironment, including the blood supply system. Using animal models, we observed on macrophages in tumor tissue a close...
Han-Sung Hwang et al.
Stem cells international, 2020, 8403192-8403192 (2020-06-27)
Preeclampsia is a syndrome characterized by deterioration of either the maternal condition or the fetal condition. The adverse intrauterine environment made by preeclampsia results into intrauterine growth restriction and increased risk of a variety of diseases in future life. Given...
Hisato Iriki et al.
Journal of dermatological science, 100(3), 166-174 (2020-10-08)
The thymus plays an essential role in removing autoreactive T cells. Autoantigen-expressing thymic epithelial cells (TECs) contribute to the tolerogenic process. The thymus transiently shrinks as an acute thymic involution (ATI) under various inflammatory conditions. However, whether ATI occurs during...
Gary J Gartling et al.
The Laryngoscope, 131(4), E1265-E1271 (2020-11-07)
This study's objective was to identify and compare the localization of Aquaporin (AQP) 1, 4, 7, Na+/K + -ATPase, E-cadherin, zona occludin (ZO)-1, and occludin in human and rabbit vocal folds (VF)s to inform the design of future studies to explore the...
Shigeo M Tanaka et al.
Annals of biomedical engineering, 43(9), 2083-2089 (2015-01-08)
The effect of mechanical stimulation on osteogenesis remains controversial, especially with respect to the loading frequency that maximizes osteogenesis. Mechanical stimulation at an optimized frequency may be beneficial for the bone tissue regeneration to promote osteoblastic calcification. The objective of...
Shinsuke Kochi et al.
Molecular and cellular biochemistry, 436(1-2), 39-48 (2017-06-09)
Gingival epithelial cells form a physiological barrier against bacterial invasion. Excessive bacterial invasion destroys the attachment between the tooth surface and the epithelium, resulting in periodontitis. Integrins play a significant role in cell attachment; therefore, we hypothesized that bacterial infection...
Said Movahedi Naini et al.
Molecular and cellular biology, 35(21), 3768-3784 (2015-08-26)
The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress. However, the mechanism underlying...
Romain Da Costa et al.
Investigative ophthalmology & visual science, 57(13), 5326-5334 (2016-10-27)
Gene therapies to treat eye disorders have been extensively studied in the past 20 years. Frequently, adeno-associated viruses were applied to the subretinal or intravitreal space of the eye to transduce retinal cells with nucleotide sequences of therapeutic potential. In...
Yuanyuan Chen et al.
Investigative ophthalmology & visual science, 56(4), 2553-2567 (2015-03-19)
Inherent instability of the P23H mutant opsin accounts for approximately 10% of autosomal dominant retinitis pigmentosa cases. Our purpose was to develop an overall set of reliable screening strategies to assess if either stabilization or enhanced degradation of mutant rhodopsin...
Cristina Bergamaschi et al.
Journal for immunotherapy of cancer, 8(1) (2020-05-29)
Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+ T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15). Several preclinical models support the...
Dal-Hoe Koo et al.
Chromosoma, 126(4), 531-540 (2016-12-03)
A crossover (CO) and its cytological signature, the chiasma, are major features of eukaryotic meiosis. The formation of at least one CO/chiasma between homologous chromosome pairs is essential for accurate chromosome segregation at the first meiotic division and genetic recombination....
Xiangchun Zhang et al.
Small (Weinheim an der Bergstrasse, Germany), 14(17), e1703684-e1703684 (2018-03-27)
Tumor cell invasion is pivotal to the development, metastasis, and prognosis of tumors. It is reported that the invasive ability of tumor cells is mainly dependent on the expression levels of membrane type-1 matrix metalloproteinase (MT1-MMP) and integrin αV β3...
Yoonjung Kwon et al.
Cell death & disease, 11(10), 874-874 (2020-10-19)
Amitriptyline is a tricyclic antidepressant commonly prescribed for major depressive disorders, as well as depressive symptoms associated with various neurological disorders. A possible correlation between the use of tricyclic antidepressants and the occurrence of Parkinson's disease has been reported, but...
Ran You et al.
eLife, 4, e09623-e09623 (2015-10-06)
Chronic inhalation of cigarette smoke is the major cause of sterile inflammation and pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke derived from the incomplete combustion of organic material, in smokers and non-smokers is less...
Lun Zhou et al.
Current medical science, 40(2), 313-319 (2020-04-28)
Ventricular septum defects (VSDs) are common types of congenital heart diseases caused by developmental defect; they contribute to 25%-30% of all adult congenital heart diseases. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is widely expressed in mammalian tissues and in the...
Xuan He et al.
Chinese medical journal, 132(14), 1713-1722 (2019-07-04)
Macrophage accumulation in the vascular wall is a hallmark of atherosclerosis. Studies showed that shifting of oxidized lipids-induced inflammatory macrophages towards an anti-inflammatory phenotype by promoting oxidative metabolism attenuated atherosclerosis progression. Therefore, this study aimed to investigate whether metformin, which...
Ulrich Siler et al.
The Journal of allergy and clinical immunology, 139(1), 212-219 (2016-07-28)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in human subjects, causing hemolytic anemia linked to impaired nicotinamide adenine dinucleotide phosphate (NADPH) production and imbalanced redox homeostasis in erythrocytes. Because G6PD is expressed by...
Peifang Ren et al.
ACS omega, 5(51), 33314-33322 (2021-01-07)
Biofilms could provide favorable conditions for the growth of cells during industrial fermentation. However, biofilm-immobilized fermentation has not yet been reported in Corynebacterium glutamicum (C. glutamicum), one of the main strains for amino acid production. This is mainly because C....
Tran Thi Hien et al.
International journal of cancer, 147(9), 2479-2492 (2020-04-23)
Potent chemotherapeutic agents are required to counteract the aggressive behavior of cancer cells and patients often experience severe side effects, due to tissue toxicity. Our study addresses if a better balance between efficacy and toxicity can be attained using the...
Weiying Kong et al.
Viral immunology, 33(1), 61-70 (2020-01-25)
The mechanistic mammalian target of rapamycin (mTOR) plays a crucial role in response to many major cellular processes, including cellular metabolism, proliferation, and autophagy. Both mTOR and autophagy are suggested to be involved in the viral infection. However, little is...
页码 1 来自 95
页码 1 来自 95