Merck
Search Within
Applied Filters:
Keyword:'s5761'
Showing 1-30 of 1843 results for "

s5761

" within Papers
Sort by Relevance
Marilis Rodriguez et al.
PloS one, 9(9), e107727-e107727 (2014-09-17)
Human babesiosis is caused by one of several babesial species transmitted by ixodid ticks that have distinct geographical distributions based on the presence of competent animal hosts. The pathology of babesiosis, like malaria, is a consequence of the parasitaemia which
Sandra Milena Bernal Ulloa et al.
Zygote (Cambridge, England), 23(3), 367-377 (2014-01-16)
Cyclic adenosine monophosphate (cAMP) modulators have been used to avoid spontaneous oocyte maturation and concomitantly improve oocyte developmental competence. The current work evaluated the effects of the addition of cAMP modulators forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cilostamide during in vitro maturation
Krishna Gokul et al.
Neurochemical research, 39(7), 1382-1394 (2014-05-17)
Although tomato seeds (an industrial by-product) are known to contain several bioactive compounds, studies describing their health effects are limited. Previously, we evidenced that aqueous extract of tomato seeds (TSE) markedly attenuated rotenone (ROT)-induced oxidative stress and neurotoxicity in Drosophila
Shinya Takada et al.
Cytotechnology, 67(4), 741-747 (2015-04-24)
The generation of a recombinant baculovirus that displays antibody Fab fragments on the surface was investigated. A recombinant baculovirus was engineered so that the heavy chain (Hc; Fd fragment) of a mouse Fab fragment was expressed as a fusion to
Jessey Erath et al.
Antimicrobial agents and chemotherapy, 59(3), 1427-1434 (2014-12-17)
Widespread resistance to most antimalaria drugs in use has prompted the search for novel candidate compounds with activity against Plasmodium asexual blood stages to be developed for treatment. In addition, the current malaria eradication programs require the development of drugs
Narayanan K Narayanan et al.
Cancer medicine, 4(11), 1767-1780 (2015-09-27)
Melinjo (Gnetum gnemon L.) seed extract (MSE) and its active ingredient gnetin C (GC), a resveratrol dimer, have been shown to possess a broad spectrum of pharmacological activities. In this study, we investigated the antitumor activity of MSE and GC
Yann S Mineur et al.
Psychopharmacology, 232(19), 3539-3549 (2015-07-07)
The a2A-noradrenergic agonist guanfacine can decreases stress-induced smoking in female, but not male, human smokers. It is not known whether these effects are due to effects on mood regulation and/or result from nicotinic-cholinergic interactions. The objective of the study was
Melissa Rosso et al.
Oncotarget, 6(33), 34573-34591 (2015-09-30)
A single nucleotide polymorphism (T to G) in the mdm2 P2 promoter, mdm2 SNP309, leads to MDM2 overexpression promoting chemotherapy resistant cancers. Two mdm2 G/G SNP309 cancer cell lines, MANCA and A875, have compromised wild-type p53 that co-localizes with MDM2
C Denoyelle et al.
Cell death & disease, 5, e1445-e1445 (2014-10-10)
We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting
A Troshchynsky et al.
Genes and immunity, 16(6), 388-398 (2015-06-05)
Human terminal deoxynucleotidyl transferase (hTdT) is a DNA polymerase that functions to generate diversity in the adaptive immune system. Here, we focus on the function of naturally occurring single-nucleotide polymorphisms (SNPs) of hTdT to evaluate their role in genetic-generated immune
Isabel Seiquer et al.
Food chemistry, 188, 496-503 (2015-06-05)
Argan oil is becoming increasingly popular in the edible-oil market as a luxury food with healthy properties. This paper analyzes (i) the bioavailability of the polyphenol content and antioxidant properties of extra virgin argan oil (EVA) by the combination of
Geethu Emily Thomas et al.
International journal of oncology, 46(1), 133-146 (2014-10-14)
Microtubule plus‑end‑binding protein (+TIP) EB1 has been shown to be upregulated in breast cancer cells and promote breast tumor growth in vivo. However, its effect on the cellular actions of microtubule‑targeted drugs in breast cancer cells has remained poorly understood. By using cellular
Camille Attané et al.
STAR protocols, 2(3), 100629-100629 (2021-07-09)
Primary human bone marrow adipocytes (BM-Ads) display a specific metabolism that is not recapitulated by in vitro differentiated bone marrow mesenchymal stromal cells. These findings highlight the need for using primary BM-Ads in studies of the metabolic impact of BM-Ads on surrounding
Janani Swaminathan et al.
Journal of liposome research, 24(4), 297-303 (2014-04-09)
The intent of this work was to assess the impact of lyophilization on the encapsulation of salmon calcitonin (sCT) into liposomes. Four different liposomal formulations were investigated, i.e. DPPC:Chol:DSPE-PEG(2000) (75:20:5 and 65:30:5) and DPPC:Chol (80:20 and 66.7:33.3). Lipid films were
Valérie Soulard et al.
Nature communications, 6, 7690-7690 (2015-07-25)
Experimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo. Here we improve on previous protocols to
John J Reho et al.
American journal of physiology. Heart and circulatory physiology, 309(9), H1468-H1478 (2015-09-16)
We examined the effect of stress in the first 2 wk of life induced by brief periods of daily maternal separation on developmental programming of rat small resistance mesenteric arteries (MAs). In MAs of littermate controls, mRNAs encoding mediators of
Yong Fang Zhu et al.
Pflugers Archiv : European journal of physiology, 466(7), 1467-1475 (2013-10-09)
Enteric sensory neurons (the AH neurons) play a role in control of gastrointestinal motor activity; AH neuron activation has been proposed to change propulsion into segmentation. We sought to find a mechanism underlying this phenomenon. We formulated the hypothesis that
Kate M Hatzopoulos et al.
Investigative ophthalmology & visual science, 55(6), 3957-3970 (2014-06-05)
Retinal angiogenesis, neural dysfunction, and microglial activation occur in both humans with retinopathy of prematurity and in animal models of the disease. The aim of this study was to assess whether blockade of the renin-angiotensin system ameliorated these effects in
Kohei Hashimoto et al.
Laboratory investigation; a journal of technical methods and pathology, 95(3), 283-295 (2015-01-13)
Neuroendocrine (NE) cells in prostate cancer have been shown to be associated with the progression of prostate cancer. However, little is known about the molecular basis of this association. We have previously demonstrated that NE cells promote metastasis of a
Siegfried Wagner et al.
Anticancer research, 35(1), 145-148 (2015-01-01)
Canine prostate cancer (PC) is a highly aggressive malignancy. However, in contrast to man, neither standard screening strategies nor curative therapeutic options exist for the companion animal. A prostate-specific membrane antigen (PSMA) screening as molecular marker akin to human PC
Eunice A Varughese et al.
PloS one, 10(11), e0142219-e0142219 (2015-11-12)
The parasite, Cryptosporidium parvum, induces human gastroenteritis through infection of host epithelial cells in the small intestine. During the initial stage of infection, C. parvum is reported to engage host mechanisms at the host cell-parasite interface to form a parasitophorous
Sun-Ah Kim et al.
Experimental cell research, 335(2), 187-196 (2015-05-30)
Epithelial-mesenchymal transition (EMT) acts as a facilitator of metastatic dissemination in the invasive margin of malignant tumors where active tumor-stromal crosstalks take place. Co-cultures of cancer cells with cancer-associated fibroblasts (CAFs) are often used as in vitro models of EMT.
Ju-Ye Ro et al.
SpringerPlus, 4, 17-17 (2015-01-30)
The effects of onion peel extract (OPE) in collagen (5 μg/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited platelet aggregation via inhibition of aggregation-inducing molecules, intracellular Ca(2+) and thromboxane A2 (TXA2) by blocking cyclooxygenase-1 (COX-1) and TXA2 synthase (TXAS) activities
James P K Armstrong et al.
Nature communications, 6, 7405-7405 (2015-06-18)
Restricted oxygen diffusion can result in central cell necrosis in engineered tissue, a problem that is exacerbated when engineering large tissue constructs for clinical application. Here we show that pre-treating human mesenchymal stem cells (hMSCs) with synthetic membrane-active myoglobin-polymer-surfactant complexes
Renata Bocian et al.
Hippocampus, 25(11), 1393-1406 (2015-03-31)
Previous in vivo data suggested that orexin neuropeptides (ORX(A) and ORX(B) ) synthetized in hypothalamic neurons were involved in the mechanism of generation of the hippocampal formation theta rhythm. Surprisingly, this suggestion has never been directly proved by experiments using
T V L Berghof et al.
PloS one, 10(6), e0131088-e0131088 (2015-06-27)
Natural antibodies (NAb) are defined as antibodies present in individuals without known antigenic challenge. Levels of NAb binding keyhole limpet hemocyanin (KLH) in chickens were earlier shown to be heritable, and to be associated with survival. Selective breeding may thus
Smriti Verma et al.
Molecular and cellular biology, 35(17), 2932-2946 (2015-06-24)
Posttranslational modifications (PTMs) can alter many fundamental properties of a protein. One or combinations of them have been known to regulate the dynamics of many cellular pathways and consequently regulate all vital processes. Understandably, pathogens have evolved sophisticated strategies to
Elizabeth J Scharman et al.
The Annals of pharmacotherapy, 47(1), 90-105 (2013-01-18)
To conduct a systematic literature review to evaluate evidence-based recommendations for the prevention of rhabdomyolysis-associated acute renal failure (ARF). PubMed (1966-December 2012), International Pharmaceutical Abstracts, Science Citation Index, and Cochrane databases (1970-December 2012) were searched. There were no language restrictions.
Nicholas J Lodge et al.
Nuclear medicine and biology, 41(6), 524-535 (2014-05-06)
A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a useful tool for neuropsychiatric investigations and the development of drugs intended to interact
Gregory M LaMonte et al.
Nature communications, 11(1), 1780-1780 (2020-04-15)
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent transmission and block infection in animal models.
Page 1 of 62
Page 1 of 62