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Lin Wang et al.
PloS one, 9(4), e94276-e94276 (2014-04-15)
The basic strategy to construct tissue engineered bone graft (TEBG) is to combine osteoblastic cells with three dimensional (3D) scaffold. Based on this strategy, we proposed the "Totally Vitalized TEBG" (TV-TEBG) which was characterized by abundant and homogenously distributed cells...
Krystal A Fontaine et al.
Journal of virology, 89(4), 2358-2366 (2014-12-17)
Viruses rely on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae family, is one of the most important arthropod-borne human pathogens worldwide. We analyzed global...
Phing-How Lou et al.
Anesthesia and analgesia, 120(2), 329-340 (2014-12-02)
The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose...
Frederika Maria Byrne et al.
Journal of diabetes research, 2015, 752481-752481 (2015-03-12)
Chronic pain is a common complication of diabetes. The aim of the present study was to characterise pain behaviour in a high fat diet/streptozotocin (HFD/STZ) model of diabetes in the rat, investigate spinal mechanisms, and determine the effects of antidiabetic...
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin...
Rachael K Nelson et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(7), 811-818 (2014-04-30)
Although regular exercise is associated with reduced cardiometabolic disease risk among overweight adults, it remains unclear whether much of the health benefits of exercise are derived from the most recent session(s) of exercise or if they are the result of...
Daifeng Cheng et al.
Scientific reports, 4, 7489-7489 (2014-12-17)
Reproduction is an important life process in insects; however, few studies have attempted to demonstrate the association between reproductive activity and energy metabolism. To address this problem, we focused on the reproductive changes in Bactrocera dorsalis males. We analyzed B....
Ramu Adela et al.
PloS one, 10(4), e0125270-e0125270 (2015-04-22)
We have previously reported that increased glucose levels were associated with higher serum nitric oxide (NO) levels in fructose-fed insulin resistant rats. However, the relationship between hyperglycemia and serum NO level was not clear. Therefore, the present study was designed...
Ranjith Rajendran et al.
BMC microbiology, 14, 303-303 (2014-12-06)
Biofilm formation by Candida albicans has shown to be highly variable and is directly associated with pathogenicity and poor clinical outcomes in patients at risk. The aim of this study was to test the hypotheses that the extracellular DNA release...
Xiao-Rong Ni et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 271-277 (2014-09-18)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Insulin resistance/hyperinsulinemia is a prevalent finding in women with PCOS, which indicates that insulin resistance/hyperinsulinemia may be an important player in the pathogenesis of the PCOS....
E M Faioni et al.
Thrombosis and haemostasis, 112(6), 1182-1189 (2014-08-12)
Arachidonic acid (AA), when cleaved from phospholipids by cytosolic phospholipase A2 alpha (cPLA2a), generates eicosanoids, with pro-hemostatic, pro-inflammatory, vasoactive and gastro-protective functions. We describe a patient (27-year-old man) and his twin-sister with early-onset bleeding diathesis and recurrent gastro-intestinal (GI) ulcers....
Jianxiong Jiang et al.
Neurobiology of disease, 76, 126-136 (2015-01-21)
As a prominent inflammatory effector of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) mediates brain inflammation and injury in many chronic central nervous system (CNS) conditions including seizures and epilepsy, largely through its receptor subtype EP2. However, EP2 receptor activation might also...
Sima Panahirad et al.
Journal of the science of food and agriculture, 94(9), 1758-1763 (2013-11-26)
One of the most important saprophytic infections in fresh pistachio fruits after harvesting is Aspergillus flavus colonization, which significantly reduces fruit quality. Salicylic acid plays a crucial role in plant tissues and has a suppression effect on some fungi. The...
Youjun Zhang et al.
FEBS letters, 588(20), 3726-3731 (2014-09-01)
Changes in carbon flow and sink/source activities can affect floral, architectural, and reproductive traits of plants. In potato, overexpression (OE) of the purple acid phosphatase 2 of Arabidopsis (AtPAP2) resulted in earlier flowering, faster growth rate, increased tubers and tuber...
Chrissy M Leopold Wager et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4060-4071 (2014-09-10)
Nonprotective immune responses to highly virulent Cryptococcus neoformans strains, such as H99, are associated with Th2-type cytokine production, alternatively activated macrophages, and inability of the host to clear the fungus. In contrast, experimental studies show that protective immune responses against...
K A Taylor et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 987-998 (2014-03-25)
Pannexin-1 (Panx1) forms an anion-selective channel with a permeability up to ~1 kDa and represents a non-lytic, non-vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related connexin gap junction proteins have been reported in platelets; however, the expression and...
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of...
Ioannis A Papaioannou et al.
Current genetics, 60(3), 135-148 (2013-11-22)
Group-I introns are widespread--though irregularly distributed--in eukaryotic organisms, and they have been extensively used for discrimination and phylogenetic analyses. Within the Verticillium genus, which comprises important phytopathogenic fungi, a group-I intron was previously identified in the SSU-rRNA (18S) gene of...
Saunders Handbook of Veterinary Drugs - E-Book: Small and Large Animal (2010)
Jide Tian et al.
PloS one, 6(9), e25338-e25338 (2011-10-04)
Adipocyte and β-cell dysfunction and macrophage-related chronic inflammation are critical for the development of obesity-related insulin resistance and type 2 diabetes mellitus (T2DM), which can be negatively regulated by Tregs. Our previous studies and those of others have shown that...
Meiyan Jiang et al.
PloS one, 9(9), e108941-e108941 (2014-10-01)
Aminoglycoside antibiotics, like gentamicin, continue to be clinically essential worldwide to treat life-threatening bacterial infections. Yet, the ototoxic and nephrotoxic side-effects of these drugs remain serious complications. A major site of gentamicin uptake and toxicity resides within kidney proximal tubules...
Fábio H Silva et al.
The journal of sexual medicine, 11(11), 2661-2670 (2014-09-10)
Cardiovascular and endocrine-metabolic diseases associated with increased oxidative stress such as obesity lead to erectile dysfunction (ED). Activators of soluble guanylyl cyclase (sGC) such as BAY 60-2770 reactivate the heme-oxidized sGC in vascular diseases. This study aimed to evaluate the...
Cong-Fei Xu et al.
Biomaterials, 51, 1-11 (2015-03-17)
Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we report...
V N Titov et al.
Terapevticheskii arkhiv, 82(10), 71-77 (2011-02-24)
If a lot of carbohydrates cannot be in vivo stored as glycogen, the synthesis of palmitic fatty acid (FA) from glucose and its adipocyte deposition as triglycerides are under way in phylogenesis. With impaired biological function of exotrophy (fasting, early...
Shaozhang Hou et al.
International journal of molecular sciences, 15(9), 15026-15043 (2014-08-28)
The aim of this study was to determine the beneficial effect of glycyrrhizic acid (GA) on type 2 diabetic nephropathy using renal tubular epithelial cell line (NRK-52E). The cells are divided into normal group (NG), high glucose group (HG), and...
Daniel P Tonge et al.
PloS one, 9(4), e93849-e93849 (2014-04-15)
Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a proton release sequencing platform with the ability to sequence reads...
Santanu Bhattacharya et al.
PloS one, 9(12), e114409-e114409 (2014-12-04)
GAIP interacting protein C terminus (GIPC) is known to play an important role in a variety of physiological and disease states. In the present study, we have identified a novel role for GIPC as a master regulator of autophagy and...
Harry P Selker et al.
The American journal of cardiology, 113(10), 1599-1605 (2014-05-06)
The Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care Trial of very early intravenous glucose-insulin-potassium (GIK) for acute coronary syndromes (ACS) in out-of-hospital emergency medical service (EMS) settings showed 80% reduction in infarct size at 30...
Zhichun Chen et al.
Progress in neurobiology, 108, 21-43 (2013-07-16)
Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which severely impacts on the global economic development and healthcare system. Though AD has been studied for more than 100 years since 1906, the exact cause(s) and pathogenic mechanism(s) remain to...
Fatemeh Talaei et al.
BMC cell biology, 15, 1-1 (2014-01-08)
Diabetes and particularly high blood glucose levels are implicated in neurodegeneration. One of the hallmarks of neurodegeneration is protein aggregation. We investigated the presence of protein aggregation in the frontal brain of Zucker diabetic fatty (ZDF) rats, an animal model...
页码 1 来自 33
页码 1 来自 33