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Simone A Beckham et al.
Nucleic acids research, 41(5), 3436-3445 (2013-01-18)
The retinoic acid inducible gene-I (RIG-I)-like family of receptors is positioned at the front line of our innate cellular defence system. RIG-I detects and binds to foreign duplex RNA in the cytoplasm of both immune and non-immune cells, and initiates...
Isabel Gómez et al.
The Biochemical journal, 459(2), 383-396 (2014-01-25)
Cry proteins from Bacillus thuringiensis are insecticidal PFTs (pore-forming toxins). In the present study, we show that two distinct functional pre-pores of Cry1Ab are formed after binding of the protoxin or the protease-activated toxin to the cadherin receptor, but before...
Dibyendu Dana et al.
Bioorganic chemistry, 85, 505-514 (2019-02-26)
Human cathepsin L is a ubiquitously expressed endopeptidase and is known to play critical roles in a wide variety of cellular signaling events. Its overexpression has been implicated in numerous human diseases, including highly invasive forms of cancer. Inhibition of...
Tian-Yu Feng et al.
Oxidative medicine and cellular longevity, 2020, 5954635-5954635 (2021-01-26)
Spermatogonial stem cells (SSCs) are the only adult stem cells that pass genes to the next generation and can be used in assisted reproductive technology and stem cell therapy. SSC cryopreservation is an important method for the preservation of immature...
Thomas L Willett et al.
Annals of biomedical engineering, 35(11), 1961-1972 (2007-09-04)
Presently, there is a lack of fundamental understanding regarding changes in collagen's molecular state due to mechanical damage. The bovine tail tendon (BTT; steers approximately 30 months) was characterized and used as an in vitro model for investigating the effect...
András Szabó et al.
The Journal of biological chemistry, 289(8), 4753-4761 (2014-01-10)
Human cationic trypsinogen, precursor of the digestive enzyme trypsin, can be rapidly degraded to protect the pancreas when pathological conditions threaten, while trypsin itself is impressively resistant to degradation. For either form, degradation is controlled by two necessary initial proteolytic...
Mian Zhou et al.
Nature, 495(7439), 111-115 (2013-02-19)
Codon-usage bias has been observed in almost all genomes and is thought to result from selection for efficient and accurate translation of highly expressed genes. Codon usage is also implicated in the control of transcription, splicing and RNA structure. Many...
Xiao-Li Zhang et al.
Die Pharmazie, 68(12), 951-954 (2014-01-10)
We previously showed that Adh1p participates in fluconazole (FLC) resistance in Candida albicans through a mechanism that may involve efflux pumps. We also found that the concomitant use of tetrandrine (TET) and FLC provided a synergistic action against C. albicans...
J S Yokhana et al.
Poultry science, 95(3), 550-559 (2015-11-18)
Two experiments were conducted to study effects of dietary insoluble fiber (IF) on digestive enzyme function in layer poultry. In Experiment 1, 8 wk old pullets were fed a control diet (Group C) or a diet (Group IF) supplemented with...
Jeffrey R Whiteaker et al.
Molecular & cellular proteomics : MCP, 10(4), M110-M110 (2011-01-20)
Stable isotope standards and capture by antipeptide antibodies (SISCAPA) couples affinity enrichment of peptides with stable isotope dilution and detection by multiple reaction monitoring mass spectrometry to provide quantitative measurement of peptides as surrogates for their respective proteins. In this...
Joshua K Endow et al.
PloS one, 11(12), e0167802-e0167802 (2016-12-10)
PolyGly is present in many proteins in various organisms. One example is found in a transmembrane β-barrel protein, translocon at the outer-envelope-membrane of chloroplasts 75 (Toc75). Toc75 requires its N-terminal extension (t75) for proper localization. t75 comprises signals for chloroplast...
Xuemei Li et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(3), 284-286 (2013-05-07)
To identify the epitope of von Willebrand factor (vWF) recognized by monoclonal antibody SZ-125 (mAb SZ-125) using immune-affinity matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) assay in combination with peptide synthesis and amino acid site-mutagenesis technology. Recombinant vWF A3...
Shilpa Gadwal et al.
The Journal of biological chemistry, 289(12), 8288-8298 (2014-01-25)
The chymotrypsin subfamily A of serine proteases consists primarily of eukaryotic proteases, including only a few proteases of bacterial origin. VesB, a newly identified serine protease that is secreted by the type II secretion system in Vibrio cholerae, belongs to...
Zhipeng Su et al.
Molecular cancer therapeutics, 18(1), 100-111 (2018-10-27)
Receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) play crucial roles in many human malignancies. Numerous drugs have been developed against kinase center of MET or HGF-mediated activation; however, the outcomes in patients are not so promising....
Kristina Nyström et al.
PLoS pathogens, 7(8), e1002188-e1002188 (2011-09-09)
Rabbit Hemorrhagic disease virus (RHDV), a calicivirus of the Lagovirus genus, and responsible for rabbit hemorrhagic disease (RHD), kills rabbits between 48 to 72 hours post infection with mortality rates as high as 50-90%. Caliciviruses, including noroviruses and RHDV, have...
Heike Weber et al.
Canadian journal of physiology and pharmacology, 92(3), 215-225 (2014-03-07)
The pathogenesis of acute pancreatitis (AP) is still poorly understood. Thus, a reliable pharmacological therapy is currently lacking. In recent years, an impairment of the energy metabolism of pancreatic acinar cells, caused by Ca(2+)-mediated depolarization of the inner mitochondrial membrane...
D F Jelinek et al.
Journal of immunology (Baltimore, Md. : 1950), 139(4), 1005-1013 (1987-08-15)
Human peripheral blood, spleen, and lymph node B cells were stimulated with Cowan I Staphylococcus aureus (SA) or F(ab')2 fragments of anti-mu antibody (anti-mu) and various lymphokines and were analyzed for proliferation and generation of Ig-secreting cells (ISC). SA alone...
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Eitan Erez Zahavi et al.
Science signaling, 11(529) (2018-05-10)
Tropomyosin-related tyrosine kinase B (TrkB) is the receptor for brain-derived neurotrophic factor (BDNF) and provides critical signaling that supports the development and function of the mammalian nervous system. Like other receptor tyrosine kinases (RTKs), TrkB is thought to signal as...
N N Kostin et al.
Fish & shellfish immunology, 81, 99-107 (2018-07-15)
Serpins are a family of serine protease inhibitors that are involved in numerous physiological processes and are known to regulate innate immunity pathways. To advance our understanding of their role in P. camtschaticus, a commercially significant species, we cloned and...
Caterina Peña et al.
Tissue & cell, 54, 72-79 (2018-10-13)
The up-regulation of HLA antigens is important during heart inflammatory events and myofibroblasts may modulate the expression of this molecule in tissues. To test this possibility, the effect of cardiac myofibroblast:macrophage contact and the production of myofibroblast inhibitor factor(s) on...
Oleg V Petrov et al.
Magnetic resonance in medicine, 81(5), 2858-2868 (2018-12-12)
The multi-exponential character of T1 relaxation in bovine articular cartilage was investigated at low magnetic fields below 0.5 T. The ultimate aim was to identify a parameter based on the T1 relaxation time distribution as a biomarker to biochemical features...
Sarah Melissa P Jacobo et al.
Molecular and cellular biology, 33(10), 1976-1990 (2013-03-13)
Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report that two common...
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Oliver R B Thomas et al.
The FEBS journal, 286(1), 66-81 (2018-12-07)
The mechanisms that underpin the formation, growth and composition of otoliths, the biomineralized stones in the inner ear of fish, are largely unknown, as only a few fish inner ear proteins have been reported. Using a partial transcriptome for the...
Jaroslav Hollý et al.
Journal of virological methods, 247, 107-113 (2017-06-15)
Infections caused by highly variable influenza A viruses (IAVs) pose perpetual threat to humans as well as to animals. Their surveillance requires reliable methods for their qualitative and quantitative analysis. The most frequently utilized quantification method is the titration by...
Chuanming Xu et al.
American journal of physiology. Renal physiology, 313(3), F641-F656 (2016-07-22)
(Pro)renin receptor (PRR) is highly expressed in the distal nephron, but it has an unclear functional implication. The present study was conducted to explore a potential role of renal PRR during high K+ (HK) loading. In normal Sprague-Dawley rats, a...
Xinhua Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6741-6756 (2020-04-01)
The intervertebral disc degeneration (IVDD)-related diseases occur in more than 90% of the population older than 50 years. Owing to the lack of understanding of the cellular mechanisms involved in IVDD formation effective treatment options are still unavailable. Primary cilia are...
Bram Van Den Eeckhout et al.
NPJ vaccines, 5, 64-64 (2020-07-28)
Annual administration and reformulation of influenza vaccines is required for protection against seasonal infections. However, the induction of strong and long-lasting T cells is critical to reach broad and potentially lifelong antiviral immunity. The NLRP3 inflammasome and its product interleukin-1β...
M D Glew et al.
Infection and immunity, 68(8), 4539-4548 (2000-07-19)
A family of abundant surface proteins (Vpmas [variable proteins of Mycoplasma agalactiae]) undergoing phase variation in M. agalactiae has been characterized using monoclonal antibodies and specific polyclonal sera. Two expressed members of 39 kDa (Vpma39) and 34 kDa (Vpma34), which...
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