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Sarah E Ehrlicher et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4602-4618 (2020-02-08)
Understanding the mechanisms regulating mitochondrial respiratory function and adaptations to metabolic challenges, such as exercise and high dietary fat, is necessary to promote skeletal muscle health and attenuate metabolic disease. Autophagy is a constitutively active degradation pathway that promotes mitochondrial...
Páraic O Cuív et al.
Applied and environmental microbiology, 79(19), 6173-6175 (2013-07-23)
Clostridium thermocellum encodes a cellulosomal, modular, and thermostable serine protease inhibitor (serpin), PinA. PinA stability but not inhibitory activity is affected by the Fn(III) and Doc(I) domains, and PinA is a broad inhibitor of subtilisin-like proteases and may play a...
Diana Lousa et al.
The journal of physical chemistry. B, 116(20), 5838-5848 (2012-05-02)
A recent X-ray structure has enabled the location of chloride and cesium ions on the surface of subtilisin Carlsberg in acetonitrile soaked crystals. (1) To complement the previous study and analyze the system in solution, molecular dynamics (MD) simulations, in...
Natthiya Wetsaphan et al.
Developmental and comparative immunology, 41(2), 110-119 (2013-05-11)
Serpin or serine proteinase inhibitor is a family of protease inhibitors that are involved in controlling the proteolytic cascade in various biological processes. In shrimp, several serpins have been identified but only a few have been characterized. Herein, the PmSERPIN3...
Dalibor Kodrík et al.
Applied biochemistry and biotechnology, 171(1), 209-224 (2013-07-05)
Several recombinant derivatives of serine protease inhibitor called silk protease inhibitor 2 (SPI2), which is a silk component in Galleria mellonella (Lepidoptera, Insecta), were prepared in the expression vector Pichia pastoris. Both the native and the recombinant protease inhibitors were...
Amandeep Singh et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(31), 13100-13105 (2009-07-23)
Leptin reduces body weight in ob/ob mice by decreasing food intake and increasing energy expenditure; however, the mechanisms by which it does the latter are not known. Here we report that 30% of the weight loss induced by leptin treatment...
Karina Jiménez-Durán et al.
Plant physiology, 161(1), 97-107 (2012-11-15)
In Solanaceae, the self-incompatibility S-RNase and S-locus F-box interactions define self-pollen recognition and rejection in an S-specific manner. This interaction triggers a cascade of events involving other gene products unlinked to the S-locus that are crucial to the self-incompatibility response....
[The use of single-dose total body irradiation before bone marrow transplantation in treatment of leukemia].
H Tang
Zhonghua fang she xue za zhi Chinese journal of radiology, 16(4), 296-300 (1982-11-01)
Vivek Kumar Morya et al.
Applied biochemistry and biotechnology, 166(1), 243-257 (2011-11-11)
A total of 49 protein sequences of alkaline proteases retrieved from GenBank representing different species of Aspergillus have been characterized for various physiochemical properties, homology search, multiple sequence alignment, motif, and super family search and phylogenetic tree construction. The sequence...
Tadashi Nakai et al.
The Journal of biological chemistry, 287(9), 6530-6538 (2012-01-12)
Quinohemoprotein amine dehydrogenase (QHNDH), an αβγ heterotrimer present in the periplasm of several Gram-negative bacteria, catalyzes the oxidative deamination of various aliphatic amines such as n-butylamine for assimilation as carbon and energy sources. The γ subunit of mature QHNDH contains...
Gang Yu et al.
Journal of microbiology (Seoul, Korea), 50(6), 939-946 (2013-01-01)
The entomopathogenic fungus Verticillium lecanii is a well-known biocontrol agent. V. lecanii produces subtilisin-like serine protease (Pr1), which is important in the biological control activity of some insect pests by degrading insect cuticles. In this study, a subtilisin-like serine protease...
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Xinmiao Zhou et al.
Drug testing and analysis, 12(8), 1054-1064 (2020-05-26)
According to the current Technical Document (TD) for erythropoietin (EPO), SAR-PAGE is the most commonly applied method for both screening and confirmation procedures. Although this method is effective and robust, it lacks an internal standard (IS) to monitor the efficiency...
S M Krieger et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 59, 165-176 (2013-06-12)
There remains a need for a simple and predictive animal model to identify potential respiratory sensitizers. The mouse intranasal test (MINT) was developed to assess the relative allergic potential of detergent enzymes, however, the experimental endpoints were limited to evaluation...
Marie Deprez et al.
American journal of respiratory and critical care medicine, 202(12), 1636-1645 (2020-07-30)
Rationale: The respiratory tract constitutes an elaborate line of defense that is based on a unique cellular ecosystem.Objectives: We aimed to investigate cell population distributions and transcriptional changes along the airways by using single-cell RNA profiling.Methods: We have explored the...
H Ikemura et al.
The Journal of biological chemistry, 262(16), 7859-7864 (1987-06-05)
Subtilisin E, an alkaline serine protease of Bacillus subtilis 168, is first produced as a precursor, pre-pro-subtilisin, which consists of a signal peptide for protein secretion (pre-sequence) and a peptide extension of 77 amino acid residues (pro-sequence) between the signal...
Akanksha Thawani et al.
Nature cell biology, 20(5), 575-585 (2018-04-27)
How microtubules (MTs) are generated in the cell is a major question in understanding how the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the universal MT nucleator of the cell. Although there is evidence that γ-tubulin...
Oi Wah Liew et al.
Journal of immunological methods, 403(1-2), 37-51 (2013-12-03)
This is a first report of recombinant production of human prepro-Urocortin 2 in Escherichia coli by N-terminal fusion with a triple His₆-SUMO-eXact tag and its subsequent use as an antigen for the production and screening of very high affinity monoclonal...
Mayuko Kawabe et al.
Frontiers in immunology, 11, 2068-2068 (2020-10-06)
Background: Recurrence of IgA nephropathy (IgAN) in the transplanted kidney is associated with graft survival, but no specific treatment is available. Tonsillectomy (TE) reportedly arrests the progression of IgAN in the native kidney. Thus, we conducted a single-center retrospective cohort...
Christoph Schiklenk et al.
The Journal of cell biology, 217(7), 2383-2401 (2018-05-08)
Although the formation of rod-shaped chromosomes is vital for the correct segregation of eukaryotic genomes during cell divisions, the molecular mechanisms that control the chromosome condensation process have remained largely unknown. Here, we identify the C2H2 zinc-finger transcription factor Zas1...
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Li-Yuan Ran et al.
The Journal of biological chemistry, 289(9), 6041-6053 (2014-01-17)
Collagen is an insoluble protein that widely distributes in the extracellular matrix of marine animals. Collagen degradation is an important step in the marine nitrogen cycle. However, the mechanism of marine collagen degradation is still largely unknown. Here, a novel...
Jia-Hua Hu et al.
Nature communications, 11(1), 1567-1567 (2020-03-29)
Voltage-gated K+ channels function in macromolecular complexes with accessory subunits to regulate brain function. Here, we describe a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)-dependent mechanism that regulates the association of the A-type K+ channel subunit Kv4.2 with its auxiliary subunit...
Neha A Shintre et al.
Current microbiology, 77(11), 3555-3564 (2020-09-10)
Phylogenetic diversity of culturable actinobacteria isolated from the intertidal regions of west coast of Maharashtra, India was studied using 16S rRNA gene sequencing. Total of 140 actinobacterial isolates were obtained, which belonged to 14 genera, 10 families and 65 putative...
Jun Yuan et al.
BMC biotechnology, 12, 36-36 (2012-07-04)
Today, thrombosis is one of the most widely occurring diseases in modern life. Drugs with thrombolytic functions are the most effective methods in the treatment of thrombosis. Among them, Douchi fibrinolytic enzyme (DFE) is a promising agent. DFE was isolated...
Andrew J Thompson et al.
Cell host & microbe, 27(5), 725-735 (2020-04-17)
Hemagglutinins (HAs) from human influenza viruses adapt to bind α2-6-linked sialosides, overcoming a receptor-defined species barrier distinct from the α2-3 specificity of avian virus progenitors. Additionally, human-adapted HAs gain glycosylation sites over time, although their biological function is poorly defined....
Comment on Enhancement of the catalytic activity of a 27 kDa subtilisin-like enzyme from Bacillus amyloliquefaciens CH51 by in vitro mutagenesis.
Beenish Viqar et al.
Journal of agricultural and food chemistry, 60(16), 4170-4172 (2012-04-06)
Veronika Gondzik et al.
American journal of physiology. Cell physiology, 303(9), C936-C946 (2012-08-24)
The mammalian collecting duct (CD) is continuously exposed to urinary proteases. The CD expresses an epithelial Na(+) channel (ENaC) that is activated after cleavage by serine proteases. ENaC also exists at the plasma membrane in the uncleaved form, rendering activation...
Corinne Cayrol et al.
Nature immunology, 19(4), 375-385 (2018-03-21)
Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore important to understand why and how the immune system responds to allergens. Here we found that full-length interleukin 33 (IL-33FL), an alarmin cytokine with critical roles...
Amy Wernimont et al.
PloS one, 4(4), e5094-e5094 (2009-04-09)
For every 100 purified proteins that enter crystallization trials, an average of 30 form crystals, and among these only 13-15 crystallize in a form that enables structure determination. In 2007, Dong et al reported that the addition of trace amounts...
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