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Sonia Assil et al.
PLoS pathogens, 15(2), e1007589-e1007589 (2019-03-01)
Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass
Ana Rodrigo-Moreno et al.
Plant science : an international journal of experimental plant biology, 264, 9-15 (2017-10-04)
Sound is a fundamental form of energy and it has been suggested that plants can make use of acoustic cues to obtain information regarding their environments and alter and fine-tune their growth and development. Despite an increasing body of evidence
Christian Proepper et al.
PloS one, 6(11), e27045-e27045 (2011-11-22)
Abelson-interacting protein 1 (Abi-1) plays an important role for dendritic branching and synapse formation in the central nervous system. It is localized at the postsynaptic density (PSD) and rapidly translocates to the nucleus upon synaptic stimulation. At PSDs Abi-1 is
Bahram Mirani et al.
European journal of pharmacology, 854, 201-212 (2019-04-12)
Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still remains a major challenge despite the various therapeutic approaches developed over the recent decades. GBM is considered as one of the most therapy-resistant human tumors. Treatment with
Mari Sepp et al.
PloS one, 6(7), e22138-e22138 (2011-07-27)
Transcription factor 4 (TCF4 alias ITF2, E2-2, ME2 or SEF2) is a ubiquitous class A basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG). While involved in the development and functioning of many different cell types, recent studies point
Sangappa B Chadchan et al.
Frontiers in cell and developmental biology, 8, 745-745 (2020-08-28)
Up to 30% of women experience early miscarriage due to impaired decidualization. For implantation to occur, the uterine endometrial stromal fibroblast-like cells must differentiate into decidual cells, but the genes required for decidualization have not been fully defined. Here, we
Miriam Sartages et al.
Biomedicines, 8(12) (2020-12-23)
Cerebral cavernous malformations (CCMs) are vascular malformations that can be the result of the deficiency of one of the CCM genes. Their only present treatment is surgical removal, which is not always possible, and an alternative pharmacological strategy to eliminate
Anthony N Hodder et al.
Molecular microbiology, 71(1), 48-65 (2008-11-15)
Virulence of Plasmodium falciparum, the most lethal parasitic disease in humans, results in part from adhesiveness and increased rigidity of infected erythrocytes. Pf332 is trafficked to the parasite-infected erythrocyte via Maurer's clefts, structures for protein sorting and export in the
Kem A Sochacki et al.
Nature cell biology, 19(4), 352-361 (2017-03-28)
Dozens of proteins capture, polymerize and reshape the clathrin lattice during clathrin-mediated endocytosis (CME). How or if this ensemble of proteins is organized in relation to the clathrin coat is unknown. Here, we map key molecules involved in CME at
Stephane Gourguechon et al.
BMC cell biology, 10, 68-68 (2009-09-24)
The Trypanosoma brucei cell cycle is regulated by combinations of cyclin/CRKs (cdc2 related kinases). Recently, two additional cyclins (CYC10, CYC11) and six new CRK (CRK7-12) homologues were identified in the T. brucei genome database 12. Individual RNAi knockdowns of these
Sergi Aranda et al.
Molecular and cellular biology, 28(19), 5899-5911 (2008-08-06)
Raf-MEK-extracellular signal-regulated kinase (Erk) signaling initiated by growth factor-engaged receptor tyrosine kinases (RTKs) is modulated by an intricate network of positive and negative feedback loops which determine the specificity and spatiotemporal characteristics of the intracellular signal. Well-known antagonists of RTK
Shannon M Conley et al.
Human molecular genetics, 26(3), 509-518 (2017-01-06)
Mutations in peripherin 2 (PRPH2), also known as retinal degeneration slow/RDS, lead to various retinal degenerations including retinitis pigmentosa (RP) and macular/pattern dystrophy (MD/PD). PRPH2-associated disease is often characterized by a phenotypic variability even within families carrying the same mutation
Hanqing Zhang et al.
Applied optics, 57(33), 9855-9862 (2018-11-22)
Phase retrieval and the twin-image problem in digital in-line holographic microscopy can be resolved by iterative reconstruction routines. However, recovering the phase properties of an object in a hologram requires an object plane to be chosen correctly for reconstruction. In
Anita Szodorai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(46), 14534-14544 (2009-11-20)
The amyloid precursor protein (APP) is anterogradely transported by conventional kinesin in a distinct transport vesicle, but both the biochemical composition of such a vesicle and the specific kinesin-1 motor responsible for transport are poorly defined. APP may be sequentially
F R C Giachini et al.
Journal of anatomy, 212(1), 31-41 (2007-12-11)
During embryo implantation, invasive trophoblast cells mediate embryo invasion into the decidualized stroma, forming a rich network of lacunae that connect the embryonic tissues to the maternal blood vessels. Placentation is probably guided by the composition and organization of the
Anthony L Cook et al.
PloS one, 6(7), e21907-e21907 (2011-07-13)
Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa (termed olfactory neurosphere-derived (hONS) cells) which express functional and genetic differences in a
Tina Rüdiger et al.
Cell adhesion & migration, 2(1), 30-37 (2008-01-01)
The neurotransmitter acetylcholine (ACh) is expressed in the developing telencephalon at the time when thalamic axons project to the cortex, long before synapses are being formed. Since previous studies demonstrated an influence of ACh on neurite extension we used different
M Lichtenberg et al.
Cell death & disease, 2, e196-e196 (2011-08-26)
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson's disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests
Kanwal Abbasi et al.
PloS one, 6(11), e26890-e26890 (2011-11-19)
In animals and fungi Rho subfamily small GTPases are involved in signal transduction, cytoskeletal function and cellular proliferation. These organisms typically possess multiple Rho paralogues and numerous downstream effectors, consistent with the highly complex contributions of Rho proteins to cellular
Milka Sarris et al.
Immunity, 28(3), 402-413 (2008-03-11)
The interaction of T cells with dendritic cells (DCs) determines whether an immune response is launched or not. Recognition of antigen leads to formation of immunological synapses at the interface between the cells. The length of interaction is likely to
Huizhong Feng et al.
Cell reports, 30(10), 3411-3423 (2020-03-12)
Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to selectively stain ferroptotic cells in tissue sections to characterize the extent of ferroptosis in animal
Masanobu Abe et al.
PloS one, 6(8), e23848-e23848 (2011-09-03)
Mammalian germ cells undergo global reprogramming of DNA methylation during their development. Global DNA demethylation occurs around the time when the primordial germ cells colonize the embryonic gonads and this coincides with dynamic changes in chromatin composition. Global de novo
Jingyun Hu et al.
Frontiers in physiology, 12, 629914-629914 (2021-03-16)
High-intensity interval training (HIIT) is reported to be beneficial to brain-derived neurotrophic factor (BDNF) biosynthesis. A key element in this may be the existence of lactate, the most obvious metabolic product of exercise. In vivo, this study investigated the effects
Peter T Jindra et al.
Biochemical and biophysical research communications, 369(2), 781-787 (2008-03-04)
The aim of this study was to characterize the interaction between mTOR and ERK in primary endothelial cells (EC) following MHC class I and integrin ligation. Ligation of MHC class I molecules or integrins on the surface of EC leads
Timothy H Scott-Taylor et al.
Clinical immunology (Orlando, Fla.), 175, 1-9 (2016-11-20)
Peripheral monocytes from patients with common variable immunodeficiency (CVID) had on average a 2 fold greater tendency to form giant cells in medium without additional cytokines. Giant cell formation was faster and 3 to 5 fold higher in most CVID
Renato G S Chirivi et al.
Cellular & molecular immunology, 18(6), 1528-1544 (2020-03-24)
Excessive release of neutrophil extracellular traps (NETs) is associated with disease severity and contributes to tissue injury, followed by severe organ damage. Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models, indicating that NETs are
Kai A Kropp et al.
Journal of virology, 94(20) (2020-07-17)
During primary infection, herpes simplex virus 2 (HSV-2) replicates in epithelial cells and enters neurites to infect neurons of the peripheral nervous system. Growth factors and attractive and repulsive directional cues influence neurite outgrowth and neuronal survival. We hypothesized that
Rajendra K Gangalum et al.
Investigative ophthalmology & visual science, 50(7), 3283-3290 (2009-02-17)
All crystallins have non-crystallin catalytic functions. Because catalytic functions do not require large concentrations of protein, as are seen in the lens, there is a perception of dichotomy in the catalytic/physiological function of crystallins within and outside the lens. The
Plamena R Angelova et al.
Methods in molecular biology (Clifton, N.J.), 2202, 33-42 (2020-08-29)
Production of reactive oxygen species (ROS) in the mitochondria plays multiple roles in physiology, and excessive production of ROS leads to the development of various pathologies. ROS in the mitochondria are generated by various enzymes, mainly in the electron transporvt
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