Search Within
显示 1-30 共 314 条结果 关于 "


" 范围 论文
J F Stover et al.
Journal of neurotrauma, 16(2), 135-142 (1999-03-31)
Glutamate contributes to secondary brain damage, resulting in cell swelling and brain edema. Under in vitro conditions, increased extracellular levels of the amino acid taurine reflect glutamate-induced osmotic cell swelling. In vivo, increases in cerebrospinal fluid (CSF) taurine could, therefore
Mitchell Miglis et al.
Platelets, 13(1), 5-10 (2002-03-29)
It is not yet clear what exact mechanisms are at work in hibernating animals that prevent clot formation and maintain tissue perfusion under conditions of very slow blood flow and increased blood viscosity brought about by the low temperatures. It
Belinda Halling Sørensen et al.
American journal of physiology. Cell physiology, 307(12), C1071-C1080 (2014-09-26)
Cisplatin resistance is a major challenge in the treatment of cancer and develops through reduced drug accumulation and an increased ability to avoid drug-induced cell damage, cell shrinkage, and hence initiation of apoptosis. Uptake and release of the semiessential amino
Márcia M Aranha et al.
PloS one, 6(8), e21396-e21396 (2011-08-23)
MicroRNAs (miRNAs or miRs) participate in the regulation of several biological processes, including cell differentiation. Recently, miR-34a has been implicated in the differentiation of monocyte-derived dendritic cells, human erythroleukemia cells, and mouse embryonic stem cells. In addition, members of the
Joydeep Das et al.
Food & function, 3(12), 1251-1264 (2012-08-30)
Taurine (2-aminoethanesulfonic acid), a conditionally essential amino acid, is found in large concentrations in all mammalian tissues and is particularly abundant in aquatic foods. Taurine exhibits membrane stabilizing, osmoregulatory and cytoprotective effects, antioxidative properties, regulates intracellular Ca(2+) concentration, modulates ion
Y Wu et al.
Clinical and experimental immunology, 179(2), 277-293 (2014-09-18)
The role of NOD-like receptor family (NLRP3) has been confirmed in various inflammatory diseases. The association between NLRP3 and hyper-bileacidaemia during the sepsis remains unclear. We aimed to investigate whether NLRP3 silencing protects against the sepsis-induced hyper-bileacidaemia. Sepsis was induced
Stéphane M Schneider et al.
The British journal of nutrition, 96(2), 365-370 (2006-08-23)
Taurine deficiency in patients on long-term parenteral nutrition may be involved in cholestasis. We aimed to assess plasma taurine and tauro-conjugated bile acids in adults with short-bowel syndrome and their response to intravenous taurine. Thirty-two adult patients, who had been
J T Atosuo et al.
TheScientificWorldJournal, 11, 2382-2390 (2011-12-24)
A recombinant Escherichia coli K-12 strain, transformed with a modified bacterial luciferase gene (luxABCDE) from Photorhabdus luminescens, was constructed in order to monitor the activity of various antimicrobial agents on a real-time basis. This E. coli-lux emitted, without any addition
Matteo Marchesini et al.
Cell chemical biology, 27(6), 678-697 (2020-05-11)
The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the innate toxicity challenge associated with SERCA inhibition, we
Velia Minicozzi et al.
The Journal of biological chemistry, 289(16), 11242-11252 (2014-03-04)
In this work we present and compare the results of extensive molecular dynamics simulations of model systems comprising an Aβ1-40 peptide in water in interaction with short peptides (β-sheet breakers) mimicking the 17-21 region of the Aβ1-40 sequence. Various systems
Ning Wang et al.
Experimental and therapeutic medicine, 2(1), 125-130 (2011-01-01)
The aim of the present study was to determine the chemical composition and in vitro cytotoxic activity of seven bile samples and bile acids using the high-performance liquid chromatography (HPLC)-evaporative light scattering detector (ELSD) method. Free and conjugated bile acid
Matthew Tcheng et al.
Blood, 137(25), 3518-3532 (2021-03-16)
Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increased mitochondrial mass, as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. To exploit this altered metabolism, we assessed publicly available
Deniz Tasdemir et al.
Bioorganic & medicinal chemistry, 15(21), 6834-6845 (2007-09-04)
The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI) enzyme inhibition assay on the n-hexane-, the CHCl(3-) and the aq MeOH extracts of
Zili Ma et al.
Poultry science, 93(7), 1724-1736 (2014-05-09)
To investigate the influence of dietary taurine and reduced housing density on hepatic functions in laying hens, green-shell laying hens were randomly assigned to 3 groups: a free-range group, a caged group with low-density, and a caged group with high-density.
Javier Vaquero et al.
Biochemical pharmacology, 86(7), 926-939 (2013-08-10)
The farnesoid X receptor (FXR) is a key sensor in bile acid homeostasis. Although four human FXR isoforms have been identified, the physiological role of this diversity is poorly understood. Here we investigated their subcellular localization, agonist sensitivity and response
P A LeWitt et al.
Neurology, 42(11), 2111-2117 (1992-11-01)
We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- SD) concentration
[Acamprosate has not proved to be efficient in the treatment of alcoholism in primary care medicine].
Rafik Bouzegaou et al.
Revue medicale suisse, 9(409), 2308-2309 (2014-01-15)
Mario Kofler et al.
Neurocritical care, 23(3), 321-329 (2015-04-22)
Cerebral edema and delayed cerebral infarction (DCI) are common complications after aneurysmal subarachnoid hemorrhage (aSAH) and associated with poor functional outcome. Experimental data suggest that the amino acid taurine is released into the brain extracellular space secondary to cytotoxic edema
The potential health benefits of taurine in cardiovascular disease.
Experimental and Clinical Cardiology, 13(2), 57-65 (2008)
N Itami et al.
Theriogenology, 83(8), 1360-1367 (2015-03-01)
During oocyte growth, the number of mitochondria drastically increases and mitochondrial function profoundly affects the oocyte competence. Resveratrol is a well-known activator of sirtuin 1 (SIRT1), which has a role in cellular energy homeostasis and mitochondrial biogenesis. The main aim
Shaiban Jubair et al.
American journal of physiology. Heart and circulatory physiology, 309(4), H676-H684 (2015-06-14)
Accumulating evidence indicates that substance P is cardioprotective following ischemia-reperfusion primarily due to its potent coronary vasodilator actions. However, an anti-apoptotic effect of substance P has been observed in tenocytes following ischemia, which involved activation of the AKT pathway. This
Elisa Belian et al.
PloS one, 10(6), e0125384-e0125384 (2015-06-06)
Adult cardiac stem cells (CSCs) express many endogenous cardiogenic transcription factors including members of the Gata, Hand, Mef2, and T-box family. Unlike its DNA-binding targets, Myocardin (Myocd)-a co-activator not only for serum response factor, but also for Gata4 and Tbx5-is
Luana Chiquetto Paracatu et al.
Food & function, 6(6), 1818-1831 (2015-05-01)
Nordihydroguaiaretic acid (NDGA) and rosmarinic acid (RA), phenolic compounds found in various plants and functional foods, have known antioxidant and anti-inflammatory properties. In the present study, we comparatively investigated the importance of hydrophobicity and oxidisability of NDGA and RA, regarding
Revital Schick et al.
Investigative ophthalmology & visual science, 61(11), 44-44 (2020-09-30)
Photoreceptor precursor cells (PRPs) differentiated from human embryonic stem cells can serve as a source for cell replacement therapy aimed at vision restoration in patients suffering from degenerative diseases of the outer retina, such as retinitis pigmentosa and AMD. In
Meng Qiao et al.
Biotechnology letters, 37(8), 1579-1584 (2015-05-15)
Taurine (Tau) is used in clinical treatments but its protection of brains against aluminum-induced oxidative damage has been explored for the first time. The positive effect of Tau was studied on the activities of antioxidant enzymes and ATPase. Aluminum (Al)
Janardhan Prasad Bhattarai et al.
Neuroscience letters, 608, 51-56 (2015-10-11)
Taurine is an essential amino-sulfonic acid having a fundamental function in the brain, participating in both cell volume regulation and neurotransmission. Using a whole cell voltage patch clamp technique, the taurine-activated neurotransmitter receptors in the preoptic hypothalamic area (PHA) neurons
[Pharmacological profiles and clinical roles of acamprosate (Regtect(®) tablets 333 mg) for the maintenance of abstinence in alcohol-dependent patients].
Tsuneharu Ohhara et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144(1), 34-41 (2014-07-11)
Maria Walczewska et al.
Przeglad lekarski, 68(6), 334-338 (2011-11-02)
Taurine chloramine (TauCl) is generated at the site of inflammation as a result of reaction of taurine with hypochlorous acid (HOCl), the product of myeloperoxidase-halide system of neutrophils. It has been shown in vitro that TauCl exerts both anti-inflammatory and
S Hu et al.
Wei sheng yan jiu = Journal of hygiene research, 26(2), 98-101 (1997-03-01)
The relationship between taurine and aging of brain neural cells was studied by using primary human fetal brain neural cells cultured in serum-free medium. The results indicated that the activity of superoxide dismutase (SOD) was significantly higher in taurine added
页码 1 来自 11
页码 1 来自 11