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Joshua P Nederveen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 8975-8989 (2020-05-29)
Skeletal muscle satellite cell (SC) function and responsiveness is regulated, in part, through interactions within the niche, in which they reside. Evidence suggests that structural changes occur in the SC niche as a function of aging. In the present study
Elisa Savino et al.
Cells, 10(10) (2021-10-24)
Mutations in the PRRT2 gene are the main cause for a group of paroxysmal neurological diseases including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. In the mature central nervous system, the protein has both a
Mahir Mohiuddin et al.
Scientific reports, 9(1), 9551-9551 (2019-07-04)
Critical limb ischemia, the most severe form of peripheral artery disease, leads to extensive damage and alterations to skeletal muscle homeostasis. Although recent research has investigated the tissue-specific responses to ischemia, the role of the muscle stem cell in the
Sean Gallagher et al.
Current protocols in molecular biology, Chapter 10, Unit 10-Unit 10 (2008-02-12)
Immunoblotting (western blotting) is used to identify specific antigens recognized by polyclonal or monoclonal antibodies. This unit provides protocols for all steps starting with solubilization of the protein samples, usually with SDS and reducing agents. Following solubilization, the material is
Silvia Bortolato et al.
Toxicology letters, 144(1), 35-47 (2003-08-16)
Trifluoroacetylated (TFA)-protein adducts were investigated by immunoblotting in liver and plasma of guinea pigs treated with the hepatotoxic anaesthetic halothane or the chlorofluorocarbon replacement 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123). Male outbred Hartley guinea pigs (320-400 g) were administered HCFC-123 (1, 5, 10 and
Nicholas J Hunt et al.
ACS nano, 15(3), 4710-4727 (2021-02-26)
Orally administered Ag2S quantum dots (QDs) rapidly cross the small intestine and are taken up by the liver. Metformin and nicotinamide mononucleotide (NMN) target metabolic and aging processes within the liver. This study examined the pharmacology and toxicology of QD-based
Grace E Peng et al.
Nature chemical biology, 17(5), 558-566 (2021-03-03)
G-protein-coupled receptor-regulated cAMP production from endosomes can specify signaling to the nucleus by moving the source of cAMP without changing its overall amount. How this is possible remains unknown because cAMP gradients dissipate over the nanoscale, whereas endosomes typically localize
Ryan J Lu et al.
Nature aging, 1(8), 715-733 (2021-09-14)
Neutrophils are the most abundant human white blood cell and constitute a first line of defense in the innate immune response. Neutrophils are short-lived cells, and thus the impact of organismal aging on neutrophil biology, especially as a function of
Prerana Ramadurgum et al.
STAR protocols, 1(2) (2020-10-01)
The use of destabilizing domains (DDs) to conditionally control the abundance of a protein of interest (POI) through a small-molecule stabilizer has gained increasing traction both in vitro and in vivo. Yet there are specific considerations for the development and
Alana M Horowitz et al.
Science (New York, N.Y.), 369(6500), 167-173 (2020-07-11)
Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice.
Mette Flinck et al.
Cells, 9(2) (2020-02-23)
Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H+ ATPases (V-ATPases) has been implicated in acid extrusion and invasiveness of some cancers, yet often on
Jianjing Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 5782-5790 (2020-03-04)
Transfer RNAs (tRNAs) are products of RNA polymerase III (Pol III) and essential for mRNA translation and ultimately cell growth and proliferation. Whether and how individual tRNA genes are specifically regulated is not clear. Here, we report that SOX4, a
Pedro F Esteban et al.
Journal of neuroscience methods, 337, 108680-108680 (2020-03-08)
Cannabinoid receptor 1 (CB1) identification by western blot (WB) has generated a great deal of controversial data making the interpretation of the results difficult. Our purpose is to find the most adequate experimental conditions to detect CB1 by WB and
Glória Conceição et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(3), 384-400 (2020-04-23)
Heart failure with preserved ejection fraction (HFpEF) is recognised as an important cause of cardiovascular mortality and morbidity, accounting for approximately 50% of heart failure cases. Metabolic-related complications, such as obesity, have been associated with the pathophysiology of this complex
S Armando Villalta et al.
Human molecular genetics, 18(3), 482-496 (2008-11-11)
Duchenne muscular dystrophy (DMD) is the most common, lethal, muscle-wasting disease of childhood. Previous investigations have shown that muscle macrophages may play an important role in promoting the pathology in the mdx mouse model of DMD. In the present study
Remedios Castelló-Cros et al.
Methods in molecular biology (Clifton, N.J.), 522, 275-305 (2009-02-28)
It is increasingly recognized that interactions between cancer cells and their surrounding stroma are critical for promoting the growth and invasiveness of tumors. For example, cancer cells alter the topography and molecular composition of stromal extracellular matrix by increasing paracrine
Immunomodulatory effect of arsenic on cytokine and HSP gene
expression in Labeo rohita fingerlings
Sudeshna Banerjee
Fish & Shellfish Immunology, 44 (2015)
Fernando Bartolomé et al.
International journal of clinical and experimental pathology, 2(4), 390-398 (2009-01-23)
Alterations in cell cycle progression seem to be associated with neuronal death in Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). We previously reported disturbances in the control of cell survival/death fate in immortalized lymphocytes from AD patients. These cell
Allaura S Cone et al.
Theranostics, 11(17), 8129-8142 (2021-08-11)
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more than 44 million people worldwide. Despite the high disease burden, there is no effective treatment for people suffering from AD. Mesenchymal stem cells (MSCs) are multipotent stromal cells that
Catherine Koch et al.
Molecular therapy. Methods & clinical development, 17, 1178-1189 (2020-06-10)
Myotubular myopathy, also called X-linked centronuclear myopathy (XL-CNM), is a severe congenital disease targeted for therapeutic trials. To date, biomarkers to monitor disease progression and therapy efficacy are lacking. The Mtm1-/y mouse is a faithful model for XL-CNM, due to
Pieter A Leermakers et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6703-6717 (2020-03-24)
Iron homeostasis is essential for mitochondrial function, and iron deficiency has been associated with skeletal muscle weakness and decreased exercise capacity in patients with different chronic disorders. We hypothesized that iron deficiency-induced loss of skeletal muscle mitochondria is caused by
Yumiko Yasui et al.
Biological & pharmaceutical bulletin, 30(3), 443-446 (2007-03-03)
Heme oxygenase (HO)-1, which is a rate-limiting enzyme involved in the catabolism of heme, is upregulated by a variety of stresses including oxidative stresses and inflammatory cytokines, in many cell types. Recent studies have suggested that upregulation of HO-1 might
Åsa Edvinsson et al.
Upsala journal of medical sciences, 125(1), 30-36 (2020-01-22)
Background: Prenatal depression is common, with an estimate that up to one in five pregnant women suffers from depressive symptoms. Maternal depression is associated with poor pregnancy outcomes such as preterm birth and low birth-weight. Such outcomes possibly affect offspring
Bruno Pok Man Ngou et al.
Nature, 592(7852), 110-115 (2021-03-12)
The plant immune system involves cell-surface receptors that detect intercellular pathogen-derived molecules, and intracellular receptors that activate immunity upon detection of pathogen-secreted effector proteins that act inside the plant cell. Immunity mediated by surface receptors has been extensively studied1, but
T G van Kooten et al.
Journal of biomedical materials research, 54(3), 385-389 (2001-02-24)
Research of cell-biomaterial interactions is building on knowledge and methods available in cell and molecular biology. Western blotting is one of the options to characterize protein expression in cell populations. Method transfer to biomaterial model systems is not trivial because
Justyna Zareba-Paslawska et al.
Frontiers in neurology, 11, 589471-589471 (2021-02-02)
The aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies. They are further subclassified based on the preferential pathological aggregation of three carboxyl-terminal repeat domains (3R) and/or
Nicholas J Hunt et al.
ACS nano, 14(2), 1492-1507 (2020-01-25)
Quantum dots (QDs) are used for imaging and transport of therapeutics. Here we demonstrate rapid absorption across the small intestine and targeted delivery of QDs with bound materials to the liver sinusoidal endothelial cells (LSECs) or hepatocytes in vitro and
Sara Krarup et al.
European journal of pharmacology, 886, 173413-173413 (2020-08-08)
The antiepileptic sodium channel blocker, carbamazepine, has long been known to be able to attenuate cAMP signals. This could be of clinical importance since cAMP signaling has been shown to be involved in epileptogenesis and seizures. However, no information on
David J Koss et al.
Brain pathology (Zurich, Switzerland), 31(1), 120-132 (2020-08-08)
Loss of function mutations within the vesicular trafficking protein Ras analogy in brain 39B (RAB39B) are associated with rare X-linked Parkinson's disease (PD). Physiologically, RAB39B is localized to Golgi vesicles and recycling endosomes and is required for glutamatergic receptor maturation
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