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D Fan et al.
Oncogene, 34(16), 2083-2093 (2014-06-10)
Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of...
Zhendong Wang et al.
Biological & pharmaceutical bulletin, 38(2), 277-284 (2015-03-10)
Multidrug resistance is one of the major causes limiting the efficacy of chemotherapeutic agents used to control osteosarcoma. Multidrug resistance protein 1 (MDR1 or ABCB1) was considered to play a critical role in multidrug resistance. Agents from traditional Chinese medicines...
Jean-Marc Navarro et al.
Nature communications, 6, 6094-6094 (2015-01-24)
T-cell acute lymphoblastic leukaemias (T-ALL) are aggressive malignant proliferations characterized by high relapse rates and great genetic heterogeneity. TAL1 is amongst the most frequently deregulated oncogenes. Yet, over half of the TAL1(+) cases lack TAL1 lesions, suggesting unrecognized (epi)genetic deregulation...
Bruna Maria Manzini et al.
Cytotherapy, 17(8), 1052-1065 (2015-07-04)
End-stage liver diseases frequently require liver transplantation. Cell therapy could be an alternative. This study aimed to analyze whether undifferentiated mesenchymal stromal cells (U-MSCs) or MSC-derived hepatocyte-like cells (DHLCs) from adipose tissue (AT), umbilical cord blood (UCB) and bone marrow...
Kathene C Johnson-Henry et al.
The Journal of nutrition, 144(11), 1725-1733 (2014-08-22)
Few studies have focused on the ability of prebiotics to prevent pathogen-induced cellular changes or alter the composition of the intestinal microbiota in complimentary relevant cell and animal models of inflammatory bowel disease. The objective of this study was to...
B Walker et al.
Journal of thrombosis and haemostasis : JTH, 13(7), 1325-1334 (2015-05-07)
Platelet secretion is critical to development of acute thrombotic occlusion. Platelet dense granules contain a variety of important hemostatically active substances. Nevertheless, biogenesis of platelet granules is poorly understood. Serum- and glucocorticoid-inducible kinase 1 (SGK1) has been shown to be...
Kalpana Sriraman et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(7), 884-903 (2015-03-18)
This study was undertaken to investigate stem cells in adult mouse ovary, the effect of chemotherapy on them and their potential to differentiate into germ cells. Very small embryonic-like stem cells (VSELs) that were SCA-1+/Lin-/CD45-, positive for nuclear octamer-binding transforming...
Venus Wenxin Huang et al.
Molecular human reproduction, 21(6), 516-526 (2015-04-11)
Oxidative damage by reactive oxygen species (ROS) is a major cause of sperm dysfunction. Excessive ROS generation reduces fertilization and enhances DNA damage of spermatozoa. Interaction between spermatozoa and oviductal epithelial cells improves the fertilizing ability of and reduces chromatin...
Janine Jahn et al.
Obesity (Silver Spring, Md.), 23(11), 2233-2241 (2015-09-24)
Natural killer (NK) cells are the first defense against malignant cells, and their functions are severely impaired in individuals with obesity. However, it is not known whether functions can be re-activated after weight loss. The alterations of NK cell functions...
Sebastian C Warth et al.
The EMBO journal, 34(9), 1195-1213 (2015-02-26)
Peripheral induction of regulatory T (Treg) cells provides essential protection from inappropriate immune responses. CD4(+) T cells that lack endogenous miRNAs are impaired to differentiate into Treg cells, but the relevant miRNAs are unknown. We performed an overexpression screen with...
André Hoerning et al.
Transplantation, 99(1), 210-219 (2014-08-08)
Immunosuppressive therapy with mammalian target of rapamycin inhibitors (mTORi) requires maintenance of an effective inhibition of the alloimmune response, whereas reducing drug-related nephrotoxicity. Therapeutic monitoring is based on mTORi trough levels, which do not necessarily reflect biologic effects on the...
Theodora Katsila et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(24), 6346-6356 (2014-10-18)
The lack of secreted biomarkers measurable by noninvasive tests hampers the development of effective targeted therapies against cancer. Our hypothesis is that cetuximab (an anti-EGFR mAb) induces a specific secretome in colorectal cancer cells that could be exploited for biomarker...
Raquel Ferreira et al.
Journal of the American Heart Association, 3(3), e000968-e000968 (2014-05-20)
Cerebral arteriovenous malformation (AVM) is a vascular disease exhibiting abnormal blood vessel morphology and function. miR-18a ameliorates the abnormal characteristics of AVM-derived brain endothelial cells (AVM-BEC) without the use of transfection reagents. Hence, our aim was to identify the mechanisms...
Helga Joos et al.
The American journal of sports medicine, 43(11), 2822-2832 (2015-09-13)
Sport injuries of the knee often lead to posttraumatic arthritis. In addition to direct damage of the cartilage, trauma-associated intra-articular bleeding may cause hemarthrosis. Both blood exposure and trauma are known to induce cell death and inflammation and to enhance...
Eric M C Britigan et al.
Molecular biology of the cell, 25(18), 2761-2773 (2014-07-25)
The ARF tumor suppressor is part of the CDKN2A locus and is mutated or undetectable in numerous cancers. The best-characterized role for ARF is in stabilizing p53 in response to cellular stress. However, ARF has tumor suppressive functions outside this...
Georgina MacKenzie et al.
Epilepsy research, 109, 13-27 (2014-12-20)
The most commonly reported precipitating factor for seizures is stress. However, the underlying mechanisms whereby stress triggers seizures are not yet fully understood. Here we demonstrate a potential mechanism underlying changes in neuronal excitability in the hippocampus following chronic stress...
S Giunco et al.
Cell death & disease, 6, e1774-e1774 (2015-05-29)
Epstein-Barr virus (EBV)-associated malignancies, as well as lymphoblastoid cell lines (LCLs), obtained in vitro by EBV infection of B cells, express latent viral proteins and maintain their ability to grow indefinitely through inappropriate activation of telomere-specific reverse transcriptase (TERT), the...
Erik L de Graaf et al.
Journal of proteome research, 14(7), 2906-2914 (2015-05-27)
We report a straightforward strategy to comprehensively monitor signal transduction pathway dynamics in mammalian systems. Combining targeted quantitative proteomics with highly selective phosphopeptide enrichment, we monitor, with great sensitivity, phosphorylation dynamics of the PI3K-mTOR and MAPK signaling networks. Our approach...
Maude Gabriel et al.
BMC cancer, 15, 227-227 (2015-04-18)
Modification of splicing by chemotherapeutic drugs has usually been evaluated on a limited number of pre-mRNAs selected for their recognized or potential importance in cell proliferation or apoptosis. However, the pathways linking splicing alterations to the efficiency of cancer therapy...
Han-Ning Huang et al.
Marine drugs, 13(5), 3241-3258 (2015-05-27)
Shrimp anti-lipopolysaccharide factor (SALF) is an antimicrobial peptide with reported anticancer activities, such as suppression of tumor progression. In this study, we prepared a potential cancer vaccine comprised of SALF in conjunction with the cell lysate of inactivated murine bladder...
Bartosz Kempisty et al.
Zygote (Cambridge, England), 23(6), 836-845 (2014-10-17)
Although the expression of estrogen and progesterone receptors within porcine ovary and cumulus-oocyte complexes (COCs) is well recognized, still little information is known regarding expression of the progesterone receptor (PGR), PGR membrane component 1 (PGRMC1) and of estrogen-related receptors (ERRγ...
Kylie A Alexander et al.
The Journal of clinical investigation, 124(10), 4266-4280 (2014-08-27)
Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin and lung. Here, we used multiple murine models of cGVHD to investigate the contribution of macrophage populations...
Colm E Nestor et al.
Genome biology, 16, 11-11 (2015-02-05)
The DNA methylation profiles of mammalian cell lines differ from those of the primary tissues from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the...
Zélia Silva et al.
International journal of biological macromolecules, 79, 44-48 (2015-04-29)
Anti-cancer treatments usually elevate the content of unfolded or misfolded proteins in the endoplasmic reticulum (ER). Here we aimed to get insights into the relation between sensitivity of melanoma cell lines to the ER stress inducer thapsigargin (THG) and the...
Mei-Juan Wei et al.
International immunopharmacology, 27(2), 238-243 (2015-06-30)
Dendritic cells (DCs) are multifunctional cells that initiate adaptive immune responses. Patients with chronic hepatitis B virus (HBV) infection have reduced numbers of DCs which may be functionally impaired, a defect that may contribute to viral persistence. Autologous DC-based immunotherapy...
Shou-Peng Fu et al.
Journal of neuroinflammation, 12, 9-9 (2015-01-18)
Accumulating evidence suggests that neuroinflammation plays an important role in the progression of Parkinson's disease (PD). Excessively activated microglia produce several pro-inflammatory enzymes and pro-inflammatory cytokines, leading to damage to surrounding neurons and eventually inducing neurodegeneration. Therefore, the inhibition of...
Ward De Spiegelaere et al.
PloS one, 10(3), e0122515-e0122515 (2015-04-01)
An appropriate normalization strategy is crucial for data analysis from real time reverse transcription polymerase chain reactions (RT-qPCR). It is widely supported to identify and validate stable reference genes, since no single biological gene is stably expressed between cell types...
Zhongyong Gou et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(2), 611-621 (2015-05-23)
There has been increasing recent attention on the antioxidative capacity of equol. This study tested the effect of equol on oxidative stress induced by lipopolysaccharide (LPS) and regulation of immunity in chicken macrophages. Chicken HD11 macrophages were challenged with LPS...
Marika Comegna et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3720-3733 (2014-05-16)
Cellular senescence is a permanent cell cycle arrest triggered by different stimuli. We recently identified up-regulation of microRNA (miR)-494 as a component of the genetic program leading to senescence of human diploid IMR90 fibroblasts. Here, we used 2-dimensional differential gel...
Rujiraporn Pitaksalee et al.
Neurotoxicity research, 27(4), 421-429 (2015-01-16)
Methamphetamine (METH) is a highly addictive CNS stimulant that its long-term use is associated with the loss of neurons in substantia nigra and development of Parkinson's disease later in life. Common form of METH is Ya-Ba tablet, in which, large...
页码 1 来自 60
页码 1 来自 60