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Guang Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(21), E4288-E4295 (2017-05-12)
Alternative splicing changes the Ca
Zichuan Liu et al.
The EMBO journal, 39(13), e103697-e103697 (2020-05-13)
Chromatin integrity is essential for cellular homeostasis. Polycomb group proteins modulate chromatin states and transcriptionally repress developmental genes to maintain cell identity. They also repress repetitive sequences such as major satellites and constitute an alternative state of pericentromeric constitutive heterochromatin...
Sara P Cuellar-Bermúdez et al.
Journal of the science of food and agriculture, 97(15), 5123-5130 (2017-04-22)
Given the importance of A. platensis as a potential food protein source, we describe an affordable deodorization process that does not significantly affect the nutritional value of algae biomass. Ethanol, acetone or hexane were used to deodorize algae biomass and then...
G D Brayer et al.
Proceedings of the National Academy of Sciences of the United States of America, 76(1), 96-100 (1979-01-01)
X-ray crystallographic data show that a specific tetrapeptide aldehyde inhibitor (N-acetylprolylalanylprolylphenylalaninal) forms a stable, covalent, tetrahedral addition complex with the serine protease, SGPA, from Streptomyces griseus. Earlier proposals, based on kinetic measurements, for the covalent nature of such linkages are...
Katherine Lakstins et al.
JOR spine, 3(4), e1116-e1116 (2021-01-05)
There is a need to further explore mechanisms of cartilage endplate (CEP) degeneration, due to its role in the onset and progression of intervertebral disc degeneration and low back pain. Therefore, the goal of this study was to evaluate structure...
Steve R Roof et al.
Frontiers in physiology, 8, 894-894 (2017-12-07)
The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. This study investigated the...
Nanhong Lou et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(4), 1074-1079 (2016-01-13)
Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular unit has not hitherto been assessed. We show here that following blood-brain barrier (BBB) breakdown, P2RY12 (purinergic...
E Canon et al.
Reproduction (Cambridge, England), 156(2), 145-161 (2018-06-06)
The POU5F1 gene encodes one of the 'core' transcription factors necessary to establish and maintain pluripotency in mammals. Its function depends on its precise level of expression, so its transcription has to be tightly regulated. To date, few conserved functional...
Protease-catalysed direct asymmetric Mannich reaction in organic solvent
Xue Y, et al.
Scientific reports, 2, 761-761 (2012)
Qadeer Aziz et al.
Bio-protocol, 10(1), e3477-e3477 (2020-01-05)
The cardiac conduction system allows the synchronized propagation of electrical activity through heart muscle. This is initiated by the spontaneous activity of the specialized pacemaker cells of the sino-atrial node (SAN). The SAN region underlies automaticity in mammals and therefore...
Alicia Olivier et al.
International journal of experimental pathology, 90(4), 431-438 (2009-08-08)
Human respiratory syncytial virus (hRSV) is a pneumovirus that causes significant respiratory disease in premature and full-term infants. It was our hypothesis that a common strain of RSV, strain A2, would infect, cause pulmonary pathology, and alter respiratory epithelial innate...
Evelien Eenjes et al.
eLife, 10 (2021-07-22)
SOX2 expression levels are crucial for the balance between maintenance and differentiation of airway progenitor cells during development and regeneration. Here, we describe patterning of the mouse proximal airway epithelium by SOX21, which coincides with high levels of SOX2 during...
An improved fractionation system for pronase on CM-sephadex.
J Jurásek et al.
Canadian journal of biochemistry, 49(11), 1195-1201 (1971-11-01)
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Martina Bertocchi et al.
International journal of molecular sciences, 21(9) (2020-05-14)
Antimicrobial resistance, an ever-growing global crisis, is strongly linked to the swine production industry. In previous studies, Melaleucaalternifolia and Rosmarinusofficinalis essential oils have been evaluated for toxicity on porcine spermatozoa and for antimicrobial capabilities in artificial insemination doses, with the...
A Chan et al.
The Journal of biological chemistry, 272(35), 22111-22117 (1997-08-29)
Although heparin has been used clinically for prophylaxis and treatment of thrombosis, it has suffered from problems such as short duration within compartments in vivo that require long term anticoagulation. A covalent antithrombin-heparin complex has been produced with high anticoagulant...
Dingyuan I Sun et al.
Cells, tissues, organs, 205(5-6), 279-292 (2018-10-10)
Na+/H+ exchangers (NHEs) represent a highly conserved family of ion transporters that regulate pH homeostasis. NHEs as well as other proton transporters were previously linked to the regulation of the Wnt signaling pathway, cell polarity signaling, and mucociliary function. Furthermore...
Jinjin Wu et al.
Heart and vessels, 35(5), 731-741 (2020-01-09)
Atrial arrhythmia is an important cause of late death in patients after the Fontan-Style operation. However, the detailed electrophysiological characteristics of the post-Fontan atrium and its underlying mechanisms are largely unknown. In this study, we investigated electrophysiological characteristics and the...
A Annandale et al.
Theriogenology, 120, 1-9 (2018-08-04)
Persistent breeding-induced endometritis (PBIE) or delayed uterine clearance (DUC) are major causes of mare subfertility. Oxytocin and its receptor are thought to play significant roles in the pathogenesis of DUC but the specific roles of oxytocin receptor (OR) distribution and...
Enis Kostallari et al.
Development (Cambridge, England), 142(7), 1242-1253 (2015-03-07)
The satellite cells, which serve as adult muscle stem cells, are both located beneath myofiber basement membranes and closely associated with capillary endothelial cells. We observed that 90% of capillaries were associated with pericytes in adult mouse and human muscle....
An optimized LC-MS/MS method as a pivotal tool to steer thiamine biofortification strategies in rice.
Verstraete, et al.
Talanta, 224, 121905-121905 (2020)
Daniel T Dugger et al.
Cell reports. Medicine, 1(4) (2020-08-06)
Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term survival is limited by chronic lung allograft dysfunction (CLAD). Persistent upper airway Pseudomonas aeruginosa (PsA) colonization can seed the allograft. While de novo PsA infection is associated with...
Dietmar Spengler et al.
American journal of physiology. Lung cellular and molecular physiology, 314(1), L32-L53 (2017-09-02)
The biological and immune-protective properties of surfactant-derived phospholipids and phospholipid subfractions in the context of neonatal inflammatory lung disease are widely unknown. Using a porcine neonatal triple-hit acute respiratory distress syndrome (ARDS) model (repeated airway lavage, overventilation, and LPS instillation...
Gustav Johansson et al.
Clinical chemistry, 66(9), 1228-1237 (2020-08-21)
Immune repertoire sequencing of the T-cell receptor can identify clonotypes that have expanded as a result of antigen recognition or hematological malignancies. However, current sequencing protocols display limitations with nonuniform amplification and polymerase-induced errors during sequencing. Here, we developed a...
Federico Giannitti et al.
Veterinary pathology, 58(1), 103-113 (2020-10-16)
Enterotoxemia caused by Clostridium perfringens type D is one of the most prevalent clostridial diseases of sheep. The lesions of the acute form of this disease, particularly the cerebral lesions, are well characterized; however, detailed descriptions of the cardiac and...
Alexis Parenté et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4026-4040 (2020-01-22)
Muscle atrophy is associated with many diseases including genetic disorders, sarcopenia, or cachexia syndromes. Myostatin (Mstn), a transforming growth factor-beta (TGF-β) member, plays a key role in skeletal muscle homeostasis as a powerful negative regulator. Over the last decade, about...
Jun Huang et al.
International journal of biological macromolecules, 78, 165-172 (2015-04-15)
Starches were isolated from rhizomes of Curcuma longa, Canna edulis and Canna indica and bulbs of Lilium lancifolium, and showed a B-type X-ray diffraction pattern. Their physicochemical properties were investigated and compared. These starches showed significantly different granule morphologies and...
S Di Blasio et al.
Nature communications, 11(1), 2749-2749 (2020-06-04)
The tumour microenvironment (TME) forms a major obstacle in effective cancer treatment and for clinical success of immunotherapy. Conventional co-cultures have shed light onto multiple aspects of cancer immunobiology, but they are limited by the lack of physiological complexity. We...
A M Brandt et al.
Domestic animal endocrinology, 62, 32-38 (2017-09-18)
Bovine satellite cell (bSC) myogenesis and skeletal muscle hypertrophy occur through the orchestrated actions of multiple autocrine and paracrine growth factors. Intimate to the bSC niche is IL6, a dual-purpose cytokine with proinflammatory and mitogenic properties. The objective of the...
Evy E Blomme et al.
The European respiratory journal, 56(3) (2020-06-06)
Occupational asthma, induced by workplace exposures to low molecular weight agents such as toluene 2,4-diisocyanate (TDI), causes a significant burden to patients and society. Little is known about innate lymphoid cells (ILCs) in TDI-induced asthma. A critical regulator of ILC...
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