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Yongyi Chen et al.
Aging, 13(2), 2101-2117 (2020-12-17)
In an effort to identify a novel microRNA (miRNA) as a gastric cancer (GC) treatment target and prognostic biomarker, we surveyed The Cancer Genome Atlas database and found that miR-588 expression is low in GC tissues. This was confirmed by
R Alvarez et al.
Journal of virology, 82(1), 471-486 (2007-10-19)
Understanding why human immunodeficiency virus (HIV) preferentially infects some CD4(+) CD45RO(+) memory T cells has implications for antiviral immunity and pathogenesis. We report that differential expression of a novel secreted factor, ps20, previously implicated in tissue remodeling, may underlie why
Erika M Boerman et al.
The Journal of physiology, 594(8), 2323-2338 (2015-05-27)
The dilatory role for sensory innervation of mesenteric arteries (MAs) is impaired in Old (∼24 months) versus Young (∼4 months) mice. We investigated the nature of this impairment in isolated pressurized MAs. With perivascular sensory nerve stimulation, dilatation and inhibition of sympathetic
Erika M Boerman et al.
Microcirculation (New York, N.Y. : 1994), 27(4), e12607-e12607 (2020-01-30)
Aging impairs MA dilation by reducing the ability of sensory nerves to counteract sympathetic vasoconstriction. This study tested whether altered SMC Ca2+ signals to sympathetic (NE) and sensory (CGRP) neurotransmitters underlie aging-related deficits in vasodilation. MAs from young and old
Patricia A Trimmer et al.
Molecular neurodegeneration, 4, 26-26 (2009-06-19)
It has been hypothesized that reduced axonal transport contributes to the degeneration of neuronal processes in Parkinson's disease (PD). Mitochondria supply the adenosine triphosphate (ATP) needed to support axonal transport and contribute to many other cellular functions essential for the
Silvia Sandini et al.
BMC microbiology, 11, 106-106 (2011-05-18)
The MP65 gene of Candida albicans (orf19.1779) encodes a putative β-glucanase mannoprotein of 65 kDa, which plays a main role in a host-fungus relationship, morphogenesis and pathogenicity. In this study, we performed an extensive analysis of a mp65Δ mutant to
Ali Samadi et al.
Advanced biomedical research, 10, 4-4 (2021-05-08)
Wounds have a bad prognostic nature and excessive discharges whose regular wound dressings are ineffective. Hydrogels are the best candidates for dressing such wounds due to their high water content and ability to exchange substances. Accordingly, the purpose of this
Yong-Woo Jun et al.
Animal cells and systems, 23(3), 164-169 (2019-06-25)
Phosphatidylinositol-4-phosphate (PI4P) plays a crucial role in cellular functions, including protein trafficking, and is mainly located in the cytoplasmic surface of intracellular membranes, which include the trans-Golgi network (TGN) and the plasma membrane. However, many PI4P-binding domains of membrane-associated proteins
Lawal Danjuma et al.
Regenerative therapy, 9, 100-110 (2018-12-14)
Anti-tuberculosis agent rifampicin is extensively used for its effectiveness. Possible complications of tuberculosis and prolonged rifampicin treatment include kidney damage; these conditions can lead to reduced efficiency of the affected kidney and consequently to other diseases. Bone marrow-derived mesenchymal stem
Lindsey M Ott et al.
Tissue engineering. Part A, 21(17-18), 2390-2403 (2015-06-23)
Tracheal stenosis is a life-threatening disease and current treatments include surgical reconstruction with autologous rib cartilage and the highly complex slide tracheoplasty surgical technique. We propose using a sustainable implant, composed of a tunable, fibrous scaffold with encapsulated chondrogenic growth
Y Ni et al.
International journal of laboratory hematology, 35(2), 170-176 (2012-10-31)
Laboratory diagnosis of von Willebrand disease (VWD) requires determination of both von Willebrand factor (VWF) protein levels and activity. Current VWF activity tests include the ristocetin cofactor assay and the collagen-binding assay (VWF:CB). The goal of this investigation is to
Ulrike Kuebler et al.
Psychosomatic medicine, 75(9), 841-848 (2013-11-05)
Psychological states relate to changes in circulating immune cells, but associations with immune cells in peripheral tissues such as macrophages have hardly been investigated. Here, we aimed to implement and validate a method for measuring the microbicidal potential of ex
Predrag Serbedzija et al.
Brain research, 1303, 179-194 (2009-09-29)
The aim of this study was to identify factors that regulate the bulk of adult brain mass, and test the hypothesis that concomitantly reduced insulin and insulin-like growth factor (IGF) levels are pathogenic for brain atrophy associated with impaired learning
Alireza Rezaeinezhad et al.
Scientific reports, 9(1), 19958-19958 (2019-12-29)
Cold atmospheric plasma (CAP) is known as the versatile tool in different biological, and medical applications. In this study, we investigated the effect of cold plasma on diabetes via in vitro and in vivo assessments. We performed the in vitro assay to evaluate the
Hongrui Zhang et al.
Biointerphases, 13(4), 041004-041004 (2018-06-13)
Cell adhesion on conducting polymers is important in organic bioelectronics, including applications such as electronically switchable surfaces and electrochemical transistors. There is a fundamental interest in understanding the conducting polymer-cellular interface though as yet no direct measurements to quantify the
Polina L Yarova et al.
Science translational medicine, 7(284), 284ra60-284ra60 (2015-04-24)
Airway hyperresponsiveness and inflammation are fundamental hallmarks of allergic asthma that are accompanied by increases in certain polycations, such as eosinophil cationic protein. Levels of these cations in body fluids correlate with asthma severity. We show that polycations and elevated
Albert Shim et al.
Bio-protocol, 7(7), e2210-e2210 (2017-04-05)
The purpose of this protocol is to provide an updated method of performing microtubule gliding assays and visualizing it using fluorescence microscopy.
Huichao Huang et al.
Aging, 12(14), 14699-14717 (2020-07-18)
Steroidogenic enzymes are crucial in prostate cancer (PCa) progression. 17β-Hydroxysteroid dehydrogenase type 4 (HSD17B4), encoded by HSD17B4, lacks catalytic capacity in androgen metabolism. Now the detailed role and molecular mechanism of PCa development are largely unknown. Here we showed that
Ulrike Kuebler et al.
Psychophysiology, 52(4), 499-508 (2014-10-23)
Anticipatory cognitive stress appraisal (ACSA) can affect the stress-induced release of stress hormones, which, in turn, can modulate microbicidal potential of macrophages. This study examines whether ACSA modulates wound-induced activation of macrophage microbicidal potential in 22 acutely stressed compared to
S Vaddiraju et al.
Biosensors & bioelectronics, 24(6), 1557-1562 (2008-10-01)
The performance of an implantable glucose sensor is strongly dependent on the ability of their outer membrane to govern the diffusion of the various participating species. In this contribution, using a series of layer-by-layer (LBL) assembled outer membranes, the role
Annie R Knight et al.
Free radical biology & medicine, 120, 246-254 (2018-03-21)
The generation of 3-nitrotyrosine, within proteins, is a post-translational modification resulting from oxidative or nitrative stress. It has been suggested that this modification could be used as a biomarker for inflammatory diseases. Despite the superiority of mass spectrometry-based determinations of
J Jason Hoth et al.
Shock (Augusta, Ga.), 31(4), 376-381 (2008-07-31)
Blunt chest trauma resulting in pulmonary contusion with an accompanying acute inflammatory response is a common but poorly understood injury. We previously demonstrated that toll-like receptor 2 (TLR-2) participates in the inflammatory response to lung injury. We hypothesized that the
Richard A E Edden et al.
Magnetic resonance in medicine, 68(3), 657-661 (2012-07-11)
Edited magnetic resonance spectroscopy makes possible noninvasive studies of the role of the inhibitory neurotransmitter GABA in the healthy brain and in disease processes. A major limitation of the methodology is coediting of macromolecular signals. Although it has previously been
Yixi Chen et al.
The European journal of neuroscience, 49(4), 510-524 (2018-11-26)
An emerging treatment for Parkinson's disease (PD) is cell replacement therapy. Authentic midbrain dopaminergic (mDA) neuronal precursors can be differentiated from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs). These laboratory-generated mDA cells have been demonstrated
Ronnie O Pedersen et al.
Journal of food protection, 80(7), 1204-1213 (2017-06-21)
A shipment of imported garlic powder was suspected of containing peanut. Samples (subs) collected from the shipment displayed considerable variability in peanut antigenicity when analyzed by enzyme-linked immunosorbent assay (ELISA). This raised questions regarding whether peanut was actually present, the
Loren Merrill et al.
Physiological and biochemical zoology : PBZ, 87(5), 740-751 (2014-09-23)
Maternally transferred antibodies have been documented in a wide range of taxa and are thought to adaptively provide protection against parasites and pathogens while the offspring immune system is developing. In most birds, transfer occurs when females deposit immunoglobulin Y
Jennifer L Grindstaff et al.
Journal of experimental zoology. Part A, Ecological and integrative physiology, 327(5), 262-272 (2017-12-05)
Developmental conditions may impact the expression of immune traits throughout an individual's life. Early-life challenges may lead to immunological constraints that are mediated by endocrine-immune interactions. In particular, individual differences in the ability to mount immune responses may be programmed
Jiahang Sun et al.
International journal of molecular medicine, 30(4), 739-746 (2012-07-31)
Status epilepticus (SE) causes neuronal loss and apoptosis by inducing several apoptosis-regulatory genes. Two such genes, cysteinyl aspartate-specific protease-3 (caspase-3), an apoptosis activator, and B-cell leukemia-2 (Bcl-2), an apoptosis suppressor, are tightly regulated for their expression and activation. Statins, inhibitors
Ulrike Kuebler et al.
PloS one, 8(2), e55875-e55875 (2013-02-23)
Psychological stress delays wound healing but the precise underlying mechanisms are unclear. Macrophages play an important role in wound healing, in particular by killing microbes. We hypothesized that (a) acute psychological stress reduces wound-induced activation of microbicidal potential of human
Ee-Chun Cheng et al.
Cell reports, 34(1), 108575-108575 (2021-01-07)
SETDB1 is a histone-lysine N-methyltransferase critical for germline development. However, its function in early meiotic prophase I remains unknown. Here, we report that Setdb1 null spermatocytes display aberrant centromere clustering during leptotene, bouquet formation during zygotene, and subsequent failure in
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