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Caveolin-1 controls mitochondrial function through regulation of m-AAA mitochondrial protease
Volonte D, et al.
Aging (Albany. NY.), 8(10), 2355-2355 (2016)
Anusua Dhara et al.
ACS omega, 4(7), 12880-12895 (2019-08-29)
Leptospira interrogans genome is predicted to encode multiple isoforms of caseinolytic proteases (ClpP1 and ClpP2). The ClpP proteins with the aid of its ATPase chaperone are known to be involved in establishing cellular proteostasis and have emerged as a target...
Contrasting effects of increased carbon input on boreal SOM decomposition with and without presence of living root system of Pinus sylvestris L.
Linden, A., et al.
Plant and Soil, 377, 145-158 (2014)
Joseph S Rom et al.
Virulence, 8(8), 1776-1790 (2017-09-15)
Staphylococcus aureus causes acute and chronic forms of infection, the latter often associated with formation of a biofilm. It has previously been demonstrated that mutation of atl, codY, rot, sarA, and sigB limits biofilm formation in the USA300 strain LAC...
Martin H Kunzmann et al.
Molecular bioSystems, 8(11), 3061-3067 (2012-09-20)
α-Alkylidene-γ-butyrolactones are quite common in nature and exhibit a broad spectrum of biological activities. We therefore synthesized a small library of xanthatine inspired α-alkylidene-γ-butyrolactones to screen non-pathogenic and uropathogenic E. coli strains by activity based protein profiling (ABPP). The identified...
A rapid solubility-optimized screening procedure for recombinant subtilisins in E. coli
Bjerga GEK, et al.
Journal of Biotechnology, 222, 38-46 (2016)
Evidences on the ability of mycorrhizal genus Piloderma to use organic nitrogen and deliver it to Scots pine
Heinonsalo J, et al.
PLoS ONE, 10(7), e0131561-e0131561 (2015)
Qiang Fu et al.
Radiation research, 175(6), 728-735 (2011-05-03)
The somatostatin analog SOM230 has potent radioprophylactic and radiation mitigating properties that are unrelated to cytoprotection but appear to be due to suppression of secretion of pancreatic enzymes into the intestinal lumen. To determine the maximal postirradiation time window for...
Jinzhun Wu et al.
Respiratory research, 21(1), 123-123 (2020-05-26)
Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respiratory system and the regulators of the immunogenicity...
Selena Gimenez-Ibanez et al.
PLoS biology, 12(2), e1001792-e1001792 (2014-02-22)
Pathogenicity of Pseudomonas syringae is dependent on a type III secretion system, which secretes a suite of virulence effector proteins into the host cytoplasm, and the production of a number of toxins such as coronatine (COR), which is a mimic...
Uma Reddy B et al.
ACS omega, 5(20), 11553-11562 (2020-06-02)
NS3/4A protease of hepatitis C virus (HCV) plays an important role in viral RNA replication. A 1,4-diphenylbutanedicarboxylic acid derivative, namely, phyllanthin, extracted from the leaf of a herbal plant, Phyllanthus amarus, inhibits HCV NS3/4A protease and replication activities. However, the...
Yana Zavros et al.
The Journal of biological chemistry, 282(46), 33265-33274 (2007-09-18)
Sonic hedgehog (Shh) is not only essential to the development of the gastrointestinal tract, but is also necessary to maintain the characteristic acid-secreting phenotype of the adult stomach. Gastrin is the only hormone capable of stimulating gastric acid and is...
M Lee et al.
Neuroscience, 229, 164-175 (2012-10-27)
Astrocytes become activated in degenerative neurological diseases. In order to gain a greater understanding of the inflammatory factors released upon activation, we stimulated adult human astrocytes with interferon-gamma and examined the resultant conditioned medium (CM) for toxicity against differentiated human...
Cameron T Landers et al.
The Journal of biological chemistry, 294(22), 8834-8847 (2019-04-18)
Proteinases are essential drivers of allergic airway disease and innate antifungal immunity in part through their ability cleave the clotting factor fibrinogen (FBG) into fibrinogen cleavage products (FCPs) that signal through Toll-like receptor 4 (TLR4). However, the mechanism by which...
Veronica Tjomsland et al.
European journal of immunology, 43(6), 1470-1483 (2013-03-26)
Induction of optimal HIV-1-specific T-cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and presentation processes occurring in DCs. Opsonization can influence the routing of antigen processing and pathways used for presentation. We studied...
Andrew Booth et al.
Physical chemistry chemical physics : PCCP, 17(24), 15579-15588 (2015-03-19)
The magnetic release of catalytically active enzymes from vesicular compartments within aggregated nanomaterials has been demonstrated. These nanomaterials, magnetic nanoparticle-vesicle aggregates (MNPVs), were formed by the self-assembly of biotinylated silica-coated Fe3O4 nanoparticles, biotinylated vesicles and tetrameric avidin. The unique features...
Emily Larkin et al.
Antimicrobial agents and chemotherapy, 61(5) (2017-02-23)
Candidaauris, a new multidrug-resistant Candida spp. which is associated with invasive infection and high rates of mortality, has recently emerged. Here, we determined the virulence factors (germination, adherence, biofilm formation, phospholipase and proteinase production) of 16 C. auris isolates and...
Céline Adam et al.
PloS one, 7(5), e38138-e38138 (2012-06-14)
Mitochondria have their own ATP-dependent proteases that maintain the functional state of the organelle. All multicellular eukaryotes, including filamentous fungi, possess the same set of mitochondrial proteases, unlike in unicellular yeasts, where ClpXP, one of the two matricial proteases, is...
Eric L Bruger et al.
The ISME journal, 15(4), 1236-1247 (2020-12-22)
As selection frequently favors noncooperating defectors in mixed populations with cooperators, mechanisms that promote cooperation stability clearly exist. One potential mechanism is bacterial cell-to-cell communication, quorum sensing (QS), which can allow cooperators to prevent invasion by defectors. However, the impact...
Fungal contamination of textile objects preserved in Slovene museums and religious institutions
Kavkler K, et al.
International Biodeterioration & Biodegradation, 97, 51-59 (2015)
Stimulation of soil organic nitrogen pool: The effect of plant and soil organic matter degrading enzymes
Kieloaho AJ, et al.
Soil Biology and Biochemistry, 96(10), 97-106 (2016)
Dramatic increase in stability and longevity of enzymes attached to monodispersive iron nanoparticles.
Sharma A, et al.
IEEE Transactions on Magnetics, 43, 2418-2420 (2007)
Joseph S Rom et al.
Virulence, 12(1), 584-600 (2021-02-05)
Using the USA300, methicillin-resistant Staphylococcus aureus strain LAC, we previously examined the impact of regulatory mutations implicated in biofilm formation on protease production and virulence in a murine sepsis model. Here we examined the impact of these mutations in the...
Alejandro Soto-Gutiérrez et al.
Nature protocols, 2(2), 347-356 (2007-04-05)
This protocol describes a co-culture system for the in vitro differentiation of mouse embryonic stem cells into hepatocyte-like cells. Differentiation involves four steps: (i) formation of embryoid bodies (EB), (ii) induction of definitive endoderm from 2-d-old EBs, (iii) induction of...
Mizuri Marutani-Hert et al.
PloS one, 15(5), e0233301-e0233301 (2020-05-30)
Bacterial spot is a destructive disease of tomato in Florida that prior to the early 1990s was caused by Xanthomonas euvesicatoria. X. perforans was first identified in Florida in 1991 and by 2006 was the only xanthomonad associated with bacterial...
Marion F Cubitt et al.
Molecular plant-microbe interactions : MPMI, 26(3), 356-366 (2012-11-02)
Plant cell wall-degrading enzymes (PCWDE) are key virulence determinants in the pathogenesis of the potato pathogen Pectobacterium atrosepticum. In this study, we report the impact on virulence of a transposon insertion mutation in the metJ gene that codes for the...