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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.

Hong-Bo Wang et al.

Nature communications, 6, 6240-6240 (2015-02-12)

Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both

Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion.

Arvind Shakya et al.

Molecular and cellular biology, 35(6), 1014-1025 (2015-01-15)

The mechanisms whereby the crucial pluripotency transcription factor Oct4 regulates target gene expression are incompletely understood. Using an assay system based on partially differentiated embryonic stem cells, we show that Oct4 opposes the accumulation of local H3K9me2 and subsequent Dnmt3a-mediated

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae.

Harsha Garadi Suresh et al.

Molecular biology of the cell, 26(9), 1601-1615 (2015-03-13)

Cells adapt to changing nutrient availability by modulating a variety of processes, including the spatial sequestration of enzymes, the physiological significance of which remains controversial. These enzyme deposits are claimed to represent aggregates of misfolded proteins, protein storage, or complexes

The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling.

Ameera Alsadeq et al.

Journal of immunology (Baltimore, Md. : 1950), 193(1), 268-276 (2014-06-06)

Signal transduction from the BCR is regulated by the equilibrium between kinases (e.g., spleen tyrosine kinase [Syk]) and phosphatases (e.g., Shp-1). Previous studies showed that Syk-deficient B cells have a developmental block at the pro/pre-B cell stage, whereas a B

Characteristics of gintonin-mediated membrane depolarization of pacemaker activity in cultured interstitial cells of Cajal.

Byung Joo Kim et al.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(3), 873-890 (2014-09-10)

Ginseng regulates gastrointestinal (GI) motor activity but the underlying components and molecular mechanisms are unknown. We investigated the effect of gintonin, a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand, on the pacemaker activity of the interstitial cells of

High-throughput determination of citrinin in rice by ultra-high-performance liquid chromatography and fluorescence detection (UHPLC-FL).

José F Huertas-Pérez et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(8), 1352-1357 (2015-07-01)

A rapid, simple and effective method for the determination of citrinin in rice by UHPLC coupled to fluorescence detection has been developed and validated. Extraction of citrinin from rice samples was achieved by applying a QuEChERS-based extraction/partitioning process with water

Subconjunctivally applied naïve Tregs support corneal graft survival in baby rats.

Antonia Hildebrand et al.

Molecular vision, 20, 1749-1757 (2015-01-06)

Corneal transplantation is the most frequent and successful form of tissue transplantation in adults (<10% rejection). In young children, any corneal opacity should be corrected as early as possible to prevent lifelong visual impairment. However, the corneal graft rejection rate

Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.

G Ayranci et al.

Psychopharmacology, 232(11), 1957-1971 (2014-12-09)

Opiate addiction is a brain disorder emerging through repeated intoxication and withdrawal episodes. Epidemiological studies also indicate that chronic exposure to opiates may lead in susceptible individuals to the emergence of depressive symptoms, strongly contributing to the severity and chronicity

Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.

Brendan N Putko et al.

PloS one, 9(6), e99495-e99495 (2014-06-14)

Various pathways have been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFPEF). Inflammation in response to comorbid conditions, such as hypertension and diabetes, may play a proportionally larger role in HFPEF as compared to HF

Circadian control of bile acid synthesis by a KLF15-Fgf15 axis.

Shuxin Han et al.

Nature communications, 6, 7231-7231 (2015-06-05)

Circadian control of nutrient availability is critical to efficiently meet the energetic demands of an organism. Production of bile acids (BAs), which facilitate digestion and absorption of nutrients, is a major regulator of this process. Here we identify a KLF15-Fgf15

Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1.

Milo B Fasken et al.

PLoS genetics, 11(3), e1005044-e1005044 (2015-03-17)

Non-coding RNAs (ncRNAs) play critical roles in gene regulation. In eukaryotic cells, ncRNAs are processed and/or degraded by the nuclear exosome, a ribonuclease complex containing catalytic subunits Dis3 and Rrp6. The TRAMP (Trf4/5-Air1/2-Mtr4 polyadenylation) complex is a critical exosome cofactor

Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis.

Jingwen Song et al.

Molecular and cellular biology, 35(11), 1926-1939 (2015-03-18)

The requirement for alternative splicing during adipogenesis is poorly understood. The Sam68 RNA binding protein is a known regulator of alternative splicing, and mice deficient for Sam68 exhibit adipogenesis defects due to defective mTOR signaling. Sam68 null preadipocytes were monitored

Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease.

Yunhui Peng et al.

International journal of molecular sciences, 16(11), 27270-27287 (2015-11-19)

Mutations in KDM5C gene are linked to X-linked mental retardation, the syndromic Claes-Jensen-type disease. This study focuses on non-synonymous mutations in the KDM5C ARID domain and evaluates the effects of two disease-associated missense mutations (A77T and D87G) and three not-yet-classified

A detailed, conductance-based computer model of intrinsic sensory neurons of the gastrointestinal tract.

Jordan D Chambers et al.

American journal of physiology. Gastrointestinal and liver physiology, 307(5), G517-G532 (2014-07-12)

Intrinsic sensory neurons (ISNs) of the enteric nervous system respond to stimuli such as muscle tension, muscle length, distortion of the mucosa, and the chemical content in the lumen. ISNs form recurrent networks that probably drive many intestinal motor patterns

Changes in hippocampal synaptic functions and protein expression in monosodium glutamate-treated obese mice during development of glucose intolerance.

Sachie Sasaki-Hamada et al.

The European journal of neuroscience, 41(11), 1393-1401 (2015-04-09)

Glucose is the sole neural fuel for the brain and is essential for cognitive function. Abnormalities in glucose tolerance may be associated with impairments in cognitive function. Experimental obese model mice can be generated by an intraperitoneal injection of monosodium

Predictive simulation approach for designing cancer therapeutic regimens with novel biological mechanisms.

Nicole A Doudican et al.

Journal of Cancer, 5(6), 406-416 (2014-05-23)

Introduction Ursolic acid (UA) is a pentacyclic triterpene acid present in many plants, including apples, basil, cranberries, and rosemary. UA suppresses proliferation and induces apoptosis in a variety of tumor cells via inhibition of nuclear factor kappa-light-chain-enhancer of activated B

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

Kirsi Penttinen et al.

PloS one, 10(5), e0125366-e0125366 (2015-05-09)

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from sarcoplasmic reticulum. Dantrolene, an inhibitor of sarcoplasmic Ca(2+) release

Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide during quantification of a cancer biomarker, human osteopontin, from plasma using capillary microflow LC-MS/MS.

Morse Faria et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 156-168 (2015-08-19)

Human osteopontin (hOPN) is a secreted plasma protein which is elevated in various cancers and is indicative of poor prognosis. Here we describe investigations involving an extended peptide internal standard to track an unstable signature peptide followed by further method

Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.

Anaël Chazeau et al.

Molecular biology of the cell, 26(5), 859-873 (2015-01-09)

The morphology of neuronal dendritic spines is a critical indicator of synaptic function. It is regulated by several factors, including the intracellular actin/myosin cytoskeleton and transcellular N-cadherin adhesions. To examine the mechanical relationship between these molecular components, we performed quantitative

Capping hazardous red mud using acidic soil with an embedded layer of zeolite for plant growth.

Yingqun Ma et al.

Environmental technology, 35(17-20), 2314-2321 (2014-08-26)

A nearly three-year microcosm experiment was conducted to test the effectiveness of capping red mud using acidic soil with an embedded layer of zeolite in sustaining the growth of a grass species. This 'sandwich-structured' design allowed self-sustaining growth of the

Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells.

Chutima Kaewpiboon et al.

Molecular medicine reports, 11(3), 2315-2321 (2014-11-15)

Despite efforts to develop efficient chemotherapeutic drug strategies to treat cancer, acquired drug resistance is a commonly encountered problem. In the present study, to investigate this phenomenon, human A549 lung cancer cells resistant to the topoisomerase inhibitor etoposide (A549RT‑eto) were

The C-terminus of tau protein plays an important role in its stability and toxicity.

Junhua Geng et al.

Journal of molecular neuroscience : MN, 55(1), 251-259 (2014-05-03)

The identification of tau fragments generated by proteolysis in the neurons of AD patients and in neurofibrillary tangles encourages research on the toxicity of truncated tau. However, the detailed mechanism underlying the proteolysis-induced toxicity of tau is not clear and

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function.

Anusha Jayaraman et al.

Journal of neuroinflammation, 11, 162-162 (2014-09-17)

Low testosterone and obesity are independent risk factors for dysfunction of the nervous system including neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we investigate the independent and cooperative interactions of testosterone and diet-induced obesity on metabolic, inflammatory

Confocal imaging with a fluorescent bile acid analogue closely mimicking hepatic taurocholate disposition.

Tom De Bruyn et al.

Journal of pharmaceutical sciences, 103(6), 1872-1881 (2014-03-22)

This study aimed to characterize the in vitro hepatic transport mechanisms in primary rat and human hepatocytes of the fluorescent bile acid derivative N-(24-[7-(4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole)]amino-3α,7α,12α-trihydroxy-27-nor-5β-cholestan-26-oyl)-2'-aminoethanesulfonate (tauro-nor-THCA-24-DBD), previously synthesized to study the activity of the bile salt export pump (BSEP). The fluorescent

Wnt5a reverses the inhibitory effect of hyperoxia on transdifferentiation of alveolar epithelial type II cells to type I cells.

Wei Xu et al.

Journal of physiology and biochemistry, 71(4), 823-838 (2015-11-09)

Transdifferentiation of alveolar epithelial type II cells (AECIIs) to type I cells (AECIs) is critical for reestablishment and maintenance of an intact alveolar epithelium. However, this process is frequently destroyed by hyperoxia treatment, which is commonly used in respiratory distress

Robust fabrication of electrospun-like polymer mats to direct cell behaviour.

José Ballester-Beltrán et al.

Biofabrication, 6(3), 035009-035009 (2014-05-29)

Currently, cell culture systems that include nanoscale topography are widely used in order to provide cells additional cues closer to the in vivo environment, seeking to mimic the natural extracellular matrix. Electrospinning is one of the most common techniques to

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.

Suganthi Chittaranjan et al.

Oncotarget, 5(17), 7960-7979 (2014-10-04)

The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromosome

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins.

Marianne S Poruchynsky et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(5), 1571-1576 (2015-01-22)

The paradigm that microtubule-targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but cannot explain MTA activity in slowly growing human cancers. Many preferred cancer regimens combine a MTA with a DNA-damaging agent (DDA). We

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells.

Martin Pesl et al.

Heart and vessels, 29(6), 834-846 (2013-11-22)

In vitro human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can differentiate into functional cardiomyocytes (CMs). Protocols for cardiac differentiation of hESCs and hiPSCs include formation of the three-dimensional cell aggregates called embryoid bodies (EBs). The

AT1R blockade in adverse milieus: role of SMRT and corepressor complexes.

Tejinder Singh et al.

American journal of physiology. Renal physiology, 309(3), F189-F203 (2015-06-19)

ANG II type 1 receptor blockade (AT1R-BLK) is used extensively to slow down the progression of proteinuric kidney diseases. We hypothesized that AT1R-BLK provides podocyte protection through regulation of silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and

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