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Noor Akmal Syed Husain Sharifah et al.
Methods in molecular biology (Clifton, N.J.), 952, 187-196 (2012-10-27)
Fluorescence in situ hybridization (FISH) is increasingly gaining importance in clinical diagnostics settings. Due to the ability of the technique to detect chromosomal abnormalities in samples with low cellularity or containing a mixed population of cells even at a single-cell...
Trine Salomón et al.
Cell chemical biology, 24(8), 935-943 (2017-08-19)
The α-oxoaldehyde methylglyoxal is a ubiquitous and highly reactive metabolite known to be involved in aging- and diabetes-related diseases. If not detoxified by the endogenous glyoxalase system, it exerts its detrimental effects primarily by reacting with biopolymers such as DNA...
E Chinedum et al.
International journal of biological macromolecules, 106, 200-206 (2017-08-15)
The effect of processing on starch digestibility, predicted glycemic indices (pGI), polyphenol contents and alpha amylase inhibitory properties of beans (Phaseolis vulgaris) and breadfruit (Treculia africana) was studied. Total starch ranged from 4.3 to 68.3g/100g, digestible starch ranged from 4.3...
Myriam M L Grundy et al.
Food & function, 7(1), 69-78 (2015-10-28)
Previous studies have provided evidence that the physical encapsulation of intracellular nutrients by cell walls of plant foods (i.e. dietary fibre) plays a predominant role in influencing macronutrient bioaccessibility (release) from plant foods during human digestion. One unexplored aspect of...
Lara E Davis et al.
Molecular cancer research : MCR, 17(3), 676-685 (2018-12-07)
Soft-tissue sarcomas such as leiomyosarcoma pose a clinical challenge because systemic treatment options show only modest therapeutic benefit. Discovery and validation of targetable vulnerabilities is essential. To discover putative kinase fusions, we analyzed existing transcriptomic data from leiomyosarcoma clinical samples....
Dongjie Liu et al.
Journal of agricultural and food chemistry, 68(2), 574-583 (2019-12-11)
Food structure is a key determinant for the release of phenolic compounds during gastric and intestinal digestion. We evaluated the bioaccessibility of polyphenols from apple tissue during gastric digestion in vitro from bio-mechanical perspectives including the effects of gastric juice...
Gastric proteinases--structure, function, evolution and mechanism of action.
B Foltmann
Essays in biochemistry, 17, 52-84 (1981-01-01)
Joseph S Fruton
The Quarterly review of biology, 77(2), 127-147 (2002-07-02)
Studies on gastric digestion during 1820-1840 led to the discovery of pepsin as the agent which, in the presence of stomach acid, causes the dissolution of nutrients such as meat or coagulated egg white. Soon afterward it was shown that...
Sophia P Pilipchuk et al.
Journal of biomedical materials research. Part A, 101(10), 2883-2895 (2013-03-19)
Natural hydrogels have been investigated for three-dimensional tissue reconstruction and regeneration given their ability to emulate the structural complexity of multi-component extracellular matrices (ECM). Hydrogels rich in ECM can be extracted and assembled from soft tissues, retain a composition specific...
Marilyn Schallom et al.
American journal of critical care : an official publication, American Association of Critical-Care Nurses, 22(5), 408-411 (2013-09-03)
Because reflux of gastric juice into the oropharynx must precede its aspiration into the lungs, it is reasonable to hypothesize that the detection of pepsin (the major gastric enzyme in gastric juice) in oral secretions may provide a relatively noninvasive...
Dragana Stanic-Vucinic et al.
Molecular nutrition & food research, 56(12), 1894-1905 (2012-10-16)
The aim of this work was to investigate the effects of high-intensity ultrasound (sonication), on the structure and allergenicity of the major cow's milk allergen, beta-lactoglobulin (BLG). Structural changes upon sonication of BLG were monitored by circular dichroism spectroscopy, tryptophan...
Mira Abou-Diab et al.
Membranes, 10(10) (2020-10-01)
Neokyotorphin (α137-141) is recognized as an antimicrobial peptide and a natural meat preservative. It is produced by conventional enzymatic hydrolysis of bovine hemoglobin, a major component of cruor, a by-product of slaughterhouses. However, during conventional hydrolysis, chemical agents are necessary...
Caroline Thum et al.
Frontiers in nutrition, 7, 91-91 (2020-08-01)
Lipids in milk are secreted as a triacylglycerol core surrounded by a trilayer membrane, the milk fat globule membrane (MFGM). This membrane, known to have important roles in infant brain and intestinal development, is composed of proteins, glycoproteins, and complex...
Ever Hernández-Olivas et al.
Food research international (Ottawa, Ont.), 137, 109454-109454 (2020-11-26)
This study aimed to evaluate the effect of some elderly in vitro gastrointestinal (GI) conditions on proteolysis and lipolysis extent, calcium, vitamins A and D bioaccessibility and lactose release in milk, yogurt, fresh and aged cheeses. To evaluate the impact...
H Cao et al.
European review for medical and pharmacological sciences, 17(11), 1427-1437 (2013-06-19)
Recently, type II collagen (CII) was found to be effective clinically for treatment of rheumatoid arthritis (RA). However, the molecular properties of CII could be changed during the preparation process. In the present study, we isolated CII from chick sternal...
Francesca Passannanti et al.
PloS one, 12(12), e0189807-e0189807 (2017-12-21)
In vivo assays cannot always be conducted because of ethical reasons, technical constraints or costs, but a better understanding of the digestive process, especially in infants, could be of great help in preventing food-related pathologies and in developing new formulas...
Gabriel Romero Liguori et al.
Frontiers in bioengineering and biotechnology, 8, 520-520 (2020-06-18)
Decellularized-organ-derived extracellular matrix (dECM) has been used for many years in tissue engineering and regenerative medicine. The manufacturing of hydrogels from dECM allows to make use of the pro-regenerative properties of the ECM and, simultaneously, to shape the material in...
Alexandra L Klinger et al.
Biochemistry, 53(49), 7724-7734 (2014-11-11)
Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer's disease typically consist of linear polypeptide segments, oriented approximately perpendicular to the long axis of the fibril, and joined together as parallel in-register β-sheets to form...
Hanh T H Nguyen et al.
Food chemistry, 317, 126419-126419 (2020-02-24)
Fermentation of milk is commonly used throughout the world to produce a variety of foods with different health benefits. We hypothesised that due to differences in physicochemical properties and protein sequences among milk from different species and their fermented yogurt...
Gaëtan Boléa et al.
Food & function, 10(7), 3942-3954 (2019-06-15)
Lipid oxidation takes place in the gastric tract after the ingestion of a Western diet rich in ω-6 polyunsaturated fatty acids (PUFA) and red meat (heme iron). The incorporation of oxidation products such as 4-hydroxy-2-nonenal (4-HNE) into low-density lipoproteins is...
Koray Soygun et al.
Microscopy research and technique, 83(1), 3-9 (2019-10-12)
This study aimed to use scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) to examine the elements that passed into the gastric acid solution after the application of a gastric acid erosive cycle to chitosan modified glass ionomer cement (GIC)....
Andrea Gómez-Maqueo et al.
Antioxidants (Basel, Switzerland), 9(2) (2020-02-23)
Although prickly pear fruits have become an important part of the Canary diet, their native varieties are yet to be characterized in terms of betalains and phenolic compounds. To exert potential health benefits, these antioxidants must be released from the...
Jun Liu et al.
Journal of agricultural and food chemistry, 66(22), 5691-5698 (2018-05-16)
Bovine α-lactalbumin (α-LA) is one of major food allergens in cow's milk. The present work sought to research the effects of ultrasonic pretreatment combined with dry heating-induced glycation between α-LA and galactose on the immunoglobulin E (IgE)/immunoglobulin G (IgG)-binding ability...
Mengdi Yao et al.
Food chemistry, 315, 126230-126230 (2020-02-06)
The dense packing and encapsulation of starch by protein are considered important for the digestion of noodles and the textural attributes. This study aims to elucidate the effect of gluten on the noodle texture and starch digestion rates. The structure...
Diana Macedo et al.
Scientific reports, 8(1), 6965-6965 (2018-05-05)
Parkinson's disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in the prevention, onset, and disease progression. Dietary...
Michelle Quintero-García et al.
Nutrients, 12(5) (2020-05-21)
Osteoporosis is a disease of the skeletal system characterized by low bone mass and bone weakening, which increase the risk of fracture. This disease is associated with menopause because hypoestrogenism induces the maturation and activation of osteoclasts. In addition, a...
Zachary J Hauseman et al.
Molecular cell, 79(1), 68-83 (2020-06-14)
BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential to membrane permeabilization, remain a mechanistic...
D Wang et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(3-4), 179-189 (2008-10-11)
Angiogenesis, or neovascularization, is known to play an important role in the neoplastic progression leading to metastasis. CD31 or Factor VIII-related antigen (F VIII RAg) immunohistochemistry is widely used in experimental studies for quantifying tumor neovascularization in immunocompromised animal models...
A mechanistic model to study the effect of the cell wall on starch digestion in intact cotyledon cells.
Rovalino-Cordova, et al.
Carbohydrate Polymers, 253, 117351-117351 (2021)
Fabiane Cristina Petry et al.
Food & function, 10(12), 8250-8262 (2019-11-14)
Carotenoid esters are present in considerable amounts in most fruits, such as in citrus. Although the bioavailability of carotenoid esters is similar or even higher compared to that of free carotenoids, these molecules are generally detected only in the free...
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