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Maritta Küspert et al.
RNA (New York, N.Y.), 21(7), 1294-1305 (2015-05-24)
mRNAs are key molecules in gene expression and subject to diverse regulatory events. Regulation is accomplished by distinct sets of trans-acting factors that interact with mRNAs and form defined mRNA-protein complexes (mRNPs). The resulting "mRNP code" determines the fate of
Christoph Roderburg et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1172-1184 (2014-07-22)
Serum concentrations of miR-122 were proposed as a marker for various inflammatory diseases, but the mechanisms driving alterations in miR-122 serum levels are unknown. We analysed miR-122 serum levels and hepatic miR-122 expression in mice after hepatic ischaemia and reperfusion
Jung-Ting Lee et al.
Endocrinology, 155(9), 3409-3420 (2014-06-11)
Macrophage metalloelastase, a matrix metallopeptidase (MMP12) predominantly expressed by mature tissue macrophages, is implicated in pathological processes. However, physiological functions for MMP12 have not been described. Because mRNA levels for the enzyme increase markedly in adipose tissue of obese mice
The many roles for fluorine in medicinal chemistry.
William K Hagmann
Journal of medicinal chemistry, 51(15), 4359-4369 (2008-06-24)
Yu Tahara et al.
Scientific reports, 5, 11417-11417 (2015-06-16)
The effects of acute stress on the peripheral circadian system are not well understood in vivo. Here, we show that sub-acute stress caused by restraint or social defeat potently altered clock gene expression in the peripheral tissues of mice. In
Andrew P Jackson et al.
Nucleic acids research, 42(11), 7113-7131 (2014-05-07)
Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes driving antigenic
Mathieu Clément-Ziza et al.
Molecular systems biology, 10, 764-764 (2014-11-30)
Our current understanding of how natural genetic variation affects gene expression beyond well-annotated coding genes is still limited. The use of deep sequencing technologies for the study of expression quantitative trait loci (eQTLs) has the potential to close this gap.
Renata P Assis et al.
BMC nephrology, 16, 50-50 (2015-04-18)
In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to
Elena R Andreeva et al.
Cells, tissues, organs, 200(5), 307-315 (2015-09-26)
A microenvironment low in O2 ('physiological' hypoxia) governs the functions of perivascular multipotent mesenchymal stromal cells, defining their involvement in tissue physiological homeostasis and regenerative remodelling. Acute hypoxic stress is considered as one of the important factors inducing tissue damage.
Willem Jonker et al.
Journal of chromatography. A, 1406, 165-174 (2015-06-28)
In this study we developed a new LC nanofractionation platform that combines a human cell (BG1.Luc) gene reporter assay with a high resolution mass spectrometer for the detection and identification of estrogenic and anti-estrogenic compounds in environmental waters. The selection
Kun Huang et al.
Molecular medicine reports, 11(3), 1685-1692 (2014-11-21)
Pulmonary fibrosis is an irreversible chronic progressive fibroproliferative lung disease, which usually has a poor prognosis. Previous studies have confirmed that the transplantation of bone marrow mesenchymal stem cells (MSCs) significantly reduces lung damage in a number of animal models.
Cécilia Abarrategui-Pontes et al.
Current gene therapy, 14(5), 365-376 (2015-02-18)
Zinc finger nucleases (ZFNs) are promising tools for genome editing for biotechnological as well as therapeutic purposes. Delivery remains a major issue impeding targeted genome modification. Lentiviral vectors are highly efficient for delivering transgenes into cell lines, primary cells and
Farhahna Allie et al.
BMC genomics, 15, 1006-1006 (2014-11-22)
Cassava mosaic disease is caused by several distinct geminivirus species, including South African cassava mosaic virus-[South Africa:99] (SACMV). To date, there is limited gene regulation information on viral stress responses in cassava, and global transcriptome profiling in SACMV-infected cassava represents
Eugen C Minca et al.
Cancer genetics, 207(7-8), 306-315 (2014-12-03)
Cytogenetic alterations are strong outcome prognosticators in uveal melanoma (UVM). Monosomy 3 (-3) and MYC amplification at 8q24 are commonly tested by fluorescence in situ hybridization (FISH). Alternatively, microarray analysis provides whole genome data, detecting partial chromosome loss, loss of
Louise Jones et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(20), 11783-11788 (2003-09-18)
Stomatal guard cells play a key role in the ability of plants to survive on dry land, because their movements regulate the exchange of gases and water vapor between the external environment and the interior of the plant. The walls
Govindasamy Chandrasekar et al.
Journal of nanoscience and nanotechnology, 14(6), 4683-4691 (2014-04-18)
Mesoporous AISBA-15 with different n(Si)/n(Al) ratios (45, 136 and 215) in the powder (P) form were synthesized by hydrothermal technique. The powder materials were shaped into cylindrical extrudates (Ex) by compounding with additives such as bentonite (binder) and methylcellulose (plasticizer).
Anna Maria Wróbel et al.
Toxicology letters, 238(2), 110-116 (2015-08-09)
In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells. Cells were exposed to methyl-, propyl- or butylparaben at
Réka Balogh et al.
Journal of chromatography. A, 1422, 140-146 (2015-10-20)
This study presents a validated, porous graphitic carbon stationary phase-based LC-MS/MS method for the identification and quantification of lacto-N-biose (LNB) and N-acetyllactosamine (LacNAc). These compounds are the major building blocks of human milk oligosaccharides, however the presence of their unbound
S A Khan et al.
Acta physiologica (Oxford, England), 214(3), 390-401 (2015-04-08)
This study investigated the role of the renal innervation in arterial and cardiopulmonary baroreflex regulation of renal sympathetic nerve activity (RSNA) and heart rate (HR) in rats fed a high-fat diet to induce obesity. Rats received either a normal (12%
R Hume et al.
Histochemistry and cell biology, 105(2), 147-152 (1996-02-01)
Reversible sulphation, catalysed by sulphotransferases and sulphatases, of biologically active compounds such as androgens and oestrogens is a sensitive mechanism for regulating their bioavailability, and we have previously hypothesised that this process plays a significant role in the regulation of
Thadeous J Kacmarczyk et al.
PloS one, 10(6), e0129350-e0129350 (2015-06-13)
Multiplexing samples in sequencing experiments is a common approach to maximize information yield while minimizing cost. In most cases the number of samples that are multiplexed is determined by financial consideration or experimental convenience, with limited understanding on the effects
Dragana M Vucić et al.
Acta poloniae pharmaceutica, 70(6), 1021-1026 (2014-01-05)
Antibacterial and antioxidant activity, total phenolic and flavonoid concentrations of aqueous, ethanol and ethyl acetate extracts from the leaves and flowers of Erica herbacea L. were studied. In vitro antibacterial activity of the extracts was determined by macrodilution method. Minimum
N Greeshma et al.
Chemico-biological interactions, 238, 118-128 (2015-06-24)
Hyperalgesia, allodynia, delayed motor nerve conduction velocity, oxidative stress and axonal damage are signs and symptoms of chemotherapy induced peripheral neuropathy (CIPN). Present treatment/preventive strategies of CIPN are futile and the neuropathy may even lead to discontinuation of chemotherapy. In
Marta Lores et al.
Talanta, 140, 134-142 (2015-06-07)
An important trend in the extraction of chemical compounds is the application of new environmentally friendly, food grade solvents. Ethyl lactate (ethyl 2-hydroxypropanoate), produced by fermentation of carbohydrates, is miscible with both hydrophilic and hydrophobic compounds being a potentially good
Piyasuda Thepnok et al.
Biochemical and biophysical research communications, 450(4), 1276-1282 (2014-07-08)
Many zinc cluster proteins have been shown to play a role in the transcriptional regulation of glucose-repressible genes during glucose exhaustion and diauxic shift. Here, we studied an additional member of this family called Yer184c (herein called Tog1) for transcriptional
Hideyuki Takeshima et al.
Cancer letters, 357(1), 328-338 (2014-12-03)
A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multiple cancers. Epigenetic alterations are frequently present in chronic inflammation-exposed tissues, but
Gabriela de Almeida Leonardi et al.
Genetics and molecular biology, 38(2), 191-198 (2015-08-15)
Eucalyptus urograndis is a hybrid eucalyptus of major economic importance to the Brazilian pulp and paper industry. Although widely used in forest nurseries around the country, little is known about the biochemical changes imposed by environmental stress in this species.
X Han et al.
Cancer gene therapy, 22(3), 122-129 (2015-01-24)
MicroRNAs (miRNAs) are important regulators that play key roles in tumorigenesis and tumor progression. In this study, we investigate whether let-7b acts as a tumor suppressor to inhibit invasion and metastasis in gastric cancers. We analyzed the expression of let-7b
T Geetha et al.
Journal of drug targeting, 23(2), 159-169 (2014-10-01)
Abstract Role of reactive oxygen species (ROS) in skin carcinogenesis is well documented. Natural molecules, like sesamol, with marked antioxidant potential can be useful in combating skin cancers. In vitro antiproliferative (using MTT assay) and DNA fragmentation studies in HL
Simon P Jochems et al.
Journal of virology, 89(13), 6918-6927 (2015-04-24)
Human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques (MAC) lead to chronic inflammation and AIDS. Natural hosts, such as African green monkeys (AGM) and sooty mangabeys (SM), are protected against SIV-induced chronic inflammation and AIDS.
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